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Marinela Capanu
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Journal Articles

Molecular and Clinical Determinants of Acquired Resistance and Treatment Duration for Targeted Therapies in Colorectal Cancer

Emily Harrold, Fergus Keane, Henry Walch, Joanne F. Chou, Jenna Sinopoli, Silvia Palladino, Duaa H. Al-Rawi, Kalyani Chadalavada, Paolo Manca, Sree Chalasani, Jessica Yang, Andrea Cercek, Jinru Shia, Marinela Capanu, Samuel F. Bakhoum, Nikolaus Schultz, Walid K. Chatila, Rona Yaeger
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (12): 2672–2683.
https://doi.org/10.1158/1078-0432.CCR-23-4005
Published: 14 June 2024
View article titled, Molecular and Clinical Determinants of Acquired Resistance and Treatment Duration for Targeted Therapies in Colorectal Cancer
Open the PDF for Molecular and Clinical Determinants of Acquired Resistance and Treatment Duration for Targeted Therapies in Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer

Steven B. Maron, Walid Chatila, Henry Walch, Joanne F. Chou, Nicholas Ceglia, Ryan Ptashkin, Richard Kinh Gian Do, Viktoriya Paroder, Neeta Pandit-Taskar, Jason S. Lewis, Tiago Biachi De Castria, Shalom Sabwa, Fiona Socolow, Lara Feder, Jasmine Thomas, Isabell Schulze, Kwanghee Kim, Arijh Elzein, Viktoria Bojilova, Matthew Zatzman, Umesh Bhanot, Rebecca J. Nagy, Jeeyun Lee, Marc Simmons, Michal Segal, Geoffrey Yuyat Ku, David H. Ilson, Marinela Capanu, Jaclyn F. Hechtman, Taha Merghoub, Sohrab Shah, Nikolaus Schultz, David B. Solit, Yelena Y. Janjigian
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (18): 3633–3640.
https://doi.org/10.1158/1078-0432.CCR-22-3769
Published: 15 September 2023
View article titled, Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer
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Includes: Supplementary data
Journal Articles

Clinico-genomic Characterization of ATM and HRD in Pancreas Cancer: Application for Practice

Wungki Park, Catherine A. O'Connor, Chaitanya Bandlamudi, Daniella Forman, Joanne F. Chou, Shigeaki Umeda, Marsha Reyngold, Anna M. Varghese, Fergus Keane, Fiyinfolu Balogun, Kenneth H. Yu, David P. Kelsen, Christopher Crane, Marinela Capanu, Christine Iacobuzio-Donahue, Eileen M. O'Reilly
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (21): 4782–4792.
https://doi.org/10.1158/1078-0432.CCR-22-1483
Published: 01 November 2022
View article titled, Clinico-genomic Characterization of <em>ATM</em> and HRD in Pancreas Cancer: Application for Practice
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Includes: Supplementary data
Journal Articles

Phase II Single-arm Study of Durvalumab and Tremelimumab with Concurrent Radiotherapy in Patients with Mismatch Repair–proficient Metastatic Colorectal Cancer

Neil H. Segal, Andrea Cercek, Geoffrey Ku, Abraham J. Wu, Andreas Rimner, Danny N. Khalil, Diane Reidy-Lagunes, John Cuaron, T. Jonathan Yang, Martin R. Weiser, Paul B. Romesser, Zsofia K. Stadler, Anna M. Varghese, Karuna Ganesh, Rona Yaeger, Louise C. Connell, David Faleck, Ghassan K. Abou-Alfa, Kathleen C. Mcauliffe, Pamela Vaiskauskas, Mark L. Solter, Martinique Ogle, Matthew J. Adamow, Aliya Holland, Pallavi Vedantam, Phillip Wong, Taha Merghoub, Efsevia Vakiani, Travis J. Hollmann, Krishna Juluru, Joanne F. Chou, Marinela Capanu, Joseph Erinjeri, Stephen Solomon, Yoshiya Yamada, Nancy Kemeny, Christopher H. Crane, Leonard B. Saltz
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (8): 2200–2208.
https://doi.org/10.1158/1078-0432.CCR-20-2474
Published: 15 April 2021
View article titled, Phase II Single-arm Study of Durvalumab and Tremelimumab with Concurrent Radiotherapy in Patients with Mismatch Repair–proficient Metastatic Colorectal Cancer
Open the PDF for Phase II Single-arm Study of Durvalumab and Tremelimumab with Concurrent Radiotherapy in Patients with Mismatch Repair–proficient Metastatic Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Genomic Methods Identify Homologous Recombination Deficiency in Pancreas Adenocarcinoma and Optimize Treatment Selection

Wungki Park, Jiapeng Chen, Joanne F. Chou, Anna M. Varghese, Kenneth H. Yu, Winston Wong, Marinela Capanu, Vinod Balachandran, Caitlin A. McIntyre, Imane El Dika, Danny N. Khalil, James J. Harding, Nima Ghalehsari, Zoe McKinnell, Sree B. Chalasani, Vladimir Makarov, Pier Selenica, Xin Pei, Nicolas Lecomte, David P. Kelsen, Ghassan K. Abou-Alfa, Mark E. Robson, Liying Zhang, Michael F. Berger, Nikolaus Schultz, Timothy A. Chan, Simon N. Powell, Jorge S. Reis-Filho, Christine A. Iacobuzio-Donahue, Nadeem Riaz, Eileen M. O'Reilly
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13): 3239–3247.
https://doi.org/10.1158/1078-0432.CCR-20-0418
Published: 01 July 2020
View article titled, Genomic Methods Identify Homologous Recombination Deficiency in Pancreas Adenocarcinoma and Optimize Treatment Selection
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Includes: Supplementary data
Journal Articles

Clinical and Molecular Predictors of Response to Immune Checkpoint Inhibitors in Patients with Advanced Esophagogastric Cancer

Megan Greally, Joanne F. Chou, Walid K. Chatila, Matthew Margolis, Marinela Capanu, Jaclyn F. Hechtman, Yaelle Tuvy, Ritika Kundra, Foysal Daian, Marc Ladanyi, David P. Kelsen, David H. Ilson, Michael F. Berger, Laura H. Tang, David B. Solit, Luis A. Diaz, Jr, Nikolaus Schultz, Yelena Y. Janjigian, Geoffrey Y. Ku
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (20): 6160–6169.
https://doi.org/10.1158/1078-0432.CCR-18-3603
Published: 15 October 2019
View article titled, Clinical and Molecular Predictors of Response to Immune Checkpoint Inhibitors in Patients with Advanced Esophagogastric Cancer
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Includes: Supplementary data
Journal Articles

Efficacy of Combined VEGFR1-3, PDGFα/β, and FGFR1-3 Blockade Using Nintedanib for Esophagogastric Cancer

Elizabeth Won, Azfar Basunia, Walid K. Chatila, Jaclyn F. Hechtman, Joanne F. Chou, Geoffrey Y. Ku, Sree B. Chalasani, Michelle S. Boyar, Zoe Goldberg, Avni M. Desai, Yaelle Tuvy, Michael F. Berger, Laura Tang, David P. Kelsen, Mark Schattner, David H. Ilson, Marinela Capanu, David B. Solit, Nikolaus Schultz, Yelena Y. Janjigian
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (13): 3811–3817.
https://doi.org/10.1158/1078-0432.CCR-18-3789
Published: 01 July 2019
View article titled, Efficacy of Combined VEGFR1-3, PDGFα/β, and FGFR1-3 Blockade Using Nintedanib for Esophagogastric Cancer
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Includes: Supplementary data
Journal Articles

Binimetinib plus Gemcitabine and Cisplatin Phase I/II Trial in Patients with Advanced Biliary Cancers

Maeve A. Lowery, Mikaela Bradley, Joanne F. Chou, Marinela Capanu, Scott Gerst, James J. Harding, Imane El Dika, Michael Berger, Ahmet Zehir, Ryan Ptashkin, Philip Wong, Teresa Rasalan-Ho, Kenneth H. Yu, Andrea Cercek, Ezra Morgono, Erica Salehi, Emily Valentino, Ellen Hollywood, Eileen M. O'Reilly, Ghassan K. Abou-Alfa
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (3): 937–945.
https://doi.org/10.1158/1078-0432.CCR-18-1927
Published: 01 February 2019
View article titled, Binimetinib plus Gemcitabine and Cisplatin Phase I/II Trial in Patients with Advanced Biliary Cancers
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Journal Articles

Comprehensive Molecular Profiling of Intrahepatic and Extrahepatic Cholangiocarcinomas: Potential Targets for Intervention

Maeve A. Lowery, Ryan Ptashkin, Emmet Jordan, Michael F. Berger, Ahmet Zehir, Marinela Capanu, Nancy E. Kemeny, Eileen M. O'Reilly, Imane El-Dika, William R. Jarnagin, James J. Harding, Michael I. D'Angelica, Andrea Cercek, Jaclyn F. Hechtman, David B. Solit, Nikolaus Schultz, David M. Hyman, David S. Klimstra, Leonard B. Saltz, Ghassan K. Abou-Alfa
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (17): 4154–4161.
https://doi.org/10.1158/1078-0432.CCR-18-0078
Published: 04 September 2018
View article titled, Comprehensive Molecular Profiling of Intrahepatic and Extrahepatic Cholangiocarcinomas: Potential Targets for Intervention
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Includes: Supplementary data
Journal Articles

Evaluating Mismatch Repair Deficiency in Pancreatic Adenocarcinoma: Challenges and Recommendations

Zishuo I. Hu, Jinru Shia, Zsofia K. Stadler, Anna M. Varghese, Marinela Capanu, Erin Salo-Mullen, Maeve A. Lowery, Luis A. Diaz, Jr, Diana Mandelker, Kenneth H. Yu, Alice Zervoudakis, David P. Kelsen, Christine A. Iacobuzio-Donahue, David S. Klimstra, Leonard B. Saltz, Ibrahim H. Sahin, Eileen M. O'Reilly
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (6): 1326–1336.
https://doi.org/10.1158/1078-0432.CCR-17-3099
Published: 14 March 2018
View article titled, Evaluating Mismatch Repair Deficiency in Pancreatic Adenocarcinoma: Challenges and Recommendations
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Journal Articles

Clinical Features and Outcomes of Patients with Colorectal Cancers Harboring NRAS Mutations

Andrea Cercek, Maria Ignez Braghiroli, Joanne F. Chou, Jaclyn F. Hechtman, Nancy Kemeny, Leonard Saltz, Marinela Capanu, Rona Yaeger
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (16): 4753–4760.
https://doi.org/10.1158/1078-0432.CCR-17-0400
Published: 14 August 2017
View article titled, Clinical Features and Outcomes of Patients with Colorectal Cancers Harboring NRAS Mutations
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Includes: Supplementary data
Journal Articles

Pilot Trial of Combined BRAF and EGFR Inhibition in BRAF-Mutant Metastatic Colorectal Cancer Patients

Rona Yaeger, Andrea Cercek, Eileen M. O'Reilly, Diane L. Reidy, Nancy Kemeny, Tamar Wolinsky, Marinela Capanu, Marc J. Gollub, Neal Rosen, Michael F. Berger, Mario E. Lacouture, Efsevia Vakiani, Leonard B. Saltz
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (6): 1313–1320.
https://doi.org/10.1158/1078-0432.CCR-14-2779
Published: 12 March 2015
View article titled, Pilot Trial of Combined BRAF and EGFR Inhibition in <em>BRAF</em>-Mutant Metastatic Colorectal Cancer Patients
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Includes: Supplementary data