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Kenneth R. Hess
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Journal Articles

Cell-free Circulating Tumor DNA Variant Allele Frequency Associates with Survival in Metastatic Cancer

Seyed Pairawan, Kenneth R. Hess, Filip Janku, Nora S. Sanchez, Kenna R. Mills Shaw, Cathy Eng, Senthilkumar Damodaran, Milind Javle, Ahmed O. Kaseb, David S. Hong, Vivek Subbiah, Siqing Fu, David R. Fogelman, Victoria M. Raymond, Richard B. Lanman, Funda Meric-Bernstam
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (8): 1924–1931.
https://doi.org/10.1158/1078-0432.CCR-19-0306
Published: 15 April 2020
View articletitled, Cell-free Circulating Tumor DNA Variant Allele Frequency Associates with Survival in Metastatic Cancer
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Includes: Supplementary data
Journal Articles

Cyclin E Overexpression Sensitizes Triple-Negative Breast Cancer to Wee1 Kinase Inhibition

Xian Chen, Kwang-Huei Low, Angela Alexander, Yufeng Jiang, Cansu Karakas, Kenneth R. Hess, Jason P.W. Carey, Tuyen N. Bui, Smruthi Vijayaraghavan, Kurt W. Evans, Min Yi, D. Christian Ellis, Kwok-Leung Cheung, Ian O. Ellis, Siqing Fu, Funda Meric-Bernstam, Kelly K. Hunt, Khandan Keyomarsi
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (24): 6594–6610.
https://doi.org/10.1158/1078-0432.CCR-18-1446
Published: 13 December 2018
View articletitled, Cyclin E Overexpression Sensitizes Triple-Negative Breast Cancer to Wee1 Kinase Inhibition
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Includes: Supplementary data
Journal Articles

Prospective Analysis of Adoptive TIL Therapy in Patients with Metastatic Melanoma: Response, Impact of Anti-CTLA4, and Biomarkers to Predict Clinical Outcome

Marie-Andrée Forget, Cara Haymaker, Kenneth R. Hess, Yuzhong Jeff Meng, Caitlin Creasy, Tatiana Karpinets, Orenthial J. Fulbright, Jason Roszik, Scott E. Woodman, Young Uk Kim, Donastas Sakellariou-Thompson, Ankit Bhatta, Arely Wahl, Esteban Flores, Shawne T. Thorsen, René J. Tavera, Renjith Ramachandran, Audrey M. Gonzalez, Christopher L. Toth, Seth Wardell, Rahmatu Mansaray, Vruti Patel, Destiny Joy Carpio, Carol Vaughn, Chantell M. Farinas, Portia G. Velasquez, Wen-Jen Hwu, Sapna P. Patel, Michael A. Davies, Adi Diab, Isabella C. Glitza, Hussein Tawbi, Michael K. Wong, Suzanne Cain, Merrick I. Ross, Jeffrey E. Lee, Jeffrey E. Gershenwald, Anthony Lucci, Richard Royal, Janice N. Cormier, Jennifer A. Wargo, Laszlo G. Radvanyi, Carlos A. Torres-Cabala, Rameen Beroukhim, Patrick Hwu, Rodabe N. Amaria, Chantale Bernatchez
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (18): 4416–4428.
https://doi.org/10.1158/1078-0432.CCR-17-3649
Published: 14 September 2018
View articletitled, Prospective Analysis of Adoptive TIL Therapy in Patients with Metastatic Melanoma: Response, Impact of Anti-CTLA4, and Biomarkers to Predict Clinical Outcome
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Includes: Supplementary data
Journal Articles

Insurance Clearance for Early-Phase Oncology Clinical Trials Following the Affordable Care Act

Kenneth L. Kehl, Cheryl P. Fullmer, Siqing Fu, Goldy C. George, Kenneth R. Hess, Filip Janku, Daniel D. Karp, Shumei Kato, Cynthia K. Kizer, Razelle Kurzrock, Aung Naing, Shubham Pant, Sarina A. Piha-Paul, Vivek Subbiah, Apostolia M. Tsimberidou, David S. Hong
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (15): 4155–4162.
https://doi.org/10.1158/1078-0432.CCR-16-3027
Published: 01 August 2017
View articletitled, Insurance Clearance for Early-Phase Oncology Clinical Trials Following the Affordable Care Act
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Includes: Supplementary data
Journal Articles

Ipilimumab with Stereotactic Ablative Radiation Therapy: Phase I Results and Immunologic Correlates from Peripheral T Cells

Chad Tang, James W. Welsh, Patricia de Groot, Erminia Massarelli, Joe Y. Chang, Kenneth R. Hess, Sreyashi Basu, Michael A. Curran, Maria E. Cabanillas, Vivek Subbiah, Siqing Fu, Apostolia M. Tsimberidou, Daniel Karp, Daniel R. Gomez, Adi Diab, Ritsuko Komaki, John V. Heymach, Padmanee Sharma, Aung Naing, David S. Hong
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (6): 1388–1396.
https://doi.org/10.1158/1078-0432.CCR-16-1432
Published: 14 March 2017
View articletitled, Ipilimumab with Stereotactic Ablative Radiation Therapy: Phase I Results and Immunologic Correlates from Peripheral T Cells
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Includes: Supplementary data
Journal Articles

Modifying the Clinical Research Infrastructure at a Dedicated Clinical Trials Unit: Assessment of Trial Development, Activation, and Participant Accrual

Chad Tang, Kenneth R. Hess, Dwana Sanders, Suzanne E. Davis, Aman U. Buzdar, Razelle Kurzrock, J. Jack Lee, Funda Meric-Bernstam, David S. Hong
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (6): 1407–1413.
https://doi.org/10.1158/1078-0432.CCR-16-1936
Published: 14 March 2017
View articletitled, Modifying the Clinical Research Infrastructure at a Dedicated Clinical Trials Unit: Assessment of Trial Development, Activation, and Participant Accrual
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Includes: Supplementary data
Journal Articles

Bayesian Optimal Interval Design: A Simple and Well-Performing Design for Phase I Oncology Trials

Ying Yuan, Kenneth R. Hess, Susan G. Hilsenbeck, Mark R. Gilbert
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (17): 4291–4301.
https://doi.org/10.1158/1078-0432.CCR-16-0592
Published: 31 August 2016
View articletitled, Bayesian Optimal Interval Design: A Simple and Well-Performing Design for Phase I Oncology Trials
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Includes: Supplementary data
Journal Articles

Getting More Out of Survival Data by Using the Hazard Function

Kenneth R. Hess, Victor A. Levin
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (6): 1404–1409.
https://doi.org/10.1158/1078-0432.CCR-13-2125
Published: 13 March 2014
View articletitled, Getting More Out of Survival Data by Using the Hazard Function
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Journal Articles

Predictive Value of Phase I Trials for Safety in Later Trials and Final Approved Dose: Analysis of 61 Approved Cancer Drugs

Denis L. Jardim, Kenneth R. Hess, Patricia LoRusso, Razelle Kurzrock, David S. Hong
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (2): 281–288.
https://doi.org/10.1158/1078-0432.CCR-13-2103
Published: 16 January 2014
View articletitled, Predictive Value of Phase I Trials for Safety in Later Trials and Final Approved Dose: Analysis of 61 Approved Cancer Drugs
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Includes: Supplementary data
Journal Articles

Evaluation of a 30-Gene Paclitaxel, Fluorouracil, Doxorubicin, and Cyclophosphamide Chemotherapy Response Predictor in a Multicenter Randomized Trial in Breast Cancer

Adel Tabchy, Vicente Valero, Tatiana Vidaurre, Ana Lluch, Henry Gomez, Miguel Martin, Yuan Qi, Luis Javier Barajas-Figueroa, Eduardo Souchon, Charles Coutant, Franco D. Doimi, Nuhad K. Ibrahim, Yun Gong, Gabriel N. Hortobagyi, Kenneth R. Hess, W. Fraser Symmans, Lajos Pusztai
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (21): 5351–5361.
https://doi.org/10.1158/1078-0432.CCR-10-1265
Published: 31 October 2010
View articletitled, Evaluation of a 30-Gene Paclitaxel, Fluorouracil, Doxorubicin, and Cyclophosphamide Chemotherapy Response Predictor in a Multicenter Randomized Trial in Breast Cancer
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Includes: Supplementary data
Journal Articles

Comparing Survival Curves Using an Easy to Interpret Statistic

Kenneth R. Hess
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (20): 4912–4913.
https://doi.org/10.1158/1078-0432.CCR-10-1540
Published: 13 October 2010
View articletitled, Comparing Survival Curves Using an Easy to Interpret Statistic
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Journal Articles

Phosphorylated Pak1 Level in the Cytoplasm Correlates with Shorter Survival Time in Patients with Glioblastoma

Hiroshi Aoki, Tomohisa Yokoyama, Keishi Fujiwara, Ana M. Tari, Raymond Sawaya, Dima Suki, Kenneth R. Hess, Kenneth D. Aldape, Seiji Kondo, Rakesh Kumar, Yasuko Kondo
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (22): 6603–6609.
https://doi.org/10.1158/1078-0432.CCR-07-0145
Published: 15 November 2007
View articletitled, Phosphorylated Pak1 Level in the Cytoplasm Correlates with Shorter Survival Time in Patients with Glioblastoma
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Journal Articles

Pharmacogenomic Predictor Discovery in Phase II Clinical Trials for Breast Cancer

Lajos Pusztai, Keith Anderson, Kenneth R. Hess
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (20): 6080–6086.
https://doi.org/10.1158/1078-0432.CCR-07-0809
Published: 18 October 2007
View articletitled, Pharmacogenomic Predictor Discovery in Phase II Clinical Trials for Breast Cancer
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Journal Articles

Reproducibility of Gene Expression Signature–Based Predictions in Replicate Experiments

Keith Anderson, Kenneth R. Hess, Mini Kapoor, Stephen Tirrell, Jean Courtemanche, Bailiang Wang, Yun Wu, Yun Gong, Gabriel N. Hortobagyi, W. Fraser Symmans, Lajos Pusztai
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (6): 1721–1727.
https://doi.org/10.1158/1078-0432.CCR-05-1539
Published: 21 March 2006
View articletitled, Reproducibility of Gene Expression Signature–Based Predictions in Replicate Experiments
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Includes: Supplementary data
Journal Articles

Breast Cancer Molecular Subtypes Respond Differently to Preoperative Chemotherapy

Roman Rouzier, Charles M. Perou, W. Fraser Symmans, Nuhad Ibrahim, Massimo Cristofanilli, Keith Anderson, Kenneth R. Hess, James Stec, Mark Ayers, Peter Wagner, Paolo Morandi, Chang Fan, Islam Rabiul, Jeffrey S. Ross, Gabriel N. Hortobagyi, Lajos Pusztai
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (16): 5678–5685.
https://doi.org/10.1158/1078-0432.CCR-04-2421
Published: 22 August 2005
View articletitled, Breast Cancer Molecular Subtypes Respond Differently to Preoperative Chemotherapy
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Includes: Supplementary data
Journal Articles

Overexpression of Tropomysin-Related Kinase B in Metastatic Human Pancreatic Cancer Cells

Guido M. Sclabas, Shuichi Fujioka, Christian Schmidt, Zhongkui Li, Wayne A.I. Frederick, Wentao Yang, Kenji Yokoi, Douglas B. Evans, James L. Abbruzzese, Kenneth R. Hess, Wei Zhang, Isaiah J. Fidler, Paul J. Chiao
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (2): 440–449.
https://doi.org/10.1158/1078-0432.440.11.2
Published: 08 February 2005
View articletitled, Overexpression of Tropomysin-Related Kinase B in Metastatic Human Pancreatic Cancer Cells
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Journal Articles

Epidermal Growth Factor Receptor VIII Peptide Vaccination Is Efficacious against Established Intracerebral Tumors

Amy B. Heimberger, Laura E. Crotty, Gary E. Archer, Kenneth R. Hess, Carol J. Wikstrand, Allan H. Friedman, Henry S. Friedman, Darell D. Bigner, John H. Sampson
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (11): 4247–4254.
Published: 30 September 2003
View articletitled, Epidermal Growth Factor Receptor VIII Peptide Vaccination Is Efficacious against Established Intracerebral Tumors
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Journal Articles

The Expression of PAX6, PTEN, Vascular Endothelial Growth Factor, and Epidermal Growth Factor Receptor in Gliomas: Relationship to Tumor Grade and Survival

Yi-Hong Zhou, Fang Tan, Kenneth R. Hess, W. K. Alfred Yung
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (9): 3369–3375.
Published: 05 September 2003
View articletitled, The Expression of PAX6, PTEN, Vascular Endothelial Growth Factor, and Epidermal Growth Factor Receptor in Gliomas: Relationship to Tumor Grade and Survival
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Journal Articles

Phase III Randomized Study of Postradiotherapy Chemotherapy with Combination α-Difluoromethylornithine-PCV versus PCV for Anaplastic Gliomas

Victor A. Levin, Kenneth R. Hess, Ali Choucair, Patrick J. Flynn, Kurt A. Jaeckle, Athanassios P. Kyritsis, W. K. Alfred Yung, Michael D. Prados, Janet M. Bruner, Sandra Ictech, Mary Jo Gleason, Hyung-Woo Kim
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (3): 981–990.
Published: 01 March 2003
View articletitled, Phase III Randomized Study of Postradiotherapy Chemotherapy with Combination α-Difluoromethylornithine-PCV versus PCV for Anaplastic Gliomas
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Journal Articles

Automated Quantification of Apoptosis after Neoadjuvant Chemotherapy for Breast Cancer: Early Assessment Predicts Clinical Response

Darren W. Davis, Thomas A. Buchholz, Kenneth R. Hess, Aysegul A. Sahin, Vincente Valero, David J. McConkey
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (3): 955–960.
Published: 01 March 2003
View articletitled, Automated Quantification of Apoptosis after Neoadjuvant Chemotherapy for Breast Cancer: Early Assessment Predicts Clinical Response
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