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Journal Articles

Comprehensive Molecular and Clinicopathologic Analysis of 200 Pulmonary Invasive Mucinous Adenocarcinomas Identifies Distinct Characteristics of Molecular Subtypes

Clin Cancer Res (2021) 27 (14): 4066–4076.

DOI: https://doi.org/10.1158/1078-0432.CCR-21-0423

Published: 15 July 2021

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Includes: Supplementary data

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The Anti-HER3 mAb Seribantumab Effectively Inhibits Growth of Patient-Derived and Isogenic Cell Line and Xenograft Models with Oncogenic NRG1 Fusions

Igor Odintsov, Allan J.W. Lui, Whitney J. Sisso, Eric Gladstone, Zebing Liu, Lukas Delasos, Renate I. Kurth, Exequiel M. Sisso, Morana Vojnic, Inna Khodos, Marissa S. Mattar, Elisa de Stanchina, Shawn M. Leland, Marc Ladanyi, Romel Somwar

Clin Cancer Res (2021) 27 (11): 3154–3166.

DOI: https://doi.org/10.1158/1078-0432.CCR-20-3605

Published: 01 June 2021

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Response to Standard Therapies and Comprehensive Genomic Analysis for Patients with Lung Adenocarcinoma with EGFR Exon 20 Insertions

Noura J. Choudhury, Adam J. Schoenfeld, Jessica Flynn, Christina J. Falcon, Hira Rizvi, Charles M. Rudin, Mark G. Kris, Maria E. Arcila, Glenn Heller, Helena A. Yu, Marc Ladanyi, Gregory J. Riely

Clin Cancer Res (2021) 27 (10): 2920–2927.

DOI: https://doi.org/10.1158/1078-0432.CCR-20-4650

Published: 15 May 2021

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Clinicopathologic and Genomic Analysis of TP53-Mutated Endometrial Carcinomas

Amir Momeni-Boroujeni, Wissam Dahoud, Chad M. Vanderbilt, Sarah Chiang, Rajmohan Murali, Eric V. Rios-Doria, Kaled M. Alektiar, Carol Aghajanian, Nadeem R. Abu-Rustum, Marc Ladanyi, Lora H. Ellenson, Britta Weigelt, Robert A. Soslow

Clin Cancer Res (2021) 27 (9): 2613–2623.

DOI: https://doi.org/10.1158/1078-0432.CCR-20-4436

Published: 01 May 2021

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Treatment Outcomes and Clinical Characteristics of Patients with KRAS-G12C–Mutant Non–Small Cell Lung Cancer

Kathryn C. Arbour, Hira Rizvi, Andrew J. Plodkowski, Matthew D. Hellmann, Andrea Knezevic, Glenn Heller, Helena A. Yu, Marc Ladanyi, Mark G. Kris, Maria E. Arcila, Charles M. Rudin, Piro Lito, Gregory J. Riely

Clin Cancer Res (2021) 27 (8): 2209–2215.

DOI: https://doi.org/10.1158/1078-0432.CCR-20-4023

Published: 15 April 2021

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A Performance Comparison of Commonly Used Assays to Detect RET Fusions

Soo-Ryum Yang, Umut Aypar, Ezra Y. Rosen, Douglas A. Mata, Ryma Benayed, Kerry Mullaney, Gowtham Jayakumaran, Yanming Zhang, Denise Frosina, Alexander Drilon, Marc Ladanyi, Achim A. Jungbluth, Natasha Rekhtman, Jaclyn F. Hechtman

Clin Cancer Res (2021) 27 (5): 1316–1328.

DOI: https://doi.org/10.1158/1078-0432.CCR-20-3208

Published: 01 March 2021

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Therapeutic Potential of NTRK3 Inhibition in Desmoplastic Small Round Cell Tumor

Clin Cancer Res (2021) 27 (4): 1184–1194.

DOI: https://doi.org/10.1158/1078-0432.CCR-20-2585

Published: 15 February 2021

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Overcoming MET-Dependent Resistance to Selective RET Inhibition in Patients with RET Fusion–Positive Lung Cancer by Combining Selpercatinib with Crizotinib

Clin Cancer Res (2021) 27 (1): 34–42.

DOI: https://doi.org/10.1158/1078-0432.CCR-20-2278

Published: 04 January 2021

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The Genomic Landscape of SMARCA4 Alterations and Associations with Outcomes in Patients with Lung Cancer

Clin Cancer Res (2020) 26 (21): 5701–5708.

DOI: https://doi.org/10.1158/1078-0432.CCR-20-1825

Published: 02 November 2020

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Abstract 12: Characterizing KRAS G12C and other mutations in plasma ctDNA from patients with lung cancer

Clin Cancer Res (2020) 26 (12_Supplement_1): 12.

DOI: https://doi.org/10.1158/1557-3265.ADVPRECMED20-12

Published: 15 June 2020

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MAPK Pathway Alterations Correlate with Poor Survival and Drive Resistance to Therapy in Patients with Lung Cancers Driven by ROS1 Fusions

Clin Cancer Res (2020) 26 (12): 2932–2945.

DOI: https://doi.org/10.1158/1078-0432.CCR-19-3321

Published: 15 June 2020

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Abstract PR08: Validation and clinical implementation of MSK-ACCESS, an ultra-deep sequencing assay for noninvasive somatic mutation profiling

Clin Cancer Res (2020) 26 (11_Supplement): PR08.

DOI: https://doi.org/10.1158/1557-3265.LiqBiop20-PR08

Published: 01 June 2020

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Journal Articles

Tumor Analyses Reveal Squamous Transformation and Off-Target Alterations As Early Resistance Mechanisms to First-line Osimertinib in EGFR-Mutant Lung Cancer

Adam J. Schoenfeld, Joseph M. Chan, Daisuke Kubota, Hiroki Sato, Hira Rizvi, Yahya Daneshbod, Jason C. Chang, Paul K. Paik, Michael Offin, Maria E. Arcila, Monika A. Davare, Ujwal Shinde, Dana Pe'er, Natasha Rekhtman, Mark G. Kris, Romel Somwar, Gregory J. Riely, Marc Ladanyi, Helena A. Yu

Clin Cancer Res (2020) 26 (11): 2654–2663.

DOI: https://doi.org/10.1158/1078-0432.CCR-19-3563

Published: 01 June 2020

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Genomic Profiling Identifies Association of IDH1/IDH2 Mutation with Longer Relapse-Free and Metastasis-Free Survival in High-Grade Chondrosarcoma

Guo Gord Zhu, Khedoudja Nafa, Narasimhan Agaram, Ahmet Zehir, Ryma Benayed, Justyna Sadowska, Laetitia Borsu, Ciara Kelly, William D. Tap, Nicola Fabbri, Edward Athanasian, Patrick J. Boland, John H. Healey, Michael F. Berger, Marc Ladanyi, Meera Hameed

Clin Cancer Res (2020) 26 (2): 419–427.

DOI: https://doi.org/10.1158/1078-0432.CCR-18-4212

Published: 15 January 2020

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Analysis of Tumor Genomic Pathway Alterations Using Broad-Panel Next-Generation Sequencing in Surgically Resected Lung Adenocarcinoma

Clin Cancer Res (2019) 25 (24): 7475–7484.

DOI: https://doi.org/10.1158/1078-0432.CCR-19-1651

Published: 13 December 2019

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Comprehensive Next-Generation Sequencing Unambiguously Distinguishes Separate Primary Lung Carcinomas From Intrapulmonary Metastases: Comparison with Standard Histopathologic Approach

Jason C. Chang, Deepu Alex, Matthew Bott, Kay See Tan, Venkatraman Seshan, Andrew Golden, Jennifer L. Sauter, Darren J. Buonocore, Chad M. Vanderbilt, Sounak Gupta, Patrice Desmeules, Francis M. Bodd, Gregory J. Riely, Valerie W. Rusch, David R. Jones, Maria E. Arcila, William D. Travis, Marc Ladanyi, Natasha Rekhtman

Clin Cancer Res (2019) 25 (23): 7113–7125.

DOI: https://doi.org/10.1158/1078-0432.CCR-19-1700

Published: 02 December 2019

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Journal Articles

Clinical Genomic Sequencing of Pediatric and Adult Osteosarcoma Reveals Distinct Molecular Subsets with Potentially Targetable Alterations

Yoshiyuki Suehara, Deepu Alex, Anita Bowman, Sumit Middha, Ahmet Zehir, Debyani Chakravarty, Lu Wang, George Jour, Khedoudja Nafa, Takuo Hayashi, Achim A. Jungbluth, Denise Frosina, Emily Slotkin, Neerav Shukla, Paul Meyers, John H. Healey, Meera Hameed, Marc Ladanyi

Clin Cancer Res (2019) 25 (21): 6346–6356.

DOI: https://doi.org/10.1158/1078-0432.CCR-18-4032

Published: 01 November 2019

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Journal Articles

Clinical and Molecular Predictors of Response to Immune Checkpoint Inhibitors in Patients with Advanced Esophagogastric Cancer

Megan Greally, Joanne F. Chou, Walid K. Chatila, Matthew Margolis, Marinela Capanu, Jaclyn F. Hechtman, Yaelle Tuvy, Ritika Kundra, Foysal Daian, Marc Ladanyi, David P. Kelsen, David H. Ilson, Michael F. Berger, Laura H. Tang, David B. Solit, Luis A. Diaz, Jr, Nikolaus Schultz, Yelena Y. Janjigian, Geoffrey Y. Ku

Clin Cancer Res (2019) 25 (20): 6160–6169.

DOI: https://doi.org/10.1158/1078-0432.CCR-18-3603

Published: 15 October 2019

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Journal Articles

Genomic Correlates of Disease Progression and Treatment Response in Prospectively Characterized Gliomas

Clin Cancer Res (2019) 25 (18): 5537–5547.

DOI: https://doi.org/10.1158/1078-0432.CCR-19-0032

Published: 13 September 2019

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Journal Articles

High Yield of RNA Sequencing for Targetable Kinase Fusions in Lung Adenocarcinomas with No Mitogenic Driver Alteration Detected by DNA Sequencing and Low Tumor Mutation Burden

Ryma Benayed, Michael Offin, Kerry Mullaney, Purvil Sukhadia, Kelly Rios, Patrice Desmeules, Ryan Ptashkin, Helen Won, Jason Chang, Darragh Halpenny, Alison M. Schram, Charles M. Rudin, David M. Hyman, Maria E. Arcila, Michael F. Berger, Ahmet Zehir, Mark G. Kris, Alexander Drilon, Marc Ladanyi

Clin Cancer Res (2019) 25 (15): 4712–4722.

DOI: https://doi.org/10.1158/1078-0432.CCR-19-0225

Published: 01 August 2019

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Includes: Supplementary data

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NARROW

Comprehensive Molecular and Clinicopathologic Analysis of 200 Pulmonary Invasive Mucinous Adenocarcinomas Identifies Distinct Characteristics of Molecular Subtypes

The Anti-HER3 mAb Seribantumab Effectively Inhibits Growth of Patient-Derived and Isogenic Cell Line and Xenograft Models with Oncogenic NRG1 Fusions

Response to Standard Therapies and Comprehensive Genomic Analysis for Patients with Lung Adenocarcinoma with EGFR Exon 20 Insertions

Clinicopathologic and Genomic Analysis of TP53-Mutated Endometrial Carcinomas

Treatment Outcomes and Clinical Characteristics of Patients with KRAS-G12C–Mutant Non–Small Cell Lung Cancer

A Performance Comparison of Commonly Used Assays to Detect RET Fusions

Therapeutic Potential of NTRK3 Inhibition in Desmoplastic Small Round Cell Tumor

Overcoming MET-Dependent Resistance to Selective RET Inhibition in Patients with RET Fusion–Positive Lung Cancer by Combining Selpercatinib with Crizotinib

The Genomic Landscape of SMARCA4 Alterations and Associations with Outcomes in Patients with Lung Cancer

Abstract 12: Characterizing KRAS G12C and other mutations in plasma ctDNA from patients with lung cancer

MAPK Pathway Alterations Correlate with Poor Survival and Drive Resistance to Therapy in Patients with Lung Cancers Driven by ROS1 Fusions

Abstract PR08: Validation and clinical implementation of MSK-ACCESS, an ultra-deep sequencing assay for noninvasive somatic mutation profiling

Tumor Analyses Reveal Squamous Transformation and Off-Target Alterations As Early Resistance Mechanisms to First-line Osimertinib in EGFR-Mutant Lung Cancer

Genomic Profiling Identifies Association of IDH1/IDH2 Mutation with Longer Relapse-Free and Metastasis-Free Survival in High-Grade Chondrosarcoma

Analysis of Tumor Genomic Pathway Alterations Using Broad-Panel Next-Generation Sequencing in Surgically Resected Lung Adenocarcinoma

Comprehensive Next-Generation Sequencing Unambiguously Distinguishes Separate Primary Lung Carcinomas From Intrapulmonary Metastases: Comparison with Standard Histopathologic Approach

Clinical Genomic Sequencing of Pediatric and Adult Osteosarcoma Reveals Distinct Molecular Subsets with Potentially Targetable Alterations

Clinical and Molecular Predictors of Response to Immune Checkpoint Inhibitors in Patients with Advanced Esophagogastric Cancer

Genomic Correlates of Disease Progression and Treatment Response in Prospectively Characterized Gliomas

High Yield of RNA Sequencing for Targetable Kinase Fusions in Lung Adenocarcinomas with No Mitogenic Driver Alteration Detected by DNA Sequencing and Low Tumor Mutation Burden

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