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Kenneth C. Anderson
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Journal Articles

Microenvironment Is a Key Determinant of Immune Checkpoint Inhibitor Response

Shih-Feng Cho, Kenneth C. Anderson, Yu-Tzu Tai
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (8): 1479–1481.
DOI: https://doi.org/10.1158/1078-0432.CCR-22-0015
Published: 14 April 2022
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Single-Cell Profiling Reveals Metabolic Reprogramming as a Resistance Mechanism in BRAF-Mutated Multiple Myeloma

Johannes M. Waldschmidt, Jake A. Kloeber, Praveen Anand, Julia Frede, Antonis Kokkalis, Valeriya Dimitrova, Sayalee Potdar, Monica S. Nair, Tushara Vijaykumar, Nam Gyu Im, Amy Guillaumet-Adkins, Nitish Chopra, Hannah Stuart, Lillian Budano, Noori Sotudeh, Guangwu Guo, Clemens Grassberger, Andrew J. Yee, Jacob P. Laubach, Paul G. Richardson, Kenneth C. Anderson, Noopur S. Raje, Birgit Knoechel, Jens G. Lohr
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (23): 6432–6444.
DOI: https://doi.org/10.1158/1078-0432.CCR-21-2040
Published: 01 December 2021
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Includes: Supplementary data
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BCMA-Specific ADC MEDI2228 and Daratumumab Induce Synergistic Myeloma Cytotoxicity via IFN-Driven Immune Responses and Enhanced CD38 Expression

Lijie Xing, Su Wang, Jiye Liu, Tengteng Yu, Hailin Chen, Kenneth Wen, Yuyin Li, Liang Lin, Phillip A. Hsieh, Shih-Feng Cho, Gang An, Lugui Qiu, Krista Kinneer, Nikhil Munshi, Kenneth C. Anderson, Yu-Tzu Tai
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (19): 5376–5388.
DOI: https://doi.org/10.1158/1078-0432.CCR-21-1621
Published: 01 October 2021
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Minimal Residual Disease in Myeloma: Application for Clinical Care and New Drug Registration

Kenneth C. Anderson, Daniel Auclair, Stacey J. Adam, Amit Agarwal, Melissa Anderson, Hervé Avet-Loiseau, Mark Bustoros, Jessica Chapman, Dana E. Connors, Ajeeta Dash, Alessandra Di Bacco, Ling Du, Thierry Facon, Juan Flores-Montero, Francesca Gay, Irene M. Ghobrial, Nicole J. Gormley, Ira Gupta, Howard Higley, Jens Hillengass, Bindu Kanapuru, Dickran Kazandjian, Gary J. Kelloff, Ilan R. Kirsch, Brandon Kremer, Ola Landgren, Elizabeth Lightbody, Oliver C. Lomas, Sagar Lonial, María-Victoria Mateos, Rocio Montes de Oca, Lata Mukundan, Nikhil C. Munshi, Elizabeth K. O'Donnell, Alberto Orfao, Bruno Paiva, Reshma Patel, Trevor J. Pugh, Karthik Ramasamy, Jill Ray, Mikhail Roshal, Jeremy A. Ross, Caroline C. Sigman, Katie L. Thoren, Suzanne Trudel, Gary Ulaner, Nancy Valente, Brendan M. Weiss, Elena Zamagni, Shaji K. Kumar
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (19): 5195–5212.
DOI: https://doi.org/10.1158/1078-0432.CCR-21-1059
Published: 01 October 2021
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Facts and Hopes in Multiple Myeloma Immunotherapy

Adam S. Sperling, Kenneth C. Anderson
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (16): 4468–4477.
DOI: https://doi.org/10.1158/1078-0432.CCR-20-3600
Published: 15 August 2021
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A Phase Ib/II Trial of the First-in-Class Anti-CXCR4 Antibody Ulocuplumab in Combination with Lenalidomide or Bortezomib Plus Dexamethasone in Relapsed Multiple Myeloma

Irene M. Ghobrial, Chia-Jen Liu, Robert A. Redd, Raymond P. Perez, Rachid Baz, Oksana Zavidij, Romanos Sklavenitis-Pistofidis, Paul G. Richardson, Kenneth C. Anderson, Jacob Laubach, Patrick Henrick, Alexandra Savell, Kaitlen Reyes, Kalvis Hornburg, Stacey Chuma, Peter Sabbatini, Michael D. Robbins, Pamela S. Becker
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (2): 344–353.
DOI: https://doi.org/10.1158/1078-0432.CCR-19-0647
Published: 15 January 2020
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Correction: Resveratrol Exerts Antiproliferative Activity and Induces Apoptosis in Waldenström Macroglobulinemia

Aldo M. Roccaro, Xavier Leleu, Antonio Sacco, Anne-Sophie Moreau, Evdoxia Hatjiharissi, Xiaoying Jia, Lian Xu, Bryan Ciccarelli, Christopher J. Patterson, Hai T. Ngo, Domenico Russo, Angelo Vacca, Franco Dammacco, Kenneth C. Anderson, Irene M. Ghobrial, Steven P. Treon
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (15): 4860.
DOI: https://doi.org/10.1158/1078-0432.CCR-19-2051
Published: 01 August 2019
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Correction: Dual Inhibition of Canonical and Noncanonical NF-κB Pathways Demonstrates Significant Antitumor Activities in Multiple Myeloma

Claire Fabre, Naoya Mimura, Kathryn Bobb, Sun-Young Kong, Güllü Gorgun, Diana Cirstea, Yiguo Hu, Jiro Minami, Hiroto Ohguchi, Jie Zhang, Jeffrey Meshulam, Ruben D. Carrasco, Yu-Tzu Tai, Paul G. Richardson, Teru Hideshima, Kenneth C. Anderson
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (9): 2938.
DOI: https://doi.org/10.1158/1078-0432.CCR-19-0959
Published: 01 May 2019
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A Phase I/II Study of Evofosfamide, A Hypoxia-activated Prodrug with or without Bortezomib in Subjects with Relapsed/Refractory Multiple Myeloma

Jacob P. Laubach, Chia-Jen Liu, Noopur S. Raje, Andrew J. Yee, Philippe Armand, Robert L. Schlossman, Jacalyn Rosenblatt, Jacquelyn Hedlund, Michael Martin, Craig Reynolds, Kenneth H. Shain, Ira Zackon, Laura Stampleman, Patrick Henrick, Bradley Rivotto, Kalvis T.V. Hornburg, Henry J. Dumke, Stacey Chuma, Alexandra Savell, Damian R. Handisides, Stew Kroll, Kenneth C. Anderson, Paul G. Richardson, Irene M. Ghobrial
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (2): 478–486.
DOI: https://doi.org/10.1158/1078-0432.CCR-18-1325
Published: 15 January 2019
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Dual PAK4-NAMPT Inhibition Impacts Growth and Survival, and Increases Sensitivity to DNA-Damaging Agents in Waldenström Macroglobulinemia

Na Li, Michael A. Lopez, Maria Linares, Subodh Kumar, Stefania Oliva, Joaquin Martinez-Lopez, Lian Xu, Yan Xu, Tommaso Perini, William Senapedis, Erkan Baloglu, Masood A. Shammas, Zachary Hunter, Kenneth C. Anderson, Steven P. Treon, Nikhil C. Munshi, Mariateresa Fulciniti
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (1): 369–377.
DOI: https://doi.org/10.1158/1078-0432.CCR-18-1776
Published: 03 January 2019
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SLC46A3 as a Potential Predictive Biomarker for Antibody–Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads

Krista Kinneer, John Meekin, Arnaud C. Tiberghien, Yu-Tzu Tai, Sandrina Phipps, Christine Mione Kiefer, Marlon C. Rebelatto, Nazzareno Dimasi, Alyssa Moriarty, Kyriakos P. Papadopoulos, Sriram Sridhar, Stephen J. Gregson, Michael J. Wick, Luke Masterson, Kenneth C. Anderson, Ronald Herbst, Philip W. Howard, David A. Tice
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (24): 6570–6582.
DOI: https://doi.org/10.1158/1078-0432.CCR-18-1300
Published: 13 December 2018
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Abstract PR13: p53-related protein kinase is a novel prognostic marker and therapeutic target in multiple myeloma

Francesca Cottini, Teru Hideshima, Yoshihisa Nozawa, Hiroto Ohguchi, Teruhiro Utsugi, Kenneth C Anderson
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (24_Supplement): PR13.
DOI: https://doi.org/10.1158/1557-3265.HEMMAL17-PR13
Published: 14 December 2017
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Ribonucleotide Reductase Catalytic Subunit M1 (RRM1) as a Novel Therapeutic Target in Multiple Myeloma

Morihiko Sagawa, Hiroto Ohguchi, Takeshi Harada, Mehmet K. Samur, Yu-Tzu Tai, Nikhil C. Munshi, Masahiro Kizaki, Teru Hideshima, Kenneth C. Anderson
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (17): 5225–5237.
DOI: https://doi.org/10.1158/1078-0432.CCR-17-0263
Published: 31 August 2017
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Blockade of Deubiquitylating Enzyme USP1 Inhibits DNA Repair and Triggers Apoptosis in Multiple Myeloma Cells

Deepika Sharma Das, Abhishek Das, Arghya Ray, Yan Song, Mehmet Kemal Samur, Nikhil C. Munshi, Dharminder Chauhan, Kenneth C. Anderson
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (15): 4280–4289.
DOI: https://doi.org/10.1158/1078-0432.CCR-16-2692
Published: 01 August 2017
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Targeting CD38 Suppresses Induction and Function of T Regulatory Cells to Mitigate Immunosuppression in Multiple Myeloma

Xiaoyan Feng, Li Zhang, Chirag Acharya, Gang An, Kenneth Wen, Lugui Qiu, Nikhil C. Munshi, Yu-Tzu Tai, Kenneth C. Anderson
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (15): 4290–4300.
DOI: https://doi.org/10.1158/1078-0432.CCR-16-3192
Published: 01 August 2017
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The Role of Minimal Residual Disease Testing in Myeloma Treatment Selection and Drug Development: Current Value and Future Applications

Kenneth C. Anderson, Daniel Auclair, Gary J. Kelloff, Caroline C. Sigman, Hervé Avet-Loiseau, Ann T. Farrell, Nicole J. Gormley, Shaji K. Kumar, Ola Landgren, Nikhil C. Munshi, Michele Cavo, Faith E. Davies, Alessandra Di Bacco, Jennifer S. Dickey, Steven I. Gutman, Howard R. Higley, Mohamad A. Hussein, J. Milburn Jessup, Ilan R. Kirsch, Richard F. Little, Robert D. Loberg, Jens G. Lohr, Lata Mukundan, James L. Omel, Trevor J. Pugh, Gregory H. Reaman, Michael D. Robbins, A. Kate Sasser, Nancy Valente, Elena Zamagni
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (15): 3980–3993.
DOI: https://doi.org/10.1158/1078-0432.CCR-16-2895
Published: 01 August 2017
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Dual NAMPT and BTK Targeting Leads to Synergistic Killing of Waldenström Macroglobulinemia Cells Regardless of MYD88 and CXCR4 Somatic Mutation Status

Michele Cea, Antonia Cagnetta, Chirag Acharya, Prakrati Acharya, Yu-Tzu Tai, Cao Yang, Davide Lovera, Debora Soncini, Maurizio Miglino, Giulio Fraternali-Orcioni, Luca Mastracci, Alessio Nencioni, Fabrizio Montecucco, Fiammetta Monacelli, Alberto Ballestrero, Teru Hideshima, Dharminder Chauhan, Marco Gobbi, Roberto M. Lemoli, Nikhil Munshi, Steven P. Treon, Kenneth C. Anderson
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (24): 6099–6109.
DOI: https://doi.org/10.1158/1078-0432.CCR-16-0630
Published: 15 December 2016
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Phase 1 Study of Tabalumab, a Human Anti-B-Cell Activating Factor Antibody, and Bortezomib in Patients with Relapsed/Refractory Multiple Myeloma

Noopur S. Raje, Edward A. Faber, Jr, Paul G. Richardson, Gary Schiller, Raymond J. Hohl, Adam D. Cohen, Andres Forero, Susan Carpenter, Tuan S. Nguyen, Ilaria Conti, Christopher J. Kaiser, Damien M. Cronier, James E. Wooldridge, Kenneth C. Anderson
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (23): 5688–5695.
DOI: https://doi.org/10.1158/1078-0432.CCR-16-0201
Published: 30 November 2016
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Progress and Paradigms in Multiple Myeloma

Kenneth C. Anderson
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (22): 5419–5427.
DOI: https://doi.org/10.1158/1078-0432.CCR-16-0625
Published: 14 November 2016
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Immune Therapies in Multiple Myeloma

Shaji K. Kumar, Kenneth C. Anderson
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (22): 5453–5460.
DOI: https://doi.org/10.1158/1078-0432.CCR-16-0868
Published: 14 November 2016
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