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Laurent Vernillet
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Journal Articles

Bridging the Gap between Preclinical and Clinical Studies Using Pharmacokinetic–Pharmacodynamic Modeling: An Analysis of GDC-0973, a MEK Inhibitor

Harvey Wong, Laurent Vernillet, Amy Peterson, Joseph A. Ware, Lillian Lee, Jean-Francois Martini, Peiwen Yu, Congfen Li, Geoffrey Del Rosario, Edna F. Choo, Klaus P. Hoeflich, Yongchang Shi, Blake T. Aftab, Ron Aoyama, Sanh Tan Lam, Marcia Belvin, John Prescott
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (11): 3090–3099.
https://doi.org/10.1158/1078-0432.CCR-12-0445
Published: 31 May 2012
View article titled, Bridging the Gap between Preclinical and Clinical Studies Using Pharmacokinetic–Pharmacodynamic Modeling: An Analysis of GDC-0973, a MEK Inhibitor
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Includes: Supplementary data
Journal Articles

A Phase I Study of Docetaxel Plus Cyclophosphamide in Solid Tumors followed by a Phase II Study as First-Line Therapy in Metastatic Breast Cancer

Jonathan C. Trent, Vicente Valero, Daniel J. Booser, Laura T. Esparza-Guerra, Nuhad Ibrahim, Zia Rahman, Laurent Vernillet, Shreyaskumar Patel, Cynthia L. David, James L. Murray, Massimo Cristofanilli, Gabriel N. Hortobagyi
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (7): 2426–2434.
Published: 01 July 2003
View article titled, A Phase I Study of Docetaxel Plus Cyclophosphamide in Solid Tumors followed by a Phase II Study as First-Line Therapy in Metastatic Breast Cancer
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Journal Articles

Metabolism of Irinotecan (CPT-11) by CYP3A4 and CYP3A5 in Humans

Alexandre Santos, Sylvie Zanetta, Thierry Cresteil, Alain Deroussent, François Pein, Eric Raymond, Laurent Vernillet, Marie-Laure Risse, Valerie Boige, Alain Gouyette, Gilles Vassal
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (5): 2012–2020.
Published: 01 May 2000
View article titled, Metabolism of Irinotecan (CPT-11) by CYP3A4 and CYP3A5 in Humans
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Journal Articles

Drug-Administration Sequence Does Not Change Pharmacodynamics and Kinetics of Irinotecan and Cisplatin

Maja J. A. de Jonge, Jaap Verweij, André S. T. Planting, Maria E. L. van der Burg, Gerrit Stoter, Maureen M. de Boer-Dennert, Peter de Bruijn, Eric Brouwer, Laurent Vernillet, Alex Sparreboom
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (8): 2012–2017.
Published: 01 August 1999
View article titled, Drug-Administration Sequence Does Not Change Pharmacodynamics and Kinetics of Irinotecan and Cisplatin
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