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Journal Articles

RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer

Harshabad Singh, Pranshu Sahgal, Kevin Kapner, Steven M. Corsello, Hersh Gupta, Rahul Gujrathi, Yvonne Y. Li, Andrew D. Cherniack, Raquelle El Alam, Joseph Kerfoot, Elizabeth Andrews, Annette Lee, Chetan Nambiar, Alison M. Hannigan, Joshua Remland, Lauren Brais, Meghan E. Leahy, Douglas A. Rubinson, Benjamin L. Schlechter, Matthew Meyerson, Yanan Kuang, Cloud P. Paweletz, Jessica K. Lee, Julia C.F. Quintanilha, Andrew J. Aguirre, Kimberly J. Perez, Brandon M. Huffman, Humberto Rossi, Thomas A. Abrams, Sheheryar Kabraji, Livio Trusolino, Andrea Bertotti, Ewa T. Sicinska, Aparna R. Parikh, Brian M. Wolpin, Alexa B. Schrock, Marios Giannakis, Kimmie Ng, Jeffrey A. Meyerhardt, Jason L. Hornick, Nilay S. Sethi, James M. Cleary
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (8): 1669–1684.
https://doi.org/10.1158/1078-0432.CCR-23-2581
Published: 15 April 2024
View article titled, <em>RAS/RAF</em> Comutation and <em>ERBB2</em> Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

A Phase I Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-dose Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma

Brandon M. Huffman, Hanrong Feng, Kalindi Parmar, Junning Wang, Kevin S. Kapner, Bose Kochupurakkal, David B. Martignetti, Golbahar Sadatrezaei, Thomas A. Abrams, Leah H. Biller, Marios Giannakis, Kimmie Ng, Anuj K. Patel, Kimberly J. Perez, Harshabad Singh, Douglas A. Rubinson, Benjamin L. Schlechter, Elizabeth Andrews, Alison M. Hannigan, Stanley Dunwell, Zoe Getchell, Srivatsan Raghavan, Brian M. Wolpin, Caroline Fortier, Alan D. D'Andrea, Andrew J. Aguirre, Geoffrey I. Shapiro, James M. Cleary
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (24): 5047–5056.
https://doi.org/10.1158/1078-0432.CCR-23-2005
Published: 15 December 2023
View article titled, A Phase I Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-dose Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma
Open the PDF for A Phase I Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-dose Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Oncogenic Drivers and Therapeutic Vulnerabilities in KRAS Wild-Type Pancreatic Cancer

Harshabad Singh, Rachel B. Keller, Kevin S. Kapner, Julien Dilly, Srivatsan Raghavan, Chen Yuan, Elizabeth F. Cohen, Michael Tolstorukov, Elizabeth Andrews, Lauren K. Brais, Annacarolina da Silva, Kimberly Perez, Douglas A. Rubinson, Rishi Surana, Marios Giannakis, Kimmie Ng, Thomas E. Clancy, Matthew B. Yurgelun, Benjamin L. Schlechter, Jeffrey W. Clark, Geoffrey I. Shapiro, Michael H. Rosenthal, Jason L. Hornick, Valentina Nardi, Yvonne Y. Li, Hersh Gupta, Andrew D. Cherniack, Matthew Meyerson, James M. Cleary, Jonathan A. Nowak, Brian M. Wolpin, Andrew J. Aguirre
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (22): 4627–4643.
https://doi.org/10.1158/1078-0432.CCR-22-3930
Published: 14 November 2023
View article titled, Oncogenic Drivers and Therapeutic Vulnerabilities in KRAS Wild-Type Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Plasma 25-Hydroxyvitamin D Levels and Survival in Stage III Colon Cancer: Findings from CALGB/SWOG 80702 (Alliance)

Qiao-Li Wang, Chao Ma, Chen Yuan, Qian Shi, Brian M. Wolpin, Yin Zhang, Charles S. Fuchs, Jeffrey Meyer, Tyler Zemla, En Cheng, Priya Kumthekar, Katherine A. Guthrie, Felix Couture, Philip Kuebler, Pankaj Kumar, Benjamin Tan, Smitha Krishnamurthi, Richard M. Goldberg, Alan Venook, Charles Blanke, Anthony F. Shields, Eileen M. O'Reilly, Jeffrey A. Meyerhardt, Kimmie Ng
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (14): 2621–2630.
https://doi.org/10.1158/1078-0432.CCR-23-0447
Published: 14 July 2023
View article titled, Plasma 25-Hydroxyvitamin D Levels and Survival in Stage III Colon Cancer: Findings from CALGB/SWOG 80702 (Alliance)
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Includes: Supplementary data
Journal Articles

Neoadjuvant Chemotherapy Is Associated with Altered Immune Cell Infiltration and an Anti-Tumorigenic Microenvironment in Resected Pancreatic Cancer

Andressa Dias Costa, Sara A. Väyrynen, Akhil Chawla, Jinming Zhang, Juha P. Väyrynen, Mai Chan Lau, Hannah L. Williams, Chen Yuan, Vicente Morales-Oyarvide, Dalia Elganainy, Harshabad Singh, James M. Cleary, Kimberly Perez, Kimmie Ng, William Freed-Pastor, Joseph D. Mancias, Stephanie K. Dougan, Jiping Wang, Douglas A. Rubinson, Richard F. Dunne, Margaret M. Kozak, Lauren Brais, Emma Reilly, Thomas Clancy, David C. Linehan, Daniel T. Chang, Aram F. Hezel, Albert C. Koong, Andrew J. Aguirre, Brian M. Wolpin, Jonathan A. Nowak
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (23): 5167–5179.
https://doi.org/10.1158/1078-0432.CCR-22-1125
Published: 01 December 2022
View article titled, Neoadjuvant Chemotherapy Is Associated with Altered Immune Cell Infiltration and an Anti-Tumorigenic Microenvironment in Resected Pancreatic Cancer
Open the PDF for Neoadjuvant Chemotherapy Is Associated with Altered Immune Cell Infiltration and an Anti-Tumorigenic Microenvironment in Resected Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Association of Fusobacterium nucleatum with Specific T-cell Subsets in the Colorectal Carcinoma Microenvironment

Jennifer Borowsky, Koichiro Haruki, Mai Chan Lau, Andressa Dias Costa, Juha P. Väyrynen, Tomotaka Ugai, Kota Arima, Annacarolina da Silva, Kristen D. Felt, Melissa Zhao, Carino Gurjao, Tyler S. Twombly, Kenji Fujiyoshi, Sara A. Väyrynen, Tsuyoshi Hamada, Kosuke Mima, Susan Bullman, Tabitha A. Harrison, Amanda I. Phipps, Ulrike Peters, Kimmie Ng, Jeffrey A. Meyerhardt, Mingyang Song, Edward L. Giovannucci, Kana Wu, Xuehong Zhang, Gordon J. Freeman, Curtis Huttenhower, Wendy S. Garrett, Andrew T. Chan, Barbara A. Leggett, Vicki L.J. Whitehall, Neal Walker, Ian Brown, Mark Bettington, Reiko Nishihara, Charles S. Fuchs, Jochen K. Lennerz, Marios Giannakis, Jonathan A. Nowak, Shuji Ogino
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (10): 2816–2826.
https://doi.org/10.1158/1078-0432.CCR-20-4009
Published: 15 May 2021
View article titled, Association of <em>Fusobacterium nucleatum</em> with Specific T-cell Subsets in the Colorectal Carcinoma Microenvironment
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Includes: Supplementary data
Journal Articles

Molecular Characterization and Therapeutic Targeting of Colorectal Cancers Harboring Receptor Tyrosine Kinase Fusions

Harshabad Singh, Yvonne Y. Li, Liam F. Spurr, Atul B. Shinagare, Ritika Abhyankar, Emma Reilly, Lauren K. Brais, Anwesha Nag, Matthew D. Ducar, Aaron R. Thorner, Geoffrey I. Shapiro, Rachel B. Keller, Cheta Siletti, Jeffrey W. Clark, Anna F. Farago, Jessica J. Lin, George D. Demetri, Rahul Gujrathi, Matthew H. Kulke, Laura E. MacConaill, Azra H. Ligon, Ewa Sicinska, Matthew L. Meyerson, Jeffrey A. Meyerhardt, Andrew D. Cherniack, Brian M. Wolpin, Kimmie Ng, Marios Giannakis, Jason L. Hornick, James M. Cleary
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (6): 1695–1705.
https://doi.org/10.1158/1078-0432.CCR-20-4073
Published: 15 March 2021
View article titled, Molecular Characterization and Therapeutic Targeting of Colorectal Cancers Harboring Receptor Tyrosine Kinase Fusions
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Includes: Supplementary data
Journal Articles

Plasma 25-Hydroxyvitamin D Levels and Survival in Patients with Advanced or Metastatic Colorectal Cancer: Findings from CALGB/SWOG 80405 (Alliance)

Chen Yuan, Kaori Sato, Bruce W. Hollis, Sui Zhang, Donna Niedzwiecki, Fang-Shu Ou, I-Wen Chang, Bert H. O'Neil, Federico Innocenti, Heinz-Josef Lenz, Charles D. Blanke, Richard M. Goldberg, Alan P. Venook, Robert J. Mayer, Charles S. Fuchs, Jeffrey A. Meyerhardt, Kimmie Ng
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (24): 7497–7505.
https://doi.org/10.1158/1078-0432.CCR-19-0877
Published: 13 December 2019
View article titled, Plasma 25-Hydroxyvitamin D Levels and Survival in Patients with Advanced or Metastatic Colorectal Cancer: Findings from CALGB/SWOG 80405 (Alliance)
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Includes: Supplementary data
Journal Articles

Calcium Intake and Survival after Colorectal Cancer Diagnosis

Wanshui Yang, Yanan Ma, Stephanie Smith-Warner, Mingyang Song, Kana Wu, Molin Wang, Andrew T. Chan, Shuji Ogino, Charles S. Fuchs, Vitaliy Poylin, Kimmie Ng, Jeffrey A. Meyerhardt, Edward L. Giovannucci, Xuehong Zhang
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (6): 1980–1988.
https://doi.org/10.1158/1078-0432.CCR-18-2965
Published: 15 March 2019
View article titled, Calcium Intake and Survival after Colorectal Cancer Diagnosis
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Includes: Supplementary data
Journal Articles

Phase II Study of Everolimus in Patients with Metastatic Colorectal Adenocarcinoma Previously Treated with Bevacizumab-, Fluoropyrimidine-, Oxaliplatin-, and Irinotecan-Based Regimens

Kimmie Ng, Josep Tabernero, Jimmy Hwang, Emilio Bajetta, Sunil Sharma, Salvatore A. Del Prete, Edward R. Arrowsmith, David P. Ryan, Michaela Sedova, Jin Jin, Kamel Malek, Charles S. Fuchs
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (14): 3987–3995.
https://doi.org/10.1158/1078-0432.CCR-13-0027
Published: 15 July 2013
View article titled, Phase II Study of Everolimus in Patients with Metastatic Colorectal Adenocarcinoma Previously Treated with Bevacizumab-, Fluoropyrimidine-, Oxaliplatin-, and Irinotecan-Based Regimens
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Journal Articles

Predictive and Prognostic Roles of BRAF Mutation in Stage III Colon Cancer: Results from Intergroup Trial CALGB 89803

Shuji Ogino, Kaori Shima, Jeffrey A. Meyerhardt, Nadine J. McCleary, Kimmie Ng, Donna Hollis, Leonard B. Saltz, Robert J. Mayer, Paul Schaefer, Renaud Whittom, Alexander Hantel, Al B. Benson, III, Donna Spiegelman, Richard M. Goldberg, Monica M. Bertagnolli, Charles S. Fuchs
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (3): 890–900.
https://doi.org/10.1158/1078-0432.CCR-11-2246
Published: 31 January 2012
View article titled, Predictive and Prognostic Roles of <em>BRAF</em> Mutation in Stage III Colon Cancer: Results from Intergroup Trial CALGB 89803
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Includes: Supplementary data
Journal Articles

Interaction of Molecular Markers and Physical Activity on Mortality in Patients with Colon Cancer

Jeffrey A. Meyerhardt, Shuji Ogino, Gregory J. Kirkner, Andrew T. Chan, Brian Wolpin, Kimmie Ng, Katsuhiko Nosho, Kaori Shima, Edward L. Giovannucci, Massimo Loda, Charles S. Fuchs
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (18): 5931–5936.
https://doi.org/10.1158/1078-0432.CCR-09-0496
Published: 14 September 2009
View article titled, Interaction of Molecular Markers and Physical Activity on Mortality in Patients with Colon Cancer
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