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Kaye J. Williams
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Journal Articles

Abstract IA-006: Enhancing the therapeutic ratio for glioblastoma by combining radiation therapy with PARP inhibitors

Anthony J. Chalmers, Rodrigo Gutierrez-Quintana, David J. Walker, Karin Williams, Duncan Forster, Mark R. Jackson, Sarah Derby, Jon Stobo, Lorna Sweeting, Caroline Kelly, Stephen Durant, Kaye J. Williams
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (8_Supplement): IA-006.
https://doi.org/10.1158/1557-3265.RADSCI21-IA-006
Published: 15 April 2021
View article titled, Abstract IA-006: Enhancing the therapeutic ratio for glioblastoma by combining radiation therapy with PARP inhibitors
Journal Articles

Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer

Ahmed Salem, Ross A. Little, Ayşe Latif, Adam K. Featherstone, Muhammad Babur, Isabel Peset, Susan Cheung, Yvonne Watson, Victoria Tessyman, Hitesh Mistry, Garry Ashton, Caron Behan, Julian C. Matthews, Marie-Claude Asselin, Robert G. Bristow, Alan Jackson, Geoff J.M. Parker, Corinne Faivre-Finn, Kaye J. Williams, James P.B. O'Connor
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (13): 3818–3829.
https://doi.org/10.1158/1078-0432.CCR-18-3932
Published: 01 July 2019
View article titled, Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer
Open the PDF for Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Clinical Development of Novel Drug–Radiotherapy Combinations

Saif S. Ahmad, Marka R. Crittenden, Phuoc T. Tran, Paul G. Kluetz, Gideon M. Blumenthal, Helen Bulbeck, Richard D. Baird, Kaye J. Williams, Tim Illidge, Stephen M. Hahn, Theodore S. Lawrence, Patricia A. Spears, Amanda J. Walker, Ricky A. Sharma
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (5): 1455–1461.
https://doi.org/10.1158/1078-0432.CCR-18-2466
Published: 01 March 2019
View article titled, Clinical Development of Novel Drug–Radiotherapy Combinations
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Journal Articles

The Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase 1/2 Inhibitor AZD6244 (ARRY-142886) Enhances the Radiation Responsiveness of Lung and Colorectal Tumor Xenografts

Aoife M. Shannon, Brian A. Telfer, Paul D. Smith, Muhammed Babur, Armelle Logie, Robert W. Wilkinson, Camille Debray, Ian J. Stratford, Kaye J. Williams, Stephen R. Wedge
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (21): 6619–6629.
https://doi.org/10.1158/1078-0432.CCR-08-2958
Published: 02 November 2009
View article titled, The Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase 1/2 Inhibitor AZD6244 (ARRY-142886) Enhances the Radiation Responsiveness of Lung and Colorectal Tumor Xenografts
Open the PDF for The Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase 1/2 Inhibitor AZD6244 (ARRY-142886) Enhances the Radiation Responsiveness of Lung and Colorectal Tumor Xenografts in another window
Includes: Supplementary data
Journal Articles

Vasoactivity of AG014699, a Clinically Active Small Molecule Inhibitor of Poly(ADP-ribose) Polymerase: a Contributory Factor to Chemopotentiation In vivo?

Majid Ali, Brian A. Telfer, Cian McCrudden, Martin O'Rourke, Huw D. Thomas, Marzieh Kamjoo, Suzanne Kyle, Tracy Robson, Chris Shaw, David G. Hirst, Nicola J. Curtin, Kaye J. Williams
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (19): 6106–6112.
https://doi.org/10.1158/1078-0432.CCR-09-0398
Published: 30 September 2009
View article titled, Vasoactivity of AG014699, a Clinically Active Small Molecule Inhibitor of Poly(ADP-ribose) Polymerase: a Contributory Factor to Chemopotentiation <em>In vivo</em>?
Open the PDF for Vasoactivity of AG014699, a Clinically Active Small Molecule Inhibitor of Poly(ADP-ribose) Polymerase: a Contributory Factor to Chemopotentiation <em>In vivo</em>? in another window
Includes: Supplementary data
Journal Articles

Tirapazamine Administered as a Neoadjuvant to Radiotherapy Reduces Metastatic Dissemination

Sarah Jane Lunt, Brian A. Telfer, Richard J. Fitzmaurice, Ian J. Stratford, Kaye J. Williams
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (11): 4212–4216.
https://doi.org/10.1158/1078-0432.CCR-04-2162
Published: 01 June 2005
View article titled, Tirapazamine Administered as a Neoadjuvant to Radiotherapy Reduces Metastatic Dissemination
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Journal Articles

ZD6474, a Potent Inhibitor of Vascular Endothelial Growth Factor Signaling, Combined With Radiotherapy: Schedule-Dependent Enhancement of Antitumor Activity

Kaye J. Williams, Brian A. Telfer, Sandra Brave, Jane Kendrew, Lynsey Whittaker, Ian J. Stratford, Stephen R. Wedge
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (24): 8587–8593.
https://doi.org/10.1158/1078-0432.CCR-04-1147
Published: 28 December 2004
View article titled, ZD6474, a Potent Inhibitor of Vascular Endothelial Growth Factor Signaling, Combined With Radiotherapy: <subtitle>Schedule-Dependent Enhancement of Antitumor Activity</subtitle>
Open the PDF for ZD6474, a Potent Inhibitor of Vascular Endothelial Growth Factor Signaling, Combined With Radiotherapy: <subtitle>Schedule-Dependent Enhancement of Antitumor Activity</subtitle> in another window