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Lauren Averett Byers
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Journal Articles

YAP1 Status Defines Two Intrinsic Subtypes of LCNEC with Distinct Molecular Features and Therapeutic Vulnerabilities

C. Allison Stewart, Lixia Diao, Yuanxin Xi, Runsheng Wang, Kavya Ramkumar, Alejandra G. Serrano, Azusa Tanimoto, B. Leticia Rodriguez, Benjamin B. Morris, Li Shen, Bingnan Zhang, Yan Yang, Samera H. Hamad, Robert J. Cardnell, Alberto Duarte, Jr, Moushumi Sahu, Veronica Y. Novegil, Bernard E. Weissman, Michael Frumovitz, Neda Kalhor, Luisa Solis Soto, Pedro da Rocha, Natalie Vokes, Don L. Gibbons, Jing Wang, John V. Heymach, Bonnie Glisson, Lauren Averett Byers, Carl M. Gay
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (20): 4743–4754.
https://doi.org/10.1158/1078-0432.CCR-24-0361
Published: 15 October 2024
View article titled, YAP1 Status Defines Two Intrinsic Subtypes of LCNEC with Distinct Molecular Features and Therapeutic Vulnerabilities
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Includes: Supplementary data
Journal Articles

Veliparib in Combination with Carboplatin and Etoposide in Patients with Treatment-Naïve Extensive-Stage Small Cell Lung Cancer: A Phase 2 Randomized Study

Lauren Averett Byers, Dmitry Bentsion, Steven Gans, Konstantin Penkov, ChoonHee Son, Anne Sibille, Taofeek K. Owonikoko, Harry J.M. Groen, Carl M. Gay, Junya Fujimoto, Patricia de Groot, Martin Dunbar, Kingston Kang, Lei He, Vasudha Sehgal, Jaimee Glasgow, Bruce Allen Bach, Peter M. Ellis
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (14): 3884–3895.
https://doi.org/10.1158/1078-0432.CCR-20-4259
Published: 15 July 2021
View article titled, Veliparib in Combination with Carboplatin and Etoposide in Patients with Treatment-Naïve Extensive-Stage Small Cell Lung Cancer: A Phase 2 Randomized Study
Open the PDF for Veliparib in Combination with Carboplatin and Etoposide in Patients with Treatment-Naïve Extensive-Stage Small Cell Lung Cancer: A Phase 2 Randomized Study in another window
Includes: Supplementary data
Journal Articles

Targeting AXL and mTOR Pathway Overcomes Primary and Acquired Resistance to WEE1 Inhibition in Small-Cell Lung Cancer

Triparna Sen, Pan Tong, Lixia Diao, Lerong Li, Youhong Fan, Jennifer Hoff, John V. Heymach, Jing Wang, Lauren Averett Byers
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (20): 6239–6253.
https://doi.org/10.1158/1078-0432.CCR-17-1284
Published: 12 October 2017
View article titled, Targeting AXL and mTOR Pathway Overcomes Primary and Acquired Resistance to WEE1 Inhibition in Small-Cell Lung Cancer
Open the PDF for Targeting AXL and mTOR Pathway Overcomes Primary and Acquired Resistance to WEE1 Inhibition in Small-Cell Lung Cancer in another window
Includes: Supplementary data
Journal Articles

A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition

Milena P. Mak, Pan Tong, Lixia Diao, Robert J. Cardnell, Don L. Gibbons, William N. William, Ferdinandos Skoulidis, Edwin R. Parra, Jaime Rodriguez-Canales, Ignacio I. Wistuba, John V. Heymach, John N. Weinstein, Kevin R. Coombes, Jing Wang, Lauren Averett Byers
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (3): 609–620.
https://doi.org/10.1158/1078-0432.CCR-15-0876
Published: 31 January 2016
View article titled, A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition
Open the PDF for A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition in another window
Includes: Supplementary data
Journal Articles

Small Cell Lung Cancer: Will Recent Progress Lead to Improved Outcomes?

M. Catherine Pietanza, Lauren Averett Byers, John D. Minna, Charles M. Rudin
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (10): 2244–2255.
https://doi.org/10.1158/1078-0432.CCR-14-2958
Published: 14 May 2015
View article titled, Small Cell Lung Cancer: Will Recent Progress Lead to Improved Outcomes?
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Journal Articles

An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Lauren Averett Byers, Lixia Diao, Jing Wang, Pierre Saintigny, Luc Girard, Michael Peyton, Li Shen, Youhong Fan, Uma Giri, Praveen K. Tumula, Monique B. Nilsson, Jayanthi Gudikote, Hai Tran, Robert J.G. Cardnell, David J. Bearss, Steven L. Warner, Jason M. Foulks, Steven B. Kanner, Varsha Gandhi, Nancy Krett, Steven T. Rosen, Edward S. Kim, Roy S. Herbst, George R. Blumenschein, J. Jack Lee, Scott M. Lippman, K. Kian Ang, Gordon B. Mills, Waun K. Hong, John N. Weinstein, Ignacio I. Wistuba, Kevin R. Coombes, John D. Minna, John V. Heymach
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (1): 279–290.
https://doi.org/10.1158/1078-0432.CCR-12-1558
Published: 02 January 2013
View article titled, An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance
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Includes: Supplementary data
Journal Articles

Reciprocal Regulation of c-Src and STAT3 in Non-Small Cell Lung Cancer

Lauren Averett Byers, Banibrata Sen, Babita Saigal, Lixia Diao, Jing Wang, Meera Nanjundan, Tina Cascone, Gordon B. Mills, John V. Heymach, Faye M. Johnson
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (22): 6852–6861.
https://doi.org/10.1158/1078-0432.CCR-09-0767
Published: 11 November 2009
View article titled, Reciprocal Regulation of c-Src and STAT3 in Non-Small Cell Lung Cancer
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Journal Articles

Combined Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor (EGFR) Blockade Inhibits Tumor Growth in Xenograft Models of EGFR Inhibitor Resistance

George N. Naumov, Monique B. Nilsson, Tina Cascone, Alexandra Briggs, Oddbjorn Straume, Lars A. Akslen, Eugene Lifshits, Lauren Averett Byers, Li Xu, Hua-kang Wu, Pasi Jänne, Susumu Kobayashi, Balazs Halmos, Daniel Tenen, Xi M. Tang, Jeffrey Engelman, Beow Yeap, Judah Folkman, Bruce E. Johnson, John V. Heymach
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (10): 3484–3494.
https://doi.org/10.1158/1078-0432.CCR-08-2904
Published: 18 May 2009
View article titled, Combined Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor (EGFR) Blockade Inhibits Tumor Growth in Xenograft Models of EGFR Inhibitor Resistance
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