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Manel Esteller
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Journal Articles

Antitumor Activity of the Novel BTK Inhibitor TG-1701 Is Associated with Disruption of Ikaros Signaling in Patients with B-cell Non–Hodgkin Lymphoma

Marcelo Lima Ribeiro, Diana Reyes-Garau, Meritxell Vinyoles, Núria Profitós Pelejà, Juliana Carvalho Santos, Marc Armengol, Miranda Fernández-Serrano, Alícia Sedó Mor, Joan J. Bech-Serra, Pedro Blecua, Eva Musulen, Carolina De La Torre, Hari Miskin, Manel Esteller, Francesc Bosch, Pablo Menéndez, Emmanuel Normant, Gaël Roué
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (23): 6591–6601.
https://doi.org/10.1158/1078-0432.CCR-21-1067
Published: 01 December 2021
View article titled, Antitumor Activity of the Novel BTK Inhibitor TG-1701 Is Associated with Disruption of Ikaros Signaling in Patients with B-cell Non–Hodgkin Lymphoma
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Includes: Supplementary data
Journal Articles

Epigenetic EGFR Gene Repression Confers Sensitivity to Therapeutic BRAFV600E Blockade in Colon Neuroendocrine Carcinomas

Jaume Capdevila, Oriol Arqués, Jose Ramón Hernández Mora, Judit Matito, Ginevra Caratù, Francesco M. Mancuso, Stefania Landolfi, Jorge Barriuso, Paula Jimenez-Fonseca, Carlos Lopez Lopez, Rocio Garcia-Carbonero, Jorge Hernando, Ignacio Matos, Nuciforo Paolo, Javier Hernández-Losa, Manel Esteller, Anna Martínez-Cardús, Josep Tabernero, Ana Vivancos, Héctor G. Palmer
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (4): 902–909.
https://doi.org/10.1158/1078-0432.CCR-19-1266
Published: 14 February 2020
View article titled, Epigenetic <em>EGFR</em> Gene Repression Confers Sensitivity to Therapeutic BRAFV600E Blockade in Colon Neuroendocrine Carcinomas
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Includes: Supplementary data
Journal Articles

Orthoxenografts of Testicular Germ Cell Tumors Demonstrate Genomic Changes Associated with Cisplatin Resistance and Identify PDMP as a Resensitizing Agent

Josep M. Piulats, August Vidal, Francisco J. García-Rodríguez, Clara Muñoz, Marga Nadal, Catia Moutinho, María Martínez-Iniesta, Josefina Mora, Agnés Figueras, Elisabet Guinó, Laura Padullés, Àlvaro Aytés, David G. Molleví, Sara Puertas, Carmen Martínez-Fernández, Wilmar Castillo, Merce Juliachs, Victor Moreno, Purificación Muñoz, Milica Stefanovic, Miguel A. Pujana, Enric Condom, Manel Esteller, Josep R. Germà, Gabriel Capella, Lourdes Farré, Albert Morales, Francesc Viñals, Xavier García-del-Muro, Julián Cerón, Alberto Villanueva
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (15): 3755–3766.
https://doi.org/10.1158/1078-0432.CCR-17-1898
Published: 31 July 2018
View article titled, Orthoxenografts of Testicular Germ Cell Tumors Demonstrate Genomic Changes Associated with Cisplatin Resistance and Identify PDMP as a Resensitizing Agent
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Includes: Supplementary data
Journal Articles

Targeted Exome Sequencing of Krebs Cycle Genes Reveals Candidate Cancer–Predisposing Mutations in Pheochromocytomas and Paragangliomas

Laura Remacha, Iñaki Comino-Méndez, Susan Richter, Laura Contreras, María Currás-Freixes, Guillermo Pita, Rocío Letón, Antonio Galarreta, Rafael Torres-Pérez, Emiliano Honrado, Scherezade Jiménez, Lorena Maestre, Sebastian Moran, Manel Esteller, Jorgina Satrústegui, Graeme Eisenhofer, Mercedes Robledo, Alberto Cascón
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (20): 6315–6324.
https://doi.org/10.1158/1078-0432.CCR-16-2250
Published: 12 October 2017
View article titled, Targeted Exome Sequencing of Krebs Cycle Genes Reveals Candidate Cancer–Predisposing Mutations in Pheochromocytomas and Paragangliomas
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Includes: Supplementary data
Journal Articles

A Novel Epigenetic Signature for Early Diagnosis in Lung Cancer

Angel Diaz-Lagares, Jesus Mendez-Gonzalez, David Hervas, Maria Saigi, Maria J. Pajares, Diana Garcia, Ana B. Crujerias, Ruben Pio, Luis M. Montuenga, Javier Zulueta, Ernest Nadal, Antoni Rosell, Manel Esteller, Juan Sandoval
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (13): 3361–3371.
https://doi.org/10.1158/1078-0432.CCR-15-2346
Published: 30 June 2016
View article titled, A Novel Epigenetic Signature for Early Diagnosis in Lung Cancer
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Includes: Supplementary data
Journal Articles

Case history: Lessons learned from the MGMT methylation experience

Manel Esteller
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (19_Supplement): PL-03.
Published: 15 August 2014
View article titled, Case history: Lessons learned from the MGMT methylation experience
Journal Articles

Promoter CpG Island Hypermethylation of the DNA Repair Enzyme MGMT Predicts Clinical Response to Dacarbazine in a Phase II Study for Metastatic Colorectal Cancer

Alessio Amatu, Andrea Sartore-Bianchi, Catia Moutinho, Alessandro Belotti, Katia Bencardino, Giuseppe Chirico, Andrea Cassingena, Francesca Rusconi, Anna Esposito, Michele Nichelatti, Manel Esteller, Salvatore Siena
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (8): 2265–2272.
https://doi.org/10.1158/1078-0432.CCR-12-3518
Published: 15 April 2013
View article titled, Promoter CpG Island Hypermethylation of the DNA Repair Enzyme MGMT Predicts Clinical Response to Dacarbazine in a Phase II Study for Metastatic Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Abstract PR3: Patient derived BRCA1-deficient triple-negative breast cancer xenografts develop resistance to DNA damaging agents via genetic and epigenetic mechanisms

Petra ter Brugge, Jelle Wesseling, Jos Jonkers, Eline van der Burg, Petra Kristel, Ute Boon, Cátia Moutinho, Manel Esteller, Frans Hogervorst, Heidrun Gevensleber, Nicholas Turner
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (10_Supplement): PR3.
https://doi.org/10.1158/1078-0432.MECHRES-PR3
Published: 04 March 2013
View article titled, Abstract PR3: Patient derived BRCA1-deficient triple-negative breast cancer xenografts develop resistance to DNA damaging agents via genetic and epigenetic mechanisms
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Journal Articles

Lurbinectedin (PM01183), a New DNA Minor Groove Binder, Inhibits Growth of Orthotopic Primary Graft of Cisplatin-Resistant Epithelial Ovarian Cancer

August Vidal, Clara Muñoz, María-José Guillén, Jemina Moretó, Sara Puertas, María Martínez-Iniesta, Agnés Figueras, Laura Padullés, Francisco J. García-Rodriguez, Mireia Berdiel-Acer, Miguel A. Pujana, Ramón Salazar, Marta Gil-Martin, Lola Martí, Jordi Ponce, David G. Molleví, Gabriel Capella, Enric Condom, Francesc Viñals, Dori Huertas, Carmen Cuevas, Manel Esteller, Pablo Avilés, Alberto Villanueva
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (19): 5399–5411.
https://doi.org/10.1158/1078-0432.CCR-12-1513
Published: 30 September 2012
View article titled, Lurbinectedin (PM01183), a New DNA Minor Groove Binder, Inhibits Growth of Orthotopic Primary Graft of Cisplatin-Resistant Epithelial Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Moving Closer to a Prognostic DNA Methylation Signature in Colon Cancer

F. Javier Carmona, Manel Esteller
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (6): 1215–1217.
https://doi.org/10.1158/1078-0432.CCR-10-3446
Published: 15 March 2011
View article titled, Moving Closer to a Prognostic DNA Methylation Signature in Colon Cancer
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Includes: Supplementary data
Journal Articles

Identification of PMF1 Methylation in Association with Bladder Cancer Progression

Ainel Aleman, Virginia Cebrian, Miguel Alvarez, Virginia Lopez, Esteban Orenes, Lidia Lopez-Serra, Ferran Algaba, Joaquin Bellmunt, Antonio López-Beltrán, Pilar Gonzalez-Peramato, Carlos Cordon-Cardo, Javier García, Javier García del Muro, Manel Esteller, Marta Sánchez-Carbayo
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (24): 8236–8243.
https://doi.org/10.1158/1078-0432.CCR-08-0778
Published: 15 December 2008
View article titled, Identification of PMF1 Methylation in Association with Bladder Cancer Progression
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Includes: Supplementary data
Journal Articles

Lack of Methylthioadenosine Phosphorylase Expression in Mantle Cell Lymphoma Is Associated with Shorter Survival: Implications for a Potential Targeted Therapy

Silvia Marcé, Olga Balagué, Luis Colomo, Antonio Martinez, Sylvia Höller, Neus Villamor, Francesc Bosch, German Ott, Andreas Rosenwald, Lorenzo Leoni, Manel Esteller, Mario F. Fraga, Emili Montserrat, Dolors Colomer, Elias Campo
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (12): 3754–3761.
https://doi.org/10.1158/1078-0432.CCR-05-2780
Published: 15 June 2006
View article titled, Lack of Methylthioadenosine Phosphorylase Expression in Mantle Cell Lymphoma Is Associated with Shorter Survival: Implications for a Potential Targeted Therapy
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Journal Articles

Cyclooxygenase 2 Expression in Colorectal Cancer with DNA Mismatch Repair Deficiency

Antoni Castells, Artemio Payá, Cristina Alenda, Francisco Rodríguez-Moranta, Rubén Agrelo, Montserrat Andreu, Virgínia Piñol, Sergi Castellví-Bel, Rodrigo Jover, Xavier Llor, Elisenda Pons, J. Ignasi Elizalde, Xavier Bessa, Javier Alcedo, Joan Saló, Enrique Medina, Antonio Naranjo, Manel Esteller, Josep M. Piqué, for the Gastrointestinal Oncology Group of the Spanish Gastroenterological Association
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (6): 1686–1692.
https://doi.org/10.1158/1078-0432.CCR-05-1581
Published: 21 March 2006
View article titled, Cyclooxygenase 2 Expression in Colorectal Cancer with DNA Mismatch Repair Deficiency
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Journal Articles

A Predictor Based on the Somatic Genomic Changes of the BRCA1/BRCA2 Breast Cancer Tumors Identifies the Non-BRCA1/BRCA2 Tumors with BRCA1 Promoter Hypermethylation

Sara Alvarez, Ramon Diaz-Uriarte, Ana Osorio, Alicia Barroso, Lorenzo Melchor, Maria Fe Paz, Emiliano Honrado, Raquel Rodríguez, Miguel Urioste, Laura Valle, Orland Díez, Juan Cruz Cigudosa, Joaquin Dopazo, Manel Esteller, Javier Benitez
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (3): 1146–1153.
https://doi.org/10.1158/1078-0432.1146.11.3
Published: 11 February 2005
View article titled, A Predictor Based on the Somatic Genomic Changes of the BRCA1/BRCA2 Breast Cancer Tumors Identifies the Non-BRCA1/BRCA2 Tumors with BRCA1 Promoter Hypermethylation
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Journal Articles

CpG Island Hypermethylation of the DNA Repair Enzyme Methyltransferase Predicts Response to Temozolomide in Primary Gliomas

Maria F. Paz, Ricard Yaya-Tur, Iñigo Rojas-Marcos, Gaspar Reynes, Marina Pollan, Lucinda Aguirre-Cruz, Jose Luis García-Lopez, Jose Piquer, María-Jose Safont, Carmen Balaña, Montserrat Sanchez-Cespedes, Mercedes García-Villanueva, Leoncio Arribas, Manel Esteller
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (15): 4933–4938.
https://doi.org/10.1158/1078-0432.CCR-04-0392
Published: 05 August 2004
View article titled, CpG Island Hypermethylation of the DNA Repair Enzyme Methyltransferase Predicts Response to Temozolomide in Primary Gliomas
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Journal Articles

Detection of Lymph Node Micrometastases by Gene Promoter Hypermethylation in Samples Obtained by Endosonography- Guided Fine-Needle Aspiration Biopsy

Maria Pellisé, Antoni Castells, Àngels Ginès, Rubén Agrelo, Manel Solé, Sergi Castellví-Bel, Glòria Fernández-Esparrach, Josep Llach, Manel Esteller, Josep M. Bordas, Josep M. Piqué
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (13): 4444–4449.
https://doi.org/10.1158/1078-0432.CCR-03-0600
Published: 06 July 2004
View article titled, Detection of Lymph Node Micrometastases by Gene Promoter Hypermethylation in Samples Obtained by Endosonography- Guided Fine-Needle Aspiration Biopsy
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Journal Articles

Molecular Detection of Prostate Cancer in Urine by GSTP1 Hypermethylation

Paul Cairns, Manel Esteller, James G. Herman, Mark Schoenberg, Carmen Jeronimo, Montserrat Sanchez-Cespedes, Nan-Haw Chow, Marc Grasso, Li Wu, William B. Westra, David Sidransky
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (9): 2727–2730.
Published: 01 September 2001
View article titled, Molecular Detection of Prostate Cancer in Urine by GSTP1 Hypermethylation
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Journal Articles

Molecular Detection of Neoplastic Cells in Lymph Nodes of Metastatic Colorectal Cancer Patients Predicts Recurrence

Montserrat Sanchez-Cespedes, Manel Esteller, Kenji Hibi, Frederick O. Cope, William H. Westra, Steven Piantadosi, James G. Herman, Jin Jen, David Sidransky
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (9): 2450–2454.
Published: 01 September 1999
View article titled, Molecular Detection of Neoplastic Cells in Lymph Nodes of Metastatic Colorectal Cancer Patients Predicts Recurrence
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