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Konrad H. Stopsack
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Journal Articles

Prevalence of Mismatch Repair Deficiency in Primary Prostate Cancer in a Large Prospective Cohort

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Ciara S. McNevin, Anna Keogh, Mutaz Mohammed Nur, Brianán McGovern, Julie McFadden, Anne-Marie Baird, Karen Cadoo, Sarah Mc Carron, Cathal O’Brien, Martin P. Barr, Steven G. Gray, Orla Sheils, Lesley A. Sutton, Sinead Flanagan, Lorelei A. Mucci, Konrad H. Stopsack, Stephen P. Finn
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (9): 1746–1753.
https://doi.org/10.1158/1078-0432.CCR-24-1210
Published: 01 May 2025
View article titled, Prevalence of Mismatch Repair Deficiency in Primary Prostate Cancer in a Large Prospective Cohort
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Includes: Supplementary data
Journal Articles

Germline DNA Damage Repair Variants and Prognosis of Patients with High-Risk or Metastatic Prostate Cancer

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Konrad H. Stopsack, Joseph Vijai, Michael Conry, Jacob E. Berchuck, Yelena Kemel, Samantha E. Vasselman, Dory A. Freeman, Gwo-Shu M. Lee, Diana Mandelker, David B. Solit, Michael J. Morris, Kathryn L. Penney, Wassim Abida, Kenneth Offit, Lorelei A. Mucci, Philip W. Kantoff, Mark M. Pomerantz
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (1): 122–129.
https://doi.org/10.1158/1078-0432.CCR-24-2483
Published: 06 January 2025
View article titled, Germline DNA Damage Repair Variants and Prognosis of Patients with High-Risk or Metastatic Prostate Cancer
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Includes: Supplementary data
Journal Articles

Microsatellite Instability, Tumor Mutational Burden, and Response to Immune Checkpoint Blockade in Patients with Prostate Cancer

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Andrew T. Lenis, Vignesh Ravichandran, Samantha Brown, Syed M. Alam, Andrew Katims, Hong Truong, Peter A. Reisz, Samantha Vasselman, Barbara Nweji, Karen A. Autio, Michael J. Morris, Susan F. Slovin, Dana Rathkopf, Daniel Danila, Sungmin Woo, Hebert A. Vargas, Vincent P. Laudone, Behfar Ehdaie, Victor Reuter, Maria Arcila, Michael F. Berger, Agnes Viale, Howard I. Scher, Nikolaus Schultz, Anuradha Gopalan, Mark T.A. Donoghue, Irina Ostrovnaya, Konrad H. Stopsack, David B. Solit, Wassim Abida
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (17): 3894–3903.
https://doi.org/10.1158/1078-0432.CCR-23-3403
Published: 03 September 2024
View article titled, Microsatellite Instability, Tumor Mutational Burden, and Response to Immune Checkpoint Blockade in Patients with Prostate Cancer
Open the PDF for Microsatellite Instability, Tumor Mutational Burden, and Response to Immune Checkpoint Blockade in Patients with Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Family History of Prostate and Breast Cancer Integrated with a Polygenic Risk Score Identifies Men at Highest Risk of Dying from Prostate Cancer before Age 75 Years

Open Access
Anna Plym, Yiwen Zhang, Konrad H. Stopsack, Yon Ho Jee, Fredrik Wiklund, Adam S. Kibel, Peter Kraft, Edward Giovannucci, Kathryn L. Penney, Lorelei A. Mucci
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (22): 4926–4933.
https://doi.org/10.1158/1078-0432.CCR-22-1723
Published: 14 November 2022
View article titled, Family History of Prostate and Breast Cancer Integrated with a Polygenic Risk Score Identifies Men at Highest Risk of Dying from Prostate Cancer before Age 75 Years
Open the PDF for Family History of Prostate and Breast Cancer Integrated with a Polygenic Risk Score Identifies Men at Highest Risk of Dying from Prostate Cancer before Age 75 Years in another window
Includes: Supplementary data
Journal Articles

The Impact of PIK3R1 Mutations and Insulin–PI3K–Glycolytic Pathway Regulation in Prostate Cancer

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Goutam Chakraborty, Subhiksha Nandakumar, Rahim Hirani, Bastien Nguyen, Konrad H. Stopsack, Christoph Kreitzer, Sai Harisha Rajanala, Romina Ghale, Ying Z. Mazzu, Naga Vara Kishore Pillarsetty, Gwo-Shu Mary Lee, Howard I. Scher, Michael J. Morris, Tiffany Traina, Pedram Razavi, Wassim Abida, Jeremy C. Durack, Stephen B. Solomon, Matthew G. Vander Heiden, Lorelei A. Mucci, Andreas G. Wibmer, Nikolaus Schultz, Philip W. Kantoff
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (16): 3603–3617.
https://doi.org/10.1158/1078-0432.CCR-21-4272
Published: 15 August 2022
View article titled, The Impact of PIK3R1 Mutations and Insulin–PI3K–Glycolytic Pathway Regulation in Prostate Cancer
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Includes: Supplementary data
Journal Articles

Differences in Prostate Cancer Genomes by Self-reported Race: Contributions of Genetic Ancestry, Modifiable Cancer Risk Factors, and Clinical Factors

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Konrad H. Stopsack, Subhiksha Nandakumar, Kanika Arora, Bastien Nguyen, Samantha E. Vasselman, Barbara Nweji, Sean M. McBride, Michael J. Morris, Dana E. Rathkopf, Susan F. Slovin, Daniel C. Danila, Karen A. Autio, Howard I. Scher, Lorelei A. Mucci, David B. Solit, Mithat Gönen, Yu Chen, Michael F. Berger, Nikolaus Schultz, Wassim Abida, Philip W. Kantoff
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (2): 318–326.
https://doi.org/10.1158/1078-0432.CCR-21-2577
Published: 15 January 2022
View article titled, Differences in Prostate Cancer Genomes by Self-reported Race: Contributions of Genetic Ancestry, Modifiable Cancer Risk Factors, and Clinical Factors
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Includes: Supplementary data
Journal Articles

Abiraterone Acetate Induces CREB1 Phosphorylation and Enhances the Function of the CBP-p300 Complex, Leading to Resistance in Prostate Cancer Cells

Free
Wenting Pan, Zhouwei Zhang, Hannah Kimball, Fangfang Qu, Kyler Berlind, Konrad H. Stopsack, Gwo-Shu Mary Lee, Toni K. Choueiri, Philip W. Kantoff
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (7): 2087–2099.
https://doi.org/10.1158/1078-0432.CCR-20-4391
Published: 01 April 2021
View article titled, Abiraterone Acetate Induces CREB1 Phosphorylation and Enhances the Function of the CBP-p300 Complex, Leading to Resistance in Prostate Cancer Cells
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Includes: Supplementary data
Journal Articles

Attenuation of SRC Kinase Activity Augments PARP Inhibitor–mediated Synthetic Lethality in BRCA2-altered Prostate Tumors

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Goutam Chakraborty, Nabeela Khan Patail, Rahim Hirani, Subhiksha Nandakumar, Ying Z. Mazzu, Yuki Yoshikawa, Mohammad Atiq, Lina E. Jehane, Konrad H. Stopsack, Gwo-Shu Mary Lee, Wassim Abida, Michael J. Morris, Lorelei A. Mucci, Daniel Danila, Philip W. Kantoff
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (6): 1792–1806.
https://doi.org/10.1158/1078-0432.CCR-20-2483
Published: 15 March 2021
View article titled, Attenuation of SRC Kinase Activity Augments PARP Inhibitor–mediated Synthetic Lethality in BRCA2-altered Prostate Tumors
Open the PDF for Attenuation of SRC Kinase Activity Augments PARP Inhibitor–mediated Synthetic Lethality in BRCA2-altered Prostate Tumors in another window
Includes: Supplementary data
Journal Articles

Multiplex Immunofluorescence in Formalin-Fixed Paraffin-Embedded Tumor Tissue to Identify Single-Cell–Level PI3K Pathway Activation

Free
Konrad H. Stopsack, Ying Huang, Svitlana Tyekucheva, Travis A. Gerke, Clyde Bango, Habiba Elfandy, Michaela Bowden, Kathryn L. Penney, Thomas M. Roberts, Giovanni Parmigiani, Philip W. Kantoff, Lorelei A. Mucci, Massimo Loda
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (22): 5903–5913.
https://doi.org/10.1158/1078-0432.CCR-20-2000
Published: 13 November 2020
View article titled, Multiplex Immunofluorescence in Formalin-Fixed Paraffin-Embedded Tumor Tissue to Identify Single-Cell–Level PI3K Pathway Activation
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Includes: Supplementary data
Journal Articles

Oncogenic Genomic Alterations, Clinical Phenotypes, and Outcomes in Metastatic Castration-Sensitive Prostate Cancer

Free
Konrad H. Stopsack, Subhiksha Nandakumar, Andreas G. Wibmer, Samuel Haywood, Emily S. Weg, Ethan S. Barnett, Chloe J. Kim, Emily A. Carbone, Samantha E. Vasselman, Bastien Nguyen, Melanie A. Hullings, Howard I. Scher, Michael J. Morris, David B. Solit, Nikolaus Schultz, Philip W. Kantoff, Wassim Abida
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13): 3230–3238.
https://doi.org/10.1158/1078-0432.CCR-20-0168
Published: 01 July 2020
View article titled, Oncogenic Genomic Alterations, Clinical Phenotypes, and Outcomes in Metastatic Castration-Sensitive Prostate Cancer
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Includes: Supplementary data
Journal Articles

Significance of BRCA2 and RB1 Co-loss in Aggressive Prostate Cancer Progression

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Goutam Chakraborty, Joshua Armenia, Ying Z. Mazzu, Subhiksha Nandakumar, Konrad H. Stopsack, Mohammad O. Atiq, Kazumasa Komura, Lina Jehane, Rahim Hirani, Kalyani Chadalavada, Yuki Yoshikawa, Nabeela A. Khan, Yu Chen, Wassim Abida, Lorelei A. Mucci, Gwo-Shu Mary Lee, Gouri J. Nanjangud, Philip W. Kantoff
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (8): 2047–2064.
https://doi.org/10.1158/1078-0432.CCR-19-1570
Published: 15 April 2020
View article titled, Significance of BRCA2 and RB1 Co-loss in Aggressive Prostate Cancer Progression
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Includes: Supplementary data
Journal Articles

Statin Use Is Associated with Lower Risk of PTEN-Null and Lethal Prostate Cancer

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Emma H. Allott, Ericka M. Ebot, Konrad H. Stopsack, Amparo G. Gonzalez-Feliciano, Sarah C. Markt, Kathryn M. Wilson, Thomas U. Ahearn, Travis A. Gerke, Mary K. Downer, Jennifer R. Rider, Stephen J. Freedland, Tamara L. Lotan, Philip W. Kantoff, Elizabeth A. Platz, Massimo Loda, Meir J. Stampfer, Edward Giovannucci, Christopher J. Sweeney, Stephen P. Finn, Lorelei A. Mucci
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (5): 1086–1093.
https://doi.org/10.1158/1078-0432.CCR-19-2853
Published: 02 March 2020
View article titled, Statin Use Is Associated with Lower Risk of PTEN-Null and Lethal Prostate Cancer
Open the PDF for Statin Use Is Associated with Lower Risk of PTEN-Null and Lethal Prostate Cancer in another window
Includes: Supplementary data