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Kevin R. Coombes
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Journal Articles

A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition

Milena P. Mak, Pan Tong, Lixia Diao, Robert J. Cardnell, Don L. Gibbons, William N. William, Ferdinandos Skoulidis, Edwin R. Parra, Jaime Rodriguez-Canales, Ignacio I. Wistuba, John V. Heymach, John N. Weinstein, Kevin R. Coombes, Jing Wang, Lauren Averett Byers
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (3): 609–620.
https://doi.org/10.1158/1078-0432.CCR-15-0876
Published: 31 January 2016
View article titled, A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition
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Includes: Supplementary data
Journal Articles

VEGF/VEGFR-2 Upregulates EZH2 Expression in Lung Adenocarcinoma Cells and EZH2 Depletion Enhances the Response to Platinum-Based and VEGFR-2–Targeted Therapy

Erick Riquelme, Milind Suraokar, Carmen Behrens, Heather Y. Lin, Luc Girard, Monique B. Nilsson, George Simon, Jing Wang, Kevin R. Coombes, J. Jack Lee, Waun Ki Hong, John Heymach, John D. Minna, Ignacio I. Wistuba
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (14): 3849–3861.
https://doi.org/10.1158/1078-0432.CCR-13-1916
Published: 14 July 2014
View article titled, VEGF/VEGFR-2 Upregulates EZH2 Expression in Lung Adenocarcinoma Cells and EZH2 Depletion Enhances the Response to Platinum-Based and VEGFR-2–Targeted Therapy
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Includes: Supplementary data
Journal Articles

An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Lauren Averett Byers, Lixia Diao, Jing Wang, Pierre Saintigny, Luc Girard, Michael Peyton, Li Shen, Youhong Fan, Uma Giri, Praveen K. Tumula, Monique B. Nilsson, Jayanthi Gudikote, Hai Tran, Robert J.G. Cardnell, David J. Bearss, Steven L. Warner, Jason M. Foulks, Steven B. Kanner, Varsha Gandhi, Nancy Krett, Steven T. Rosen, Edward S. Kim, Roy S. Herbst, George R. Blumenschein, J. Jack Lee, Scott M. Lippman, K. Kian Ang, Gordon B. Mills, Waun K. Hong, John N. Weinstein, Ignacio I. Wistuba, Kevin R. Coombes, John D. Minna, John V. Heymach
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (1): 279–290.
https://doi.org/10.1158/1078-0432.CCR-12-1558
Published: 02 January 2013
View article titled, An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance
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Includes: Supplementary data
Journal Articles

Robust Gene Expression Signature from Formalin-Fixed Paraffin-Embedded Samples Predicts Prognosis of Non–Small-Cell Lung Cancer Patients

Yang Xie, Guanghua Xiao, Kevin R. Coombes, Carmen Behrens, Luisa M. Solis, Gabriela Raso, Luc Girard, Heidi S. Erickson, Jack Roth, John V. Heymach, Cesar Moran, Kathy Danenberg, John D. Minna, Ignacio I. Wistuba
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (17): 5705–5714.
https://doi.org/10.1158/1078-0432.CCR-11-0196
Published: 01 September 2011
View article titled, Robust Gene Expression Signature from Formalin-Fixed Paraffin-Embedded Samples Predicts Prognosis of Non–Small-Cell Lung Cancer Patients
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Includes: Supplementary data
Journal Articles

Functional Proteomic Analysis of Advanced Serous Ovarian Cancer Using Reverse Phase Protein Array: TGF-β Pathway Signaling Indicates Response to Primary Chemotherapy

Mark S. Carey, Roshan Agarwal, Blake Gilks, Kenneth Swenerton, Steve Kalloger, Jennifer Santos, Zhenlin Ju, Yiling Lu, Fan Zhang, Kevin R. Coombes, Dianne Miller, David Huntsman, Gordon B. Mills, Bryan T. Hennessy
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (10): 2852–2860.
https://doi.org/10.1158/1078-0432.CCR-09-2502
Published: 13 May 2010
View article titled, Functional Proteomic Analysis of Advanced Serous Ovarian Cancer Using Reverse Phase Protein Array: TGF-β Pathway Signaling Indicates Response to Primary Chemotherapy
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Includes: Supplementary data
Journal Articles

Highly Phosphorylated FOXO3A Is an Adverse Prognostic Factor in Acute Myeloid Leukemia

Steven M. Kornblau, Neera Singh, YiHua Qiu, Wenjing Chen, Nianxiang Zhang, Kevin R. Coombes
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (6): 1865–1874.
https://doi.org/10.1158/1078-0432.CCR-09-2551
Published: 14 March 2010
View article titled, Highly Phosphorylated FOXO3A Is an Adverse Prognostic Factor in Acute Myeloid Leukemia
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Includes: Supplementary data
Journal Articles

Plasma Protein Profiling for Diagnosis of Pancreatic Cancer Reveals the Presence of Host Response Proteins

John M. Koomen, Lichen Nancy Shih, Kevin R. Coombes, Donghui Li, Lian-chun Xiao, Isaiah J. Fidler, James L. Abbruzzese, Ryuji Kobayashi
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (3): 1110–1118.
https://doi.org/10.1158/1078-0432.1110.11.3
Published: 11 February 2005
View article titled, Plasma Protein Profiling for Diagnosis of Pancreatic Cancer Reveals the Presence of Host Response Proteins
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Includes: Supplementary data
Journal Articles

Cancer Genomics: Promises and Complexities

Wei Zhang, Pilar M. Labordé, Kevin R. Coombes, Donald A. Berry, Stanley R. Hamilton
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (8): 2159–2167.
Published: 01 August 2001
View article titled, Cancer Genomics: <subtitle>Promises and Complexities</subtitle>
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