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Leonie S. Young
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Journal Articles

Steroid Ligands, the Forgotten Triggers of Nuclear Receptor Action; Implications for Acquired Resistance to Endocrine Therapy

Rachel Bleach, Stephen F. Madden, James Hawley, Sara Charmsaz, Cigdem Selli, Katherine M. Sheehan, Leonie S. Young, Andrew H. Sims, Pavel Souček, Arnold D. Hill, Marie McIlroy
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (14): 3980–3989.
https://doi.org/10.1158/1078-0432.CCR-20-4135
Published: 15 July 2021
View article titled, Steroid Ligands, the Forgotten Triggers of Nuclear Receptor Action; Implications for Acquired Resistance to Endocrine Therapy
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Includes: Supplementary data
Journal Articles

BET Inhibition as a Rational Therapeutic Strategy for Invasive Lobular Breast Cancer

Louise Walsh, Kathryn E. Haley, Bruce Moran, Brian Mooney, Finbarr Tarrant, Stephen F. Madden, Alessandra Di Grande, Yue Fan, Sudipto Das, Oscar M. Rueda, Catríona M. Dowling, Damir Varešlija, Suet-Feung Chin, Sabine Linn, Leonie S. Young, Karin Jirström, John P. Crown, Rene Bernards, Carlos Caldas, William M. Gallagher, Darran P. O'Connor, Tríona Ní Chonghaile
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (23): 7139–7150.
https://doi.org/10.1158/1078-0432.CCR-19-0713
Published: 02 December 2019
View article titled, BET Inhibition as a Rational Therapeutic Strategy for Invasive Lobular Breast Cancer
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Includes: Supplementary data
Journal Articles

Epigenome-wide SRC-1–Mediated Gene Silencing Represses Cellular Differentiation in Advanced Breast Cancer

Elspeth Ward, Damir Varešlija, Sara Charmsaz, Ailis Fagan, Alacoque L. Browne, Nicola Cosgrove, Sinéad Cocchiglia, Siobhan P. Purcell, Lance Hudson, Sudipto Das, Darran O'Connor, Philip J. O'Halloran, Andrew H. Sims, Arnold D. Hill, Leonie S. Young
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (15): 3692–3703.
https://doi.org/10.1158/1078-0432.CCR-17-2615
Published: 31 July 2018
View article titled, Epigenome-wide SRC-1–Mediated Gene Silencing Represses Cellular Differentiation in Advanced Breast Cancer
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Includes: Supplementary data
Journal Articles

Adaptation to AI Therapy in Breast Cancer Can Induce Dynamic Alterations in ER Activity Resulting in Estrogen-Independent Metastatic Tumors

Damir Varešlija, Jean McBryan, Ailís Fagan, Aisling M. Redmond, Yuan Hao, Andrew H. Sims, Arran Turnbull, J.M. Dixon, Peadar Ó Gaora, Lance Hudson, Siobhan Purcell, Arnold D.K. Hill, Leonie S. Young
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (11): 2765–2777.
https://doi.org/10.1158/1078-0432.CCR-15-1583
Published: 31 May 2016
View article titled, Adaptation to AI Therapy in Breast Cancer Can Induce Dynamic Alterations in ER Activity Resulting in Estrogen-Independent Metastatic Tumors
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Includes: Supplementary data
Journal Articles

Transcriptomic Profiling of Sequential Tumors from Breast Cancer Patients Provides a Global View of Metastatic Expression Changes Following Endocrine Therapy

Jean McBryan, Ailís Fagan, Damian McCartan, Fiona T. Bane, Damir Varešlija, Sinéad Cocchiglia, Christopher Byrne, Jarlath Bolger, Marie McIlroy, Lance Hudson, Paul Tibbitts, Peadar Ó Gaora, Arnold D. Hill, Leonie S. Young
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2015) 21 (23): 5371–5379.
https://doi.org/10.1158/1078-0432.CCR-14-2155
Published: 30 November 2015
View article titled, Transcriptomic Profiling of Sequential Tumors from Breast Cancer Patients Provides a Global View of Metastatic Expression Changes Following Endocrine Therapy
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Includes: Supplementary data
Journal Articles

AIB1:ERα Transcriptional Activity Is Selectively Enhanced in Aromatase Inhibitor–Resistant Breast Cancer Cells

Jane O'Hara, Damir Vareslija, Jean McBryan, Fiona Bane, Paul Tibbitts, Christopher Byrne, Ronán M. Conroy, Yuan Hao, Peadar Ó Gaora, Arnold D.K. Hill, Marie McIlroy, Leonie S. Young
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (12): 3305–3315.
https://doi.org/10.1158/1078-0432.CCR-11-3300
Published: 14 June 2012
View article titled, AIB1:ERα Transcriptional Activity Is Selectively Enhanced in Aromatase Inhibitor–Resistant Breast Cancer Cells
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Includes: Supplementary data
Journal Articles

Coassociation of Estrogen Receptor and p160 Proteins Predicts Resistance to Endocrine Treatment; SRC-1 is an Independent Predictor of Breast Cancer Recurrence

Aisling M. Redmond, Fiona T. Bane, Anthony T. Stafford, Marie McIlroy, Mary F. Dillon, Thomas B. Crotty, Arnold D. Hill, Leonie S. Young
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (6): 2098–2106.
https://doi.org/10.1158/1078-0432.CCR-08-1649
Published: 16 March 2009
View article titled, Coassociation of Estrogen Receptor and p160 Proteins Predicts Resistance to Endocrine Treatment; SRC-1 is an Independent Predictor of Breast Cancer Recurrence
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Includes: Supplementary data
Journal Articles

Associations and Interactions between Ets-1 and Ets-2 and Coregulatory Proteins, SRC-1, AIB1, and NCoR in Breast Cancer

Eddie Myers, Arnold D.K. Hill, Gabrielle Kelly, Enda W. McDermott, Niall J. O'Higgins, Yvonne Buggy, Leonie S. Young
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (6): 2111–2122.
https://doi.org/10.1158/1078-0432.CCR-04-1192
Published: 23 March 2005
View article titled, Associations and Interactions between Ets-1 and Ets-2 and Coregulatory Proteins, SRC-1, AIB1, and NCoR in Breast Cancer
Open the PDF for Associations and Interactions between Ets-1 and Ets-2 and Coregulatory Proteins, SRC-1, AIB1, and NCoR in Breast Cancer in another window