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Martin O. Leach
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Journal Articles

Noninvasive Imaging of Cycling Hypoxia in Head and Neck Cancer Using Intrinsic Susceptibility MRI

Rafal Panek, Liam Welsh, Lauren C.J. Baker, Maria A. Schmidt, Kee H. Wong, Angela M. Riddell, Dow-Mu Koh, Alex Dunlop, Dualta Mcquaid, James A. d'Arcy, Shreerang A. Bhide, Kevin J. Harrington, Christopher M. Nutting, Georgina Hopkinson, Cheryl Richardson, Carol Box, Suzanne A. Eccles, Martin O. Leach, Simon P. Robinson, Kate L. Newbold
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (15): 4233–4241.
https://doi.org/10.1158/1078-0432.CCR-16-1209
Published: 01 August 2017
View articletitled, Noninvasive Imaging of Cycling Hypoxia in Head and Neck Cancer Using Intrinsic Susceptibility MRI
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Includes: Supplementary data
Journal Articles

Interrogating Two Schedules of the AKT Inhibitor MK-2206 in Patients with Advanced Solid Tumors Incorporating Novel Pharmacodynamic and Functional Imaging Biomarkers

Timothy A. Yap, Li Yan, Amita Patnaik, Nina Tunariu, Andrea Biondo, Ivy Fearen, Kyriakos P. Papadopoulos, David Olmos, Richard Baird, Liliana Delgado, Ernestina Tetteh, Robert A. Beckman, Lisa Lupinacci, Ruth Riisnaes, Shaun Decordova, Simon P. Heaton, Karen Swales, Nandita M. deSouza, Martin O. Leach, Michelle D. Garrett, Daniel M. Sullivan, Johann S. de Bono, Anthony W. Tolcher
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (22): 5672–5685.
https://doi.org/10.1158/1078-0432.CCR-14-0868
Published: 13 November 2014
View articletitled, Interrogating Two Schedules of the AKT Inhibitor MK-2206 in Patients with Advanced Solid Tumors Incorporating Novel Pharmacodynamic and Functional Imaging Biomarkers
Open the PDF for Interrogating Two Schedules of the AKT Inhibitor MK-2206 in Patients with Advanced Solid Tumors Incorporating Novel Pharmacodynamic and Functional Imaging Biomarkers in another window
Includes: Supplementary data
Journal Articles

Minimally invasive pharmacokinetic and pharmacodynamic technologies in hypothesis-testing clinical trials of innovative therapies: experience and recommendations

Paul Workman, Hayley Farmer, Eric O. Aboagye, Yuen L. Chung, John R. Griffiths, Rachel Hart, Martin O. Leach, Ross J. Maxwell, Paul M. McSheehy, Pat M. Price, Jamal Zweit
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (19_Supplement): B73.
Published: 15 August 2014
View articletitled, Minimally invasive pharmacokinetic and pharmacodynamic technologies in hypothesis-testing clinical trials of innovative therapies: experience and recommendations
Journal Articles

Abstract B61: Picropodophyllin (PPP) increases glucose metabolism and lactate production in paediatric glioblastoma cells

Anne-Christine Wong Te Fong, Thomas R. Eykyn, Harry G. Parkes, Aleksandra Bielen, Chris Jones, Ian R. Judson, John R. Griffiths, Martin O. Leach, Yuen-Li Chung
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (10_Supplement): B61.
https://doi.org/10.1158/1078-0432.MECHRES-B61
Published: 04 March 2013
View articletitled, Abstract B61: Picropodophyllin (PPP) increases glucose metabolism and lactate production in paediatric glioblastoma cells
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Journal Articles

First-in-Human Phase I Trial of Two Schedules of OSI-930, a Novel Multikinase Inhibitor, Incorporating Translational Proof-of-Mechanism Studies

Timothy A. Yap, Hendrik-Tobias Arkenau, D. Ross Camidge, Suzanne George, Natalie J. Serkova, Stephen J. Gwyther, Jennifer L. Spratlin, Rohit Lal, James Spicer, Nandita M. Desouza, Martin O. Leach, Jon Chick, Srinivasu Poondru, Ramesh Boinpally, Richard Gedrich, Katie Brock, Andrew Stephens, S. Gail Eckhardt, Stan B. Kaye, George Demetri, Michelle Scurr
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (4): 909–919.
https://doi.org/10.1158/1078-0432.CCR-12-2258
Published: 14 February 2013
View articletitled, First-in-Human Phase I Trial of Two Schedules of OSI-930, a Novel Multikinase Inhibitor, Incorporating Translational Proof-of-Mechanism Studies
Open the PDF for First-in-Human Phase I Trial of Two Schedules of OSI-930, a Novel Multikinase Inhibitor, Incorporating Translational Proof-of-Mechanism Studies in another window
Includes: Supplementary data
Journal Articles

Phase I Trial of Combretastatin A4 Phosphate (CA4P) in Combination with Bevacizumab in Patients with Advanced Cancer

Paul Nathan, Martin Zweifel, Anwar R. Padhani, Dow-Mu Koh, Matthew Ng, David J. Collins, Adrian Harris, Craig Carden, Jon Smythe, Nita Fisher, N. Jane Taylor, J. James Stirling, Shiao-Ping Lu, Martin O. Leach, Gordon J.S. Rustin, Ian Judson
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (12): 3428–3439.
https://doi.org/10.1158/1078-0432.CCR-11-3376
Published: 14 June 2012
View articletitled, Phase I Trial of Combretastatin A4 Phosphate (CA4P) in Combination with Bevacizumab in Patients with Advanced Cancer
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Journal Articles

BRCA1 Mutation and Young Age Predict Fast Breast Cancer Growth in the Dutch, United Kingdom, and Canadian Magnetic Resonance Imaging Screening Trials

Madeleine M.A. Tilanus-Linthorst, Inge-Marie Obdeijn, Wim C.J. Hop, Petrina A. Causer, Martin O. Leach, Ellen Warner, Linda Pointon, Kimberley Hill, Jan G.M. Klijn, Ruth M.L. Warren, Fiona J. Gilbert
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (24): 7357–7362.
https://doi.org/10.1158/1078-0432.CCR-07-0689
Published: 19 December 2007
View articletitled, BRCA1 Mutation and Young Age Predict Fast Breast Cancer Growth in the Dutch, United Kingdom, and Canadian Magnetic Resonance Imaging Screening Trials
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Journal Articles

Noninvasive Measurements of Capecitabine Metabolism in Bladder Tumors Overexpressing Thymidine Phosphorylase by Fluorine-19 Magnetic Resonance Spectroscopy

Yuen-Li Chung, Helen Troy, Ian R. Judson, Russell Leek, Martin O. Leach, Marion Stubbs, Adrian L. Harris, John R. Griffiths
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (11): 3863–3870.
https://doi.org/10.1158/1078-0432.CCR-03-0237
Published: 01 June 2004
View articletitled, Noninvasive Measurements of Capecitabine Metabolism in Bladder Tumors Overexpressing Thymidine Phosphorylase by Fluorine-19 Magnetic Resonance Spectroscopy
Open the PDF for Noninvasive Measurements of Capecitabine Metabolism in Bladder Tumors Overexpressing Thymidine Phosphorylase by Fluorine-19 Magnetic Resonance Spectroscopy in another window
Journal Articles

A Phase I Study of SR-4554 via Intravenous Administration for Noninvasive Investigation of Tumor Hypoxia by Magnetic Resonance Spectroscopy in Patients with Malignancy

Beatrice M. Seddon, Geoffrey S. Payne, Laura Simmons, Ruth Ruddle, Rachel Grimshaw, Siew Tan, Alison Turner, Florence Raynaud, Gavin Halbert, Martin O. Leach, Ian Judson, Paul Workman
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (14): 5101–5112.
Published: 12 November 2003
View articletitled, A Phase I Study of SR-4554 via Intravenous Administration for Noninvasive Investigation of Tumor Hypoxia by Magnetic Resonance Spectroscopy in Patients with Malignancy
Open the PDF for A Phase I Study of SR-4554 via Intravenous Administration for Noninvasive Investigation of Tumor Hypoxia by Magnetic Resonance Spectroscopy in Patients with Malignancy in another window