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Marco A. Marra
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Journal Articles

Uncovering Clinically Relevant Gene Fusions with Integrated Genomic and Transcriptomic Profiling of Metastatic Cancers

Erica S. Tsang, Cameron J. Grisdale, Erin Pleasance, James T. Topham, Karen Mungall, Caralyn Reisle, Caleb Choo, Marcus Carreira, Reanne Bowlby, Joanna M. Karasinska, Daniel MacMillan, Laura M. Williamson, Eric Chuah, Richard A. Moore, Andrew J. Mungall, Yongjun Zhao, Basile Tessier-Cloutier, Tony Ng, Sophie Sun, Howard J. Lim, David F. Schaeffer, Daniel J. Renouf, Stephen Yip, Janessa Laskin, Marco A. Marra, Steven J.M. Jones, Jonathan M. Loree
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (2): 522–531.
https://doi.org/10.1158/1078-0432.CCR-20-1900
Published: 19 January 2021
View article titled, Uncovering Clinically Relevant Gene Fusions with Integrated Genomic and Transcriptomic Profiling of Metastatic Cancers
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Includes: Supplementary data
Journal Articles

Genome and Transcriptome Biomarkers of Response to Immune Checkpoint Inhibitors in Advanced Solid Tumors

Alexandra Pender, Emma Titmuss, Erin D. Pleasance, Kevin Y. Fan, Hillary Pearson, Scott D. Brown, Cameron J. Grisdale, James T. Topham, Yaoqing Shen, Melika Bonakdar, Gregory A. Taylor, Laura M. Williamson, Karen L. Mungall, Eric Chuah, Andrew J. Mungall, Richard A. Moore, Jean-Michel Lavoie, Stephen Yip, Howard Lim, Daniel J. Renouf, Sophie Sun, Robert A. Holt, Steven J.M. Jones, Marco A. Marra, Janessa Laskin
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (1): 202–212.
https://doi.org/10.1158/1078-0432.CCR-20-1163
Published: 04 January 2021
View article titled, Genome and Transcriptome Biomarkers of Response to Immune Checkpoint Inhibitors in Advanced Solid Tumors
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Includes: Supplementary data
Journal Articles

Subtype-Discordant Pancreatic Ductal Adenocarcinoma Tumors Show Intermediate Clinical and Molecular Characteristics

James T. Topham, Joanna M. Karasinska, Michael K.C. Lee, Veronika Csizmok, Laura M. Williamson, Gun Ho Jang, Robert E. Denroche, Erica S. Tsang, Steve E. Kalloger, Hui-li Wong, Grainne M. O'Kane, Richard A. Moore, Andrew J. Mungall, Faiyaz Notta, Jonathan M. Loree, Julie M. Wilson, Oliver Bathe, Patricia A. Tang, Rachel Goodwin, Jennifer J. Knox, Steven Gallinger, Janessa Laskin, Marco A. Marra, Steven J.M. Jones, Daniel J. Renouf, David F. Schaeffer
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (1): 150–157.
https://doi.org/10.1158/1078-0432.CCR-20-2831
Published: 04 January 2021
View article titled, Subtype-Discordant Pancreatic Ductal Adenocarcinoma Tumors Show Intermediate Clinical and Molecular Characteristics
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Includes: Supplementary data
Journal Articles

Delving into Early-onset Pancreatic Ductal Adenocarcinoma: How Does Age Fit In?

Erica S. Tsang, James T. Topham, Joanna M. Karasinska, Michael K.C. Lee, Laura M. Williamson, Shehara Mendis, Robert E. Denroche, Gun Ho Jang, Steve E. Kalloger, Richard A. Moore, Andrew J. Mungall, Oliver F. Bathe, Patricia A. Tang, Faiyaz Notta, Julie M. Wilson, Janessa Laskin, Grainne M. O'Kane, Jennifer J. Knox, Rachel A. Goodwin, Jonathan M. Loree, Steven J.M. Jones, Marco A. Marra, Steven Gallinger, David F. Schaeffer, Daniel J. Renouf
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (1): 246–254.
https://doi.org/10.1158/1078-0432.CCR-20-1042
Published: 04 January 2021
View article titled, Delving into Early-onset Pancreatic Ductal Adenocarcinoma: How Does Age Fit In?
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Includes: Supplementary data
Journal Articles

Altered Gene Expression along the Glycolysis–Cholesterol Synthesis Axis Is Associated with Outcome in Pancreatic Cancer

Joanna M. Karasinska, James T. Topham, Steve E. Kalloger, Gun Ho Jang, Robert E. Denroche, Luka Culibrk, Laura M. Williamson, Hui-Li Wong, Michael K.C. Lee, Grainne M. O'Kane, Richard A. Moore, Andrew J. Mungall, Malcolm J. Moore, Cassia Warren, Andrew Metcalfe, Faiyaz Notta, Jennifer J. Knox, Steven Gallinger, Janessa Laskin, Marco A. Marra, Steven J.M. Jones, Daniel J. Renouf, David F. Schaeffer
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (1): 135–146.
https://doi.org/10.1158/1078-0432.CCR-19-1543
Published: 03 January 2020
View article titled, Altered Gene Expression along the Glycolysis–Cholesterol Synthesis Axis Is Associated with Outcome in Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

NRG1 Gene Fusions Are Recurrent, Clinically Actionable Gene Rearrangements in KRAS Wild-Type Pancreatic Ductal Adenocarcinoma

Martin R. Jones, Laura M. Williamson, James T. Topham, Michael K.C. Lee, Angela Goytain, Julie Ho, Robert E. Denroche, GunHo Jang, Erin Pleasance, Yaoquing Shen, Joanna M. Karasinska, John P. McGhie, Sharlene Gill, Howard J. Lim, Malcolm J. Moore, Hui-li Wong, Tony Ng, Stephen Yip, Wei Zhang, Sara Sadeghi, Carolyn Reisle, Andrew J. Mungall, Karen L. Mungall, Richard A. Moore, Yussanne Ma, Jennifer J. Knox, Steven Gallinger, Janessa Laskin, Marco A. Marra, David F. Schaeffer, Steven J.M. Jones, Daniel J. Renouf
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (15): 4674–4681.
https://doi.org/10.1158/1078-0432.CCR-19-0191
Published: 01 August 2019
View article titled, <em>NRG1</em> Gene Fusions Are Recurrent, Clinically Actionable Gene Rearrangements in <em>KRAS</em> Wild-Type Pancreatic Ductal Adenocarcinoma
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Includes: Supplementary data
Journal Articles

Homologous Recombination Deficiency and Platinum-Based Therapy Outcomes in Advanced Breast Cancer

Eric Y. Zhao, Yaoqing Shen, Erin Pleasance, Katayoon Kasaian, Sreeja Leelakumari, Martin Jones, Pinaki Bose, Carolyn Ch'ng, Caralyn Reisle, Peter Eirew, Richard Corbett, Karen L. Mungall, Nina Thiessen, Yussanne Ma, Jacqueline E. Schein, Andrew J. Mungall, Yongjun Zhao, Richard A. Moore, Wendie Den Brok, Sheridan Wilson, Diego Villa, Tamara Shenkier, Caroline Lohrisch, Stephen Chia, Stephen Yip, Karen Gelmon, Howard Lim, Daniel Renouf, Sophie Sun, Kasmintan A. Schrader, Sean Young, Ian Bosdet, Aly Karsan, Janessa Laskin, Marco A. Marra, Steven J.M. Jones
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (24): 7521–7530.
https://doi.org/10.1158/1078-0432.CCR-17-1941
Published: 14 December 2017
View article titled, Homologous Recombination Deficiency and Platinum-Based Therapy Outcomes in Advanced Breast Cancer
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Includes: Supplementary data
Journal Articles

Significance of TP53 Mutation in Wilms Tumors with Diffuse Anaplasia: A Report from the Children's Oncology Group

Ariadne H.A.G. Ooms, Samantha Gadd, Daniela S. Gerhard, Malcolm A. Smith, Jaime M. Guidry Auvil, Daoud Meerzaman, Qing-Rong Chen, Chih Hao Hsu, Chunhua Yan, Cu Nguyen, Ying Hu, Yussanne Ma, Zusheng Zong, Andrew J. Mungall, Richard A. Moore, Marco A. Marra, Vicki Huff, Jeffrey S. Dome, Yueh-Yun Chi, Jing Tian, James I. Geller, Charles G. Mullighan, Jing Ma, David A. Wheeler, Oliver A. Hampton, Amy L. Walz, Marry M. van den Heuvel-Eibrink, Ronald R. de Krijger, Nicole Ross, Julie M. Gastier-Foster, Elizabeth J. Perlman
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (22): 5582–5591.
https://doi.org/10.1158/1078-0432.CCR-16-0985
Published: 14 November 2016
View article titled, Significance of <em>TP53</em> Mutation in Wilms Tumors with Diffuse Anaplasia: A Report from the Children's Oncology Group
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Includes: Supplementary data
Journal Articles

Toward Personalized Lymphoma Immunotherapy: Identification of Common Driver Mutations Recognized by Patient CD8+ T Cells

Julie S. Nielsen, Colin G. Sedgwick, Aniqa Shahid, Zusheng Zong, Zabrina L. Brumme, Stephen Yu, Lewis Liu, David R. Kroeger, Steven P. Treon, Joseph M. Connors, Randy D. Gascoyne, Brian R. Berry, Marco A. Marra, Ryan D. Morin, Nicol Macpherson, Brad H. Nelson
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (9): 2226–2236.
https://doi.org/10.1158/1078-0432.CCR-15-2023
Published: 01 May 2016
View article titled, Toward Personalized Lymphoma Immunotherapy: Identification of Common Driver Mutations Recognized by Patient CD8<sup>+</sup> T Cells
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Includes: Supplementary data
Journal Articles

Abstract PR02: Integrated genomic analysis of a recurrent ghost cell odontogenic carcinoma

Pinaki Bose, Erin Pleasance, Martin Jones, Yaoqing Shen, Carolyn Ch'ng, Caralyn Reisle, Jacqueline E. Schein, Andrew Mungall, Richard Moore, Yussanne Ma, Brandon S. Sheffield, Thomas Thomson, Steven Rasmussen, Christopher Lee, Stephen Yip, Marco A. Marra, Janessa Laskin, Cheryl Ho, Steven J. M. Jones
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (1_Supplement): PR02.
https://doi.org/10.1158/1557-3265.PMSCLINGEN15-PR02
Published: 03 January 2016
View article titled, Abstract PR02: Integrated genomic analysis of a recurrent ghost cell odontogenic carcinoma
Journal Articles

Abstract AS18: The somatic mutational landscape of endometriosis associated ovarian cancers and precursor lesions

Michael S Anglesio, Ali Bashashati, Yikan Wang, Gavin Ha, Janine Senz, Winnie Yang, Steve E Kalloger, Leah M Prentice, Satoshi Yanagida, Clara Salamanca, Galina Soukhatcheva, Anthony Kazernis, Hector Chang, Anne-Marie Mes-Mason, Aikou Okamoto, Marco A Marra, Blake Gilks, Sohrab P Shah, David G Huntsman
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (16_Supplement): AS18.
https://doi.org/10.1158/1557-3265.OVCASYMP14-AS18
Published: 15 August 2015
View article titled, Abstract AS18: The somatic mutational landscape of endometriosis associated ovarian cancers and precursor lesions
Journal Articles

Abstract POSTER-BIOL-1327: Small cell carcinoma of the ovary, hypercalcemic type displays frequent inactivating germline and somatic mutations in SMARCA4

Pilar Ramos, Anthony N. Karnezis, David W. Craig, Aleksandar Sekulic, Megan L. Russell, William P.D. Hendricks, Jason J. Corneveaux, Michael T. Barrett, Karey Shumansky, Yidong Yang, Sohrab P. Shah, Leah M. Prentice, Marco A. Marra, Jeffrey Kiefer, Victoria L. Zismann, Troy A. McEachron, Bodour Salhia, Jaime Prat, Blaise A. Clarke, Joseph G. Pressey, John H. Farley, Stephen P. Anthony, Richard B.S. Roden, Heather E. Cunliffe, David G. Huntsman, Jeffrey M. Trent
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (16_Supplement): POSTER-BIOL-1327.
https://doi.org/10.1158/1557-3265.OVCASYMP14-POSTER-BIOL-1327
Published: 15 August 2015
View article titled, Abstract POSTER-BIOL-1327: Small cell carcinoma of the ovary, hypercalcemic type displays frequent inactivating germline and somatic mutations in SMARCA4
Journal Articles

System-Level Analysis of Neuroblastoma Tumor–Initiating Cells Implicates AURKB as a Novel Drug Target for Neuroblastoma

Olena Morozova, Milijana Vojvodic, Natalie Grinshtein, Loen M. Hansford, Kim M. Blakely, Alexandra Maslova, Martin Hirst, Timothee Cezard, Ryan D. Morin, Richard Moore, Kristen M. Smith, Freda Miller, Paul Taylor, Nina Thiessen, Richard Varhol, Yongjun Zhao, Steven Jones, Jason Moffat, Thomas Kislinger, Michael F. Moran, David R. Kaplan, Marco A. Marra
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (18): 4572–4582.
https://doi.org/10.1158/1078-0432.CCR-10-0627
Published: 14 September 2010
View article titled, System-Level Analysis of Neuroblastoma Tumor–Initiating Cells Implicates AURKB as a Novel Drug Target for Neuroblastoma
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Includes: Supplementary data
Journal Articles

Sequence Variant Discovery in DNA Repair Genes from Radiosensitive and Radiotolerant Prostate Brachytherapy Patients

Trevor J. Pugh, Mira Keyes, Lorena Barclay, Allen Delaney, Martin Krzywinski, Dallas Thomas, Karen Novik, Cindy Yang, Alexander Agranovich, Michael McKenzie, W. Jim Morris, Peggy L. Olive, Marco A. Marra, Richard A. Moore
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (15): 5008–5016.
https://doi.org/10.1158/1078-0432.CCR-08-3357
Published: 29 July 2009
View article titled, Sequence Variant Discovery in DNA Repair Genes from Radiosensitive and Radiotolerant Prostate Brachytherapy Patients
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Includes: Supplementary data