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Martin E. Gleave
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Journal Articles

Evolution of Castration-Resistant Prostate Cancer in ctDNA during Sequential Androgen Receptor Pathway Inhibition

Matti Annala, Sinja Taavitsainen, Daniel J. Khalaf, Gillian Vandekerkhove, Kevin Beja, Joonatan Sipola, Evan W. Warner, Cameron Herberts, Amanda Wong, Simon Fu, Daygen L. Finch, Conrad D. Oja, Joanna Vergidis, Muhammad Zulfiqar, Bernhard J. Eigl, Christian K. Kollmansberger, Matti Nykter, Martin E. Gleave, Kim N. Chi, Alexander W. Wyatt
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (16): 4610–4623.
https://doi.org/10.1158/1078-0432.CCR-21-1625
Published: 15 August 2021
View article titled, Evolution of Castration-Resistant Prostate Cancer in ctDNA during Sequential Androgen Receptor Pathway Inhibition
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Includes: Supplementary data
Journal Articles

Abstract A18: Plasma circulating tumor DNA is scarce and confounded by clonal hematopoiesis in metastatic renal cell carcinoma

Jack V. W. Bacon, Matti Annala, Maryam Soleimani, Jean-Michel Lavoie, Alan I. So, Martin E. Gleave, Ladan Fazli, Kim N. Chi, Christian K. Kollmannsberger, Alexander W. Wyatt, Lucia Nappi
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (11_Supplement): A18.
https://doi.org/10.1158/1557-3265.LiqBiop20-A18
Published: 01 June 2020
View article titled, Abstract A18: Plasma circulating tumor DNA is scarce and confounded by clonal hematopoiesis in metastatic renal cell carcinoma
Journal Articles

Abstract A24: Identifying the genomic and clinical features of AKT1/PIK3CA mutant metastatic prostate cancer using circulating tumor DNA

Cameron M. Herberts, Andrew J. Murtha, Simon Fu, Gang Wang, Elena Schönlau, Anna Gleave, Steven Yip, Arkhjamil Angeles, Sebastien Hotte, Abdulraheem Alshangiti, Ben Tran, Scott North, Sinja Taavitsainen, Kevin Beja, Gillian Vandekerkhove, Elie Ritch, Fred Saad, Nayyer Iqbal, Martin E. Gleave, Matti Annala, Kim N. Chi, Alexander W. Wyatt
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (11_Supplement): A24.
https://doi.org/10.1158/1557-3265.LiqBiop20-A24
Published: 01 June 2020
View article titled, Abstract A24: Identifying the genomic and clinical features of AKT1/PIK3CA mutant metastatic prostate cancer using circulating tumor DNA
Journal Articles

Transient Sox9 Expression Facilitates Resistance to Androgen-Targeted Therapy in Prostate Cancer

Mannan Nouri, Shabnam Massah, Josselin Caradec, Amy A. Lubik, Na Li, Sarah Truong, Ahn R. Lee, Ladan Fazli, Varune R. Ramnarine, Jessica M. Lovnicki, Jackson Moore, Mike Wang, Jane Foo, Martin E. Gleave, Brett G. Hollier, Colleen Nelson, Colin Collins, Xuesen Dong, Ralph Buttyan
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (7): 1678–1689.
https://doi.org/10.1158/1078-0432.CCR-19-0098
Published: 01 April 2020
View article titled, Transient Sox9 Expression Facilitates Resistance to Androgen-Targeted Therapy in Prostate Cancer
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Includes: Supplementary data
Journal Articles

Impact of Therapy on Genomics and Transcriptomics in High-Risk Prostate Cancer Treated with Neoadjuvant Docetaxel and Androgen Deprivation Therapy

Himisha Beltran, Alexander W. Wyatt, Edmund C. Chedgy, Adam Donoghue, Matti Annala, Evan W. Warner, Kevin Beja, Michael Sigouros, Fan Mo, Ladan Fazli, Colin C. Collins, James Eastham, Michael Morris, Mary-Ellen Taplin, Andrea Sboner, Susan Halabi, Martin E. Gleave
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (22): 6802–6811.
https://doi.org/10.1158/1078-0432.CCR-17-1034
Published: 14 November 2017
View article titled, Impact of Therapy on Genomics and Transcriptomics in High-Risk Prostate Cancer Treated with Neoadjuvant Docetaxel and Androgen Deprivation Therapy
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Includes: Supplementary data
Journal Articles

Neoadjuvant Enzalutamide Prior to Prostatectomy

Bruce Montgomery, Maria S. Tretiakova, Anthony M. Joshua, Martin E. Gleave, Neil Fleshner, Glenn J. Bubley, Elahe A. Mostaghel, Kim N. Chi, Daniel W. Lin, Martin Sanda, William Novotny, Kenneth Wu, Philip W. Kantoff, Brett T. Marck, Stephen Plymate, Steven P. Balk, Peter S. Nelson, Alvin M. Matsumoto, Rosina T. Lis, Adam Kibel, Gabriel P. Haas, Andrew Krivoshik, Alison Hannah, Mary-Ellen Taplin
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (9): 2169–2176.
https://doi.org/10.1158/1078-0432.CCR-16-1357
Published: 30 April 2017
View article titled, Neoadjuvant Enzalutamide Prior to Prostatectomy
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Includes: Supplementary data
Journal Articles

BIRC6 Targeting as Potential Therapy for Advanced, Enzalutamide-Resistant Prostate Cancer

Iris Sze Ue Luk, Raunak Shrestha, Hui Xue, Yuwei Wang, Fang Zhang, Dong Lin, Anne Haegert, Rebecca Wu, Xin Dong, Colin C. Collins, Amina Zoubeidi, Martin E. Gleave, Peter W. Gout, Yuzhuo Wang
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (6): 1542–1551.
https://doi.org/10.1158/1078-0432.CCR-16-0718
Published: 14 March 2017
View article titled, <em>BIRC6</em> Targeting as Potential Therapy for Advanced, Enzalutamide-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

The MCT4 Gene: A Novel, Potential Target for Therapy of Advanced Prostate Cancer

Stephen Yiu Chuen Choi, Hui Xue, Rebecca Wu, Ladan Fazli, Dong Lin, Colin C. Collins, Martin E. Gleave, Peter W. Gout, Yuzhuo Wang
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (11): 2721–2733.
https://doi.org/10.1158/1078-0432.CCR-15-1624
Published: 31 May 2016
View article titled, The <em>MCT4</em> Gene: A Novel, Potential Target for Therapy of Advanced Prostate Cancer
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Includes: Supplementary data
Journal Articles

Abstract A39: A newly defined role of clusterin in the formation of exosomes derived from prostate cancer cells

Elham Hosseini-Beheshti, Amina Zoubeidi, Ka Mun Nip, Martin E. Gleave, Emma S. Guns
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (7_Supplement): A39.
https://doi.org/10.1158/1078-0432.TCME10-A39
Published: 02 February 2016
View article titled, Abstract A39: A newly defined role of clusterin in the formation of exosomes derived from prostate cancer cells
Journal Articles

Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer

Arun A. Azad, Stanislav V. Volik, Alexander W. Wyatt, Anne Haegert, Stephane Le Bihan, Robert H. Bell, Shawn A. Anderson, Brian McConeghy, Robert Shukin, Jenny Bazov, Jack Youngren, Pamela Paris, George Thomas, Eric J. Small, Yuzhuo Wang, Martin E. Gleave, Colin C. Collins, Kim N. Chi
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (10): 2315–2324.
https://doi.org/10.1158/1078-0432.CCR-14-2666
Published: 14 May 2015
View article titled, Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Abstract A12: Identification of pathways associated with abiraterone resistance in metastatic castration resistant prostate cancer: Preliminary results from the SU2C/AACR West Coast Prostate Cancer Dream Team

Jack F. Youngren, Adam Foye, George Thomas, Joshua M. Stuart, Ted Goldstein, Baertsch Robert, Adrian Bivol, Artem Sokolov, Charles J. Ryan, Nader Pourmand, Tomasz M. Beer, Christopher P. Evans, Christopher P. Evans, Primo Lara, Jr., Martin E. Gleave, Kim N. Chi, Robert E. Reiter, Matthew Rettig, Owen Witte, Eric J. Small
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (4_Supplement): A12.
https://doi.org/10.1158/1557-3265.PMS14-A12
Published: 13 February 2015
View article titled, Abstract A12: Identification of pathways associated with abiraterone resistance in metastatic castration resistant prostate cancer: Preliminary results from the SU2C/AACR West Coast Prostate Cancer Dream Team
Journal Articles

Aggressive Variants of Castration-Resistant Prostate Cancer

Himisha Beltran, Scott Tomlins, Ana Aparicio, Vivek Arora, David Rickman, Gustavo Ayala, Jiaoti Huang, Lawrence True, Martin E. Gleave, Howard Soule, Christopher Logothetis, Mark A. Rubin
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (11): 2846–2850.
https://doi.org/10.1158/1078-0432.CCR-13-3309
Published: 29 May 2014
View article titled, Aggressive Variants of Castration-Resistant Prostate Cancer
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Journal Articles

Urinary TMPRSS2:ERG and PCA3 in an Active Surveillance Cohort: Results from a Baseline Analysis in the Canary Prostate Active Surveillance Study

Daniel W. Lin, Lisa F. Newcomb, Elissa C. Brown, James D. Brooks, Peter R. Carroll, Ziding Feng, Martin E. Gleave, Raymond S. Lance, Martin G. Sanda, Ian M. Thompson, John T. Wei, Peter S. Nelson, for the Canary Prostate Active Surveillance Study Investigators
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (9): 2442–2450.
https://doi.org/10.1158/1078-0432.CCR-12-3283
Published: 30 April 2013
View article titled, Urinary TMPRSS2:ERG and PCA3 in an Active Surveillance Cohort: Results from a Baseline Analysis in the Canary Prostate Active Surveillance Study
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Includes: Supplementary data
Journal Articles

Blocked Autophagy Using Lysosomotropic Agents Sensitizes Resistant Prostate Tumor Cells to the Novel Akt Inhibitor AZD5363

Francois Lamoureux, Christian Thomas, Claire Crafter, Masafumi Kumano, Fan Zhang, Barry R. Davies, Martin E. Gleave, Amina Zoubeidi
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (4): 833–844.
https://doi.org/10.1158/1078-0432.CCR-12-3114
Published: 14 February 2013
View article titled, Blocked Autophagy Using Lysosomotropic Agents Sensitizes Resistant Prostate Tumor Cells to the Novel Akt Inhibitor AZD5363
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Includes: Supplementary data
Journal Articles

A Phase II Pharmacodynamic Study of Preoperative Figitumumab in Patients with Localized Prostate Cancer

Kim N. Chi, Martin E. Gleave, Ladan Fazli, S. Larry Goldenberg, Alan So, Christian Kollmannsberger, Nevin Murray, Anna Tinker, Michael Pollak
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (12): 3407–3413.
https://doi.org/10.1158/1078-0432.CCR-12-0482
Published: 14 June 2012
View article titled, A Phase II Pharmacodynamic Study of Preoperative Figitumumab in Patients with Localized Prostate Cancer
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Journal Articles

In vivo Evaluation of Mucoadhesive Nanoparticulate Docetaxel for Intravesical Treatment of Non–Muscle-Invasive Bladder Cancer

Clement Mugabe, Yoshiyuki Matsui, Alan I. So, Martin E. Gleave, Jennifer H. E. Baker, Andrew I. Minchinton, Irina Manisali, Richard Liggins, Donald E. Brooks, Helen M. Burt
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (9): 2788–2798.
https://doi.org/10.1158/1078-0432.CCR-10-2981
Published: 01 May 2011
View article titled, <em>In vivo</em> Evaluation of Mucoadhesive Nanoparticulate Docetaxel for Intravesical Treatment of Non–Muscle-Invasive Bladder Cancer
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Includes: Supplementary data
Journal Articles

A Novel HSP90 Inhibitor Delays Castrate-Resistant Prostate Cancer without Altering Serum PSA Levels and Inhibits Osteoclastogenesis

Francois Lamoureux, Christian Thomas, Min-Jean Yin, Hidetoshi Kuruma, Ladan Fazli, Martin E. Gleave, Amina Zoubeidi
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (8): 2301–2313.
https://doi.org/10.1158/1078-0432.CCR-10-3077
Published: 14 April 2011
View article titled, A Novel HSP90 Inhibitor Delays Castrate-Resistant Prostate Cancer without Altering Serum PSA Levels and Inhibits Osteoclastogenesis
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Includes: Supplementary data
Journal Articles

In vivo Knockdown of the Androgen Receptor Results in Growth Inhibition and Regression of Well-Established, Castration-Resistant Prostate Tumors

Robert Snoek, Helen Cheng, Katia Margiotti, Latif A. Wafa, Charmaine A. Wong, Erica Chan Wong, Ladan Fazli, Colleen C. Nelson, Martin E. Gleave, Paul S. Rennie
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (1): 39–47.
https://doi.org/10.1158/1078-0432.CCR-08-1726
Published: 31 December 2008
View article titled, <em>In vivo</em> Knockdown of the Androgen Receptor Results in Growth Inhibition and Regression of Well-Established, Castration-Resistant Prostate Tumors
Open the PDF for <em>In vivo</em> Knockdown of the Androgen Receptor Results in Growth Inhibition and Regression of Well-Established, Castration-Resistant Prostate Tumors in another window
Includes: Supplementary data
Journal Articles

GLI2 Knockdown Using an Antisense Oligonucleotide Induces Apoptosis and Chemosensitizes Cells to Paclitaxel in Androgen-Independent Prostate Cancer

Shintaro Narita, Alan So, Susan Ettinger, Norihiro Hayashi, Mototsugu Muramaki, Ladan Fazli, Youngsoo Kim, Martin E. Gleave
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (18): 5769–5777.
https://doi.org/10.1158/1078-0432.CCR-07-4282
Published: 14 September 2008
View article titled, GLI2 Knockdown Using an Antisense Oligonucleotide Induces Apoptosis and Chemosensitizes Cells to Paclitaxel in Androgen-Independent Prostate Cancer
Open the PDF for GLI2 Knockdown Using an Antisense Oligonucleotide Induces Apoptosis and Chemosensitizes Cells to Paclitaxel in Androgen-Independent Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Intravesical Chemotherapy of High-Grade Bladder Cancer with HTI-286, A Synthetic Analogue of the Marine Sponge Product Hemiasterlin

Boris A. Hadaschik, Hans Adomat, Ladan Fazli, Yves Fradet, Raymond J. Andersen, Martin E. Gleave, Alan I. So
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (5): 1510–1518.
https://doi.org/10.1158/1078-0432.CCR-07-4475
Published: 03 March 2008
View article titled, Intravesical Chemotherapy of High-Grade Bladder Cancer with HTI-286, A Synthetic Analogue of the Marine Sponge Product Hemiasterlin
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