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Kazuko Sakai
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Journal Articles

A Randomized Phase II Study Comparing Nivolumab with Carboplatin–Pemetrexed for EGFR-Mutated NSCLC with Resistance to EGFR Tyrosine Kinase Inhibitors (WJOG8515L)

Hidetoshi Hayashi, Shunichi Sugawara, Yasushi Fukuda, Daichi Fujimoto, Satoru Miura, Keiichi Ota, Yuichi Ozawa, Satoshi Hara, Junko Tanizaki, Koichi Azuma, Shota Omori, Motoko Tachihara, Kazumi Nishino, Akihiro Bessho, Yasutaka Chiba, Koji Haratani, Kazuko Sakai, Kazuto Nishio, Nobuyuki Yamamoto, Kazuhiko Nakagawa
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (5): 893–902.
https://doi.org/10.1158/1078-0432.CCR-21-3194
Published: 01 March 2022
View article titled, A Randomized Phase II Study Comparing Nivolumab with Carboplatin–Pemetrexed for <em>EGFR</em>-Mutated NSCLC with Resistance to EGFR Tyrosine Kinase Inhibitors (WJOG8515L)
Open the PDF for A Randomized Phase II Study Comparing Nivolumab with Carboplatin–Pemetrexed for <em>EGFR</em>-Mutated NSCLC with Resistance to EGFR Tyrosine Kinase Inhibitors (WJOG8515L) in another window
Includes: Supplementary data
Journal Articles

Correction: KRAS Inhibitor Resistance in MET-Amplified KRASG12C Non–Small Cell Lung Cancer Induced By RAS- and Non–RAS-Mediated Cell Signaling Mechanisms

Shinichiro Suzuki, Kimio Yonesaka, Takeshi Teramura, Toshiyuki Takehara, Ryoji Kato, Hitomi Sakai, Koji Haratani, Junko Tanizaki, Hisato Kawakami, Hidetoshi Hayashi, Kazuko Sakai, Kazuto Nishio, Kazuhiko Nakagawa
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (2): 428.
https://doi.org/10.1158/1078-0432.CCR-21-4240
Published: 19 January 2022
View article titled, Correction: KRAS Inhibitor Resistance in <em>MET</em>-Amplified <em>KRAS</em><sup>G12C</sup> Non–Small Cell Lung Cancer Induced By RAS- and Non–RAS-Mediated Cell Signaling Mechanisms
Open the PDF for Correction: KRAS Inhibitor Resistance in <em>MET</em>-Amplified <em>KRAS</em><sup>G12C</sup> Non–Small Cell Lung Cancer Induced By RAS- and Non–RAS-Mediated Cell Signaling Mechanisms in another window
Journal Articles

HER3 Augmentation via Blockade of EGFR/AKT Signaling Enhances Anticancer Activity of HER3-Targeting Patritumab Deruxtecan in EGFR-Mutated Non–Small Cell Lung Cancer

Kimio Yonesaka, Junko Tanizaki, Osamu Maenishi, Koji Haratani, Hisato Kawakami, Kaoru Tanaka, Hidetoshi Hayashi, Kazuko Sakai, Yasutaka Chiba, Asuka Tsuya, Hiroki Goto, Eri Otsuka, Hiroaki Okida, Maki Kobayashi, Ryoto Yoshimoto, Masanori Funabashi, Yuuri Hashimoto, Kenji Hirotani, Takashi Kagari, Kazuto Nishio, Kazuhiko Nakagawa
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (2): 390–403.
https://doi.org/10.1158/1078-0432.CCR-21-3359
Published: 15 January 2022
View article titled, HER3 Augmentation via Blockade of EGFR/AKT Signaling Enhances Anticancer Activity of HER3-Targeting Patritumab Deruxtecan in EGFR-Mutated Non–Small Cell Lung Cancer
Open the PDF for HER3 Augmentation via Blockade of EGFR/AKT Signaling Enhances Anticancer Activity of HER3-Targeting Patritumab Deruxtecan in EGFR-Mutated Non–Small Cell Lung Cancer in another window
Includes: Supplementary data
Journal Articles

KRAS Inhibitor Resistance in MET-Amplified KRASG12C Non–Small Cell Lung Cancer Induced By RAS- and Non–RAS-Mediated Cell Signaling Mechanisms

Shinichiro Suzuki, Kimio Yonesaka, Takeshi Teramura, Toshiyuki Takehara, Ryoji Kato, Hitomi Sakai, Koji Haratani, Junko Tanizaki, Hisato Kawakami, Hidetoshi Hayashi, Kazuko Sakai, Kazuto Nishio, Kazuhiko Nakagawa
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (20): 5697–5707.
https://doi.org/10.1158/1078-0432.CCR-21-0856
Published: 01 October 2021
View article titled, KRAS Inhibitor Resistance in <em>MET</em>-Amplified <em>KRAS</em><sup>G12C</sup> Non–Small Cell Lung Cancer Induced By RAS- and Non–RAS-Mediated Cell Signaling Mechanisms
Open the PDF for KRAS Inhibitor Resistance in <em>MET</em>-Amplified <em>KRAS</em><sup>G12C</sup> Non–Small Cell Lung Cancer Induced By RAS- and Non–RAS-Mediated Cell Signaling Mechanisms in another window
Includes: Supplementary data
Journal Articles

B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity

Kimio Yonesaka, Koji Haratani, Shiki Takamura, Hitomi Sakai, Ryoji Kato, Naoki Takegawa, Takayuki Takahama, Kaoru Tanaka, Hidetoshi Hayashi, Masayuki Takeda, Sigeki Kato, Osamu Maenishi, Kazuko Sakai, Yasutaka Chiba, Takafumi Okabe, Keita Kudo, Yoshikazu Hasegawa, Hiroyasu Kaneda, Michiko Yamato, Kenji Hirotani, Masaaki Miyazawa, Kazuto Nishio, Kazuhiko Nakagawa
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (11): 2653–2664.
https://doi.org/10.1158/1078-0432.CCR-17-2852
Published: 31 May 2018
View article titled, B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity
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Includes: Supplementary data
Journal Articles

Functional Analyses of Mutations in Receptor Tyrosine Kinase Genes in Non–Small Cell Lung Cancer: Double-Edged Sword of DDR2

Masato Terashima, Yosuke Togashi, Katsuaki Sato, Hiroshi Mizuuchi, Kazuko Sakai, Kenichi Suda, Yu Nakamura, Eri Banno, Hidetoshi Hayashi, Marco A. De Velasco, Yoshihiko Fujita, Shuta Tomida, Tetsuya Mitsudomi, Kazuto Nishio
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (14): 3663–3671.
https://doi.org/10.1158/1078-0432.CCR-15-2093
Published: 14 July 2016
View article titled, Functional Analyses of Mutations in Receptor Tyrosine Kinase Genes in Non–Small Cell Lung Cancer: Double-Edged Sword of <em>DDR2</em>
Open the PDF for Functional Analyses of Mutations in Receptor Tyrosine Kinase Genes in Non–Small Cell Lung Cancer: Double-Edged Sword of <em>DDR2</em> in another window
Includes: Supplementary data
Journal Articles

Randomized Phase II Study of Adjuvant Chemotherapy with Long-term S-1 versus Cisplatin+S-1 in Completely Resected Stage II–IIIA Non–Small Cell Lung Cancer

Yasuo Iwamoto, Tetsuya Mitsudomi, Kazuko Sakai, Takeharu Yamanaka, Hiroshige Yoshioka, Makoto Takahama, Masahiro Yoshimura, Ichiro Yoshino, Masayuki Takeda, Shunichi Sugawara, Tomoya Kawaguchi, Toshiaki Takahashi, Mitsunori Ohta, Yukito Ichinose, Shinji Atagi, Morihito Okada, Hideo Saka, Kazuhiko Nakagawa, Yoichi Nakanishi, Kazuto Nishio
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (23): 5245–5252.
https://doi.org/10.1158/1078-0432.CCR-14-3160
Published: 30 November 2015
View article titled, Randomized Phase II Study of Adjuvant Chemotherapy with Long-term S-1 versus Cisplatin+S-1 in Completely Resected Stage II–IIIA Non–Small Cell Lung Cancer
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Journal Articles

Activation of HER Family Signaling as a Mechanism of Acquired Resistance to ALK Inhibitors in EML4-ALK–Positive Non–Small Cell Lung Cancer

Junko Tanizaki, Isamu Okamoto, Takafumi Okabe, Kazuko Sakai, Kaoru Tanaka, Hidetoshi Hayashi, Hiroyasu Kaneda, Ken Takezawa, Kiyoko Kuwata, Haruka Yamaguchi, Erina Hatashita, Kazuto Nishio, Kazuhiko Nakagawa
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (22): 6219–6226.
https://doi.org/10.1158/1078-0432.CCR-12-0392
Published: 14 November 2012
View article titled, Activation of HER Family Signaling as a Mechanism of Acquired Resistance to ALK Inhibitors in EML4-ALK–Positive Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Antitumor Activity of BIBF 1120, a Triple Angiokinase Inhibitor, and Use of VEGFR2+pTyr+ Peripheral Blood Leukocytes as a Pharmacodynamic Biomarker In Vivo

Kanae Kudo, Tokuzo Arao, Kaoru Tanaka, Tomoyuki Nagai, Kazuyuki Furuta, Kazuko Sakai, Hiroyasu Kaneda, Kazuko Matsumoto, Daisuke Tamura, Keiichi Aomatsu, Marco A. De Velasco, Yoshihiko Fujita, Nagahiro Saijo, Masatoshi Kudo, Kazuto Nishio
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (6): 1373–1381.
https://doi.org/10.1158/1078-0432.CCR-09-2755
Published: 15 March 2011
View article titled, Antitumor Activity of BIBF 1120, a Triple Angiokinase Inhibitor, and Use of VEGFR2<sup>+</sup>pTyr<sup>+</sup> Peripheral Blood Leukocytes as a Pharmacodynamic Biomarker <em>In Vivo</em>
Open the PDF for Antitumor Activity of BIBF 1120, a Triple Angiokinase Inhibitor, and Use of VEGFR2<sup>+</sup>pTyr<sup>+</sup> Peripheral Blood Leukocytes as a Pharmacodynamic Biomarker <em>In Vivo</em> in another window
Includes: Supplementary data
Journal Articles

Impact of Serum Hepatocyte Growth Factor on Treatment Response to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients with Non–Small Cell Lung Adenocarcinoma

Kazuo Kasahara, Tokuzo Arao, Kazuko Sakai, Kazuko Matsumoto, Asao Sakai, Hideharu Kimura, Takashi Sone, Atsushi Horiike, Makoto Nishio, Tatsuo Ohira, Norihiko Ikeda, Takeharu Yamanaka, Nagahiro Saijo, Kazuto Nishio
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (18): 4616–4624.
https://doi.org/10.1158/1078-0432.CCR-10-0383
Published: 14 September 2010
View article titled, Impact of Serum Hepatocyte Growth Factor on Treatment Response to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients with Non–Small Cell Lung Adenocarcinoma
Open the PDF for Impact of Serum Hepatocyte Growth Factor on Treatment Response to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients with Non–Small Cell Lung Adenocarcinoma in another window