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Mark W. Dewhirst
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Journal Articles

Long-term Consequences of Pelvic Irradiation: Toxicities, Challenges, and Therapeutic Opportunities with Pharmacologic Mitigators

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Jung Wook Huh, Jarred Tanksley, Junzo Chino, Christopher G. Willett, Mark W. Dewhirst
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13): 3079–3090.
https://doi.org/10.1158/1078-0432.CCR-19-2744
Published: 01 July 2020
View articletitled, Long-term Consequences of Pelvic Irradiation: Toxicities, Challenges, and Therapeutic Opportunities with Pharmacologic Mitigators
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Includes: Supplementary data
Journal Articles

Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials

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C. Norman Coleman, Geoff S. Higgins, J. Martin Brown, Michael Baumann, David G. Kirsch, Henning Willers, Pataje G.S. Prasanna, Mark W. Dewhirst, Eric J. Bernhard, Mansoor M. Ahmed
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (13): 3138–3147.
https://doi.org/10.1158/1078-0432.CCR-16-0069
Published: 30 June 2016
View articletitled, Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials
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Includes: Supplementary data
Journal Articles

Bevacizumab-Induced Alterations in Vascular Permeability and Drug Delivery: A Novel Approach to Augment Regional Chemotherapy for In-Transit Melanoma

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Ryan S. Turley, Andrew N. Fontanella, James C. Padussis, Hiroaki Toshimitsu, Yoshihiro Tokuhisa, Eugenia H. Cho, Gabi Hanna, Georgia M. Beasley, Christina K. Augustine, Mark W. Dewhirst, Douglas S. Tyler
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (12): 3328–3339.
https://doi.org/10.1158/1078-0432.CCR-11-3000
Published: 14 June 2012
View articletitled, Bevacizumab-Induced Alterations in Vascular Permeability and Drug Delivery: A Novel Approach to Augment Regional Chemotherapy for In-Transit Melanoma
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Includes: Supplementary data
Journal Articles

Comparison of Genomics and Functional Imaging from Canine Sarcomas Treated with Thermoradiotherapy Predicts Therapeutic Response and Identifies Combination Therapeutics

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Jen-Tsan Chi, Donald E. Thrall, Chen Jiang, Stacey Snyder, Diane Fels, Chelsea Landon, Linda McCall, Lan Lan, Marlene Hauck, James R. MacFall, Benjamin L. Viglianti, Mark W. Dewhirst
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (8): 2549–2560.
https://doi.org/10.1158/1078-0432.CCR-10-2583
Published: 14 April 2011
View articletitled, Comparison of Genomics and Functional Imaging from Canine Sarcomas Treated with Thermoradiotherapy Predicts Therapeutic Response and Identifies Combination Therapeutics
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Includes: Supplementary data
Journal Articles

Dynamic Contrast-enhanced Magnetic Resonance Imaging as a Predictor of Clinical Outcome in Canine Spontaneous Soft Tissue Sarcomas Treated with Thermoradiotherapy

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Benjamin L. Viglianti, Michael Lora-Michiels, Jeanie M. Poulson, Lan Lan, Dahio Yu, Linda Sanders, Oana Craciunescu, Zeljko Vujaskovic, Donald E. Thrall, James MacFall, Cecil H. Charles, Terence Wong, Mark W. Dewhirst
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (15): 4993–5001.
https://doi.org/10.1158/1078-0432.CCR-08-2222
Published: 29 July 2009
View articletitled, Dynamic Contrast-enhanced Magnetic Resonance Imaging as a Predictor of Clinical Outcome in Canine Spontaneous Soft Tissue Sarcomas Treated with Thermoradiotherapy
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Includes: Supplementary data
Journal Articles

Multiple Etiologies of Tumor Hypoxia Require Multifaceted Solutions

Free
Mark W. Dewhirst, Isabel Cardenas Navia, David M. Brizel, Christopher Willett, Timothy W. Secomb
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (2): 375–377.
https://doi.org/10.1158/1078-0432.CCR-06-2629
Published: 25 January 2007
View articletitled, Multiple Etiologies of Tumor Hypoxia Require Multifaceted Solutions
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Journal Articles

A Tracer Dose of Technetium-99m–Labeled Liposomes Can Estimate the Effect of Hyperthermia on Intratumoral Doxil Extravasation

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Miriam M. Kleiter, Daohai Yu, Lenore A. Mohammadian, Nelsen Niehaus, Ivan Spasojevic, Linda Sanders, Benjamin L. Viglianti, Pavel S. Yarmolenko, Marlene Hauck, Neil A. Petry, Terence Z. Wong, Mark W. Dewhirst, Donald E. Thrall
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (22): 6800–6807.
https://doi.org/10.1158/1078-0432.CCR-06-0839
Published: 22 November 2006
View articletitled, A Tracer Dose of Technetium-99m–Labeled Liposomes Can Estimate the Effect of Hyperthermia on Intratumoral Doxil Extravasation
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Journal Articles

Extracellular pH and P-31 Magnetic Resonance Spectroscopic Variables are Related to Outcome in Canine Soft Tissue Sarcomas Treated with Thermoradiotherapy

Free
Michaël Lora-Michiels, Daohai Yu, Linda Sanders, Jean M. Poulson, Chieko Azuma, Beth Case, Zeljko Vujaskovic, Donald E. Thrall, H. Cecil Charles, Mark W. Dewhirst
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (19): 5733–5740.
https://doi.org/10.1158/1078-0432.CCR-05-2669
Published: 04 October 2006
View articletitled, Extracellular pH and P-31 Magnetic Resonance Spectroscopic Variables are Related to Outcome in Canine Soft Tissue Sarcomas Treated with Thermoradiotherapy
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Journal Articles

Phase I Trial of Doxorubicin-Containing Low Temperature Sensitive Liposomes in Spontaneous Canine Tumors

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Marlene L. Hauck, Susan M. LaRue, William P. Petros, Jean M. Poulson, Daohai Yu, Ivan Spasojevic, Amy F. Pruitt, Allison Klein, Beth Case, Donald E. Thrall, David Needham, Mark W. Dewhirst
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (13): 4004–4010.
https://doi.org/10.1158/1078-0432.CCR-06-0226
Published: 03 July 2006
View articletitled, Phase I Trial of Doxorubicin-Containing Low Temperature Sensitive Liposomes in Spontaneous Canine Tumors
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Journal Articles

A Clinically Proven, Prospective, Thermal Dose Descriptor Exists

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Donald E. Thrall, Mark W. Dewhirst, Ellen L. Jones, Zeljko Vujaskovic, Daohai Yu, Oana I. Craciunescu
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (6): 1944–1945.
https://doi.org/10.1158/1078-0432.CCR-05-2446
Published: 21 March 2006
View articletitled, A Clinically Proven, Prospective, Thermal Dose Descriptor Exists
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Journal Articles

Gene Expression Profiles of Multiple Breast Cancer Phenotypes and Response to Neoadjuvant Chemotherapy

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Holly K. Dressman, Christopher Hans, Andrea Bild, John A. Olson, Eric Rosen, P. Kelly Marcom, Vlayka B. Liotcheva, Ellen L. Jones, Zeljko Vujaskovic, Jeffrey Marks, Mark W. Dewhirst, Mike West, Joseph R. Nevins, Kimberly Blackwell
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (3): 819–826.
https://doi.org/10.1158/1078-0432.CCR-05-1447
Published: 07 February 2006
View articletitled, Gene Expression Profiles of Multiple Breast Cancer Phenotypes and Response to Neoadjuvant Chemotherapy
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Includes: Supplementary data
Journal Articles

Erythropoietin Biology in Cancer

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Matthew E. Hardee, Murat O. Arcasoy, Kimberly L. Blackwell, John P. Kirkpatrick, Mark W. Dewhirst
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (2): 332–339.
https://doi.org/10.1158/1078-0432.CCR-05-1771
Published: 20 January 2006
View articletitled, Erythropoietin Biology in Cancer
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Journal Articles

Optimizing a Novel Regional Chemotherapeutic Agent against Melanoma: Hyperthermia-Induced Enhancement of Temozolomide Cytotoxicity

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Sae Hee Ko, Tomio Ueno, Yasunori Yoshimoto, Jin Soo Yoo, Omar I. Abdel-Wahab, Zeinab Abdel-Wahab, Edward Chu, Scott K. Pruitt, Henry S. Friedman, Mark W. Dewhirst, Douglas S. Tyler
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (1): 289–297.
https://doi.org/10.1158/1078-0432.CCR-05-0210
Published: 05 January 2006
View articletitled, Optimizing a Novel Regional Chemotherapeutic Agent against Melanoma: Hyperthermia-Induced Enhancement of Temozolomide Cytotoxicity
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Journal Articles

Thermal Dose Is Related to Duration of Local Control in Canine Sarcomas Treated with Thermoradiotherapy

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Donald E. Thrall, Susan M. LaRue, Daohai Yu, Thaddeus Samulski, Linda Sanders, Beth Case, Gary Rosner, Chieko Azuma, Jeannie Poulson, Amy F. Pruitt, Wilma Stanley, Marlene L. Hauck, Laurel Williams, Paul Hess, Mark W. Dewhirst
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (14): 5206–5214.
https://doi.org/10.1158/1078-0432.CCR-05-0091
Published: 20 July 2005
View articletitled, Thermal Dose Is Related to Duration of Local Control in Canine Sarcomas Treated with Thermoradiotherapy
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Journal Articles

Carbonic Anhydrase IX in Early-Stage Non–Small Cell Lung Cancer

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Seok Jin Kim, Zahid N. Rabbani, Robin T. Vollmer, Ernst-Gilbert Schreiber, Egbert Oosterwijk, Mark W. Dewhirst, Zeljko Vujaskovic, Michael J. Kelley
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (23): 7925–7933.
https://doi.org/10.1158/1078-0432.CCR-04-0636
Published: 07 December 2004
View articletitled, Carbonic Anhydrase IX in Early-Stage Non–Small Cell Lung Cancer
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Journal Articles

The Role of Hyperthermia in Regional Alkylating Agent Chemotherapy

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Omar I. Abdel-Wahab, Elizabeth Grubbs, Benjamin L. Viglianti, Tsung-Yen Cheng, Tomio Ueno, SaeHee Ko, Zahid Rabbani, Simon Curtis, Scott K. Pruitt, Mark W. Dewhirst, Doug S. Tyler
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (17): 5919–5929.
https://doi.org/10.1158/1078-0432.CCR-04-0096
Published: 08 September 2004
View articletitled, The Role of Hyperthermia in Regional Alkylating Agent Chemotherapy
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Journal Articles

Thermochemoradiotherapy Improves Oxygenation in Locally Advanced Breast Cancer

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Ellen L. Jones, Leonard R. Prosnitz, Mark W. Dewhirst, P. Kelly Marcom, Patricia H. Hardenbergh, Lawrence B. Marks, David M. Brizel, Zeljko Vujaskovic
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (13): 4287–4293.
https://doi.org/10.1158/1078-0432.CCR-04-0133
Published: 06 July 2004
View articletitled, Thermochemoradiotherapy Improves Oxygenation in Locally Advanced Breast Cancer
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Journal Articles

HER-2 Gene Amplification Correlates with Higher Levels of Angiogenesis and Lower Levels of Hypoxia in Primary Breast Tumors

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Kimberly L. Blackwell, Mark W. Dewhirst, Vlayka Liotcheva, Stacey Snyder, Gloria Broadwater, Rex Bentley, Anita Lal, Gregory Riggins, Steve Anderson, Jim Vredenburgh, Alan Proia, Lyndsay N. Harris
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (12): 4083–4088.
https://doi.org/10.1158/1078-0432.CCR-03-0695
Published: 24 June 2004
View articletitled, HER-2 Gene Amplification Correlates with Higher Levels of Angiogenesis and Lower Levels of Hypoxia in Primary Breast Tumors
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Journal Articles

Increased Resistance of Tumor Cells to Hyperthermia Mediated By Integrin-linked Kinase

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Xiuwu Zhang, Yongping Li, Qian Huang, He Wang, Bin Yan, Mark W. Dewhirst, Chuan-Yuan Li
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (3): 1155–1160.
Published: 01 March 2003
View articletitled, Increased Resistance of Tumor Cells to Hyperthermia Mediated By Integrin-linked Kinase
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Journal Articles

Reduction of Wound Angiogenesis in Patients Treated with BMS-275291, a Broad Spectrum Matrix Metalloproteinase Inhibitor

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A. Craig Lockhart, Rod D. Braun, Daohai Yu, Joel R. Ross, Mark W. Dewhirst, Jeffrey S. Humphrey, Seth Thompson, Kathleen M. Williams, Bruce Klitzman, Fan Yuan, James M. Grichnik, Alan D. Proia, Delina A. Conway, Herbert I. Hurwitz
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (2): 586–593.
Published: 01 February 2003
View articletitled, Reduction of Wound Angiogenesis in Patients Treated with BMS-275291, a Broad Spectrum Matrix Metalloproteinase Inhibitor
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