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Journal Articles

HER2 Antibody–Drug Conjugates Are Active against Desmoplastic Small Round Cell Tumor

Tom Zhang, Christopher A. Febres-Aldana, Zebing Liu, Jenna-Marie Dix, Ryan Cheng, Raymond G. Dematteo, Allan J.W. Lui, Inna Khodos, Leo Gili, Marissa S. Mattar, Jeanine Lisanti, Charlene Kwong, Irina Linkov, Murray J. Tipping, Elisa de Stanchina, Igor Odintsov, Marc Ladanyi, Romel Somwar
Journal: Clinical Cancer Research
Clin Cancer Res OF1–OF13.
https://doi.org/10.1158/1078-0432.CCR-24-1835
Published: 16 September 2024
View article titled, HER2 Antibody–Drug Conjugates Are Active against Desmoplastic Small Round Cell Tumor
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Includes: Supplementary data
Journal Articles

Tumor-Agnostic Genomic and Clinical Analysis of BRAF Fusions Identifies Actionable Targets

Monica F. Chen, Soo-Ryum Yang, Jessica J. Tao, Antoine Desilets, Eli L. Diamond, Clare Wilhelm, Ezra Rosen, Yixiao Gong, Kerry Mullaney, Jean Torrisi, Robert J. Young, Romel Somwar, Helena A. Yu, Mark G. Kris, Gregory J. Riely, Maria E. Arcila, Marc Ladanyi, Mark T.A. Donoghue, Neal Rosen, Rona Yaeger, Alexander Drilon, Yonina R. Murciano-Goroff, Michael Offin
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (17): 3812–3823.
https://doi.org/10.1158/1078-0432.CCR-23-3981
Published: 03 September 2024
View article titled, Tumor-Agnostic Genomic and Clinical Analysis of <em>BRAF</em> Fusions Identifies Actionable Targets
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Includes: Supplementary data
Journal Articles

Diffuse Pleural Mesotheliomas with Genomic Near-Haploidization: A Newly Recognized Subset with Distinct Clinical, Histologic, and Molecular Features

Soo-Ryum Yang, Gowtham Jayakumaran, Jamal Benhamida, Christopher A. Febres-Aldana, Rachel Fanaroff, Jason Chang, Erika Gedvilaite, Liliana B. Villafania, Jennifer L. Sauter, Michael Offin, Marjorie G. Zauderer, Marc Ladanyi
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (13): 2780–2789.
https://doi.org/10.1158/1078-0432.CCR-24-0085
Published: 01 July 2024
View article titled, Diffuse Pleural Mesotheliomas with Genomic Near-Haploidization: A Newly Recognized Subset with Distinct Clinical, Histologic, and Molecular Features
Open the PDF for Diffuse Pleural Mesotheliomas with Genomic Near-Haploidization: A Newly Recognized Subset with Distinct Clinical, Histologic, and Molecular Features in another window
Includes: Supplementary data
Journal Articles

Clinical and Molecular Features of Long-term Response to Immune Checkpoint Inhibitors in Patients with Advanced Non–Small Cell Lung Cancer

Rohit Thummalapalli, Biagio Ricciuti, Chaitanya Bandlamudi, Daniel Muldoon, Hira Rizvi, Arielle Elkrief, Jia Luo, Joao V. Alessi, Federica Pecci, Giuseppe Lamberti, Alessandro Di Federico, Lingzhi Hong, Jianjun Zhang, John V. Heymach, Don L. Gibbons, Andrew J. Plodkowski, Vignesh Ravichandran, Mark T.A. Donoghue, Chad Vanderbilt, Marc Ladanyi, Charles M. Rudin, Mark G. Kris, Gregory J. Riely, Jamie E. Chaft, Matthew D. Hellmann, Natalie I. Vokes, Mark M. Awad, Adam J. Schoenfeld
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (21): 4408–4418.
https://doi.org/10.1158/1078-0432.CCR-23-1207
Published: 01 November 2023
View article titled, Clinical and Molecular Features of Long-term Response to Immune Checkpoint Inhibitors in Patients with Advanced Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Clinicopathologic, Genomic, and Immunophenotypic Landscape of ATM Mutations in Non–Small Cell Lung Cancer

Biagio Ricciuti, Arielle Elkrief, Joao Alessi, Xinan Wang, Yvonne Li, Hersh Gupta, Daniel M. Muldoon, Arrien A. Bertram, Federica Pecci, Giuseppe Lamberti, Alessandro Di Federico, Adriana Barrichello, Victor R. Vaz, Malini Gandhi, Elinton Lee, Geoffrey I. Shapiro, Hyesun Park, Mizuki Nishino, James Lindsay, Kristen D. Felt, Bijaya Sharma, Andrew D. Cherniack, Scott Rodig, Daniel R. Gomez, Narek Shaverdian, Mehrdad Rakaee, Chaitanya Bandlamudi, Marc Ladanyi, Pasi A. Janne, Adam J. Schoenfeld, Lynette M. Sholl, Mark M. Awad, Michael L. Cheng
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (13): 2540–2550.
https://doi.org/10.1158/1078-0432.CCR-22-3413
Published: 05 July 2023
View article titled, Clinicopathologic, Genomic, and Immunophenotypic Landscape of <em>ATM</em> Mutations in Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Overcoming Barriers to Tumor Genomic Profiling through Direct-to-Patient Outreach

Seyram A. Doe-Tetteh, Sabrina Y. Camp, Dalicia Reales, Jett Crowdis, Anne Marie Noronha, Bernadette Wolff, Tina Alano, Jesse Galle, S. Duygu Selcuklu, Agnes Viale, Nicholas D. Socci, Ying L. Liu, William P. Tew, Carol Aghajanian, Marc Ladanyi, Meng Xiao He, Saud H. AlDubayan, Roei David Mazor, Ofer Shpilberg, Oshrat Hershkovitz-Rokah, Jose A. Riancho, Jose L. Hernandez, M. Carmen Gonzalez-Vela, Justin J. Buthorn, Manda Wilson, Amy E. Webber, Mariko Yabe, Kseniya Petrova-Drus, Marc Rosenblum, Benjamin H. Durham, Omar Abdel-Wahab, Michael F. Berger, Mark T.A. Donoghue, Andrew L. Kung, Julia Glade Bender, Neerav N. Shukla, Samuel A. Funt, Ahmet Dogan, Robert A. Soslow, Hikmat Al-Ahmadie, Darren R. Feldman, Eliezer M. Van Allen, Eli L. Diamond, David B. Solit
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (13): 2445–2455.
https://doi.org/10.1158/1078-0432.CCR-22-3247
Published: 05 July 2023
View article titled, Overcoming Barriers to Tumor Genomic Profiling through Direct-to-Patient Outreach
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Includes: Supplementary data
Journal Articles

Brief Report: Combination of Osimertinib and Dacomitinib to Mitigate Primary and Acquired Resistance in EGFR-Mutant Lung Adenocarcinomas

Arielle Elkrief, Alex Makhnin, Khadeja A. Moses, Linda S. Ahn, Isabel R. Preeshagul, Afsheen N. Iqbal, Sara A. Hayes, Andrew J. Plodkowski, Paul K. Paik, Marc Ladanyi, Mark G. Kris, Gregory J. Riely, Franziska Michor, Helena A. Yu
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (8): 1423–1428.
https://doi.org/10.1158/1078-0432.CCR-22-3484
Published: 14 April 2023
View article titled, Brief Report: Combination of Osimertinib and Dacomitinib to Mitigate Primary and Acquired Resistance in <em>EGFR</em>-Mutant Lung Adenocarcinomas
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Includes: Supplementary data
Journal Articles

Predicting Molecular Subtype and Survival of Rhabdomyosarcoma Patients Using Deep Learning of H&E Images: A Report from the Children's Oncology Group

David Milewski, Hyun Jung, G. Thomas Brown, Yanling Liu, Ben Somerville, Curtis Lisle, Marc Ladanyi, Erin R. Rudzinski, Hyoyoung Choo-Wosoba, Donald A. Barkauskas, Tammy Lo, David Hall, Corinne M. Linardic, Jun S. Wei, Hsien-Chao Chou, Stephen X. Skapek, Rajkumar Venkatramani, Peter K. Bode, Seth M. Steinberg, George Zaki, Igor B. Kuznetsov, Douglas S. Hawkins, Jack F. Shern, Jack Collins, Javed Khan
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (2): 364–378.
https://doi.org/10.1158/1078-0432.CCR-22-1663
Published: 17 January 2023
View article titled, Predicting Molecular Subtype and Survival of Rhabdomyosarcoma Patients Using Deep Learning of H&amp;E Images: A Report from the Children's Oncology Group
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Includes: Supplementary data
Journal Articles

Comprehensive Molecular Characterization of Gallbladder Carcinoma and Potential Targets for Intervention

Nicolas A. Giraldo, Esther Drill, Baby A. Satravada, Imane El Dika, A. Rose Brannon, Josephine Dermawan, Abhinita Mohanty, Kerem Ozcan, Debyani Chakravarty, Ryma Benayed, Efsevia Vakiani, Ghassan K. Abou-Alfa, Ritika Kundra, Nikolaus Schultz, Bob T. Li, Michael F. Berger, James J. Harding, Marc Ladanyi, Eileen M. O'Reilly, William Jarnagin, Chad Vanderbilt, Olca Basturk, Maria E. Arcila
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (24): 5359–5367.
https://doi.org/10.1158/1078-0432.CCR-22-1954
Published: 15 December 2022
View article titled, Comprehensive Molecular Characterization of Gallbladder Carcinoma and Potential Targets for Intervention
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Includes: Supplementary data
Journal Articles

Rb Tumor Suppressor in Small Cell Lung Cancer: Combined Genomic and IHC Analysis with a Description of a Distinct Rb-Proficient Subset

Christopher A. Febres-Aldana, Jason C. Chang, Ryan Ptashkin, Yuhan Wang, Erika Gedvilaite, Marina K. Baine, William D. Travis, Katia Ventura, Francis Bodd, Helena A. Yu, Alvaro Quintanal-Villalonga, W. Victoria Lai, Jacklynn V. Egger, Michael Offin, Marc Ladanyi, Charles M. Rudin, Natasha Rekhtman
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (21): 4702–4713.
https://doi.org/10.1158/1078-0432.CCR-22-1115
Published: 01 November 2022
View article titled, Rb Tumor Suppressor in Small Cell Lung Cancer: Combined Genomic and IHC Analysis with a Description of a Distinct Rb-Proficient Subset
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Includes: Supplementary data
Journal Articles

Bioinformatically Expanded Next-Generation Sequencing Analysis Optimizes Identification of Therapeutically Relevant MET Copy Number Alterations in >50,000 Tumors

James P. Solomon, Soo-Ryum Yang, Noura J. Choudhury, Ryan N. Ptashkin, Nasrin Eslamdoost, Christina J. Falcon, Axel Martin, Andrew Plodkowski, Clare Wilhelm, Ronglai Shen, Marc Ladanyi, Michael Berger, Yanming Zhang, Alexander Drilon, Maria E. Arcila
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (21): 4649–4659.
https://doi.org/10.1158/1078-0432.CCR-22-1321
Published: 01 November 2022
View article titled, Bioinformatically Expanded Next-Generation Sequencing Analysis Optimizes Identification of Therapeutically Relevant <em>MET</em> Copy Number Alterations in &gt;50,000 Tumors
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Includes: Supplementary data
Journal Articles

Abstract PR012: Targeted sequencing of 2,138 bone and soft tissue sarcomas reveals commonly altered pathways, subtype-independent genetic clusters, and potential therapeutic targets

Benjamin A. Nacev, Francisco Sanchez-Vega, Shaleigh Smith, Cristina Antonescu, Evan Rosenbaum, Hongyu Shi, Cerise Tang, Nicholas Socci, Satshil Rana, Rodrigo Gularte-Merida, Ahmet Zehir, Mrinal Gounder, Timothy Bowler, Anisha Luthra, Bhumika Jadeja, Azusa Okada, Jonathan Strong, Jake Stoller, Jason Chan, Ping Chi, Sandra D'Angelo, Mark Dickson, Ciara Kelly, Mary Louise Keohan, Sujana Movva, Katherine Thornton, Paul Meyers, Leonard Wexler, Emily Slotkin, Julia Glade Bender, Neerav Shukla, Martee Hensley, John Healey, Michael La Quaglia, Kaled Alektiar, Aimee Crago, Sam Yoon, Brian Untch, Sarah Chiang, Narasimhan Agaram, Meera Hameed, Michael Berger, David Solit, Nikolaus Schultz, Marc Ladanyi, Samuel Singer, William Tap
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (18_Supplement): PR012.
https://doi.org/10.1158/1557-3265.SARCOMAS22-PR012
Published: 15 September 2022
View article titled, Abstract PR012: Targeted sequencing of 2,138 bone and soft tissue sarcomas reveals commonly altered pathways, subtype-independent genetic clusters, and potential therapeutic targets
Journal Articles

Abstract B023: Prospective clinical genomic profiling of ewing sarcoma: ERF and FGFR1 mutations as recurrent secondary alterations of potential biological and therapeutic relevance

Arielle Elkrief, Koichi Ogura, Anita S. Bowman, Richard P. Koche, Ryma Benayed, Audrey Mauguen, Marissa S. Mattar, Inna Khodos, Elisa de Stanchina, Paul A. Meyers, John H. Healey, William D. Tap, Neerav Shukla, Meera Hameed, Ahmet Zehir, Charles Sawyers, Rohit Bose, Emily Slotkin, Marc Ladanyi
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (18_Supplement): B023.
https://doi.org/10.1158/1557-3265.SARCOMAS22-B023
Published: 15 September 2022
View article titled, Abstract B023: Prospective clinical genomic profiling of ewing sarcoma: <em>ERF</em> and <em>FGFR1</em> mutations as recurrent secondary alterations of potential biological and therapeutic relevance
Journal Articles

Comprehensive Molecular and Clinicopathologic Analysis of 200 Pulmonary Invasive Mucinous Adenocarcinomas Identifies Distinct Characteristics of Molecular Subtypes

Jason C. Chang, Michael Offin, Christina Falcon, David Brown, Brian R. Houck-Loomis, Fanli Meng, Vasilisa A. Rudneva, Helen H. Won, Sharon Amir, Joseph Montecalvo, Patrice Desmeules, Kyuichi Kadota, Prasad S. Adusumilli, Valerie W. Rusch, Sarah Teed, Joshua K. Sabari, Ryma Benayed, Khedoudja Nafa, Laetitia Borsu, Bob T. Li, Alison M. Schram, Maria E. Arcila, William D. Travis, Marc Ladanyi, Alexander Drilon, Natasha Rekhtman
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (14): 4066–4076.
https://doi.org/10.1158/1078-0432.CCR-21-0423
Published: 15 July 2021
View article titled, Comprehensive Molecular and Clinicopathologic Analysis of 200 Pulmonary Invasive Mucinous Adenocarcinomas Identifies Distinct Characteristics of Molecular Subtypes
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Includes: Supplementary data
Journal Articles

The Anti-HER3 mAb Seribantumab Effectively Inhibits Growth of Patient-Derived and Isogenic Cell Line and Xenograft Models with Oncogenic NRG1 Fusions

Igor Odintsov, Allan J.W. Lui, Whitney J. Sisso, Eric Gladstone, Zebing Liu, Lukas Delasos, Renate I. Kurth, Exequiel M. Sisso, Morana Vojnic, Inna Khodos, Marissa S. Mattar, Elisa de Stanchina, Shawn M. Leland, Marc Ladanyi, Romel Somwar
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (11): 3154–3166.
https://doi.org/10.1158/1078-0432.CCR-20-3605
Published: 01 June 2021
View article titled, The Anti-HER3 mAb Seribantumab Effectively Inhibits Growth of Patient-Derived and Isogenic Cell Line and Xenograft Models with Oncogenic <em>NRG1</em> Fusions
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Includes: Supplementary data
Journal Articles

Response to Standard Therapies and Comprehensive Genomic Analysis for Patients with Lung Adenocarcinoma with EGFR Exon 20 Insertions

Noura J. Choudhury, Adam J. Schoenfeld, Jessica Flynn, Christina J. Falcon, Hira Rizvi, Charles M. Rudin, Mark G. Kris, Maria E. Arcila, Glenn Heller, Helena A. Yu, Marc Ladanyi, Gregory J. Riely
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (10): 2920–2927.
https://doi.org/10.1158/1078-0432.CCR-20-4650
Published: 15 May 2021
View article titled, Response to Standard Therapies and Comprehensive Genomic Analysis for Patients with Lung Adenocarcinoma with <em>EGFR</em> Exon 20 Insertions
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Includes: Supplementary data
Journal Articles

Clinicopathologic and Genomic Analysis of TP53-Mutated Endometrial Carcinomas

Amir Momeni-Boroujeni, Wissam Dahoud, Chad M. Vanderbilt, Sarah Chiang, Rajmohan Murali, Eric V. Rios-Doria, Kaled M. Alektiar, Carol Aghajanian, Nadeem R. Abu-Rustum, Marc Ladanyi, Lora H. Ellenson, Britta Weigelt, Robert A. Soslow
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (9): 2613–2623.
https://doi.org/10.1158/1078-0432.CCR-20-4436
Published: 01 May 2021
View article titled, Clinicopathologic and Genomic Analysis of <em>TP53</em>-Mutated Endometrial Carcinomas
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Includes: Supplementary data
Journal Articles

Treatment Outcomes and Clinical Characteristics of Patients with KRAS-G12C–Mutant Non–Small Cell Lung Cancer

Kathryn C. Arbour, Hira Rizvi, Andrew J. Plodkowski, Matthew D. Hellmann, Andrea Knezevic, Glenn Heller, Helena A. Yu, Marc Ladanyi, Mark G. Kris, Maria E. Arcila, Charles M. Rudin, Piro Lito, Gregory J. Riely
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (8): 2209–2215.
https://doi.org/10.1158/1078-0432.CCR-20-4023
Published: 15 April 2021
View article titled, Treatment Outcomes and Clinical Characteristics of Patients with KRAS-G12C–Mutant Non–Small Cell Lung Cancer
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Journal Articles

A Performance Comparison of Commonly Used Assays to Detect RET Fusions

Soo-Ryum Yang, Umut Aypar, Ezra Y. Rosen, Douglas A. Mata, Ryma Benayed, Kerry Mullaney, Gowtham Jayakumaran, Yanming Zhang, Denise Frosina, Alexander Drilon, Marc Ladanyi, Achim A. Jungbluth, Natasha Rekhtman, Jaclyn F. Hechtman
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (5): 1316–1328.
https://doi.org/10.1158/1078-0432.CCR-20-3208
Published: 01 March 2021
View article titled, A Performance Comparison of Commonly Used Assays to Detect RET Fusions
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Includes: Supplementary data
Journal Articles

Therapeutic Potential of NTRK3 Inhibition in Desmoplastic Small Round Cell Tumor

Koichi Ogura, Romel Somwar, Julija Hmeljak, Heather Magnan, Ryma Benayed, Amir Momeni Boroujeni, Anita S. Bowman, Marissa S. Mattar, Inna Khodos, Elisa de Stanchina, Achim Jungbluth, Marina Asher, Igor Odintsov, Alifiani B. Hartono, Michael P. LaQuaglia, Emily Slotkin, Christine A. Pratilas, Sean Bong Lee, Lee Spraggon, Marc Ladanyi
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (4): 1184–1194.
https://doi.org/10.1158/1078-0432.CCR-20-2585
Published: 15 February 2021
View article titled, Therapeutic Potential of NTRK3 Inhibition in Desmoplastic Small Round Cell Tumor
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Includes: Supplementary data