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Lloyd J. Old
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Journal Articles

Prostate Cancer Progression Correlates with Increased Humoral Immune Response to a Human Endogenous Retrovirus GAG Protein

Bernardo Sgarbi Reis, Achim A. Jungbluth, Denise Frosina, Megan Holz, Erika Ritter, Eiichi Nakayama, Toshiaki Ishida, Yuichi Obata, Brett Carver, Howard Scher, Peter T. Scardino, Susan Slovin, Sumit K. Subudhi, Victor E. Reuter, Caroline Savage, James P. Allison, Jonathan Melamed, Elke Jäger, Gerd Ritter, Lloyd J. Old, Sacha Gnjatic
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (22): 6112–6125.
https://doi.org/10.1158/1078-0432.CCR-12-3580
Published: 14 November 2013
View article titled, Prostate Cancer Progression Correlates with Increased Humoral Immune Response to a Human Endogenous Retrovirus GAG Protein
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Includes: Supplementary data
Journal Articles

Phase I Trial of Overlapping Long Peptides from a Tumor Self-Antigen and Poly-ICLC Shows Rapid Induction of Integrated Immune Response in Ovarian Cancer Patients

Paul Sabbatini, Takemasa Tsuji, Luis Ferran, Erika Ritter, Christine Sedrak, Kevin Tuballes, Achim A. Jungbluth, Gerd Ritter, Carol Aghajanian, Katherine Bell-McGuinn, Martee L. Hensley, Jason Konner, William Tew, David R. Spriggs, Eric W. Hoffman, Ralph Venhaus, Linda Pan, Andres M. Salazar, Catherine Magid Diefenbach, Lloyd J. Old, Sacha Gnjatic
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (23): 6497–6508.
https://doi.org/10.1158/1078-0432.CCR-12-2189
Published: 29 November 2012
View article titled, Phase I Trial of Overlapping Long Peptides from a Tumor Self-Antigen and Poly-ICLC Shows Rapid Induction of Integrated Immune Response in Ovarian Cancer Patients
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Includes: Supplementary data
Journal Articles

Phase I Clinical Trial of Mixed Bacterial Vaccine (Coley's Toxins) in Patients with NY-ESO-1 Expressing Cancers: Immunological Effects and Clinical Activity

Julia Karbach, Antje Neumann, Kathrin Brand, Claudia Wahle, Ekkehard Siegel, Markus Maeurer, Erika Ritter, Takamasa Tsuji, Sacha Gnjatic, Lloyd J. Old, Gerd Ritter, Elke Jäger
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (19): 5449–5459.
https://doi.org/10.1158/1078-0432.CCR-12-1116
Published: 30 September 2012
View article titled, Phase I Clinical Trial of Mixed Bacterial Vaccine (Coley's Toxins) in Patients with NY-ESO-1 Expressing Cancers: Immunological Effects and Clinical Activity
Open the PDF for Phase I Clinical Trial of Mixed Bacterial Vaccine (Coley's Toxins) in Patients with NY-ESO-1 Expressing Cancers: Immunological Effects and Clinical Activity in another window
Includes: Supplementary data
Journal Articles

MAGE-A Inhibits Apoptosis in Proliferating Myeloma Cells through Repression of Bax and Maintenance of Survivin

Tricia Nardiello, Achim A. Jungbluth, Anna Mei, Maurizio DiLiberto, Xiangao Huang, Ania Dabrowski, Valéria C.C. Andrade, Rebecca Wasserstrum, Scott Ely, Ruben Niesvizky, Roger Pearse, Morton Coleman, David S. Jayabalan, Nina Bhardwaj, Lloyd J. Old, Selina Chen-Kiang, Hearn Jay Cho
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (13): 4309–4319.
https://doi.org/10.1158/1078-0432.CCR-10-1820
Published: 05 July 2011
View article titled, MAGE-A Inhibits Apoptosis in Proliferating Myeloma Cells through Repression of Bax and Maintenance of Survivin
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Includes: Supplementary data
Journal Articles

Efficient In vivo Priming by Vaccination with Recombinant NY-ESO-1 Protein and CpG in Antigen Naïve Prostate Cancer Patients

Julia Karbach, Antje Neumann, Akin Atmaca, Claudia Wahle, Kathrin Brand, Lotta von Boehmer, Alexander Knuth, Armin Bender, Gerd Ritter, Lloyd J. Old, Elke Jäger
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (4): 861–870.
https://doi.org/10.1158/1078-0432.CCR-10-1811
Published: 15 February 2011
View article titled, Efficient <em>In vivo</em> Priming by Vaccination with Recombinant NY-ESO-1 Protein and CpG in Antigen Naïve Prostate Cancer Patients
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Includes: Supplementary data
Journal Articles

Farletuzumab, a Humanized Monoclonal Antibody against Folate Receptor α, in Epithelial Ovarian Cancer: a Phase I Study

Jason A. Konner, Katherine M. Bell-McGuinn, Paul Sabbatini, Martee L. Hensley, William P. Tew, Neeta Pandit-Taskar, Nicholas Vander Els, Martin D. Phillips, Charles Schweizer, Susan C. Weil, Steven M. Larson, Lloyd J. Old
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (21): 5288–5295.
https://doi.org/10.1158/1078-0432.CCR-10-0700
Published: 31 October 2010
View article titled, Farletuzumab, a Humanized Monoclonal Antibody against Folate Receptor α, in Epithelial Ovarian Cancer: a Phase I Study
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Journal Articles

Assessment of Vaccine-Induced CD4 T Cell Responses to the 119-143 Immunodominant Region of the Tumor-Specific Antigen NY-ESO-1 Using DRB1*0101 Tetramers

Maha Ayyoub, Pascale Pignon, Danijel Dojcinovic, Isabelle Raimbaud, Lloyd J. Old, Immanuel Luescher, Danila Valmori
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (18): 4607–4615.
https://doi.org/10.1158/1078-0432.CCR-10-1485
Published: 14 September 2010
View article titled, Assessment of Vaccine-Induced CD4 T Cell Responses to the 119-143 Immunodominant Region of the Tumor-Specific Antigen NY-ESO-1 Using DRB1*0101 Tetramers
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Journal Articles

Two Distinct Mechanisms of Augmented Antitumor Activity by Modulation of Immunostimulatory/Inhibitory Signals

Jun Mitsui, Hiroyoshi Nishikawa, Daisuke Muraoka, Linan Wang, Takuro Noguchi, Eiichi Sato, Satoshi Kondo, James P. Allison, Shimon Sakaguchi, Lloyd J. Old, Takuma Kato, Hiroshi Shiku
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (10): 2781–2791.
https://doi.org/10.1158/1078-0432.CCR-09-3243
Published: 13 May 2010
View article titled, Two Distinct Mechanisms of Augmented Antitumor Activity by Modulation of Immunostimulatory/Inhibitory Signals
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Includes: Supplementary data
Journal Articles

Vaccination with Recombinant NY-ESO-1 Protein Elicits Immunodominant HLA-DR52b-restricted CD4+ T Cell Responses with a Conserved T Cell Receptor Repertoire

Gilles Bioley, Christelle Dousset, Alice Yeh, Bo Dupont, Nina Bhardwaj, Gregory Mears, Lloyd J. Old, Maha Ayyoub, Danila Valmori
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (13): 4467–4474.
https://doi.org/10.1158/1078-0432.CCR-09-0582
Published: 01 July 2009
View article titled, Vaccination with Recombinant NY-ESO-1 Protein Elicits Immunodominant HLA-DR52b-restricted CD4<sup>+</sup> T Cell Responses with a Conserved T Cell Receptor Repertoire
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Journal Articles

NY-ESO-1 DNA Vaccine Induces T-Cell Responses That Are Suppressed by Regulatory T Cells

Sacha Gnjatic, Nasser K. Altorki, Derek Ng Tang, Shi-Ming Tu, Vikas Kundra, Gerd Ritter, Lloyd J. Old, Christopher J. Logothetis, Padmanee Sharma
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (6): 2130–2139.
https://doi.org/10.1158/1078-0432.CCR-08-2632
Published: 16 March 2009
View article titled, NY-ESO-1 DNA Vaccine Induces T-Cell Responses That Are Suppressed by Regulatory T Cells
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Includes: Supplementary data
Journal Articles

HLA Class I–Associated Immunodominance Affects CTL Responsiveness to an ESO Recombinant Protein Tumor Antigen Vaccine

Gilles Bioley, Philippe Guillaume, Immanuel Luescher, Alice Yeh, Bo Dupont, Nina Bhardwaj, Gregory Mears, Lloyd J. Old, Danila Valmori, Maha Ayyoub
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (1): 299–306.
https://doi.org/10.1158/1078-0432.CCR-08-1747
Published: 31 December 2008
View article titled, HLA Class I–Associated Immunodominance Affects CTL Responsiveness to an ESO Recombinant Protein Tumor Antigen Vaccine
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Includes: Supplementary data
Journal Articles

Safety and Immunogenicity Study of NY-ESO-1b Peptide and Montanide ISA-51 Vaccination of Patients with Epithelial Ovarian Cancer in High-Risk First Remission

Catherine S.M. Diefenbach, Sacha Gnjatic, Paul Sabbatini, Carol Aghajanian, Martee L. Hensley, David R. Spriggs, Alexia Iasonos, Helen Lee, Bo Dupont, Sandra Pezzulli, Achim A. Jungbluth, Lloyd J. Old, Jakob Dupont
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (9): 2740–2748.
https://doi.org/10.1158/1078-0432.CCR-07-4619
Published: 01 May 2008
View article titled, Safety and Immunogenicity Study of NY-ESO-1b Peptide and Montanide ISA-51 Vaccination of Patients with Epithelial Ovarian Cancer in High-Risk First Remission
Open the PDF for Safety and Immunogenicity Study of NY-ESO-1b Peptide and Montanide ISA-51 Vaccination of Patients with Epithelial Ovarian Cancer in High-Risk First Remission in another window
Journal Articles

CD8+ Foxp3+ Regulatory T Cells Mediate Immunosuppression in Prostate Cancer

Yukiko Kiniwa, Yoshihiro Miyahara, Helen Y. Wang, Weiyi Peng, Guangyong Peng, Thomas M. Wheeler, Timothy C. Thompson, Lloyd J. Old, Rong-Fu Wang
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (23): 6947–6958.
https://doi.org/10.1158/1078-0432.CCR-07-0842
Published: 03 December 2007
View article titled, CD8<sup>+</sup> Foxp3<sup>+</sup> Regulatory T Cells Mediate Immunosuppression in Prostate Cancer
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Journal Articles

A Phase I Biodistribution and Pharmacokinetic Trial of Humanized Monoclonal Antibody Hu3s193 in Patients with Advanced Epithelial Cancers that Express the Lewis-Y Antigen

Andrew M. Scott, Niall Tebbutt, Fook-Thean Lee, Tina Cavicchiolo, Zhanqi Liu, Sanjeev Gill, Aurora M.T. Poon, Wendie Hopkins, Fiona E. Smyth, Carmel Murone, Duncan MacGregor, Anthony T. Papenfuss, Bridget Chappell, Timothy H. Saunder, Martin W. Brechbiel, Ian D. Davis, Roger Murphy, Geoffrey Chong, Eric W. Hoffman, Lloyd J. Old
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (11): 3286–3292.
https://doi.org/10.1158/1078-0432.CCR-07-0284
Published: 01 June 2007
View article titled, A Phase I Biodistribution and Pharmacokinetic Trial of Humanized Monoclonal Antibody Hu3s193 in Patients with Advanced Epithelial Cancers that Express the Lewis-Y Antigen
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Journal Articles

HER2-Specific T-Cell Immune Responses in Patients Vaccinated with Truncated HER2 Protein Complexed with Nanogels of Cholesteryl Pullulan

Shigehisa Kitano, Shinichi Kageyama, Yasuhiro Nagata, Yoshihiro Miyahara, Atsunori Hiasa, Hiroaki Naota, Satoshi Okumura, Hiroshi Imai, Taizo Shiraishi, Masahiro Masuya, Masakatsu Nishikawa, Junzo Sunamoto, Kazunari Akiyoshi, Takashi Kanematsu, Andrew M. Scott, Roger Murphy, Eric W. Hoffman, Lloyd J. Old, Hiroshi Shiku
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (24): 7397–7405.
https://doi.org/10.1158/1078-0432.CCR-06-1546
Published: 22 December 2006
View article titled, HER2-Specific T-Cell Immune Responses in Patients Vaccinated with Truncated HER2 Protein Complexed with Nanogels of Cholesteryl Pullulan
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Journal Articles

Cancer-Testis Antigens: Expression and Correlation with Survival in Human Urothelial Carcinoma

Padmanee Sharma, Yu Shen, Sijin Wen, Dean F. Bajorin, Victor E. Reuter, Lloyd J. Old, Achim A. Jungbluth
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (18): 5442–5447.
https://doi.org/10.1158/1078-0432.CCR-06-0527
Published: 25 September 2006
View article titled, Cancer-Testis Antigens: Expression and Correlation with Survival in Human Urothelial Carcinoma
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Includes: Supplementary data
Journal Articles

Preferential Nuclear and Cytoplasmic NY-BR-1 Protein Expression in Primary Breast Cancer and Lymph Node Metastases

Zsuzsanna Varga, Jean-Philippe Theurillat, Valeriy Filonenko, Bernd Sasse, Bernhard Odermatt, Achim A. Jungbluth, Yao-Tseng Chen, Lloyd J. Old, Alexander Knuth, Dirk Jäger, Holger Moch
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (9): 2745–2751.
https://doi.org/10.1158/1078-0432.CCR-05-2192
Published: 04 May 2006
View article titled, Preferential Nuclear and Cytoplasmic NY-BR-1 Protein Expression in Primary Breast Cancer and Lymph Node Metastases
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Journal Articles

In vitro Stimulation of CD8 and CD4 T Cells by Dendritic Cells Loaded with a Complex of Cholesterol-Bearing Hydrophobized Pullulan and NY-ESO-1 Protein: Identification of a New HLA-DR15–Binding CD4 T-Cell Epitope

Kosei Hasegawa, Yuji Noguchi, Fumihito Koizumi, Akiko Uenaka, Motoyuki Tanaka, Michihide Shimono, Hideo Nakamura, Hiroshi Shiku, Sacha Gnjatic, Roger Murphy, Yuji Hiramatsu, Lloyd J. Old, Eiichi Nakayama
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (6): 1921–1927.
https://doi.org/10.1158/1078-0432.CCR-05-1900
Published: 21 March 2006
View article titled, <em>In vitro</em> Stimulation of CD8 and CD4 T Cells by Dendritic Cells Loaded with a Complex of Cholesterol-Bearing Hydrophobized Pullulan and NY-ESO-1 Protein: Identification of a New HLA-DR15–Binding CD4 T-Cell Epitope
Open the PDF for <em>In vitro</em> Stimulation of CD8 and CD4 T Cells by Dendritic Cells Loaded with a Complex of Cholesterol-Bearing Hydrophobized Pullulan and NY-ESO-1 Protein: Identification of a New HLA-DR15–Binding CD4 T-Cell Epitope in another window
Journal Articles

Expression of Synovial Sarcoma X (SSX) Antigens in Epithelial Ovarian Cancer and Identification of SSX-4 Epitopes Recognized by CD4+ T Cells

Danila Valmori, Feng Qian, Maha Ayyoub, Christoph Renner, Andrea Merlo, Sacha Gjnatic, Elisabeth Stockert, Deborah Driscoll, Shashikant Lele, Lloyd J. Old, Kunle Odunsi
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (2): 398–404.
https://doi.org/10.1158/1078-0432.CCR-05-1902
Published: 20 January 2006
View article titled, Expression of Synovial Sarcoma X (SSX) Antigens in Epithelial Ovarian Cancer and Identification of SSX-4 Epitopes Recognized by CD4<sup>+</sup> T Cells
Open the PDF for Expression of Synovial Sarcoma X (SSX) Antigens in Epithelial Ovarian Cancer and Identification of SSX-4 Epitopes Recognized by CD4<sup>+</sup> T Cells in another window
Journal Articles

Cancer-Testis Genes Are Coordinately Expressed and Are Markers of Poor Outcome in Non–Small Cell Lung Cancer

Ali O. Gure, Ramon Chua, Barbara Williamson, Mithat Gonen, Cathy A. Ferrera, Sacha Gnjatic, Gerd Ritter, Andrew J.G. Simpson, Yao-T. Chen, Lloyd J. Old, Nasser K. Altorki
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (22): 8055–8062.
https://doi.org/10.1158/1078-0432.CCR-05-1203
Published: 18 November 2005
View article titled, Cancer-Testis Genes Are Coordinately Expressed and Are Markers of Poor Outcome in Non–Small Cell Lung Cancer
Open the PDF for Cancer-Testis Genes Are Coordinately Expressed and Are Markers of Poor Outcome in Non–Small Cell Lung Cancer in another window
Includes: Supplementary data