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Lorelei A. Mucci
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Journal Articles

Germline DNA Damage Repair Variants and Prognosis of Patients with High-Risk or Metastatic Prostate Cancer

Konrad H. Stopsack, Joseph Vijai, Michael Conry, Jacob E. Berchuck, Yelena Kemel, Samantha E. Vasselman, Dory A. Freeman, Gwo-Shu M. Lee, Diana Mandelker, David B. Solit, Michael J. Morris, Kathryn L. Penney, Wassim Abida, Kenneth Offit, Lorelei A. Mucci, Philip W. Kantoff, Mark M. Pomerantz
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (1): 122–129.
https://doi.org/10.1158/1078-0432.CCR-24-2483
Published: 06 January 2025
View article titled, Germline DNA Damage Repair Variants and Prognosis of Patients with High-Risk or Metastatic Prostate Cancer
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Includes: Supplementary data
Journal Articles

Family History of Prostate and Breast Cancer Integrated with a Polygenic Risk Score Identifies Men at Highest Risk of Dying from Prostate Cancer before Age 75 Years

Anna Plym, Yiwen Zhang, Konrad H. Stopsack, Yon Ho Jee, Fredrik Wiklund, Adam S. Kibel, Peter Kraft, Edward Giovannucci, Kathryn L. Penney, Lorelei A. Mucci
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (22): 4926–4933.
https://doi.org/10.1158/1078-0432.CCR-22-1723
Published: 14 November 2022
View article titled, Family History of Prostate and Breast Cancer Integrated with a Polygenic Risk Score Identifies Men at Highest Risk of Dying from Prostate Cancer before Age 75 Years
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Includes: Supplementary data
Journal Articles

The Impact of PIK3R1 Mutations and Insulin–PI3K–Glycolytic Pathway Regulation in Prostate Cancer

Goutam Chakraborty, Subhiksha Nandakumar, Rahim Hirani, Bastien Nguyen, Konrad H. Stopsack, Christoph Kreitzer, Sai Harisha Rajanala, Romina Ghale, Ying Z. Mazzu, Naga Vara Kishore Pillarsetty, Gwo-Shu Mary Lee, Howard I. Scher, Michael J. Morris, Tiffany Traina, Pedram Razavi, Wassim Abida, Jeremy C. Durack, Stephen B. Solomon, Matthew G. Vander Heiden, Lorelei A. Mucci, Andreas G. Wibmer, Nikolaus Schultz, Philip W. Kantoff
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (16): 3603–3617.
https://doi.org/10.1158/1078-0432.CCR-21-4272
Published: 15 August 2022
View article titled, The Impact of PIK3R1 Mutations and Insulin–PI3K–Glycolytic Pathway Regulation in Prostate Cancer
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Includes: Supplementary data
Journal Articles

Differences in Prostate Cancer Genomes by Self-reported Race: Contributions of Genetic Ancestry, Modifiable Cancer Risk Factors, and Clinical Factors

Konrad H. Stopsack, Subhiksha Nandakumar, Kanika Arora, Bastien Nguyen, Samantha E. Vasselman, Barbara Nweji, Sean M. McBride, Michael J. Morris, Dana E. Rathkopf, Susan F. Slovin, Daniel C. Danila, Karen A. Autio, Howard I. Scher, Lorelei A. Mucci, David B. Solit, Mithat Gönen, Yu Chen, Michael F. Berger, Nikolaus Schultz, Wassim Abida, Philip W. Kantoff
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (2): 318–326.
https://doi.org/10.1158/1078-0432.CCR-21-2577
Published: 15 January 2022
View article titled, Differences in Prostate Cancer Genomes by Self-reported Race: Contributions of Genetic Ancestry, Modifiable Cancer Risk Factors, and Clinical Factors
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Includes: Supplementary data
Journal Articles

Attenuation of SRC Kinase Activity Augments PARP Inhibitor–mediated Synthetic Lethality in BRCA2-altered Prostate Tumors

Goutam Chakraborty, Nabeela Khan Patail, Rahim Hirani, Subhiksha Nandakumar, Ying Z. Mazzu, Yuki Yoshikawa, Mohammad Atiq, Lina E. Jehane, Konrad H. Stopsack, Gwo-Shu Mary Lee, Wassim Abida, Michael J. Morris, Lorelei A. Mucci, Daniel Danila, Philip W. Kantoff
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (6): 1792–1806.
https://doi.org/10.1158/1078-0432.CCR-20-2483
Published: 15 March 2021
View article titled, Attenuation of SRC Kinase Activity Augments PARP Inhibitor–mediated Synthetic Lethality in <em>BRCA2</em>-altered Prostate Tumors
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Includes: Supplementary data
Journal Articles

Multiplex Immunofluorescence in Formalin-Fixed Paraffin-Embedded Tumor Tissue to Identify Single-Cell–Level PI3K Pathway Activation

Konrad H. Stopsack, Ying Huang, Svitlana Tyekucheva, Travis A. Gerke, Clyde Bango, Habiba Elfandy, Michaela Bowden, Kathryn L. Penney, Thomas M. Roberts, Giovanni Parmigiani, Philip W. Kantoff, Lorelei A. Mucci, Massimo Loda
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (22): 5903–5913.
https://doi.org/10.1158/1078-0432.CCR-20-2000
Published: 13 November 2020
View article titled, Multiplex Immunofluorescence in Formalin-Fixed Paraffin-Embedded Tumor Tissue to Identify Single-Cell–Level PI3K Pathway Activation
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Includes: Supplementary data
Journal Articles

Significance of BRCA2 and RB1 Co-loss in Aggressive Prostate Cancer Progression

Goutam Chakraborty, Joshua Armenia, Ying Z. Mazzu, Subhiksha Nandakumar, Konrad H. Stopsack, Mohammad O. Atiq, Kazumasa Komura, Lina Jehane, Rahim Hirani, Kalyani Chadalavada, Yuki Yoshikawa, Nabeela A. Khan, Yu Chen, Wassim Abida, Lorelei A. Mucci, Gwo-Shu Mary Lee, Gouri J. Nanjangud, Philip W. Kantoff
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (8): 2047–2064.
https://doi.org/10.1158/1078-0432.CCR-19-1570
Published: 15 April 2020
View article titled, Significance of <em>BRCA2</em> and <em>RB1</em> Co-loss in Aggressive Prostate Cancer Progression
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Includes: Supplementary data
Journal Articles

Statin Use Is Associated with Lower Risk of PTEN-Null and Lethal Prostate Cancer

Emma H. Allott, Ericka M. Ebot, Konrad H. Stopsack, Amparo G. Gonzalez-Feliciano, Sarah C. Markt, Kathryn M. Wilson, Thomas U. Ahearn, Travis A. Gerke, Mary K. Downer, Jennifer R. Rider, Stephen J. Freedland, Tamara L. Lotan, Philip W. Kantoff, Elizabeth A. Platz, Massimo Loda, Meir J. Stampfer, Edward Giovannucci, Christopher J. Sweeney, Stephen P. Finn, Lorelei A. Mucci
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (5): 1086–1093.
https://doi.org/10.1158/1078-0432.CCR-19-2853
Published: 02 March 2020
View article titled, Statin Use Is Associated with Lower Risk of PTEN-Null and Lethal Prostate Cancer
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Includes: Supplementary data
Journal Articles

Family History of Breast or Prostate Cancer and Prostate Cancer Risk

Lauren Barber, Travis Gerke, Sarah C. Markt, Samuel F. Peisch, Kathryn M. Wilson, Thomas Ahearn, Edward Giovannucci, Giovanni Parmigiani, Lorelei A. Mucci
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (23): 5910–5917.
https://doi.org/10.1158/1078-0432.CCR-18-0370
Published: 03 December 2018
View article titled, Family History of Breast or Prostate Cancer and Prostate Cancer Risk
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Journal Articles

Prognostic Utility of a New mRNA Expression Signature of Gleason Score

Jennifer A. Sinnott, Sam F. Peisch, Svitlana Tyekucheva, Travis Gerke, Rosina Lis, Jennifer R. Rider, Michelangelo Fiorentino, Meir J. Stampfer, Lorelei A. Mucci, Massimo Loda, Kathryn L. Penney
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (1): 81–87.
https://doi.org/10.1158/1078-0432.CCR-16-1245
Published: 02 January 2017
View article titled, Prognostic Utility of a New mRNA Expression Signature of Gleason Score
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Includes: Supplementary data
Journal Articles

Stress-Related Signaling Pathways in Lethal and Nonlethal Prostate Cancer

Donghao Lu, Jennifer A. Sinnott, Unnur Valdimarsdóttir, Fang Fang, Travis Gerke, Svitlana Tyekucheva, Michelangelo Fiorentino, Mats Lambe, Howard D. Sesso, Christopher J. Sweeney, Kathryn M. Wilson, Edward L. Giovannucci, Massimo Loda, Lorelei A. Mucci, Katja Fall
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (3): 765–772.
https://doi.org/10.1158/1078-0432.CCR-15-0101
Published: 31 January 2016
View article titled, Stress-Related Signaling Pathways in Lethal and Nonlethal Prostate Cancer
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Includes: Supplementary data
Journal Articles

Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer

Paula J. Hurley, Debasish Sundi, Brian Shinder, Brian W. Simons, Robert M. Hughes, Rebecca M. Miller, Benjamin Benzon, Sheila F. Faraj, George J. Netto, Ismael A. Vergara, Nicholas Erho, Elai Davicioni, R. Jeffrey Karnes, Guifang Yan, Charles Ewing, Sarah D. Isaacs, David M. Berman, Jennifer R. Rider, Kristina M. Jordahl, Lorelei A. Mucci, Jessie Huang, Steven S. An, Ben H. Park, William B. Isaacs, Luigi Marchionni, Ashley E. Ross, Edward M. Schaeffer
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (2): 448–458.
https://doi.org/10.1158/1078-0432.CCR-15-0256
Published: 14 January 2016
View article titled, Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer
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Includes: Supplementary data
Journal Articles

SPINK1 Protein Expression and Prostate Cancer Progression

Richard Flavin, Andreas Pettersson, Whitney K. Hendrickson, Michelangelo Fiorentino, Stephen Finn, Lauren Kunz, Gregory L. Judson, Rosina Lis, Dyane Bailey, Christopher Fiore, Elizabeth Nuttall, Neil E. Martin, Edward Stack, Kathryn L. Penney, Jennifer R. Rider, Jennifer Sinnott, Christopher Sweeney, Howard D. Sesso, Katja Fall, Edward Giovannucci, Philip Kantoff, Meir Stampfer, Massimo Loda, Lorelei A. Mucci
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (18): 4904–4911.
https://doi.org/10.1158/1078-0432.CCR-13-1341
Published: 14 September 2014
View article titled, SPINK1 Protein Expression and Prostate Cancer Progression
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Journal Articles

A Single Nucleotide Polymorphism in Inflammatory Gene RNASEL Predicts Outcome after Radiation Therapy for Localized Prostate Cancer

Jonathan D. Schoenfeld, Danielle N. Margalit, Julie L. Kasperzyk, Irene M. Shui, Jennifer R. Rider, Mara M. Epstein, Allison Meisner, Stacey A. Kenfield, Neil E. Martin, Paul L. Nguyen, Philip W. Kantoff, Edward L. Giovannucci, Meir J. Stampfer, Lorelei A. Mucci
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (6): 1612–1619.
https://doi.org/10.1158/1078-0432.CCR-12-2718
Published: 14 March 2013
View article titled, A Single Nucleotide Polymorphism in Inflammatory Gene <em>RNASEL</em> Predicts Outcome after Radiation Therapy for Localized Prostate Cancer
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Includes: Supplementary data