1-5 of 5
Leslie B. Lee
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Targeting Activated Akt with GDC-0068, a Novel Selective Akt Inhibitor That Is Efficacious in Multiple Tumor Models

Jie Lin, Deepak Sampath, Michelle A. Nannini, Brian B. Lee, Michael Degtyarev, Jason Oeh, Heidi Savage, Zhengyu Guan, Rebecca Hong, Robert Kassees, Leslie B. Lee, Tyler Risom, Stefan Gross, Bianca M. Liederer, Hartmut Koeppen, Nicholas J. Skelton, Jeffrey J. Wallin, Marcia Belvin, Elizabeth Punnoose, Lori S. Friedman, Kui Lin
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (7): 1760–1772.
https://doi.org/10.1158/1078-0432.CCR-12-3072
Published: 02 April 2013
View article titled, Targeting Activated Akt with GDC-0068, a Novel Selective Akt Inhibitor That Is Efficacious in Multiple Tumor Models
Open the PDF for Targeting Activated Akt with GDC-0068, a Novel Selective Akt Inhibitor That Is Efficacious in Multiple Tumor Models in another window
Includes: Supplementary data
Journal Articles

Targeting the PI3K Pathway in the Brain—Efficacy of a PI3K Inhibitor Optimized to Cross the Blood–Brain Barrier

Laurent Salphati, Timothy P. Heffron, Bruno Alicke, Merry Nishimura, Kai Barck, Richard A. Carano, Jonathan Cheong, Kyle A. Edgar, Joan Greve, Samir Kharbanda, Hartmut Koeppen, Shari Lau, Leslie B. Lee, Jodie Pang, Emile G. Plise, Jenny L. Pokorny, Hani Bou Reslan, Jann N. Sarkaria, Jeffrey J. Wallin, Xiaolin Zhang, Stephen E. Gould, Alan G. Olivero, Heidi S. Phillips
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (22): 6239–6248.
https://doi.org/10.1158/1078-0432.CCR-12-0720
Published: 14 November 2012
View article titled, Targeting the PI3K Pathway in the Brain—Efficacy of a PI3K Inhibitor Optimized to Cross the Blood–Brain Barrier
Open the PDF for Targeting the PI3K Pathway in the Brain—Efficacy of a PI3K Inhibitor Optimized to Cross the Blood–Brain Barrier in another window
Includes: Supplementary data
Journal Articles

GDC-0941, a Novel Class I Selective PI3K Inhibitor, Enhances the Efficacy of Docetaxel in Human Breast Cancer Models by Increasing Cell Death In Vitro and In Vivo

Jeffrey J. Wallin, Jane Guan, Wei Wei Prior, Leslie B. Lee, Leanne Berry, Lisa D. Belmont, Hartmut Koeppen, Marcia Belvin, Lori S. Friedman, Deepak Sampath
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (14): 3901–3911.
https://doi.org/10.1158/1078-0432.CCR-11-2088
Published: 15 July 2012
View article titled, GDC-0941, a Novel Class I Selective PI3K Inhibitor, Enhances the Efficacy of Docetaxel in Human Breast Cancer Models by Increasing Cell Death <em>In Vitro</em> and <em>In Vivo</em>
Open the PDF for GDC-0941, a Novel Class I Selective PI3K Inhibitor, Enhances the Efficacy of Docetaxel in Human Breast Cancer Models by Increasing Cell Death <em>In Vitro</em> and <em>In Vivo</em> in another window
Includes: Supplementary data
Journal Articles

Proof of Target for SU11654: Inhibition of KIT Phosphorylation in Canine Mast Cell Tumors

Nancy K. Pryer, Leslie B. Lee, Regina Zadovaskaya, Xiaoming Yu, Juthamas Sukbuntherng, Julie M. Cherrington, Cheryl A. London
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (15): 5729–5734.
Published: 03 December 2003
View article titled, Proof of Target for SU11654: <subtitle>Inhibition of KIT Phosphorylation in Canine Mast Cell Tumors</subtitle>
Open the PDF for Proof of Target for SU11654: <subtitle>Inhibition of KIT Phosphorylation in Canine Mast Cell Tumors</subtitle> in another window
Journal Articles

In Vivo Antitumor Activity of SU11248, a Novel Tyrosine Kinase Inhibitor Targeting Vascular Endothelial Growth Factor and Platelet-derived Growth Factor Receptors: Determination of a Pharmacokinetic/Pharmacodynamic Relationship

Dirk B. Mendel, A. Douglas Laird, Xiaohua Xin, Sharianne G. Louie, James G. Christensen, Guangmin Li, Randall E. Schreck, Tinya J. Abrams, Theresa J. Ngai, Leslie B. Lee, Lesley J. Murray, Jeremy Carver, Emily Chan, Katherine G. Moss, Joshua Ö. Haznedar, Juthamas Sukbuntherng, Robert A. Blake, Li Sun, Cho Tang, Todd Miller, Sheri Shirazian, Gerald McMahon, Julie M. Cherrington
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (1): 327–337.
Published: 01 January 2003
View article titled, <em>In Vivo</em> Antitumor Activity of SU11248, a Novel Tyrosine Kinase Inhibitor Targeting Vascular Endothelial Growth Factor and Platelet-derived Growth Factor Receptors: <subtitle>Determination of a Pharmacokinetic/Pharmacodynamic Relationship</subtitle>
Open the PDF for <em>In Vivo</em> Antitumor Activity of SU11248, a Novel Tyrosine Kinase Inhibitor Targeting Vascular Endothelial Growth Factor and Platelet-derived Growth Factor Receptors: <subtitle>Determination of a Pharmacokinetic/Pharmacodynamic Relationship</subtitle> in another window