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Lauren A. Byers
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Journal Articles

Targeting BCL2 Overcomes Resistance and Augments Response to Aurora Kinase B Inhibition by AZD2811 in Small Cell Lung Cancer

Kavya Ramkumar, Azusa Tanimoto, Carminia M. Della Corte, C. Allison Stewart, Qi Wang, Li Shen, Robert J. Cardnell, Jing Wang, Urszula M. Polanska, Courtney Andersen, Jamal Saeh, J. Elizabeth Pease, Jon Travers, Giulia Fabbri, Carl M. Gay, Jelena Urosevic, Lauren A. Byers
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (16): 3237–3249.
https://doi.org/10.1158/1078-0432.CCR-23-0375
Published: 15 August 2023
View article titled, Targeting BCL2 Overcomes Resistance and Augments Response to Aurora Kinase B Inhibition by AZD2811 in Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

PARP Inhibitors: Extending Benefit Beyond BRCA-Mutant Cancers

Patrick G. Pilié, Carl M. Gay, Lauren A. Byers, Mark J. O'Connor, Timothy A. Yap
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (13): 3759–3771.
https://doi.org/10.1158/1078-0432.CCR-18-0968
Published: 01 July 2019
View article titled, PARP Inhibitors: Extending Benefit Beyond <em>BRCA</em>-Mutant Cancers
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Journal Articles

A Phase I Dose-Escalation Study of Veliparib Combined with Carboplatin and Etoposide in Patients with Extensive-Stage Small Cell Lung Cancer and Other Solid Tumors

Florence Atrafi, Harry J.M. Groen, Lauren A. Byers, Elena Garralda, Martijn P. Lolkema, Randeep S. Sangha, Santiago Viteri, Young Kwang Chae, D. Ross Camidge, Nashat Y. Gabrail, Beibei Hu, Tian Tian, Silpa Nuthalapati, Elizabeth Hoening, Lei He, Philip Komarnitsky, Antonio Calles
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (2): 496–505.
https://doi.org/10.1158/1078-0432.CCR-18-2014
Published: 15 January 2019
View article titled, A Phase I Dose-Escalation Study of Veliparib Combined with Carboplatin and Etoposide in Patients with Extensive-Stage Small Cell Lung Cancer and Other Solid Tumors
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Includes: Supplementary data
Journal Articles

Differential Sensitivity Analysis for Resistant Malignancies (DISARM) Identifies Common Candidate Therapies across Platinum-Resistant Cancers

Carl M. Gay, Pan Tong, Robert J. Cardnell, Triparna Sen, Xiao Su, Jun Ma, Rasha O. Bara, Faye M. Johnson, Chris Wakefield, John V. Heymach, Jing Wang, Lauren A. Byers
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (1): 346–357.
https://doi.org/10.1158/1078-0432.CCR-18-1129
Published: 03 January 2019
View article titled, Differential Sensitivity Analysis for Resistant Malignancies (DISARM) Identifies Common Candidate Therapies across Platinum-Resistant Cancers
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Includes: Supplementary data
Journal Articles

Abstract IA27: MYC drives molecular and therapeutically distinct subtype of SCLC

Gurkan Mollaoglu, Matthew R. Guthrie, Stefanie Bohm, Johannes Bragelmann, Milind D. Chalishazar, Abbie S. Ireland, Fang Huang, Zeping Hu, Robert J. Cardnell, Triparna Sen, Jason Gertz, Jane E. Johnson, Adi F. Gazdar, Lauren A. Byers, Ralph J. DeBerardinis, Robert J. Wechsler-Reya, Martin Sos, Trudy G. Oliver
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (17_Supplement): IA27.
https://doi.org/10.1158/1557-3265.AACRIASLC18-IA27
Published: 01 September 2018
View article titled, Abstract IA27: MYC drives molecular and therapeutically distinct subtype of SCLC
Journal Articles

Integrative Analysis Identifies a Novel AXL–PI3 Kinase–PD-L1 Signaling Axis Associated with Radiation Resistance in Head and Neck Cancer

Heath D. Skinner, Uma Giri, Liang P. Yang, Manish Kumar, Ying Liu, Michael D. Story, Curtis R. Pickering, Lauren A. Byers, Michelle D. Williams, Jing Wang, Li Shen, Suk Y. Yoo, You Hong Fan, David P. Molkentine, Beth M. Beadle, Raymond E. Meyn, Jeffrey N. Myers, John V. Heymach
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (11): 2713–2722.
https://doi.org/10.1158/1078-0432.CCR-16-2586
Published: 31 May 2017
View article titled, Integrative Analysis Identifies a Novel AXL–PI3 Kinase–PD-L1 Signaling Axis Associated with Radiation Resistance in Head and Neck Cancer
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Includes: Supplementary data
Journal Articles

Proteomic Profiling Identifies PTK2/FAK as a Driver of Radioresistance in HPV-negative Head and Neck Cancer

Heath D. Skinner, Uma Giri, Liang Yang, Sang Hyeok Woo, Michael D. Story, Curtis R. Pickering, Lauren A. Byers, Michelle D. Williams, Adel El-Naggar, Jing Wang, Lixia Diao, Li Shen, You Hong Fan, David P. Molkentine, Beth M. Beadle, Raymond E. Meyn, Jeffrey N. Myers, John V. Heymach
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (18): 4643–4650.
https://doi.org/10.1158/1078-0432.CCR-15-2785
Published: 15 September 2016
View article titled, Proteomic Profiling Identifies PTK2/FAK as a Driver of Radioresistance in HPV-negative Head and Neck Cancer
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Includes: Supplementary data
Journal Articles

Epithelial–Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma

Yanyan Lou, Lixia Diao, Edwin Roger Parra Cuentas, Warren L. Denning, Limo Chen, You Hong Fan, Lauren A. Byers, Jing Wang, Vassiliki A. Papadimitrakopoulou, Carmen Behrens, Jaime Canales Rodriguez, Patrick Hwu, Ignacio I. Wistuba, John V. Heymach, Don L. Gibbons
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (14): 3630–3642.
https://doi.org/10.1158/1078-0432.CCR-15-1434
Published: 14 July 2016
View article titled, Epithelial–Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma
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Includes: Supplementary data
Journal Articles

Epithelial–Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor–Mediated Apoptosis in Non–Small Cell Lung Cancer

Renata Ferrarotto, Ruchitha Goonatilake, Suk Young Yoo, Pan Tong, Uma Giri, Shaohua Peng, John Minna, Luc Girard, Yuehong Wang, Liguang Wang, Lerong Li, Lixia Diao, David H. Peng, Don L. Gibbons, Bonnie S. Glisson, John V. Heymach, Jing Wang, Lauren A. Byers, Faye M. Johnson
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (7): 1674–1686.
https://doi.org/10.1158/1078-0432.CCR-14-2890
Published: 31 March 2016
View article titled, Epithelial–Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor–Mediated Apoptosis in Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2

Robert J.G. Cardnell, Carmen Behrens, Lixia Diao, YouHong Fan, Ximing Tang, Pan Tong, John D. Minna, Gordon B. Mills, John V. Heymach, Ignacio I. Wistuba, Jing Wang, Lauren A. Byers
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (15): 3480–3491.
https://doi.org/10.1158/1078-0432.CCR-14-3286
Published: 02 August 2015
View article titled, An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2
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Includes: Supplementary data
Journal Articles

Proteomic Markers of DNA Repair and PI3K Pathway Activation Predict Response to the PARP Inhibitor BMN 673 in Small Cell Lung Cancer—Response

Robert J.G. Cardnell, Lauren A. Byers
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (8): 2237.
https://doi.org/10.1158/1078-0432.CCR-13-3391
Published: 15 April 2014
View article titled, Proteomic Markers of DNA Repair and PI3K Pathway Activation Predict Response to the PARP Inhibitor BMN 673 in Small Cell Lung Cancer—Response
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Journal Articles

Abstract A21: microRNA-200 regulates tumor cell PD-L1 expression to control lung cancer metastasis.

Don L. Gibbons, Limo Chen, Sangeeta Goswami, Young-Ho Ahn, Lauren A. Byers, Lixia Diao, Jing Wang, Angelica Cortez, Jonathon Roybal, James Welsh, Xuejun Zhang, David Dwyer, Xiaohui Yi, Chen Lieping, Ignacio Wistuba, John V. Heymach, Jonathan M. Kurie, F. Xiao-Feng Qin
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (2_Supplement): A21.
https://doi.org/10.1158/1078-0432.14AACRIASLC-A21
Published: 16 January 2014
View article titled, Abstract A21: microRNA-200 regulates tumor cell PD-L1 expression to control lung cancer metastasis.
Journal Articles

Proteomic Markers of DNA Repair and PI3K Pathway Activation Predict Response to the PARP Inhibitor BMN 673 in Small Cell Lung Cancer

Robert J. Cardnell, Ying Feng, Lixia Diao, You-Hong Fan, Fatemah Masrorpour, Jing Wang, Yuqiao Shen, Gordon B. Mills, John D. Minna, John V. Heymach, Lauren A. Byers
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (22): 6322–6328.
https://doi.org/10.1158/1078-0432.CCR-13-1975
Published: 14 November 2013
View article titled, Proteomic Markers of DNA Repair and PI3K Pathway Activation Predict Response to the PARP Inhibitor BMN 673 in Small Cell Lung Cancer
Open the PDF for Proteomic Markers of DNA Repair and PI3K Pathway Activation Predict Response to the PARP Inhibitor BMN 673 in Small Cell Lung Cancer in another window
Includes: Supplementary data
Journal Articles

DNA Repair Biomarker Profiling of Head and Neck Cancer: Ku80 Expression Predicts Locoregional Failure and Death following Radiotherapy

Benjamin J. Moeller, John S. Yordy, Michelle D. Williams, Uma Giri, Uma Raju, David P. Molkentine, Lauren A. Byers, John V. Heymach, Michael D. Story, J. Jack Lee, Erich M Sturgis, Randal S. Weber, Adam S. Garden, K. Kian Ang, David L. Schwartz
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (7): 2035–2043.
https://doi.org/10.1158/1078-0432.CCR-10-2641
Published: 31 March 2011
View article titled, DNA Repair Biomarker Profiling of Head and Neck Cancer: Ku80 Expression Predicts Locoregional Failure and Death following Radiotherapy
Open the PDF for DNA Repair Biomarker Profiling of Head and Neck Cancer: Ku80 Expression Predicts Locoregional Failure and Death following Radiotherapy in another window
Includes: Supplementary data