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Leonard B. Saltz
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Journal Articles

Phase II Single-arm Study of Durvalumab and Tremelimumab with Concurrent Radiotherapy in Patients with Mismatch Repair–proficient Metastatic Colorectal Cancer

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Neil H. Segal, Andrea Cercek, Geoffrey Ku, Abraham J. Wu, Andreas Rimner, Danny N. Khalil, Diane Reidy-Lagunes, John Cuaron, T. Jonathan Yang, Martin R. Weiser, Paul B. Romesser, Zsofia K. Stadler, Anna M. Varghese, Karuna Ganesh, Rona Yaeger, Louise C. Connell, David Faleck, Ghassan K. Abou-Alfa, Kathleen C. Mcauliffe, Pamela Vaiskauskas, Mark L. Solter, Martinique Ogle, Matthew J. Adamow, Aliya Holland, Pallavi Vedantam, Phillip Wong, Taha Merghoub, Efsevia Vakiani, Travis J. Hollmann, Krishna Juluru, Joanne F. Chou, Marinela Capanu, Joseph Erinjeri, Stephen Solomon, Yoshiya Yamada, Nancy Kemeny, Christopher H. Crane, Leonard B. Saltz
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (8): 2200–2208.
https://doi.org/10.1158/1078-0432.CCR-20-2474
Published: 15 April 2021
View articletitled, Phase II Single-arm Study of Durvalumab and Tremelimumab with Concurrent Radiotherapy in Patients with Mismatch Repair–proficient Metastatic Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Characterization and Clinical Outcomes of DNA Mismatch Repair–deficient Small Bowel Adenocarcinoma

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Alicia Latham, Jinru Shia, Zalak Patel, Diane L. Reidy-Lagunes, Neil H. Segal, Rona Yaeger, Karuna Ganesh, Louise Connell, Nancy E. Kemeny, David P. Kelsen, Jaclyn F. Hechtman, Garrett M. Nash, Philip B. Paty, Ahmet Zehir, Kaitlin A. Tkachuk, Rania Sheikh, Arnold J. Markowitz, Diana Mandelker, Kenneth Offit, Michael F. Berger, Andrea Cercek, Julio Garcia-Aguilar, Leonard B. Saltz, Martin R. Weiser, Zsofia K. Stadler
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (5): 1429–1437.
https://doi.org/10.1158/1078-0432.CCR-20-2892
Published: 01 March 2021
View articletitled, Characterization and Clinical Outcomes of DNA Mismatch Repair–deficient Small Bowel Adenocarcinoma
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Includes: Supplementary data
Journal Articles

Mismatch Repair–Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy

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Andrea Cercek, Gustavo Dos Santos Fernandes, Campbell S. Roxburgh, Karuna Ganesh, Shu Ng, Francisco Sanchez-Vega, Rona Yaeger, Neil H. Segal, Diane L. Reidy-Lagunes, Anna M. Varghese, Arnold Markowitz, Chao Wu, Bryan Szeglin, Charles-Etienne Gabriel Sauvé, Erin Salo-Mullen, Christina Tran, Zalak Patel, Asha Krishnan, Kaitlyn Tkachuk, Garrett M. Nash, Jose Guillem, Philip B. Paty, Jinru Shia, Nikolaus Schultz, Julio Garcia-Aguilar, Luis A. Diaz, Karyn Goodman, Leonard B. Saltz, Martin R. Weiser, J. Joshua Smith, Zsofia K. Stadler
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13): 3271–3279.
https://doi.org/10.1158/1078-0432.CCR-19-3728
Published: 01 July 2020
View articletitled, Mismatch Repair–Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy
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Includes: Supplementary data
Journal Articles

Phase I Study of Trifluridine/Tipiracil Plus Irinotecan and Bevacizumab in Advanced Gastrointestinal Tumors

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Anna M. Varghese, Dana B. Cardin, Jonathan Hersch, Al B. Benson, Howard S. Hochster, Lukas Makris, Kensuke Hamada, Jordan D. Berlin, Leonard B. Saltz
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (7): 1555–1562.
https://doi.org/10.1158/1078-0432.CCR-19-2743
Published: 01 April 2020
View articletitled, Phase I Study of Trifluridine/Tipiracil Plus Irinotecan and Bevacizumab in Advanced Gastrointestinal Tumors
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Includes: Supplementary data
Journal Articles

Coaltered Ras/B-raf and TP53 Is Associated with Extremes of Survivorship and Distinct Patterns of Metastasis in Patients with Metastatic Colorectal Cancer

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Jashodeep Datta, J. Joshua Smith, Walid K. Chatila, John C. McAuliffe, Cyriac Kandoth, Efsevia Vakiani, Timothy L. Frankel, Karuna Ganesh, Isaac Wasserman, Marla Lipsyc-Sharf, Jose Guillem, Garrett M. Nash, Philip B. Paty, Martin R. Weiser, Leonard B. Saltz, Michael F. Berger, William R. Jarnagin, Vinod Balachandran, T. Peter Kingham, Nancy E. Kemeny, Andrea Cercek, Julio Garcia-Aguilar, Barry S. Taylor, Agnes Viale, Rona Yaeger, David B. Solit, Nikolaus Schultz, Michael I. D'Angelica
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (5): 1077–1085.
https://doi.org/10.1158/1078-0432.CCR-19-2390
Published: 02 March 2020
View articletitled, Coaltered Ras/B-raf and TP53 Is Associated with Extremes of Survivorship and Distinct Patterns of Metastasis in Patients with Metastatic Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Understanding the Right to Try Act

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Rajiv Agarwal, Leonard B. Saltz
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (2): 340–343.
https://doi.org/10.1158/1078-0432.CCR-19-2015
Published: 15 January 2020
View articletitled, Understanding the Right to Try Act
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Journal Articles

Comprehensive Molecular Profiling of Intrahepatic and Extrahepatic Cholangiocarcinomas: Potential Targets for Intervention

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Maeve A. Lowery, Ryan Ptashkin, Emmet Jordan, Michael F. Berger, Ahmet Zehir, Marinela Capanu, Nancy E. Kemeny, Eileen M. O'Reilly, Imane El-Dika, William R. Jarnagin, James J. Harding, Michael I. D'Angelica, Andrea Cercek, Jaclyn F. Hechtman, David B. Solit, Nikolaus Schultz, David M. Hyman, David S. Klimstra, Leonard B. Saltz, Ghassan K. Abou-Alfa
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (17): 4154–4161.
https://doi.org/10.1158/1078-0432.CCR-18-0078
Published: 04 September 2018
View articletitled, Comprehensive Molecular Profiling of Intrahepatic and Extrahepatic Cholangiocarcinomas: Potential Targets for Intervention
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Includes: Supplementary data
Journal Articles

Evaluating Mismatch Repair Deficiency in Pancreatic Adenocarcinoma: Challenges and Recommendations

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Zishuo I. Hu, Jinru Shia, Zsofia K. Stadler, Anna M. Varghese, Marinela Capanu, Erin Salo-Mullen, Maeve A. Lowery, Luis A. Diaz, Jr, Diana Mandelker, Kenneth H. Yu, Alice Zervoudakis, David P. Kelsen, Christine A. Iacobuzio-Donahue, David S. Klimstra, Leonard B. Saltz, Ibrahim H. Sahin, Eileen M. O'Reilly
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (6): 1326–1336.
https://doi.org/10.1158/1078-0432.CCR-17-3099
Published: 14 March 2018
View articletitled, Evaluating Mismatch Repair Deficiency in Pancreatic Adenocarcinoma: Challenges and Recommendations
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Journal Articles

Real-Time Genomic Profiling of Pancreatic Ductal Adenocarcinoma: Potential Actionability and Correlation with Clinical Phenotype

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Maeve A. Lowery, Emmet J. Jordan, Olca Basturk, Ryan N. Ptashkin, Ahmet Zehir, Michael F. Berger, Tanisha Leach, Brian Herbst, Gokce Askan, Hannah Maynard, Danielle Glassman, Christina Covington, Nikolaus Schultz, Ghassan K. Abou-Alfa, James J. Harding, David S. Klimstra, Jaclyn F. Hechtman, David M. Hyman, Peter J. Allen, William R. Jarnagin, Vinod P. Balachandran, Anna M. Varghese, Mark A. Schattner, Kenneth H. Yu, Leonard B. Saltz, David B. Solit, Christine A. Iacobuzio-Donahue, Steven D. Leach, Eileen M. O'Reilly
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (20): 6094–6100.
https://doi.org/10.1158/1078-0432.CCR-17-0899
Published: 12 October 2017
View articletitled, Real-Time Genomic Profiling of Pancreatic Ductal Adenocarcinoma: Potential Actionability and Correlation with Clinical Phenotype
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Journal Articles

RAF plus EGFR Inhibition for BRAF-Mutant Metastatic Colorectal Cancer—Response

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Rona Yaeger, Leonard B. Saltz
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (9): 2188.
https://doi.org/10.1158/1078-0432.CCR-15-0412
Published: 30 April 2015
View articletitled, RAF plus EGFR Inhibition for BRAF-Mutant Metastatic Colorectal Cancer—Response
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Journal Articles

Pilot Trial of Combined BRAF and EGFR Inhibition in BRAF-Mutant Metastatic Colorectal Cancer Patients

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Rona Yaeger, Andrea Cercek, Eileen M. O'Reilly, Diane L. Reidy, Nancy Kemeny, Tamar Wolinsky, Marinela Capanu, Marc J. Gollub, Neal Rosen, Michael F. Berger, Mario E. Lacouture, Efsevia Vakiani, Leonard B. Saltz
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (6): 1313–1320.
https://doi.org/10.1158/1078-0432.CCR-14-2779
Published: 12 March 2015
View articletitled, Pilot Trial of Combined BRAF and EGFR Inhibition in BRAF-Mutant Metastatic Colorectal Cancer Patients
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Includes: Supplementary data
Journal Articles

Pharmacogenomic Modeling of Circulating Tumor and Invasive Cells for Prediction of Chemotherapy Response and Resistance in Pancreatic Cancer

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Kenneth H. Yu, Mark Ricigliano, Manuel Hidalgo, Ghassan K. Abou-Alfa, Maeve A. Lowery, Leonard B. Saltz, Joseph F. Crotty, Kristen Gary, Brandon Cooper, Rena Lapidus, Mariola Sadowska, Eileen M. O'Reilly
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2014) 20 (20): 5281–5289.
https://doi.org/10.1158/1078-0432.CCR-14-0531
Published: 14 October 2014
View articletitled, Pharmacogenomic Modeling of Circulating Tumor and Invasive Cells for Prediction of Chemotherapy Response and Resistance in Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Association of TP53 Mutational Status and Gender with Survival after Adjuvant Treatment for Stage III Colon Cancer: Results of CALGB 89803

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Robert S. Warren, Chloe E. Atreya, Donna Niedzwiecki, Vivian K. Weinberg, David B. Donner, Robert J. Mayer, Richard M. Goldberg, Carolyn C. Compton, Marlene B. Zuraek, Cynthia Ye, Leonard B. Saltz, Monica M. Bertagnolli
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (20): 5777–5787.
https://doi.org/10.1158/1078-0432.CCR-13-0351
Published: 14 October 2013
View articletitled, Association of TP53 Mutational Status and Gender with Survival after Adjuvant Treatment for Stage III Colon Cancer: Results of CALGB 89803
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Includes: Supplementary data
Journal Articles

Predictive and Prognostic Roles of BRAF Mutation in Stage III Colon Cancer: Results from Intergroup Trial CALGB 89803

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Shuji Ogino, Kaori Shima, Jeffrey A. Meyerhardt, Nadine J. McCleary, Kimmie Ng, Donna Hollis, Leonard B. Saltz, Robert J. Mayer, Paul Schaefer, Renaud Whittom, Alexander Hantel, Al B. Benson, III, Donna Spiegelman, Richard M. Goldberg, Monica M. Bertagnolli, Charles S. Fuchs
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (3): 890–900.
https://doi.org/10.1158/1078-0432.CCR-11-2246
Published: 31 January 2012
View articletitled, Predictive and Prognostic Roles of BRAF Mutation in Stage III Colon Cancer: Results from Intergroup Trial CALGB 89803
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Includes: Supplementary data
Journal Articles

KRAS Mutation in Stage III Colon Cancer and Clinical Outcome Following Intergroup Trial CALGB 89803

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Shuji Ogino, Jeffrey A. Meyerhardt, Natsumi Irahara, Donna Niedzwiecki, Donna Hollis, Leonard B. Saltz, Robert J. Mayer, Paul Schaefer, Renaud Whittom, Alexander Hantel, Al B. Benson, III, Richard M. Goldberg, Monica M. Bertagnolli, Charles S. Fuchs, for the Cancer and Leukemia Group B, North Central Cancer Treatment Group, Canadian Cancer Society Research Institute, Southwest Oncology Group
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (23): 7322–7329.
https://doi.org/10.1158/1078-0432.CCR-09-1570
Published: 30 November 2009
View articletitled, KRAS Mutation in Stage III Colon Cancer and Clinical Outcome Following Intergroup Trial CALGB 89803
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Journal Articles

p27Kip1 in Stage III Colon Cancer: Implications for Outcome following Adjuvant Chemotherapy in Cancer and Leukemia Group B Protocol 89803

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Monica M. Bertagnolli, Robert S. Warren, Donna Niedzwiecki, Elke Mueller, Carolyn C. Compton, Mark Redston, Margaret Hall, Hejin P. Hahn, Scott D. Jewell, Robert J. Mayer, Richard M. Goldberg, Leonard B. Saltz, Massimo Loda
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (6): 2116–2122.
https://doi.org/10.1158/1078-0432.CCR-08-2674
Published: 16 March 2009
View articletitled, p27Kip1 in Stage III Colon Cancer: Implications for Outcome following Adjuvant Chemotherapy in Cancer and Leukemia Group B Protocol 89803
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Journal Articles

Metabolic Signatures Associated with a NAD Synthesis Inhibitor–Induced Tumor Apoptosis Identified by 1H-Decoupled-31P Magnetic Resonance Spectroscopy

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Manickam Muruganandham, Alan A. Alfieri, Cornelia Matei, Yuchun Chen, George Sukenick, Isabel Schemainda, Max Hasmann, Leonard B. Saltz, Jason A. Koutcher
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (9): 3503–3513.
https://doi.org/10.1158/1078-0432.CCR-04-1399
Published: 02 May 2005
View articletitled, Metabolic Signatures Associated with a NAD Synthesis Inhibitor–Induced Tumor Apoptosis Identified by 1H-Decoupled-31P Magnetic Resonance Spectroscopy
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Journal Articles

Phase I Study of Topoisomerase I Inhibitor Exatecan Mesylate (DX-8951f) Given as Weekly 24-Hour Infusions Three of Every Four Weeks

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Sunil Sharma, Nancy Kemeny, Gary K. Schwartz, David Kelsen, Eileen O’Reilly, David Ilson, John Coyle, Robert L. De Jager, Martin P. Ducharme, Sarah Kleban, Ellen Hollywood, Leonard B. Saltz
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (12): 3963–3970.
Published: 01 December 2001
View articletitled, Phase I Study of Topoisomerase I Inhibitor Exatecan Mesylate (DX-8951f) Given as Weekly 24-Hour Infusions Three of Every Four Weeks
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