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Leonidas C. Platanias
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Journal Articles

The Use of Serial Circulating Tumor DNA to Detect Resistance Alterations in Progressive Metastatic Breast Cancer

Saya Jacob, Andrew A. Davis, Lorenzo Gerratana, Marko Velimirovic, Ami N. Shah, Firas Wehbe, Neelima Katam, Qiang Zhang, Lisa Flaum, Kalliopi P. Siziopikou, Leonidas C. Platanias, William J. Gradishar, Amir Behdad, Aditya Bardia, Massimo Cristofanilli
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (5): 1361–1370.
https://doi.org/10.1158/1078-0432.CCR-20-1566
Published: 01 March 2021
View article titled, The Use of Serial Circulating Tumor DNA to Detect Resistance Alterations in Progressive Metastatic Breast Cancer
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Includes: Supplementary data
Journal Articles

Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma

Erik Ladomersky, Lijie Zhai, Kristen L. Lauing, April Bell, Jiahui Xu, Masha Kocherginsky, Bin Zhang, Jennifer D. Wu, Joseph R. Podojil, Leonidas C. Platanias, Aaron Y. Mochizuki, Robert M. Prins, Priya Kumthekar, Jeffrey J. Raizer, Karan Dixit, Rimas V. Lukas, Craig Horbinski, Min Wei, Changyou Zhou, Graham Pawelec, Judith Campisi, Ursula Grohmann, George C. Prendergast, David H. Munn, Derek A. Wainwright
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (19): 5232–5245.
https://doi.org/10.1158/1078-0432.CCR-19-3874
Published: 01 October 2020
View article titled, Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma
Open the PDF for Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma in another window
Includes: Supplementary data
Journal Articles

IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma

Erik Ladomersky, Lijie Zhai, Alicia Lenzen, Kristen L. Lauing, Jun Qian, Denise M. Scholtens, Galina Gritsina, Xuebing Sun, Ye Liu, Fenglong Yu, Wenfeng Gong, Yong Liu, Beibei Jiang, Tristin Tang, Ricky Patel, Leonidas C. Platanias, C. David James, Roger Stupp, Rimas V. Lukas, David C. Binder, Derek A. Wainwright
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (11): 2559–2573.
https://doi.org/10.1158/1078-0432.CCR-17-3573
Published: 31 May 2018
View article titled, IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma
Open the PDF for IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma in another window
Includes: Supplementary data
Journal Articles

Cell-Free DNA and Circulating Tumor Cells: Comprehensive Liquid Biopsy Analysis in Advanced Breast Cancer

Giovanna Rossi, Zhaomei Mu, Alfred W. Rademaker, Laura K. Austin, Kimberly S. Strickland, Ricardo Lima Barros Costa, Rebecca J. Nagy, Vittorina Zagonel, Timothy J. Taxter, Amir Behdad, Firas H. Wehbe, Leonidas C. Platanias, William J. Gradishar, Massimo Cristofanilli
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (3): 560–568.
https://doi.org/10.1158/1078-0432.CCR-17-2092
Published: 31 January 2018
View article titled, Cell-Free DNA and Circulating Tumor Cells: Comprehensive Liquid Biopsy Analysis in Advanced Breast Cancer
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Includes: Supplementary data
Journal Articles

Autophagy Is a Survival Mechanism of Acute Myelogenous Leukemia Precursors during Dual mTORC2/mTORC1 Targeting

Jessica K. Altman, Amy Szilard, Dennis J. Goussetis, Antonella Sassano, Marco Colamonici, Elias Gounaris, Olga Frankfurt, Francis J. Giles, Elizabeth A. Eklund, Elspeth M. Beauchamp, Leonidas C. Platanias
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (9): 2400–2409.
https://doi.org/10.1158/1078-0432.CCR-13-3218
Published: 30 April 2014
View article titled, Autophagy Is a Survival Mechanism of Acute Myelogenous Leukemia Precursors during Dual mTORC2/mTORC1 Targeting
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Journal Articles

Dual mTORC2/mTORC1 Targeting Results in Potent Suppressive Effects on Acute Myeloid Leukemia (AML) Progenitors

Jessica K. Altman, Antonella Sassano, Surinder Kaur, Heather Glaser, Barbara Kroczynska, Amanda J. Redig, Suzanne Russo, Sharon Barr, Leonidas C. Platanias
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (13): 4378–4388.
https://doi.org/10.1158/1078-0432.CCR-10-2285
Published: 05 July 2011
View article titled, Dual mTORC2/mTORC1 Targeting Results in Potent Suppressive Effects on Acute Myeloid Leukemia (AML) Progenitors
Open the PDF for Dual mTORC2/mTORC1 Targeting Results in Potent Suppressive Effects on Acute Myeloid Leukemia (AML) Progenitors in another window
Includes: Supplementary data
Journal Articles

Arsenic Trioxide and the Phosphoinositide 3-Kinase/Akt Pathway in Chronic Lymphocytic Leukemia

Dennis J. Goussetis, Leonidas C. Platanias
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (17): 4311–4312.
https://doi.org/10.1158/1078-0432.CCR-10-1496
Published: 31 August 2010
View article titled, Arsenic Trioxide and the Phosphoinositide 3-Kinase/Akt Pathway in Chronic Lymphocytic Leukemia
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Includes: Supplementary data
Journal Articles

Statin-Dependent Suppression of the Akt/Mammalian Target of Rapamycin Signaling Cascade and Programmed Cell Death 4 Up-Regulation in Renal Cell Carcinoma

Jennifer Woodard, Antonella Sassano, Nissim Hay, Leonidas C. Platanias
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (14): 4640–4649.
https://doi.org/10.1158/1078-0432.CCR-07-5232
Published: 15 July 2008
View article titled, Statin-Dependent Suppression of the Akt/Mammalian Target of Rapamycin Signaling Cascade and Programmed Cell Death 4 Up-Regulation in Renal Cell Carcinoma
Open the PDF for Statin-Dependent Suppression of the Akt/Mammalian Target of Rapamycin Signaling Cascade and Programmed Cell Death 4 Up-Regulation in Renal Cell Carcinoma in another window