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Kim N. Chi
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Journal Articles

Abstract B064: Prevalence and clinical relevance of clonal hematopoiesis in metastatic urologic malignancies

Aslı D Munzur, Jack V W Bacon, Francine Fishbein, Gráinne Donnellan, Cecily Q Bernales, Karan Parekh, Gillian Vandekerkhove, David C Müller, Cameron Herberts, Lucia Nappi, Corinne Maurice-Dror, Kim N Chi, Bernhard J Eigl, Christian Kollmannsberger, Maryam Soleimani, Alexander W Wyatt
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (21_Supplement): B064.
https://doi.org/10.1158/1557-3265.LIQBIOP24-B064
Published: 13 November 2024
View article titled, Abstract B064: Prevalence and clinical relevance of clonal hematopoiesis in metastatic urologic malignancies
Journal Articles

Abstract A004: Clinical test design affects tumor tissue and ctDNA FGFR gene status in metastatic urothelial cancer: a prospective study

David C. Müller, Gillian Vandekerkhove, Andrew J. Murtha, Jack V.W. Bacon, Carlos Vasquez-Rios, Maria Stephenson, Kimia Rostin, Elena Schönlau, Connor Wells, Sunil Parimi, Krista Noonan, Naveen S. Basappa, Jenny J. Ko, Daygen Finch, Nimira Alimohamed, Tarek A. Bismar, Gang Wang, Andreas Papadakis, Lucia Nappi, Matti Annala, Cecily Q. Bernales, Alan Spatz, Kim N. Chi, Alexander W. Wyatt, Bernhard J. Eigl
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (10_Supplement): A004.
https://doi.org/10.1158/1557-3265.BLADDER24-A004
Published: 17 May 2024
View article titled, Abstract A004: Clinical test design affects tumor tissue and ctDNA FGFR gene status in metastatic urothelial cancer: a prospective study
Journal Articles

Abstract A007: Circulating tumor DNA and tissue staining analyses reveal heterogeneous ERBB2/HER2 status in urothelial cancer

Gillian Vandekerkhove, Andrew J. Murtha, David C. Müller, Kimia Rostin, Carlos Vasquez-Rios, Jussi Nikkola, Maria Stephenson, Emily Fung, Jaskirat Atwal, Karan Parekh, Cecily Q. Bernales, Gráinne Donnellan, Gang Wang, Tilman Todenhöfer, Piet Ost, Peter C. Black, Kim N. Chi, Bernhard J. Eigl, Alexander W. Wyatt
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (10_Supplement): A007.
https://doi.org/10.1158/1557-3265.BLADDER24-A007
Published: 17 May 2024
View article titled, Abstract A007: Circulating tumor DNA and tissue staining analyses reveal heterogeneous <em>ERBB2</em>/HER2 status in urothelial cancer
Journal Articles

Olaparib Efficacy in Patients with Metastatic Castration-resistant Prostate Cancer and BRCA1, BRCA2, or ATM Alterations Identified by Testing Circulating Tumor DNA

Nobuaki Matsubara, Johann de Bono, David Olmos, Giuseppe Procopio, Satoru Kawakami, Yüksel Ürün, Robbert van Alphen, Aude Flechon, Michael A. Carducci, Young Deuk Choi, Sebastien J. Hotte, Ernesto Korbenfeld, Gero Kramer, Neeraj Agarwal, Kim N. Chi, Simon Dearden, Christopher Gresty, Jinyu Kang, Christian Poehlein, Elizabeth A. Harrington, Maha Hussain
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (1): 92–99.
https://doi.org/10.1158/1078-0432.CCR-21-3577
Published: 04 January 2023
View article titled, Olaparib Efficacy in Patients with Metastatic Castration-resistant Prostate Cancer and <em>BRCA1, BRCA2</em>, or <em>ATM</em> Alterations Identified by Testing Circulating Tumor DNA
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Includes: Supplementary data
Journal Articles

Detection of BRCA1, BRCA2, and ATM Alterations in Matched Tumor Tissue and Circulating Tumor DNA in Patients with Prostate Cancer Screened in PROfound

Kim N. Chi, Alan Barnicle, Caroline Sibilla, Zhongwu Lai, Claire Corcoran, J. Carl Barrett, Carrie A. Adelman, Ping Qiu, Ashley Easter, Simon Dearden, Geoffrey R. Oxnard, Neeraj Agarwal, Arun Azad, Johann de Bono, Joaquin Mateo, David Olmos, Antoine Thiery-Vuillemin, Elizabeth A. Harrington
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (1): 81–91.
https://doi.org/10.1158/1078-0432.CCR-22-0931
Published: 04 January 2023
View article titled, Detection of <em>BRCA1</em>, <em>BRCA2</em>, and <em>ATM</em> Alterations in Matched Tumor Tissue and Circulating Tumor DNA in Patients with Prostate Cancer Screened in PROfound
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Includes: Supplementary data
Journal Articles

The Effect of Corticosteroids on Prostate Cancer Outcome Following Treatment with Enzalutamide: A Multivariate Analysis of the Phase III AFFIRM Trial

Jimmy L. Zhao, Karim Fizazi, Fred Saad, Kim N. Chi, Mary-Ellen Taplin, Cora N. Sternberg, Andrew J. Armstrong, Johann S. de Bono, William T. Duggan, Howard I. Scher
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (5): 860–869.
https://doi.org/10.1158/1078-0432.CCR-21-1090
Published: 01 March 2022
View article titled, The Effect of Corticosteroids on Prostate Cancer Outcome Following Treatment with Enzalutamide: A Multivariate Analysis of the Phase III AFFIRM Trial
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Includes: Supplementary data
Journal Articles

Evolution of Castration-Resistant Prostate Cancer in ctDNA during Sequential Androgen Receptor Pathway Inhibition

Matti Annala, Sinja Taavitsainen, Daniel J. Khalaf, Gillian Vandekerkhove, Kevin Beja, Joonatan Sipola, Evan W. Warner, Cameron Herberts, Amanda Wong, Simon Fu, Daygen L. Finch, Conrad D. Oja, Joanna Vergidis, Muhammad Zulfiqar, Bernhard J. Eigl, Christian K. Kollmansberger, Matti Nykter, Martin E. Gleave, Kim N. Chi, Alexander W. Wyatt
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (16): 4610–4623.
https://doi.org/10.1158/1078-0432.CCR-21-1625
Published: 15 August 2021
View article titled, Evolution of Castration-Resistant Prostate Cancer in ctDNA during Sequential Androgen Receptor Pathway Inhibition
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Includes: Supplementary data
Journal Articles

Abstract PO-077: Study evaluating metastatic castrate resistant prostate cancer (mCRPC) treatment using 177Lu-PNT2002 PSMA therapy after second-line hormonal treatment (SPLASH) - Trial in progress

Kim N. Chi, Ur Metser, Johannes Czernin, Jeremie Calais, Vikas Prasad, Matthias Eiber, Neal Shore, Jessica Jensen, Neil Fleshner, Scott Tagawa, Oliver Sartor
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (8_Supplement): PO-077.
https://doi.org/10.1158/1557-3265.RADSCI21-PO-077
Published: 15 April 2021
View article titled, Abstract PO-077: Study evaluating metastatic castrate resistant prostate cancer (mCRPC) treatment using <sup>177</sup>Lu-PNT2002 PSMA therapy after second-line hormonal treatment (SPLASH) - Trial in progress
Journal Articles

BRCA2, ATM, and CDK12 Defects Differentially Shape Prostate Tumor Driver Genomics and Clinical Aggression

Evan Warner, Cameron Herberts, Simon Fu, Steven Yip, Amanda Wong, Gang Wang, Elie Ritch, Andrew J. Murtha, Gillian Vandekerkhove, Nicolette M. Fonseca, Arkhjamil Angeles, Arshia Beigi, Elena Schönlau, Kevin Beja, Matti Annala, Daniel Khalaf, Kim N. Chi, Alexander W. Wyatt
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (6): 1650–1662.
https://doi.org/10.1158/1078-0432.CCR-20-3708
Published: 15 March 2021
View article titled, <em>BRCA2</em>, <em>ATM</em>, and <em>CDK12</em> Defects Differentially Shape Prostate Tumor Driver Genomics and Clinical Aggression
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Includes: Supplementary data
Journal Articles

Autoantibody Landscape in Patients with Advanced Prostate Cancer

William S. Chen, Winston A. Haynes, Rebecca Waitz, Kathy Kamath, Agustin Vega-Crespo, Raunak Shrestha, Minlu Zhang, Adam Foye, Ignacio Baselga Carretero, Ivan Perez Garcilazo, Meng Zhang, Shuang G. Zhao, Martin Sjöström, David A. Quigley, Jonathan Chou, Tomasz M. Beer, Matthew Rettig, Martin Gleave, Christopher P. Evans, Primo Lara, Kim N. Chi, Robert E. Reiter, Joshi J. Alumkal, Alan Ashworth, Rahul Aggarwal, Eric J. Small, Patrick S. Daugherty, Antoni Ribas, David Y. Oh, John C. Shon, Felix Y. Feng
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (23): 6204–6214.
https://doi.org/10.1158/1078-0432.CCR-20-1966
Published: 01 December 2020
View article titled, Autoantibody Landscape in Patients with Advanced Prostate Cancer
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Includes: Supplementary data
Journal Articles

Abstract PR08: The genomic landscape of metastatic urothelial carcinoma from circulating tumor DNA

Gillian R. Vandekerkhove, Matti Annala, Jean-Michel Lavoie, Nora Sundahl, Simon Walz, Takeshi Sano, Andrew Murtha, Tilman Todenhöfer, Piet Ost, Kim N. Chi, Peter C. Black, Bernhard Eigl, Alexander W. Wyatt
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (15_Supplement): PR08.
https://doi.org/10.1158/1557-3265.BLADDER19-PR08
Published: 03 August 2020
View article titled, Abstract PR08: The genomic landscape of metastatic urothelial carcinoma from circulating tumor DNA
Journal Articles

Pharmacokinetics, Safety, and Antitumor Effect of Apalutamide with Abiraterone Acetate plus Prednisone in Metastatic Castration-Resistant Prostate Cancer: Phase Ib Study

Edwin M. Posadas, Kim N. Chi, Ronald de Wit, Maja J.A. de Jonge, Gerhardt Attard, Terence W. Friedlander, Margaret K. Yu, Peter Hellemans, Caly Chien, Charlene Abrams, Juhui J. Jiao, Fred Saad
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (14): 3517–3524.
https://doi.org/10.1158/1078-0432.CCR-19-3402
Published: 15 July 2020
View article titled, Pharmacokinetics, Safety, and Antitumor Effect of Apalutamide with Abiraterone Acetate plus Prednisone in Metastatic Castration-Resistant Prostate Cancer: Phase Ib Study
Open the PDF for Pharmacokinetics, Safety, and Antitumor Effect of Apalutamide with Abiraterone Acetate plus Prednisone in Metastatic Castration-Resistant Prostate Cancer: Phase Ib Study in another window
Includes: Supplementary data
Journal Articles

Abstract A18: Plasma circulating tumor DNA is scarce and confounded by clonal hematopoiesis in metastatic renal cell carcinoma

Jack V. W. Bacon, Matti Annala, Maryam Soleimani, Jean-Michel Lavoie, Alan I. So, Martin E. Gleave, Ladan Fazli, Kim N. Chi, Christian K. Kollmannsberger, Alexander W. Wyatt, Lucia Nappi
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (11_Supplement): A18.
https://doi.org/10.1158/1557-3265.LiqBiop20-A18
Published: 01 June 2020
View article titled, Abstract A18: Plasma circulating tumor DNA is scarce and confounded by clonal hematopoiesis in metastatic renal cell carcinoma
Journal Articles

Abstract A24: Identifying the genomic and clinical features of AKT1/PIK3CA mutant metastatic prostate cancer using circulating tumor DNA

Cameron M. Herberts, Andrew J. Murtha, Simon Fu, Gang Wang, Elena Schönlau, Anna Gleave, Steven Yip, Arkhjamil Angeles, Sebastien Hotte, Abdulraheem Alshangiti, Ben Tran, Scott North, Sinja Taavitsainen, Kevin Beja, Gillian Vandekerkhove, Elie Ritch, Fred Saad, Nayyer Iqbal, Martin E. Gleave, Matti Annala, Kim N. Chi, Alexander W. Wyatt
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (11_Supplement): A24.
https://doi.org/10.1158/1557-3265.LiqBiop20-A24
Published: 01 June 2020
View article titled, Abstract A24: Identifying the genomic and clinical features of AKT1/PIK3CA mutant metastatic prostate cancer using circulating tumor DNA
Journal Articles

Identification of Hypermutation and Defective Mismatch Repair in ctDNA from Metastatic Prostate Cancer

Elie Ritch, Simon Y.F. Fu, Cameron Herberts, Gang Wang, Evan W. Warner, Elena Schönlau, Sinja Taavitsainen, Andrew J. Murtha, Gillian Vandekerkhove, Kevin Beja, Yulia Loktionova, Daniel Khalaf, Ladan Fazli, Igal Kushnir, Cristiano Ferrario, Sebastien Hotte, Matti Annala, Kim N. Chi, Alexander W. Wyatt
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (5): 1114–1125.
https://doi.org/10.1158/1078-0432.CCR-19-1623
Published: 02 March 2020
View article titled, Identification of Hypermutation and Defective Mismatch Repair in ctDNA from Metastatic Prostate Cancer
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Includes: Supplementary data
Journal Articles

Cell-Free DNA Modification Dynamics in Abiraterone Acetate-Treated Prostate Cancer Patients

Juozas Gordevičius, Algimantas Kriščiūnas, Daniel E. Groot, Steven M. Yip, Miki Susic, Andrew Kwan, Rafal Kustra, Anthony M. Joshua, Kim N. Chi, Art Petronis, Gabriel Oh
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (14): 3317–3324.
https://doi.org/10.1158/1078-0432.CCR-18-0101
Published: 15 July 2018
View article titled, Cell-Free DNA Modification Dynamics in Abiraterone Acetate-Treated Prostate Cancer Patients
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Includes: Supplementary data
Journal Articles

Circulating Tumor DNA Reveals Clinically Actionable Somatic Genome of Metastatic Bladder Cancer

Gillian Vandekerkhove, Tilman Todenhöfer, Matti Annala, Werner J. Struss, Amanda Wong, Kevin Beja, Elie Ritch, Sonal Brahmbhatt, Stanislav V. Volik, Jörg Hennenlotter, Matti Nykter, Kim N. Chi, Scott North, Arnulf Stenzl, Colin C. Collins, Bernhard J. Eigl, Peter C. Black, Alexander W. Wyatt
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (21): 6487–6497.
https://doi.org/10.1158/1078-0432.CCR-17-1140
Published: 31 October 2017
View article titled, Circulating Tumor DNA Reveals Clinically Actionable Somatic Genome of Metastatic Bladder Cancer
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Includes: Supplementary data
Journal Articles

Neoadjuvant Enzalutamide Prior to Prostatectomy

Bruce Montgomery, Maria S. Tretiakova, Anthony M. Joshua, Martin E. Gleave, Neil Fleshner, Glenn J. Bubley, Elahe A. Mostaghel, Kim N. Chi, Daniel W. Lin, Martin Sanda, William Novotny, Kenneth Wu, Philip W. Kantoff, Brett T. Marck, Stephen Plymate, Steven P. Balk, Peter S. Nelson, Alvin M. Matsumoto, Rosina T. Lis, Adam Kibel, Gabriel P. Haas, Andrew Krivoshik, Alison Hannah, Mary-Ellen Taplin
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (9): 2169–2176.
https://doi.org/10.1158/1078-0432.CCR-16-1357
Published: 30 April 2017
View article titled, Neoadjuvant Enzalutamide Prior to Prostatectomy
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Includes: Supplementary data
Journal Articles

Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer

Arun A. Azad, Stanislav V. Volik, Alexander W. Wyatt, Anne Haegert, Stephane Le Bihan, Robert H. Bell, Shawn A. Anderson, Brian McConeghy, Robert Shukin, Jenny Bazov, Jack Youngren, Pamela Paris, George Thomas, Eric J. Small, Yuzhuo Wang, Martin E. Gleave, Colin C. Collins, Kim N. Chi
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (10): 2315–2324.
https://doi.org/10.1158/1078-0432.CCR-14-2666
Published: 14 May 2015
View article titled, Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer
Open the PDF for Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract A12: Identification of pathways associated with abiraterone resistance in metastatic castration resistant prostate cancer: Preliminary results from the SU2C/AACR West Coast Prostate Cancer Dream Team

Jack F. Youngren, Adam Foye, George Thomas, Joshua M. Stuart, Ted Goldstein, Baertsch Robert, Adrian Bivol, Artem Sokolov, Charles J. Ryan, Nader Pourmand, Tomasz M. Beer, Christopher P. Evans, Christopher P. Evans, Primo Lara, Jr., Martin E. Gleave, Kim N. Chi, Robert E. Reiter, Matthew Rettig, Owen Witte, Eric J. Small
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (4_Supplement): A12.
https://doi.org/10.1158/1557-3265.PMS14-A12
Published: 13 February 2015
View article titled, Abstract A12: Identification of pathways associated with abiraterone resistance in metastatic castration resistant prostate cancer: Preliminary results from the SU2C/AACR West Coast Prostate Cancer Dream Team