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Mark J. Smyth
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Journal Articles

IL15 Stimulation with TIGIT Blockade Reverses CD155-mediated NK-Cell Dysfunction in Melanoma

Joe-Marc Chauvin, Mignane Ka, Ornella Pagliano, Carmine Menna, Quanquan Ding, Richelle DeBlasio, Cindy Sanders, Jiajie Hou, Xian-Yang Li, Soldano Ferrone, Diwakar Davar, John M. Kirkwood, Robert J. Johnston, Alan J. Korman, Mark J. Smyth, Hassane M. Zarour
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (20): 5520–5533.
https://doi.org/10.1158/1078-0432.CCR-20-0575
Published: 15 October 2020
View article titled, IL15 Stimulation with TIGIT Blockade Reverses CD155-mediated NK-Cell Dysfunction in Melanoma
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Includes: Supplementary data
Journal Articles

Tumor CD155 Expression Is Associated with Resistance to Anti-PD1 Immunotherapy in Metastatic Melanoma

Ailin Lepletier, Jason Madore, Jake S. O'Donnell, Rebecca L. Johnston, Xian-Yang Li, Elizabeth McDonald, Elizabeth Ahern, Anna Kuchel, Melissa Eastgate, Sally-Ann Pearson, Domenico Mallardo, Paolo A. Ascierto, Daniela Massi, Barbara Merelli, Mario Mandala, James S. Wilmott, Alexander M. Menzies, Charles Leduc, John Stagg, Bertrand Routy, Georgina V. Long, Richard A. Scolyer, Tobias Bald, Nicola Waddell, William C. Dougall, Michele W.L. Teng, Mark J. Smyth
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (14): 3671–3681.
https://doi.org/10.1158/1078-0432.CCR-19-3925
Published: 15 July 2020
View article titled, Tumor CD155 Expression Is Associated with Resistance to Anti-PD1 Immunotherapy in Metastatic Melanoma
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Includes: Supplementary data
Journal Articles

The Promise of Neoadjuvant Immunotherapy and Surgery for Cancer Treatment

Jake S. O'Donnell, Esmée P. Hoefsmit, Mark J. Smyth, Christian U. Blank, Michele W.L. Teng
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (19): 5743–5751.
https://doi.org/10.1158/1078-0432.CCR-18-2641
Published: 01 October 2019
View article titled, The Promise of Neoadjuvant Immunotherapy and Surgery for Cancer Treatment
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Journal Articles

Flt-3L Expansion of Recipient CD8α+ Dendritic Cells Deletes Alloreactive Donor T Cells and Represents an Alternative to Posttransplant Cyclophosphamide for the Prevention of GVHD

Kate A. Markey, Rachel D. Kuns, Daniel J. Browne, Kate H. Gartlan, Renee J. Robb, J. Paulo Martins, Andrea S. Henden, Simone A. Minnie, Melody Cheong, Motoko Koyama, Mark J. Smyth, Raymond J. Steptoe, Gabrielle T. Belz, Thomas Brocker, Mariapia A. Degli-Esposti, Steven W. Lane, Geoffrey R. Hill
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (7): 1604–1616.
https://doi.org/10.1158/1078-0432.CCR-17-2148
Published: 02 April 2018
View article titled, Flt-3L Expansion of Recipient CD8α<sup>+</sup> Dendritic Cells Deletes Alloreactive Donor T Cells and Represents an Alternative to Posttransplant Cyclophosphamide for the Prevention of GVHD
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Includes: Supplementary data
Journal Articles

Co-administration of RANKL and CTLA4 Antibodies Enhances Lymphocyte-Mediated Antitumor Immunity in Mice

Elizabeth Ahern, Heidi Harjunpää, Deborah Barkauskas, Stacey Allen, Kazuyoshi Takeda, Hideo Yagita, David Wyld, William C. Dougall, Michele W.L. Teng, Mark J. Smyth
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (19): 5789–5801.
https://doi.org/10.1158/1078-0432.CCR-17-0606
Published: 01 October 2017
View article titled, Co-administration of RANKL and CTLA4 Antibodies Enhances Lymphocyte-Mediated Antitumor Immunity in Mice
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Includes: Supplementary data
Journal Articles

Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Clare Y. Slaney, Bianca von Scheidt, Alexander J. Davenport, Paul A. Beavis, Jennifer A. Westwood, Sherly Mardiana, David C. Tscharke, Sarah Ellis, H. Miles Prince, Joseph A. Trapani, Ricky W. Johnstone, Mark J. Smyth, Michele W. Teng, Aesha Ali, Zhiya Yu, Steven A. Rosenberg, Nicholas P. Restifo, Paul Neeson, Phillip K. Darcy, Michael H. Kershaw
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (10): 2478–2490.
https://doi.org/10.1158/1078-0432.CCR-16-1860
Published: 14 May 2017
View article titled, Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting
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Includes: Supplementary data
Journal Articles

Molecular Pathways: Targeting CD96 and TIGIT for Cancer Immunotherapy

Stephen J. Blake, William C. Dougall, John J. Miles, Michele W.L. Teng, Mark J. Smyth
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (21): 5183–5188.
https://doi.org/10.1158/1078-0432.CCR-16-0933
Published: 31 October 2016
View article titled, Molecular Pathways: Targeting CD96 and TIGIT for Cancer Immunotherapy
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Journal Articles

Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs

Bertrand Allard, Sandra Pommey, Mark J. Smyth, John Stagg
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (20): 5626–5635.
https://doi.org/10.1158/1078-0432.CCR-13-0545
Published: 14 October 2013
View article titled, Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs
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Includes: Supplementary data
Journal Articles

Anti-PD-1 Antibody Therapy Potently Enhances the Eradication of Established Tumors By Gene-Modified T Cells

Liza B. John, Christel Devaud, Connie P.M. Duong, Carmen S. Yong, Paul A. Beavis, Nicole M. Haynes, Melvyn T. Chow, Mark J. Smyth, Michael H. Kershaw, Phillip K. Darcy
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2013) 19 (20): 5636–5646.
https://doi.org/10.1158/1078-0432.CCR-13-0458
Published: 14 October 2013
View article titled, Anti-PD-1 Antibody Therapy Potently Enhances the Eradication of Established Tumors By Gene-Modified T Cells
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Includes: Supplementary data
Journal Articles

Toll-Like Receptor Triggering and T-Cell Costimulation Induce Potent Antitumor Immunity in Mice

Jennifer A. Westwood, Nicole M. Haynes, Janelle Sharkey, Nicole McLaughlin, Hollie J. Pegram, Reto A. Schwendener, Mark J. Smyth, Phillip K. Darcy, Michael H. Kershaw
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (24): 7624–7633.
https://doi.org/10.1158/1078-0432.CCR-09-2201
Published: 14 December 2009
View article titled, Toll-Like Receptor Triggering and T-Cell Costimulation Induce Potent Antitumor Immunity in Mice
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Includes: Supplementary data
Journal Articles

Interleukin-21 Signaling: Functions in Cancer and Autoimmunity

Ian D. Davis, Kresten Skak, Mark J. Smyth, Paul E.G. Kristjansen, Dennis M. Miller, Pallavur V. Sivakumar
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (23): 6926–6932.
https://doi.org/10.1158/1078-0432.CCR-07-1238
Published: 03 December 2007
View article titled, Interleukin-21 Signaling: Functions in Cancer and Autoimmunity
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