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Journal Articles

In Memoriam: José Baselga's Journey in Cancer Medicine

Rakesh Kumar, Gabriel N. Hortobagy, Joan Albanell, Joaquín Arribas, Larry Norton
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (12): 3499–3502.
https://doi.org/10.1158/1078-0432.CCR-21-1624
Published: 15 June 2021
View article titled, In Memoriam: José Baselga's Journey in Cancer Medicine
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Journal Articles

First-in-Human Trial of Epichaperome-Targeted PET in Patients with Cancer

Mark P.S. Dunphy, Christina Pressl, Nagavarakishore Pillarsetty, Milan Grkovski, Shanu Modi, Komal Jhaveri, Larry Norton, Bradley J. Beattie, Pat B. Zanzonico, Danuta Zatorska, Tony Taldone, Stefan O. Ochiana, Mohammad M. Uddin, Eva M. Burnazi, Serge K. Lyashchenko, Clifford A. Hudis, Jacqueline Bromberg, Heiko M. Schöder, Josef J. Fox, Hanwen Zhang, Gabriela Chiosis, Jason S. Lewis, Steven M. Larson
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (19): 5178–5187.
https://doi.org/10.1158/1078-0432.CCR-19-3704
Published: 01 October 2020
View article titled, First-in-Human Trial of Epichaperome-Targeted PET in Patients with Cancer
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Includes: Supplementary data
Journal Articles

Phase I Study of Intermittent High-Dose Lapatinib Alternating with Capecitabine for HER2-Positive Breast Cancer Patients with Central Nervous System Metastases

Aki Morikawa, Elisa de Stanchina, Elena Pentsova, Margaret M. Kemeny, Bob T. Li, Kendrick Tang, Sujata Patil, Martin Fleisher, Catherine Van Poznak, Larry Norton, Andrew D. Seidman
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (13): 3784–3792.
https://doi.org/10.1158/1078-0432.CCR-18-3502
Published: 01 July 2019
View article titled, Phase I Study of Intermittent High-Dose Lapatinib Alternating with Capecitabine for HER2-Positive Breast Cancer Patients with Central Nervous System Metastases
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Includes: Supplementary data
Journal Articles

Diverse BRCA1 and BRCA2 Reversion Mutations in Circulating Cell-Free DNA of Therapy-Resistant Breast or Ovarian Cancer

Britta Weigelt, Iñaki Comino-Méndez, Ino de Bruijn, Lei Tian, Jane L. Meisel, Isaac García-Murillas, Charlotte Fribbens, Ros Cutts, Luciano G. Martelotto, Charlotte K.Y. Ng, Raymond S. Lim, Pier Selenica, Salvatore Piscuoglio, Carol Aghajanian, Larry Norton, Rajmohan Murali, David M. Hyman, Laetitia Borsu, Maria E. Arcila, Jason Konner, Jorge S. Reis-Filho, Roger A. Greenberg, Mark E. Robson, Nicholas C. Turner
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (21): 6708–6720.
https://doi.org/10.1158/1078-0432.CCR-17-0544
Published: 31 October 2017
View article titled, Diverse <em>BRCA1</em> and <em>BRCA2</em> Reversion Mutations in Circulating Cell-Free DNA of Therapy-Resistant Breast or Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Genetic Heterogeneity in Therapy-Naïve Synchronous Primary Breast Cancers and Their Metastases

Charlotte K.Y. Ng, Francois-Clement Bidard, Salvatore Piscuoglio, Felipe C. Geyer, Raymond S. Lim, Ino de Bruijn, Ronglai Shen, Fresia Pareja, Samuel H. Berman, Lu Wang, Jean-Yves Pierga, Anne Vincent-Salomon, Agnes Viale, Larry Norton, Brigitte Sigal, Britta Weigelt, Paul Cottu, Jorge S. Reis-Filho
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (15): 4402–4415.
https://doi.org/10.1158/1078-0432.CCR-16-3115
Published: 01 August 2017
View article titled, Genetic Heterogeneity in Therapy-Naïve Synchronous Primary Breast Cancers and Their Metastases
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Includes: Supplementary data
Journal Articles

The Landscape of Somatic Genetic Alterations in Metaplastic Breast Carcinomas

Charlotte K.Y. Ng, Salvatore Piscuoglio, Felipe C. Geyer, Kathleen A. Burke, Fresia Pareja, Carey A. Eberle, Raymond S. Lim, Rachael Natrajan, Nadeem Riaz, Odette Mariani, Larry Norton, Anne Vincent-Salomon, Y. Hannah Wen, Britta Weigelt, Jorge S. Reis-Filho
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (14): 3859–3870.
https://doi.org/10.1158/1078-0432.CCR-16-2857
Published: 13 July 2017
View article titled, The Landscape of Somatic Genetic Alterations in Metaplastic Breast Carcinomas
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Includes: Supplementary data
Journal Articles

A Pilot Study of Preoperative Single-Dose Ipilimumab and/or Cryoablation in Women with Early-Stage Breast Cancer with Comprehensive Immune Profiling

Heather L. McArthur, Adi Diab, David B. Page, Jianda Yuan, Stephen B. Solomon, Virgilio Sacchini, Christopher Comstock, Jeremy C. Durack, Majid Maybody, Janice Sung, Arielle Ginsberg, Phillip Wong, Afsar Barlas, Zhiwan Dong, Chunjun Zhao, Brian Blum, Sujata Patil, Deirdre Neville, Elizabeth A. Comen, Elizabeth A. Morris, Alan Kotin, Edi Brogi, Y. Hannah Wen, Monica Morrow, Mario E. Lacouture, Padmanee Sharma, James P. Allison, Clifford A. Hudis, Jedd D. Wolchok, Larry Norton
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (23): 5729–5737.
https://doi.org/10.1158/1078-0432.CCR-16-0190
Published: 30 November 2016
View article titled, A Pilot Study of Preoperative Single-Dose Ipilimumab and/or Cryoablation in Women with Early-Stage Breast Cancer with Comprehensive Immune Profiling
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Journal Articles

The Genomic Landscape of Male Breast Cancers

Salvatore Piscuoglio, Charlotte K.Y. Ng, Melissa P. Murray, Elena Guerini-Rocco, Luciano G. Martelotto, Felipe C. Geyer, Francois-Clement Bidard, Samuel Berman, Nicola Fusco, Rita A. Sakr, Carey A. Eberle, Leticia De Mattos-Arruda, Gabriel S. Macedo, Muzaffar Akram, Timour Baslan, James B. Hicks, Tari A. King, Edi Brogi, Larry Norton, Britta Weigelt, Clifford A. Hudis, Jorge S. Reis-Filho
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16): 4045–4056.
https://doi.org/10.1158/1078-0432.CCR-15-2840
Published: 14 August 2016
View article titled, The Genomic Landscape of Male Breast Cancers
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Includes: Supplementary data
Journal Articles

Abstract B40: Paracrine interactions through CXCL1/2 chemokines promote breast cancer metastasis and chemoresistance

Swarnali Acharyya, Thordur Oskarsson, Sakari Vanharanta, Srinivas Malladi, Juliet Kim, Edi Brogi, Larry Norton, Joan Massague
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (10_Supplement): B40.
https://doi.org/10.1158/1078-0432.MECHRES-B40
Published: 04 March 2013
View article titled, Abstract B40: Paracrine interactions through CXCL1/2 chemokines promote breast cancer metastasis and chemoresistance
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Journal Articles

Frequent Mutational Activation of the PI3K-AKT Pathway in Trastuzumab-Resistant Breast Cancer

Sarat Chandarlapaty, Rita A. Sakr, Dilip Giri, Sujata Patil, Adriana Heguy, Monica Morrow, Shanu Modi, Larry Norton, Neal Rosen, Clifford Hudis, Tari A. King
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (24): 6784–6791.
https://doi.org/10.1158/1078-0432.CCR-12-1785
Published: 16 December 2012
View article titled, Frequent Mutational Activation of the PI3K-AKT Pathway in Trastuzumab-Resistant Breast Cancer
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Includes: Supplementary data
Journal Articles

p53 Expression in Node-Positive Breast Cancer Patients: Results from the Cancer and Leukemia Group B 9344 Trial (159905)

Jonathan F. Lara, Ann D. Thor, Lynn G. Dressler, Gloria Broadwater, Ira J. Bleiweiss, Susan Edgerton, David Cowan, Lori J. Goldstein, Silvana Martino, James N. Ingle, I. Craig Henderson, Larry Norton, Eric P. Winer, Clifford A. Hudis, Matthew J. Ellis, Donald A. Berry, Daniel F. Hayes, for the Cancer and Leukemia Group B
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (15): 5170–5178.
https://doi.org/10.1158/1078-0432.CCR-11-0484
Published: 31 July 2011
View article titled, p53 Expression in Node-Positive Breast Cancer Patients: Results from the Cancer and Leukemia Group B 9344 Trial (159905)
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Journal Articles

HSP90 Inhibition Is Effective in Breast Cancer: A Phase II Trial of Tanespimycin (17-AAG) Plus Trastuzumab in Patients with HER2-Positive Metastatic Breast Cancer Progressing on Trastuzumab

Shanu Modi, Alison Stopeck, Hannah Linden, David Solit, Sarat Chandarlapaty, Neal Rosen, Gabriella D'Andrea, Maura Dickler, Mary E. Moynahan, Steven Sugarman, Weining Ma, Sujata Patil, Larry Norton, Alison L. Hannah, Clifford Hudis
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (15): 5132–5139.
https://doi.org/10.1158/1078-0432.CCR-11-0072
Published: 31 July 2011
View article titled, HSP90 Inhibition Is Effective in Breast Cancer: A Phase II Trial of Tanespimycin (17-AAG) Plus Trastuzumab in Patients with HER2-Positive Metastatic Breast Cancer Progressing on Trastuzumab
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Includes: Supplementary data
Journal Articles

A Feasibility Study of Bevacizumab plus Dose-Dense Doxorubicin–Cyclophosphamide (AC) Followed by Nanoparticle Albumin–Bound Paclitaxel in Early-Stage Breast Cancer

Heather L. McArthur, Hope Rugo, Benjamin Nulsen, Laura Hawks, Jill Grothusen, Michelle Melisko, Mark Moasser, Matthew Paulson, Tiffany Traina, Sujata Patil, Qin Zhou, Richard Steingart, Chau Dang, Monica Morrow, Peter Cordeiro, Monica Fornier, John Park, Andrew Seidman, Diana Lake, Theresa Gilewski, Maria Theodoulou, Shanu Modi, Gabriella D'Andrea, Nancy Sklarin, Mark Robson, Mary Ellen Moynahan, Steven Sugarman, Jane E. Sealey, John H. Laragh, Carmen Merali, Larry Norton, Clifford A. Hudis, Maura N. Dickler
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (10): 3398–3407.
https://doi.org/10.1158/1078-0432.CCR-10-1969
Published: 15 May 2011
View article titled, A Feasibility Study of Bevacizumab plus Dose-Dense Doxorubicin–Cyclophosphamide (AC) Followed by Nanoparticle Albumin–Bound Paclitaxel in Early-Stage Breast Cancer
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Journal Articles

Troponin I and C-Reactive Protein Are Commonly Detected in Patients with Breast Cancer Treated with Dose-Dense Chemotherapy Incorporating Trastuzumab and Lapatinib

Patrick G. Morris, Carol Chen, Richard Steingart, Martin Fleisher, Nancy Lin, Beverly Moy, Steven Come, Steven Sugarman, Alyson Abbruzzi, Robert Lehman, Sujata Patil, Maura Dickler, Heather L. McArthur, Eric Winer, Larry Norton, Clifford A. Hudis, Chau T. Dang
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (10): 3490–3499.
https://doi.org/10.1158/1078-0432.CCR-10-1359
Published: 15 May 2011
View article titled, Troponin I and C-Reactive Protein Are Commonly Detected in Patients with Breast Cancer Treated with Dose-Dense Chemotherapy Incorporating Trastuzumab and Lapatinib
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Journal Articles

Germline BRCA Mutations Denote a Clinicopathologic Subset of Prostate Cancer

David J. Gallagher, Mia M. Gaudet, Prodipto Pal, Tomas Kirchhoff, Lisa Balistreri, Kinjal Vora, Jasmine Bhatia, Zsofia Stadler, Samson W. Fine, Victor Reuter, Michael Zelefsky, Michael J. Morris, Howard I. Scher, Robert J. Klein, Larry Norton, James A. Eastham, Peter T. Scardino, Mark E. Robson, Kenneth Offit
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (7): 2115–2121.
https://doi.org/10.1158/1078-0432.CCR-09-2871
Published: 31 March 2010
View article titled, Germline <em>BRCA</em> Mutations Denote a Clinicopathologic Subset of Prostate Cancer
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Journal Articles

A Phase II Trial of Erlotinib in Combination with Bevacizumab in Patients with Metastatic Breast Cancer

Maura N. Dickler, Hope S. Rugo, Carey A. Eberle, Edi Brogi, James F. Caravelli, Katherine S. Panageas, Jeff Boyd, Benjamin Yeh, Diana E. Lake, Chau T. Dang, Teresa A. Gilewski, Jacqueline F. Bromberg, Andrew D. Seidman, Gabriella M. D'Andrea, Mark M. Moasser, Michele Melisko, John W. Park, Janet Dancey, Larry Norton, Clifford A. Hudis
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (23): 7878–7883.
https://doi.org/10.1158/1078-0432.CCR-08-0141
Published: 01 December 2008
View article titled, A Phase II Trial of Erlotinib in Combination with Bevacizumab in Patients with Metastatic Breast Cancer
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Includes: Supplementary data
Journal Articles

SNX2112, a Synthetic Heat Shock Protein 90 Inhibitor, Has Potent Antitumor Activity against HER Kinase–Dependent Cancers

Sarat Chandarlapaty, Ayana Sawai, Qing Ye, Anisa Scott, Melanie Silinski, Ken Huang, Pat Fadden, Jeff Partdrige, Steven Hall, Paul Steed, Larry Norton, Neal Rosen, David B. Solit
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (1): 240–248.
https://doi.org/10.1158/1078-0432.CCR-07-1667
Published: 02 January 2008
View article titled, SNX2112, a Synthetic Heat Shock Protein 90 Inhibitor, Has Potent Antitumor Activity against HER Kinase–Dependent Cancers
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Journal Articles

Antibody and CD8+ T Cell Responses against HER2/neu Required for Tumor Eradication after DNA Immunization with a Flt-3 Ligand Fusion Vaccine

Francesca Orlandi, Franco M. Venanzi, Antonio Concetti, Hanako Yamauchi, Shakuntala Tiwari, Larry Norton, Jedd D. Wolchok, Alan N. Houghton, Polly D. Gregor
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (20): 6195–6203.
https://doi.org/10.1158/1078-0432.CCR-07-0258
Published: 18 October 2007
View article titled, Antibody and CD8<sup>+</sup> T Cell Responses against HER2/neu Required for Tumor Eradication after DNA Immunization with a Flt-3 Ligand Fusion Vaccine
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Journal Articles

Immunization of High-Risk Breast Cancer Patients with Clustered sTn-KLH Conjugate plus the Immunologic Adjuvant QS-21

Teresa A. Gilewski, Govind Ragupathi, Maura Dickler, Shemeeakah Powell, Sonal Bhuta, Kathy Panageas, R. Rao Koganty, Jeannette Chin-Eng, Clifford Hudis, Larry Norton, Alan N. Houghton, Philip O. Livingston
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (10): 2977–2985.
https://doi.org/10.1158/1078-0432.CCR-06-2189
Published: 15 May 2007
View article titled, Immunization of High-Risk Breast Cancer Patients with Clustered sTn-KLH Conjugate plus the Immunologic Adjuvant QS-21
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Journal Articles

Increased Dose Density Is Feasible: A Pilot Study of Adjuvant Epirubicin and Cyclophosphamide followed by Paclitaxel, at 10- or 11-Day Intervals with Filgrastim Support in Women with Breast Cancer

Monica N. Fornier, Andrew D. Seidman, Diana Lake, Gabriella D'Andrea, Jacqueline Bromberg, Mark Robson, Catherine Van Poznak, Katherine S. Panageas, Marietta Atienza, Larry Norton, Clifford Hudis
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (1): 223–227.
https://doi.org/10.1158/1078-0432.CCR-06-1731
Published: 02 January 2007
View article titled, Increased Dose Density Is Feasible: A Pilot Study of Adjuvant Epirubicin and Cyclophosphamide followed by Paclitaxel, at 10- or 11-Day Intervals with Filgrastim Support in Women with Breast Cancer
Open the PDF for Increased Dose Density Is Feasible: A Pilot Study of Adjuvant Epirubicin and Cyclophosphamide followed by Paclitaxel, at 10- or 11-Day Intervals with Filgrastim Support in Women with Breast Cancer in another window