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Li-Xuan Qin
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Journal Articles

Histology-Specific Clinical Trial of Lenvatinib and Pembrolizumab in Patients with Sarcoma

Sujana Movva, Kenneth Seier, Viswatej Avutu, Lauren B. Banks, Jason Chan, Ping Chi, Mark A. Dickson, Mrinal M. Gounder, Ciara M. Kelly, Mary L. Keohan, Robert Maki, Evan Rosenbaum, Tiffany Salcito, Kaithleen Rodriguez, Rebecca Dempsey, Paul A. Meyers, Seth M. Cohen, Martee L. Hensley, Jason A. Konner, Alison M. Schram, Robert A. Lefkowitz, Joseph P. Erinjeri, Li-Xuan Qin, William D. Tap, Sandra P. D’Angelo
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (24): 5612–5619.
https://doi.org/10.1158/1078-0432.CCR-24-2519
Published: 16 December 2024
View article titled, Histology-Specific Clinical Trial of Lenvatinib and Pembrolizumab in Patients with Sarcoma
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Includes: Supplementary data
Journal Articles

Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma

Caroline E. Gleason, Mark A. Dickson, Mary E. Klein (Dooley), Cristina R. Antonescu, Rodrigo Gularte-Mérida, Marimar Benitez, Juliana I. Delgado, Raghu P. Kataru, Mark Wei Yi Tan, Martina Bradic, Travis E. Adamson, Kenneth Seier, Allison L. Richards, Marta Palafox, Eric Chan, Sandra P. D'Angelo, Mrinal M. Gounder, Mary Louise Keohan, Ciara M. Kelly, Ping Chi, Sujana Movva, Jonathan Landa, Aimee M. Crago, Mark T.A. Donoghue, Li-Xuan Qin, Violetta Serra, Mesruh Turkekul, Afsar Barlas, Daniel M. Firester, Katia Manova-Todorova, Babak J. Mehrara, Marta Kovatcheva, Nguan Soon Tan, Samuel Singer, William D. Tap, Andrew Koff
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (4): 703–718.
https://doi.org/10.1158/1078-0432.CCR-23-2378
Published: 16 February 2024
View article titled, Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma
Open the PDF for Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma in another window
Includes: Supplementary data
Journal Articles

PDGFRβ Signaling Cooperates with β-Catenin to Modulate c-Abl and Biologic Behavior of Desmoid-Type Fibromatosis

Jia Hu, Meera R. Hameed, Narasimhan P. Agaram, Karissa A. Whiting, Li-Xuan Qin, Anthony M. Villano, Rachael B. O'Connor, Julian M. Rozenberg, Sonia Cohen, Katherine Prendergast, Sara Kryeziu, Richard L. White, Jr, Mitchell C. Posner, Nicholas D. Socci, Mrinal M. Gounder, Samuel Singer, Aimee M. Crago
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (2): 450–461.
https://doi.org/10.1158/1078-0432.CCR-23-2313
Published: 17 January 2024
View article titled, PDGFRβ Signaling Cooperates with β-Catenin to Modulate c-Abl and Biologic Behavior of Desmoid-Type Fibromatosis
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Includes: Supplementary data
Journal Articles

A Phase II Study of Epacadostat and Pembrolizumab in Patients with Advanced Sarcoma

Ciara M. Kelly, Li-Xuan Qin, Karissa A. Whiting, Allison L. Richards, Viswatej Avutu, Jason E. Chan, Ping Chi, Mark A. Dickson, Mrinal M. Gounder, Mary Louise Keohan, Sujana Movva, Benjamin A. Nacev, Evan Rosenbaum, Travis Adamson, Samuel Singer, Edmund K. Bartlett, Aimee M. Crago, Sam S. Yoon, Sinchun Hwang, Joseph P. Erinjeri, Cristina R. Antonescu, William D. Tap, Sandra P. D'Angelo
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (11): 2043–2051.
https://doi.org/10.1158/1078-0432.CCR-22-3911
Published: 01 June 2023
View article titled, A Phase II Study of Epacadostat and Pembrolizumab in Patients with Advanced Sarcoma
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Includes: Supplementary data
Journal Articles

A Phase Ib/II Randomized Study of RO4929097, a Gamma-Secretase or Notch Inhibitor with or without Vismodegib, a Hedgehog Inhibitor, in Advanced Sarcoma

Mrinal M. Gounder, Evan Rosenbaum, Nian Wu, Mark A. Dickson, Tahir N. Sheikh, Sandra P. D'Angelo, Ping Chi, Mary Lou Keohan, Joseph P. Erinjeri, Cristina R. Antonescu, Narasimhan Agaram, Meera R. Hameed, Moriah Martindale, Robert A. Lefkowitz, Aimee M. Crago, Sam Singer, William D. Tap, Naoko Takebe, Li-Xuan Qin, Gary K. Schwartz
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (8): 1586–1594.
https://doi.org/10.1158/1078-0432.CCR-21-3874
Published: 14 April 2022
View article titled, A Phase Ib/II Randomized Study of RO4929097, a Gamma-Secretase or Notch Inhibitor with or without Vismodegib, a Hedgehog Inhibitor, in Advanced Sarcoma
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Includes: Supplementary data
Journal Articles

Phase Ib Trial of the Combination of Imatinib and Binimetinib in Patients with Advanced Gastrointestinal Stromal Tumors

Ping Chi, Li-Xuan Qin, Niedzica Camacho, Ciara M. Kelly, Sandra P. D'Angelo, Mark A. Dickson, Mrinal M. Gounder, Mary L. Keohan, Sujana Movva, Benjamin A. Nacev, Evan Rosenbaum, Katherine A. Thornton, Aimee M. Crago, Jasmine H. Francis, Moriah Martindale, Haley T. Phelan, Matthew D. Biniakewitz, Cindy J. Lee, Samuel Singer, Sinchun Hwang, Michael F. Berger, Yu Chen, Cristina R. Antonescu, William D. Tap
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (8): 1507–1517.
https://doi.org/10.1158/1078-0432.CCR-21-3909
Published: 14 April 2022
View article titled, Phase Ib Trial of the Combination of Imatinib and Binimetinib in Patients with Advanced Gastrointestinal Stromal Tumors
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Includes: Supplementary data
Journal Articles

HLA Genotyping in Synovial Sarcoma: Identifying HLA-A*02 and Its Association with Clinical Outcome

Evan Rosenbaum, Kenneth Seier, Chaitanya Bandlamudi, Mark Dickson, Mrinal Gounder, Mary L. Keohan, Ping Chi, Ciara Kelly, Sujana Movva, Benjamin Nacev, Noemi Simeone, Mark Donoghue, Emily K. Slotkin, Li-Xuan Qin, Cristina R. Antonescu, William D. Tap, Sandra P. D'Angelo
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (20): 5448–5455.
https://doi.org/10.1158/1078-0432.CCR-20-0832
Published: 15 October 2020
View article titled, HLA Genotyping in Synovial Sarcoma: Identifying HLA-A*02 and Its Association with Clinical Outcome
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Includes: Supplementary data
Journal Articles

Abstract PR16: Multiplatform analysis of paired primary and recurrent well- and dedifferentiated liposarcoma samples defines copy number alterations as dominant drivers of initiation and progression

Aimee M. Crago, Nicholas D. Socci, Li-Xuan Qin, Fatima Wilder, Rachael O'Connor, Amanda Craig, Willem van Houdt, Nils Weinhold, Cyriac Kandoth, Agnes Viale, Cristina Antonescu, Sam Singer
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (2_Supplement): PR16.
https://doi.org/10.1158/1557-3265.SARCOMAS17-PR16
Published: 15 January 2018
View article titled, Abstract PR16: Multiplatform analysis of paired primary and recurrent well- and dedifferentiated liposarcoma samples defines copy number alterations as dominant drivers of initiation and progression
Journal Articles

Combined KIT and CTLA-4 Blockade in Patients with Refractory GIST and Other Advanced Sarcomas: A Phase Ib Study of Dasatinib plus Ipilimumab

Sandra P. D'Angelo, Alexander N. Shoushtari, Mary Louise Keohan, Mark A. Dickson, Mrinal M. Gounder, Ping Chi, Jennifer K. Loo, Leigh Gaffney, Lee Schneider, Zarine Patel, Joseph Patrick Erinjeri, Mark J. Bluth, Ana Sjoberg, Howard Streicher, Naoko Takebe, Li-Xuan Qin, Cristina Antonescu, Ronald P. DeMatteo, Richard D. Carvajal, William D. Tap
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (12): 2972–2980.
https://doi.org/10.1158/1078-0432.CCR-16-2349
Published: 14 June 2017
View article titled, Combined KIT and CTLA-4 Blockade in Patients with Refractory GIST and Other Advanced Sarcomas: A Phase Ib Study of Dasatinib plus Ipilimumab
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Includes: Supplementary data
Journal Articles

Abstract B11: An empirical evaluation of array normalization for Agilent microRNA expression arrays

Li-Xuan Qin, Jaya Satagopan, Samuel Singer
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (14_Supplement): B11.
https://doi.org/10.1158/1078-0432.TCMUSA10-B11
Published: 02 February 2016
View article titled, Abstract B11: An empirical evaluation of array normalization for Agilent microRNA expression arrays
Journal Articles

Evaluation of the feasibility of expression microarray analysis in endoscopically obtained biopsies of gastric carcinoma and their clinical applicability

Minaxi Jhawer, Li-Xuan Qin, Hans Gerdes, David Klimstra, Mark Schattner, Agnes Viale, David Kelsen, Manish Shah
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (19_Supplement): A48.
Published: 15 August 2014
View article titled, Evaluation of the feasibility of expression microarray analysis in endoscopically obtained biopsies of gastric carcinoma and their clinical applicability
Journal Articles

Blocking and Randomization to Improve Molecular Biomarker Discovery

Li-Xuan Qin, Qin Zhou, Faina Bogomolniy, Liliana Villafania, Narciso Olvera, Magali Cavatore, Jaya M. Satagopan, Colin B. Begg, Douglas A. Levine
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (13): 3371–3378.
https://doi.org/10.1158/1078-0432.CCR-13-3155
Published: 30 June 2014
View article titled, Blocking and Randomization to Improve Molecular Biomarker Discovery
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Includes: Supplementary data
Journal Articles

Identification of Unique MEK-Dependent Genes in GNAQ Mutant Uveal Melanoma Involved in Cell Growth, Tumor Cell Invasion, and MEK Resistance

Grazia Ambrosini, Christine A. Pratilas, Li-Xuan Qin, Madhavi Tadi, Oliver Surriga, Richard D. Carvajal, Gary K. Schwartz
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (13): 3552–3561.
https://doi.org/10.1158/1078-0432.CCR-11-3086
Published: 01 July 2012
View article titled, Identification of Unique MEK-Dependent Genes in GNAQ Mutant Uveal Melanoma Involved in Cell Growth, Tumor Cell Invasion, and MEK Resistance
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Includes: Supplementary data
Journal Articles

Copy Number Losses Define Subgroups of Dedifferentiated Liposarcoma with Poor Prognosis and Genomic Instability

Aimee M. Crago, Nicholas D. Socci, Penelope DeCarolis, Rachael O'Connor, Barry S. Taylor, Li-Xuan Qin, Cristina R. Antonescu, Samuel Singer
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (5): 1334–1340.
https://doi.org/10.1158/1078-0432.CCR-11-2820
Published: 01 March 2012
View article titled, Copy Number Losses Define Subgroups of Dedifferentiated Liposarcoma with Poor Prognosis and Genomic Instability
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Includes: Supplementary data
Journal Articles

Cyst Fluid Interleukin-1β (IL1β) Levels Predict the Risk of Carcinoma in Intraductal Papillary Mucinous Neoplasms of the Pancreas

Ajay V. Maker, Nora Katabi, Li-Xuan Qin, David S. Klimstra, Mark Schattner, Murray F. Brennan, William R. Jarnagin, Peter J. Allen
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (6): 1502–1508.
https://doi.org/10.1158/1078-0432.CCR-10-1561
Published: 15 March 2011
View article titled, Cyst Fluid Interleukin-1β (IL1β) Levels Predict the Risk of Carcinoma in Intraductal Papillary Mucinous Neoplasms of the Pancreas
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Journal Articles

A Synovial Sarcoma-Specific Preoperative Nomogram Supports a Survival Benefit to Ifosfamide-Based Chemotherapy and Improves Risk Stratification for Patients

Robert J. Canter, Li-Xuan Qin, Robert G. Maki, Murray F. Brennan, Marc Ladanyi, Samuel Singer
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (24): 8191–8197.
https://doi.org/10.1158/1078-0432.CCR-08-0843
Published: 15 December 2008
View article titled, A Synovial Sarcoma-Specific Preoperative Nomogram Supports a Survival Benefit to Ifosfamide-Based Chemotherapy and Improves Risk Stratification for Patients
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