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Journal Articles

Molecular and Pathologic Characterization of YAP1-Expressing Small Cell Lung Cancer Cell Lines Leads to Reclassification as SMARCA4-Deficient Malignancies

Jin Ng, Ling Cai, Luc Girard, Owen W.J. Prall, Neeha Rajan, Christine Khoo, Ahida Batrouney, David J. Byrne, Danielle K. Boyd, Ariena J. Kersbergen, Michael Christie, John D. Minna, Marian L. Burr, Kate D. Sutherland
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (9): 1846–1858.
https://doi.org/10.1158/1078-0432.CCR-23-2360
Published: 01 May 2024
View article titled, Molecular and Pathologic Characterization of YAP1-Expressing Small Cell Lung Cancer Cell Lines Leads to Reclassification as SMARCA4-Deficient Malignancies
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Includes: Supplementary data
Journal Articles

Kub5-HeraRPRD1B Deficiency Promotes “BRCAness” and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers

Edward A. Motea, Farjana J. Fattah, Ling Xiao, Luc Girard, Amy Rommel, Julio C. Morales, Praveen Patidar, Yunyun Zhou, Andrew Porter, Yang Xie, John D. Minna, David A. Boothman
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (24): 6459–6470.
https://doi.org/10.1158/1078-0432.CCR-17-1118
Published: 13 December 2018
View article titled, Kub5-Hera<em><sup>RPRD1B</sup></em> Deficiency Promotes “BRCAness” and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers
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Includes: Supplementary data
Journal Articles

Abstract B03: Suppression of lung adenocarcinoma growth and metastasis by stromal Hedgehog pathway activation

Sahba Kasiri, Baozhi Chen, Alexandra Wilson, Annika Reczek, Ummay Marriam, Zhiqun Zeng, Luc Girard, James Kim
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (17_Supplement): B03.
https://doi.org/10.1158/1557-3265.AACRIASLC18-B03
Published: 01 September 2018
View article titled, Abstract B03: Suppression of lung adenocarcinoma growth and metastasis by stromal Hedgehog pathway activation
Journal Articles

Abstract IA12: Developing precision medicine-based new lung cancer therapeutics

John D. Minna, Elizabeth McMillan, Luc Girard, Michael Peyton, Kenneth Huffman, Dhruba Deb, Paul Yenerall, Amit Das, Longshan Li, Maithili Dalvi, Boning Gao, Yang Xie, Yonghao Yu, Suzie Hight, Rachel Vaden, Caroline Diep, Michael Roth, Bruce Posner, John MacMillan, Ralph Deberardinis, David Wheeler, John V. Heymach, Ignacio I. Wistuba, Adi Gazdar, Michael White
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (17_Supplement): IA12.
https://doi.org/10.1158/1557-3265.AACRIASLC18-IA12
Published: 01 September 2018
View article titled, Abstract IA12: Developing precision medicine-based new lung cancer therapeutics
Journal Articles

An Expression Signature as an Aid to the Histologic Classification of Non–Small Cell Lung Cancer

Luc Girard, Jaime Rodriguez-Canales, Carmen Behrens, Debrah M. Thompson, Ihab W. Botros, Hao Tang, Yang Xie, Natasha Rekhtman, William D. Travis, Ignacio I. Wistuba, John D. Minna, Adi F. Gazdar
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (19): 4880–4889.
https://doi.org/10.1158/1078-0432.CCR-15-2900
Published: 02 October 2016
View article titled, An Expression Signature as an Aid to the Histologic Classification of Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Epithelial–Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor–Mediated Apoptosis in Non–Small Cell Lung Cancer

Renata Ferrarotto, Ruchitha Goonatilake, Suk Young Yoo, Pan Tong, Uma Giri, Shaohua Peng, John Minna, Luc Girard, Yuehong Wang, Liguang Wang, Lerong Li, Lixia Diao, David H. Peng, Don L. Gibbons, Bonnie S. Glisson, John V. Heymach, Jing Wang, Lauren A. Byers, Faye M. Johnson
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (7): 1674–1686.
https://doi.org/10.1158/1078-0432.CCR-14-2890
Published: 31 March 2016
View article titled, Epithelial–Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor–Mediated Apoptosis in Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Essential Role of Aldehyde Dehydrogenase 1A3 for the Maintenance of Non–Small Cell Lung Cancer Stem Cells Is Associated with the STAT3 Pathway

Chunli Shao, James P. Sullivan, Luc Girard, Alexander Augustyn, Paul Yenerall, Jaime Rodriguez-Canales, Hui Liu, Carmen Behrens, Jerry W. Shay, Ignacio I. Wistuba, John D. Minna
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (15): 4154–4166.
https://doi.org/10.1158/1078-0432.CCR-13-3292
Published: 31 July 2014
View article titled, Essential Role of Aldehyde Dehydrogenase 1A3 for the Maintenance of Non–Small Cell Lung Cancer Stem Cells Is Associated with the STAT3 Pathway
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Includes: Supplementary data
Journal Articles

VEGF/VEGFR-2 Upregulates EZH2 Expression in Lung Adenocarcinoma Cells and EZH2 Depletion Enhances the Response to Platinum-Based and VEGFR-2–Targeted Therapy

Erick Riquelme, Milind Suraokar, Carmen Behrens, Heather Y. Lin, Luc Girard, Monique B. Nilsson, George Simon, Jing Wang, Kevin R. Coombes, J. Jack Lee, Waun Ki Hong, John Heymach, John D. Minna, Ignacio I. Wistuba
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (14): 3849–3861.
https://doi.org/10.1158/1078-0432.CCR-13-1916
Published: 14 July 2014
View article titled, VEGF/VEGFR-2 Upregulates EZH2 Expression in Lung Adenocarcinoma Cells and EZH2 Depletion Enhances the Response to Platinum-Based and VEGFR-2–Targeted Therapy
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Includes: Supplementary data
Journal Articles

Radiation-Enhanced Lung Cancer Progression in a Transgenic Mouse Model of Lung Cancer Is Predictive of Outcomes in Human Lung and Breast Cancer

Oliver Delgado, Kimberly G. Batten, James A. Richardson, Xian-Jin Xie, Adi F. Gazdar, Aadil A. Kaisani, Luc Girard, Carmen Behrens, Milind Suraokar, Gail Fasciani, Woodring E. Wright, Michael D. Story, Ignacio I. Wistuba, John D. Minna, Jerry W. Shay
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2014) 20 (6): 1610–1622.
https://doi.org/10.1158/1078-0432.CCR-13-2589
Published: 13 March 2014
View article titled, Radiation-Enhanced Lung Cancer Progression in a Transgenic Mouse Model of Lung Cancer Is Predictive of Outcomes in Human Lung and Breast Cancer
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Includes: Supplementary data
Journal Articles

Abstract B24: A systematic search for cancer/testis antigens in lung cancer identifies VCX/Y genes expanding the repertoire of potential immunotherapeutic targets.

Ayumu Taguchi, Allen D. Taylor, Jaime Rodriguez, Muge Celiktas, Hui Liu, Xiaotu Ma, Qing Zhang, Chee-Hong Wong, Alice Chin, Luc Girard, Carmen Behrens, Wan Lam, Stephen Lam, John D. Minna, Ignacio I. Wistuba, Adi F. Gazdar, Samir M. Hanash
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (2_Supplement): B24.
https://doi.org/10.1158/1078-0432.14AACRIASLC-B24
Published: 16 January 2014
View article titled, Abstract B24: A systematic search for cancer/testis antigens in lung cancer identifies VCX/Y genes expanding the repertoire of potential immunotherapeutic targets.
Journal Articles

Abstract IA21: Developing a new functional classification of lung cancer based on tumor acquired vulnerabilities.

John D. Minna, Adi Gazdar, Alexander Augustyn, Rebecca Britt, Ryan Carstens, Patrick Dospoy, Boning Gao, Luc Girard, Suzie Hight, Kenneth Huffman, Jill Larsen, Michael Peyton, Chunli Shao, David Mangelsdorf, Rolf Brekken, Ralph Deberardinis, Pei-Hsuan Chen, Carmen Behrens, Lauren Byers, John Heymach, Jack Roth, Ignacio Wistuba, Yang Xie, Caleb Davis, David Wheeler, Richard Gibbs, Edward Marcotte, Joseph Ready, Deepak Nijhawan, Noelle Williams, Steven McKnight, Bruce Posner, John MacMillan, Michael Roth, Michael White
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (2_Supplement): IA21.
https://doi.org/10.1158/1078-0432.14AACRIASLC-IA21
Published: 16 January 2014
View article titled, Abstract IA21: Developing a new functional classification of lung cancer based on tumor acquired vulnerabilities.
Journal Articles

Comprehensive Biomarker Analysis and Final Efficacy Results of Sorafenib in the BATTLE Trial

George R. Blumenschein, Jr, Pierre Saintigny, Suyu Liu, Edward S. Kim, Anne S. Tsao, Roy S. Herbst, Christine Alden, J. Jack Lee, Ximing Tang, David J. Stewart, Merrill S. Kies, Frank V. Fossella, Hai T. Tran, L. Mao, Marshall E. Hicks, Jeremy Erasmus, Jr, Sanjay Gupta, Luc Girard, Michael Peyton, Lixia Diao, Jing Wang, Suzanne E. Davis, John D. Minna, Ignacio Wistuba, Waun K. Hong, John V. Heymach, Scott M. Lippman
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (24): 6967–6975.
https://doi.org/10.1158/1078-0432.CCR-12-1818
Published: 16 December 2013
View article titled, Comprehensive Biomarker Analysis and Final Efficacy Results of Sorafenib in the BATTLE Trial
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Includes: Supplementary data
Journal Articles

An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Lauren Averett Byers, Lixia Diao, Jing Wang, Pierre Saintigny, Luc Girard, Michael Peyton, Li Shen, Youhong Fan, Uma Giri, Praveen K. Tumula, Monique B. Nilsson, Jayanthi Gudikote, Hai Tran, Robert J.G. Cardnell, David J. Bearss, Steven L. Warner, Jason M. Foulks, Steven B. Kanner, Varsha Gandhi, Nancy Krett, Steven T. Rosen, Edward S. Kim, Roy S. Herbst, George R. Blumenschein, J. Jack Lee, Scott M. Lippman, K. Kian Ang, Gordon B. Mills, Waun K. Hong, John N. Weinstein, Ignacio I. Wistuba, Kevin R. Coombes, John D. Minna, John V. Heymach
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (1): 279–290.
https://doi.org/10.1158/1078-0432.CCR-12-1558
Published: 02 January 2013
View article titled, An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance
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Includes: Supplementary data
Journal Articles

Abstract IA3: Lung cancer stem cells, acquired vulnerabilities, and molecular portraits: Translation to the clinic

John D. Minna, Chunli Shao, Amit Das, Chris Desevo, Patrick Dospoy, Boning Gao, Rachel Greer, Suzie Hight, Kenneth Huffman, Jill Larsen, Michael Peyton, Misty Shields, James P. Sullivan, Laura Sullivan, David Gerber, David Mangelsdorf, Joan Schiller, Jerry Shay, Alexander Pertsemlidis, Kevin Coombes, John V. Heymach, Jonathan Kurie, Jack Roth, Luc Girard, Xifeng Wu, Carmen Behrens, Heidi Erickson, Ignacio Wistuba, Bruce Posner, Michael Roth, Adi Gazdar, Michael White, Yang Xie, Alex Augustyn, Rolf Brekken, Rebecca Britt, Robin Frink, Ryan Carstens
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (3_Supplement): IA3.
https://doi.org/10.1158/1078-0432.12AACRIASLC-IA3
Published: 01 February 2012
View article titled, Abstract IA3: Lung cancer stem cells, acquired vulnerabilities, and molecular portraits: Translation to the clinic
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Journal Articles

Abstract A46: Identification of ALDH1A3 as an important biomarker and therapeutic target for non-small cell lung cancer (NSCLC) cancer stem cells (CSCs)

Chunli Shao, James P. Sullivan, Luc Girard, Laura A. Sullivan, Alexander Augustyn, Yang Xie, Carmen Behrens, Ignacio Wistuba, John D. Minna
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (3_Supplement): A46.
https://doi.org/10.1158/1078-0432.12AACRIASLC-A46
Published: 01 February 2012
View article titled, Abstract A46: Identification of ALDH1A3 as an important biomarker and therapeutic target for non-small cell lung cancer (NSCLC) cancer stem cells (CSCs)
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Journal Articles

Abstract A12: High-throughput mutation analysis of NSCLC circulating tumor cells

Heidi S. Erickson, Nana E. Hanson, Hai Tran, Gordon B. Mills, Ed S. Kim, John V. Heymach, Ignacio I. Wistuba, Hector G. Galindo, Katherine Stemke-Hale, Uma Giri, Christina McDowell, Luc Girard, Jack J. Lee, Roy Herbst, John Minna, Farideh Z. Bischoff
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (3_Supplement): A12.
https://doi.org/10.1158/1078-0432.12AACRIASLC-A12
Published: 01 February 2012
View article titled, Abstract A12: High-throughput mutation analysis of NSCLC circulating tumor cells
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Journal Articles

Abstract B42: The lineage-specific transcription factor ASCL1 defines a subtype of neuroendocrine non-small cell lung cancers with poor prognosis and points to potential therapeutic targets

Alexander Augustyn, John Minna, Christopher Tan, James Sullivan, Mark Borromeo, Luc Girard, Jane Johnson, Carmen Behrens, Ignacio Wistuba, Yang Xie
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (3_Supplement): B42.
https://doi.org/10.1158/1078-0432.12AACRIASLC-B42
Published: 01 February 2012
View article titled, Abstract B42: The lineage-specific transcription factor ASCL1 defines a subtype of neuroendocrine non-small cell lung cancers with poor prognosis and points to potential therapeutic targets
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Journal Articles

Robust Gene Expression Signature from Formalin-Fixed Paraffin-Embedded Samples Predicts Prognosis of Non–Small-Cell Lung Cancer Patients

Yang Xie, Guanghua Xiao, Kevin R. Coombes, Carmen Behrens, Luisa M. Solis, Gabriela Raso, Luc Girard, Heidi S. Erickson, Jack Roth, John V. Heymach, Cesar Moran, Kathy Danenberg, John D. Minna, Ignacio I. Wistuba
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (17): 5705–5714.
https://doi.org/10.1158/1078-0432.CCR-11-0196
Published: 01 September 2011
View article titled, Robust Gene Expression Signature from Formalin-Fixed Paraffin-Embedded Samples Predicts Prognosis of Non–Small-Cell Lung Cancer Patients
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Includes: Supplementary data
Journal Articles

Fine Mapping of Chromosome 6q23-25 Region in Familial Lung Cancer Families Reveals RGS17 as a Likely Candidate Gene

Ming You, Daolong Wang, Pengyuan Liu, Haris Vikis, Michael James, Yan Lu, Yian Wang, Min Wang, Qiong Chen, Dongmei Jia, Yan Liu, Weidong Wen, Ping Yang, Zhifu Sun, Susan M. Pinney, Wei Zheng, Xiao-Ou Shu, Jirong Long, Yu-Tang Gao, Yong-Bing Xiang, Wong-Ho Chow, Nat Rothman, Gloria M. Petersen, Mariza de Andrade, Yanhong Wu, Julie M. Cunningham, Jonathan S. Wiest, Pamela R. Fain, Ann G. Schwartz, Luc Girard, Adi Gazdar, Colette Gaba, Henry Rothschild, Diptasri Mandal, Teresa Coons, Juwon Lee, Elena Kupert, Daniela Seminara, John Minna, Joan E. Bailey-Wilson, Christopher I. Amos, Marshall W. Anderson
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (8): 2666–2674.
https://doi.org/10.1158/1078-0432.CCR-08-2335
Published: 15 April 2009
View article titled, Fine Mapping of Chromosome 6q23-25 Region in Familial Lung Cancer Families Reveals <em>RGS17</em> as a Likely Candidate Gene
Open the PDF for Fine Mapping of Chromosome 6q23-25 Region in Familial Lung Cancer Families Reveals <em>RGS17</em> as a Likely Candidate Gene in another window
Includes: Supplementary data
Journal Articles

Distinct Epidermal Growth Factor Receptor and KRAS Mutation Patterns in Non–Small Cell Lung Cancer Patients with Different Tobacco Exposure and Clinicopathologic Features

Issan Yee San Tam, Lap Ping Chung, Wai Sing Suen, Elaine Wang, May C.M. Wong, Kok Keung Ho, Wah Kit Lam, Shui Wah Chiu, Luc Girard, John D. Minna, Adi F. Gazdar, Maria P. Wong
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (5): 1647–1653.
https://doi.org/10.1158/1078-0432.CCR-05-1981
Published: 06 March 2006
View article titled, Distinct Epidermal Growth Factor Receptor and <em>KRAS</em> Mutation Patterns in Non–Small Cell Lung Cancer Patients with Different Tobacco Exposure and Clinicopathologic Features
Open the PDF for Distinct Epidermal Growth Factor Receptor and <em>KRAS</em> Mutation Patterns in Non–Small Cell Lung Cancer Patients with Different Tobacco Exposure and Clinicopathologic Features in another window