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Ladan Fazli
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Journal Articles

Abstract A18: Plasma circulating tumor DNA is scarce and confounded by clonal hematopoiesis in metastatic renal cell carcinoma

Jack V. W. Bacon, Matti Annala, Maryam Soleimani, Jean-Michel Lavoie, Alan I. So, Martin E. Gleave, Ladan Fazli, Kim N. Chi, Christian K. Kollmannsberger, Alexander W. Wyatt, Lucia Nappi
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (11_Supplement): A18.
https://doi.org/10.1158/1557-3265.LiqBiop20-A18
Published: 01 June 2020
View article titled, Abstract A18: Plasma circulating tumor DNA is scarce and confounded by clonal hematopoiesis in metastatic renal cell carcinoma
Journal Articles

Transient Sox9 Expression Facilitates Resistance to Androgen-Targeted Therapy in Prostate Cancer

Mannan Nouri, Shabnam Massah, Josselin Caradec, Amy A. Lubik, Na Li, Sarah Truong, Ahn R. Lee, Ladan Fazli, Varune R. Ramnarine, Jessica M. Lovnicki, Jackson Moore, Mike Wang, Jane Foo, Martin E. Gleave, Brett G. Hollier, Colleen Nelson, Colin Collins, Xuesen Dong, Ralph Buttyan
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (7): 1678–1689.
https://doi.org/10.1158/1078-0432.CCR-19-0098
Published: 01 April 2020
View article titled, Transient Sox9 Expression Facilitates Resistance to Androgen-Targeted Therapy in Prostate Cancer
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Includes: Supplementary data
Journal Articles

Identification of Hypermutation and Defective Mismatch Repair in ctDNA from Metastatic Prostate Cancer

Elie Ritch, Simon Y.F. Fu, Cameron Herberts, Gang Wang, Evan W. Warner, Elena Schönlau, Sinja Taavitsainen, Andrew J. Murtha, Gillian Vandekerkhove, Kevin Beja, Yulia Loktionova, Daniel Khalaf, Ladan Fazli, Igal Kushnir, Cristiano Ferrario, Sebastien Hotte, Matti Annala, Kim N. Chi, Alexander W. Wyatt
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (5): 1114–1125.
https://doi.org/10.1158/1078-0432.CCR-19-1623
Published: 02 March 2020
View article titled, Identification of Hypermutation and Defective Mismatch Repair in ctDNA from Metastatic Prostate Cancer
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Includes: Supplementary data
Journal Articles

Molecular Characterization of Neuroendocrine-like Bladder Cancer

José Batista da Costa, Ewan A. Gibb, Trinity J. Bivalacqua, Yang Liu, Htoo Zarni Oo, David T. Miyamoto, Mohammed Alshalalfa, Elai Davicioni, Jonathan Wright, Marc A. Dall’Era, James Douglas, Joost L. Boormans, Michiel S. Van der Heijden, Chin-Lee Wu, Bas W.G. van Rhijn, Shilpa Gupta, Petros Grivas, Kent W. Mouw, Paari Murugan, Ladan Fazli, Seong Ra, Badrinath R. Konety, Roland Seiler, Siamak Daneshmand, Omar Y. Mian, Jason A. Efstathiou, Yair Lotan, Peter C. Black
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (13): 3908–3920.
https://doi.org/10.1158/1078-0432.CCR-18-3558
Published: 01 July 2019
View article titled, Molecular Characterization of Neuroendocrine-like Bladder Cancer
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Includes: Supplementary data
Journal Articles

Regulation of eIF4F Translation Initiation Complex by the Peptidyl Prolyl Isomerase FKBP7 in Taxane-resistant Prostate Cancer

Marine F. Garrido, Nicolas J.-P. Martin, Matthieu Bertrand, Catherine Gaudin, Frédéric Commo, Nassif El Kalaany, Nader Al Nakouzi, Ladan Fazli, Elaine Del Nery, Jacques Camonis, Franck Perez, Stéphanie Lerondel, Alain Le Pape, Daniel Compagno, Martin Gleave, Yohann Loriot, Laurent Désaubry, Stéphan Vagner, Karim Fizazi, Anne Chauchereau
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (2): 710–723.
https://doi.org/10.1158/1078-0432.CCR-18-0704
Published: 15 January 2019
View article titled, Regulation of eIF4F Translation Initiation Complex by the Peptidyl Prolyl Isomerase FKBP7 in Taxane-resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Proteogenomic Characterization of Patient-Derived Xenografts Highlights the Role of REST in Neuroendocrine Differentiation of Castration-Resistant Prostate Cancer

Amilcar Flores-Morales, Tobias B. Bergmann, Charlotte Lavallee, Tanveer S. Batth, Dong Lin, Mads Lerdrup, Stine Friis, Anette Bartels, Gitte Kristensen, Agnieszka Krzyzanowska, Hui Xue, Ladan Fazli, Klaus H. Hansen, Martin A. Røder, Klaus Brasso, José M. Moreira, Anders Bjartell, Yuzhuo Wang, Jesper V. Olsen, Colin C. Collins, Diego Iglesias-Gato
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (2): 595–608.
https://doi.org/10.1158/1078-0432.CCR-18-0729
Published: 15 January 2019
View article titled, Proteogenomic Characterization of Patient-Derived Xenografts Highlights the Role of REST in Neuroendocrine Differentiation of Castration-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Impact of Therapy on Genomics and Transcriptomics in High-Risk Prostate Cancer Treated with Neoadjuvant Docetaxel and Androgen Deprivation Therapy

Himisha Beltran, Alexander W. Wyatt, Edmund C. Chedgy, Adam Donoghue, Matti Annala, Evan W. Warner, Kevin Beja, Michael Sigouros, Fan Mo, Ladan Fazli, Colin C. Collins, James Eastham, Michael Morris, Mary-Ellen Taplin, Andrea Sboner, Susan Halabi, Martin E. Gleave
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (22): 6802–6811.
https://doi.org/10.1158/1078-0432.CCR-17-1034
Published: 14 November 2017
View article titled, Impact of Therapy on Genomics and Transcriptomics in High-Risk Prostate Cancer Treated with Neoadjuvant Docetaxel and Androgen Deprivation Therapy
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Includes: Supplementary data
Journal Articles

Not all NOTCH Is Created Equal: The Oncogenic Role of NOTCH2 in Bladder Cancer and Its Implications for Targeted Therapy

Tetsutaro Hayashi, Kilian M. Gust, Alexander W. Wyatt, Akihiro Goriki, Wolfgang Jäger, Shannon Awrey, Na Li, Htoo Zarni Oo, Manuel Altamirano-Dimas, Ralph Buttyan, Ladan Fazli, Akio Matsubara, Peter C. Black
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (12): 2981–2992.
https://doi.org/10.1158/1078-0432.CCR-15-2360
Published: 14 June 2016
View article titled, Not all NOTCH Is Created Equal: The Oncogenic Role of NOTCH2 in Bladder Cancer and Its Implications for Targeted Therapy
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Includes: Supplementary data
Journal Articles

The MCT4 Gene: A Novel, Potential Target for Therapy of Advanced Prostate Cancer

Stephen Yiu Chuen Choi, Hui Xue, Rebecca Wu, Ladan Fazli, Dong Lin, Colin C. Collins, Martin E. Gleave, Peter W. Gout, Yuzhuo Wang
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (11): 2721–2733.
https://doi.org/10.1158/1078-0432.CCR-15-1624
Published: 31 May 2016
View article titled, The <em>MCT4</em> Gene: A Novel, Potential Target for Therapy of Advanced Prostate Cancer
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Includes: Supplementary data
Journal Articles

Targeting Cancer Stem Cells in Castration-Resistant Prostate Cancer

Eun-Jin Yun, Jiancheng Zhou, Chun-Jung Lin, Elizabeth Hernandez, Ladan Fazli, Martin Gleave, Jer-Tsong Hsieh
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (3): 670–679.
https://doi.org/10.1158/1078-0432.CCR-15-0190
Published: 31 January 2016
View article titled, Targeting Cancer Stem Cells in Castration-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

siRNA Lipid Nanoparticle Potently Silences Clusterin and Delays Progression When Combined with Androgen Receptor Cotargeting in Enzalutamide-Resistant Prostate Cancer

Yoshiaki Yamamoto, Paulo J.C. Lin, Eliana Beraldi, Fan Zhang, Yoshihisa Kawai, Jeffrey Leong, Hidemasa Katsumi, Ladan Fazli, Robert Fraser, Pieter R. Cullis, Martin Gleave
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (21): 4845–4855.
https://doi.org/10.1158/1078-0432.CCR-15-0866
Published: 01 November 2015
View article titled, siRNA Lipid Nanoparticle Potently Silences Clusterin and Delays Progression When Combined with Androgen Receptor Cotargeting in Enzalutamide-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Generation 2.5 Antisense Oligonucleotides Targeting the Androgen Receptor and Its Splice Variants Suppress Enzalutamide-Resistant Prostate Cancer Cell Growth

Yoshiaki Yamamoto, Yohann Loriot, Eliana Beraldi, Fan Zhang, Alexander W. Wyatt, Nader Al Nakouzi, Fan Mo, Tianyuan Zhou, Youngsoo Kim, Brett P. Monia, A. Robert MacLeod, Ladan Fazli, Yuzhuo Wang, Colin C. Collins, Amina Zoubeidi, Martin Gleave
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (7): 1675–1687.
https://doi.org/10.1158/1078-0432.CCR-14-1108
Published: 31 March 2015
View article titled, Generation 2.5 Antisense Oligonucleotides Targeting the Androgen Receptor and Its Splice Variants Suppress Enzalutamide-Resistant Prostate Cancer Cell Growth
Open the PDF for Generation 2.5 Antisense Oligonucleotides Targeting the Androgen Receptor and Its Splice Variants Suppress Enzalutamide-Resistant Prostate Cancer Cell Growth in another window
Includes: Supplementary data
Journal Articles

miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer

Sajni Josson, Murali Gururajan, Peizhen Hu, Chen Shao, Gina Chia-Yi Chu, Haiyen E. Zhau, Chunyan Liu, Kaiqin Lao, Chia-Lun Lu, Yi-Tsung Lu, Jake Lichterman, Srinivas Nandana, Quanlin Li, Andre Rogatko, Dror Berel, Edwin M. Posadas, Ladan Fazli, Dhruv Sareen, Leland W.K. Chung
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (17): 4636–4646.
https://doi.org/10.1158/1078-0432.CCR-14-0305
Published: 01 September 2014
View article titled, miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
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Includes: Supplementary data
Journal Articles

IGFBP-5 in the bone and bone marrow is a therapeutic target for metastatic prostate cancer

Chang Xu, Lynn F. Graf, Ladan Fazli, Peter S. Nelson, Stephen R. Plymate, Michael E. Cox, Beverly J. Torok-Storb, Beatrice S. Knudsen
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (19_Supplement): B38.
Published: 15 August 2014
View article titled, IGFBP-5 in the bone and bone marrow is a therapeutic target for metastatic prostate cancer
Journal Articles

The Mechanism of DAB2IP in Chemoresistance of Prostate Cancer Cells

Kaijie Wu, Daxing Xie, Yonglong Zou, Tingting Zhang, Rey-Chen Pong, Guanghua Xiao, Ladan Fazli, Martin Gleave, Dalin He, David A. Boothman, Jer-Tsong Hsieh
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (17): 4740–4749.
https://doi.org/10.1158/1078-0432.CCR-13-0954
Published: 02 September 2013
View article titled, The Mechanism of DAB2IP in Chemoresistance of Prostate Cancer Cells
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Includes: Supplementary data
Journal Articles

A Phase II Pharmacodynamic Study of Preoperative Figitumumab in Patients with Localized Prostate Cancer

Kim N. Chi, Martin E. Gleave, Ladan Fazli, S. Larry Goldenberg, Alan So, Christian Kollmannsberger, Nevin Murray, Anna Tinker, Michael Pollak
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (12): 3407–3413.
https://doi.org/10.1158/1078-0432.CCR-12-0482
Published: 14 June 2012
View article titled, A Phase II Pharmacodynamic Study of Preoperative Figitumumab in Patients with Localized Prostate Cancer
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Journal Articles

A Novel HSP90 Inhibitor Delays Castrate-Resistant Prostate Cancer without Altering Serum PSA Levels and Inhibits Osteoclastogenesis

Francois Lamoureux, Christian Thomas, Min-Jean Yin, Hidetoshi Kuruma, Ladan Fazli, Martin E. Gleave, Amina Zoubeidi
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (8): 2301–2313.
https://doi.org/10.1158/1078-0432.CCR-10-3077
Published: 14 April 2011
View article titled, A Novel HSP90 Inhibitor Delays Castrate-Resistant Prostate Cancer without Altering Serum PSA Levels and Inhibits Osteoclastogenesis
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Includes: Supplementary data
Journal Articles

In vivo Knockdown of the Androgen Receptor Results in Growth Inhibition and Regression of Well-Established, Castration-Resistant Prostate Tumors

Robert Snoek, Helen Cheng, Katia Margiotti, Latif A. Wafa, Charmaine A. Wong, Erica Chan Wong, Ladan Fazli, Colleen C. Nelson, Martin E. Gleave, Paul S. Rennie
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (1): 39–47.
https://doi.org/10.1158/1078-0432.CCR-08-1726
Published: 31 December 2008
View article titled, <em>In vivo</em> Knockdown of the Androgen Receptor Results in Growth Inhibition and Regression of Well-Established, Castration-Resistant Prostate Tumors
Open the PDF for <em>In vivo</em> Knockdown of the Androgen Receptor Results in Growth Inhibition and Regression of Well-Established, Castration-Resistant Prostate Tumors in another window
Includes: Supplementary data
Journal Articles

Insulin-Like Growth Factor Binding Protein-2 Is a Novel Therapeutic Target Associated with Breast Cancer

Alan I. So, Randy J. Levitt, Bernhard Eigl, Ladan Fazli, Motosugu Muramaki, Sam Leung, Maggie C.U. Cheang, Torsten O. Nielsen, Martin Gleave, Michael Pollak
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (21): 6944–6954.
https://doi.org/10.1158/1078-0432.CCR-08-0408
Published: 03 November 2008
View article titled, Insulin-Like Growth Factor Binding Protein-2 Is a Novel Therapeutic Target Associated with Breast Cancer
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Journal Articles

GLI2 Knockdown Using an Antisense Oligonucleotide Induces Apoptosis and Chemosensitizes Cells to Paclitaxel in Androgen-Independent Prostate Cancer

Shintaro Narita, Alan So, Susan Ettinger, Norihiro Hayashi, Mototsugu Muramaki, Ladan Fazli, Youngsoo Kim, Martin E. Gleave
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (18): 5769–5777.
https://doi.org/10.1158/1078-0432.CCR-07-4282
Published: 14 September 2008
View article titled, GLI2 Knockdown Using an Antisense Oligonucleotide Induces Apoptosis and Chemosensitizes Cells to Paclitaxel in Androgen-Independent Prostate Cancer
Open the PDF for GLI2 Knockdown Using an Antisense Oligonucleotide Induces Apoptosis and Chemosensitizes Cells to Paclitaxel in Androgen-Independent Prostate Cancer in another window
Includes: Supplementary data