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Katherine L. Nathanson
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Journal Articles

Pathogenic variants in cancer susceptibility genes predispose to Ductal Carcinoma In situ of the breast

Huaizhi Huang, Ronan E. Couch, Rachid Karam, Chunling Hu, Nicholas Boddicker, Eric C. Polley, Jie Na, Christine B. Ambrosone, Song Yao, Amy Trentham-Dietz, A. Heather Eliassen, Kathryn Penney, Kristen Brantley, Clara Bodelon, Lauren R. Teras, James Hodge, Alpa Patel, Christopher A. Haiman, Esther M. John, Susan L. Neuhausen, Elena Martinez, James V. Lacey, Katie M. O'Brien, Dale P. Sandler, Clarice R. Weinberg, Julie R. Palmer, Kimberly A. Bertrand, Celine M. Vachon, Janet E. Olson, Kathryn E. Ruddy, Hoda Anton-Culver, Argyrios Ziogas, David E. Goldgar, Katherine L. Nathanson, Susan M. Domchek, Jeffrey N. Weitzel, Peter Kraft, Jill S. Dolinsky, Tina Pesaran, Marcy E. Richardson, Siddhartha Yadav, Fergus J. Couch
Journal: Clinical Cancer Research
Clin Cancer Res (2024)
https://doi.org/10.1158/1078-0432.CCR-24-1884
Published: 08 November 2024
View article titled, Pathogenic variants in cancer susceptibility genes predispose to Ductal Carcinoma <em>In situ</em> of the breast
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Includes: Supplementary data
Journal Articles

NBN Pathogenic Germline Variants are Associated with Pan-Cancer Susceptibility and In Vitro DNA Damage Response Defects

Sami Belhadj, Aliya Khurram, Chaitanya Bandlamudi, Guillermo Palou-Márquez, Vignesh Ravichandran, Zoe Steinsnyder, Temima Wildman, Amanda Catchings, Yelena Kemel, Semanti Mukherjee, Benjamin Fesko, Kanika Arora, Miika Mehine, Sita Dandiker, Aalin Izhar, John Petrini, Susan Domchek, Katherine L. Nathanson, Jamie Brower, Fergus Couch, Zsofia Stadler, Mark Robson, Michael Walsh, Joseph Vijai, Michael Berger, Fran Supek, Rachid Karam, Sabine Topka, Kenneth Offit
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (2): 422–431.
https://doi.org/10.1158/1078-0432.CCR-22-1703
Published: 17 January 2023
View article titled, <em>NBN</em> Pathogenic Germline Variants are Associated with Pan-Cancer Susceptibility and <em>In Vitro</em> DNA Damage Response Defects
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Includes: Supplementary data
Journal Articles

Genomic Signatures Predict the Immunogenicity of BRCA-Deficient Breast Cancer

Adam A. Kraya, Kara N. Maxwell, Bradley Wubbenhorst, Brandon M. Wenz, John Pluta, Andrew J. Rech, Liza M. Dorfman, Nicole Lunceford, Amanda Barrett, Nandita Mitra, Jennifer J.D. Morrissette, Michael Feldman, Anupma Nayak, Susan M. Domchek, Robert H. Vonderheide, Katherine L. Nathanson
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (14): 4363–4374.
https://doi.org/10.1158/1078-0432.CCR-18-0468
Published: 15 July 2019
View article titled, Genomic Signatures Predict the Immunogenicity of BRCA-Deficient Breast Cancer
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Includes: Supplementary data
Journal Articles

Cancer Screening Recommendations and Clinical Management of Inherited Gastrointestinal Cancer Syndromes in Childhood

Maria Isabel Achatz, Christopher C. Porter, Laurence Brugières, Harriet Druker, Thierry Frebourg, William D. Foulkes, Christian P. Kratz, Roland P. Kuiper, Jordan R. Hansford, Hector Salvador Hernandez, Katherine L. Nathanson, Wendy K. Kohlmann, Leslie Doros, Kenan Onel, Kami Wolfe Schneider, Sarah R. Scollon, Uri Tabori, Gail E. Tomlinson, D. Gareth R. Evans, Sharon E. Plon
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (13): e107–e114.
https://doi.org/10.1158/1078-0432.CCR-17-0790
Published: 02 July 2017
View article titled, Cancer Screening Recommendations and Clinical Management of Inherited Gastrointestinal Cancer Syndromes in Childhood
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Journal Articles

Multiple Endocrine Neoplasia and Hyperparathyroid-Jaw Tumor Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood

Jonathan D. Wasserman, Gail E. Tomlinson, Harriet Druker, Junne Kamihara, Wendy K. Kohlmann, Christian P. Kratz, Katherine L. Nathanson, Kristian W. Pajtler, Andreu Parareda, Surya P. Rednam, Lisa J. States, Anita Villani, Michael F. Walsh, Kristin Zelley, Joshua D. Schiffman
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (13): e123–e132.
https://doi.org/10.1158/1078-0432.CCR-17-0548
Published: 02 July 2017
View article titled, Multiple Endocrine Neoplasia and Hyperparathyroid-Jaw Tumor Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood
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Journal Articles

Von Hippel–Lindau and Hereditary Pheochromocytoma/Paraganglioma Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood

Surya P. Rednam, Ayelet Erez, Harriet Druker, Katherine A. Janeway, Junne Kamihara, Wendy K. Kohlmann, Katherine L. Nathanson, Lisa J. States, Gail E. Tomlinson, Anita Villani, Stephan D. Voss, Joshua D. Schiffman, Jonathan D. Wasserman
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (12): e68–e75.
https://doi.org/10.1158/1078-0432.CCR-17-0547
Published: 14 June 2017
View article titled, Von Hippel–Lindau and Hereditary Pheochromocytoma/Paraganglioma Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood
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Includes: Supplementary data
Journal Articles

Recommendations for Cancer Surveillance in Individuals with RASopathies and Other Rare Genetic Conditions with Increased Cancer Risk

Anita Villani, Mary-Louise C. Greer, Jennifer M. Kalish, Akira Nakagawara, Katherine L. Nathanson, Kristian W. Pajtler, Stefan M. Pfister, Michael F. Walsh, Jonathan D. Wasserman, Kristin Zelley, Christian P. Kratz
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (12): e83–e90.
https://doi.org/10.1158/1078-0432.CCR-17-0631
Published: 14 June 2017
View article titled, Recommendations for Cancer Surveillance in Individuals with RASopathies and Other Rare Genetic Conditions with Increased Cancer Risk
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Journal Articles

Abstract A01: A comprehensive collection of patient derived xenografts of human melanoma with clinical, genomic, and biological characterization

Clemens Krepler, Katrin Sproesser, Marilda Beqiri, Min Xiao, Patricia Brafford, Wei Xu, Bradley Garman, Jennifer Wargo, Michael A. Davies, Dennie T. Frederick, Keith T. Flaherty, David Hoon, Joseph J. Bennett, Michael Guarino, Nicholas J. Petrelli, David Elder, Xiaowei Xu, Giorgos Karakousis, KATHERINE L. NATHANSON, Lynn Schuchter, Meenhard Herlyn
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16_Supplement): A01.
https://doi.org/10.1158/1557-3265.PDX16-A01
Published: 15 August 2016
View article titled, Abstract A01: A comprehensive collection of patient derived xenografts of human melanoma with clinical, genomic, and biological characterization
Journal Articles

Personalized Preclinical Trials in BRAF Inhibitor–Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies

Clemens Krepler, Min Xiao, Katrin Sproesser, Patricia A. Brafford, Batool Shannan, Marilda Beqiri, Qin Liu, Wei Xu, Bradley Garman, Katherine L. Nathanson, Xiaowei Xu, Giorgos C. Karakousis, Gordon B. Mills, Yiling Lu, Tamer A. Ahmed, Poulikos I. Poulikakos, Giordano Caponigro, Markus Boehm, Malte Peters, Lynn M. Schuchter, Ashani T. Weeraratna, Meenhard Herlyn
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (7): 1592–1602.
https://doi.org/10.1158/1078-0432.CCR-15-1762
Published: 31 March 2016
View article titled, Personalized Preclinical Trials in BRAF Inhibitor–Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies
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Includes: Supplementary data
Journal Articles

Copy Number Changes Are Associated with Response to Treatment with Carboplatin, Paclitaxel, and Sorafenib in Melanoma

Melissa A. Wilson, Fengmin Zhao, Sanika Khare, Jason Roszik, Scott E. Woodman, Kurt D'Andrea, Bradley Wubbenhorst, David L. Rimm, John M. Kirkwood, Harriet M. Kluger, Lynn M. Schuchter, Sandra J. Lee, Keith T. Flaherty, Katherine L. Nathanson
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (2): 374–382.
https://doi.org/10.1158/1078-0432.CCR-15-1162
Published: 14 January 2016
View article titled, Copy Number Changes Are Associated with Response to Treatment with Carboplatin, Paclitaxel, and Sorafenib in Melanoma
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Includes: Supplementary data
Journal Articles

Multiple Gastrointestinal Polyps in Patients Treated with BRAF Inhibitors

Ravi K. Amaravadi, Kathryn E. Hamilton, Xiaohong Ma, Shengfu Piao, Armando Del Portillo, Katherine L. Nathanson, Matteo S. Carlino, Georgina V. Long, Igor Puzanov, Xiaowei Xu, Jennifer J.D. Morrissette, Kenneth Y. Tsai, Keith T. Flaherty, Jeffrey A. Sosman, Grant R. Goodman, Grant A. McArthur, Anil K. Rustgi, David C. Metz, Lynn M. Schuchter, Paul B. Chapman, Antonia R. Sepulveda
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (23): 5215–5221.
https://doi.org/10.1158/1078-0432.CCR-15-0469
Published: 30 November 2015
View article titled, Multiple Gastrointestinal Polyps in Patients Treated with BRAF Inhibitors
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Includes: Supplementary data
Journal Articles

Molecular Profiling of Patient-Matched Brain and Extracranial Melanoma Metastases Implicates the PI3K Pathway as a Therapeutic Target

Guo Chen, Nitin Chakravarti, Kimberly Aardalen, Alexander J. Lazar, Michael T. Tetzlaff, Bradley Wubbenhorst, Sang-Bae Kim, Scott Kopetz, Alicia A. Ledoux, Y.N. Vashisht Gopal, Cristiano Goncalves Pereira, Wanleng Deng, Ju-Seog Lee, Katherine L. Nathanson, Kenneth D. Aldape, Victor G. Prieto, Darrin Stuart, Michael A. Davies
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (21): 5537–5546.
https://doi.org/10.1158/1078-0432.CCR-13-3003
Published: 30 October 2014
View article titled, Molecular Profiling of Patient-Matched Brain and Extracranial Melanoma Metastases Implicates the PI3K Pathway as a Therapeutic Target
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Includes: Supplementary data
Journal Articles

Correlation of Somatic Mutations and Clinical Outcome in Melanoma Patients Treated with Carboplatin, Paclitaxel, and Sorafenib

Melissa A. Wilson, Fengmin Zhao, Richard Letrero, Kurt D'Andrea, David L. Rimm, John M. Kirkwood, Harriet M. Kluger, Sandra J. Lee, Lynn M. Schuchter, Keith T. Flaherty, Katherine L. Nathanson
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (12): 3328–3337.
https://doi.org/10.1158/1078-0432.CCR-14-0093
Published: 12 June 2014
View article titled, Correlation of Somatic Mutations and Clinical Outcome in Melanoma Patients Treated with Carboplatin, Paclitaxel, and Sorafenib
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Includes: Supplementary data
Journal Articles

Tumor Genetic Analyses of Patients with Metastatic Melanoma Treated with the BRAF Inhibitor Dabrafenib (GSK2118436)

Katherine L. Nathanson, Anne-Marie Martin, Bradley Wubbenhorst, Joel Greshock, Richard Letrero, Kurt D'Andrea, Steven O'Day, Jeffrey R. Infante, Gerald S. Falchook, Hendrik-Tobias Arkenau, Michael Millward, Michael P. Brown, Anna Pavlick, Michael A. Davies, Bo Ma, Robert Gagnon, Martin Curtis, Peter F. Lebowitz, Richard Kefford, Georgina V. Long
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (17): 4868–4878.
https://doi.org/10.1158/1078-0432.CCR-13-0827
Published: 02 September 2013
View article titled, Tumor Genetic Analyses of Patients with Metastatic Melanoma Treated with the BRAF Inhibitor Dabrafenib (GSK2118436)
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Includes: Supplementary data
Journal Articles

The Novel SMAC Mimetic Birinapant Exhibits Potent Activity against Human Melanoma Cells

Clemens Krepler, Srinivas K. Chunduru, Molly B. Halloran, Xu He, Min Xiao, Adina Vultur, Jessie Villanueva, Yasuhiro Mitsuuchi, Eric M. Neiman, Christopher Benetatos, Katherine L. Nathanson, Ravi K. Amaravadi, Hubert Pehamberger, Mark McKinlay, Meenhard Herlyn
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (7): 1784–1794.
https://doi.org/10.1158/1078-0432.CCR-12-2518
Published: 02 April 2013
View article titled, The Novel SMAC Mimetic Birinapant Exhibits Potent Activity against Human Melanoma Cells
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Includes: Supplementary data
Journal Articles

The Role of KRAS rs61764370 in Invasive Epithelial Ovarian Cancer: Implications for Clinical Testing

Paul D. P. Pharoah, Rachel T. Palmieri, Susan J. Ramus, Simon A. Gayther, Irene L. Andrulis, Hoda Anton-Culver, Natalia Antonenkova, Antonis C. Antoniou, David Goldgar, Mary S. Beattie, Matthias W. Beckmann, Michael J. Birrer, Natalia Bogdanova, Kelly L. Bolton, Wendy Brewster, Angela Brooks-Wilson, Robert Brown, Ralf Butzow, Trinidad Caldes, Maria Adelaide Caligo, Ian Campbell, Jenny Chang-Claude, Y. Ann Chen, Linda S. Cook, Fergus J. Couch, Daniel W. Cramer, Julie M. Cunningham, Evelyn Despierre, Jennifer A. Doherty, Thilo Dörk, Matthias Dürst, Diana M. Eccles, Arif B. Ekici, Douglas Easton, Peter A. Fasching, Anna de Fazio, David A. Fenstermacher, James M. Flanagan, Brooke L. Fridley, Eitan Friedman, Bo Gao, Olga Sinilnikova, Aleksandra Gentry-Maharaj, Andrew K. Godwin, Ellen L. Goode, Marc T. Goodman, Jenny Gross, Thomas V. O. Hansen, Paul Harnett, Matti Rookus, Tuomas Heikkinen, Rebecca Hein, Claus Høgdall, Estrid Høgdall, Edwin S. Iversen, Anna Jakubowska, Sharon E. Johnatty, Beth Y. Karlan, Noah D. Kauff, Stanley B. Kaye, Georgia Chenevix-Trench, Linda E. Kelemen, Lambertus A. Kiemeney, Susanne Krüger Kjaer, Diether Lambrechts, James P. LaPolla, Conxi Lázaro, Nhu D. Le, Arto Leminen, Karin Leunen, Douglas A. Levine, Yi Lu, Lene Lundvall, Stuart Macgregor, Tamara Marees, Leon F. Massuger, John R. McLaughlin, Usha Menon, Marco Montagna, Kirsten B. Moysich, Steven A. Narod, Katherine L. Nathanson, Lotte Nedergaard, Roberta B. Ness, Heli Nevanlinna, Stefan Nickels, Ana Osorio, Jim Paul, Celeste Leigh Pearce, Catherine M. Phelan, Malcolm C. Pike, Paolo Radice, Mary Anne Rossing, Joellen M. Schildkraut, Thomas A. Sellers, Christian F. Singer, Honglin Song, Daniel O. Stram, Rebecca Sutphen, Annika Lindblom, Kathryn L. Terry, Ya-Yu Tsai, Anne M. van Altena, Ignace Vergote, Robert A. Vierkant, Allison F. Vitonis, Christine Walsh, Shan Wang-Gohrke, Barbara Wappenschmidt, Anna H. Wu, Argyrios Ziogas, Andrew Berchuck, Harvey A. Risch
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (11): 3742–3750.
https://doi.org/10.1158/1078-0432.CCR-10-3405
Published: 01 June 2011
View article titled, The Role of <em>KRAS</em> rs61764370 in Invasive Epithelial Ovarian Cancer: Implications for Clinical Testing
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Journal Articles

Measurements of Tumor Cell Autophagy Predict Invasiveness, Resistance to Chemotherapy, and Survival in Melanoma

Xiao-Hong Ma, Shengfu Piao, Dan Wang, Quentin W. Mcafee, Katherine L. Nathanson, Julian J. Lum, Lin Z. Li, Ravi K. Amaravadi
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (10): 3478–3489.
https://doi.org/10.1158/1078-0432.CCR-10-2372
Published: 15 May 2011
View article titled, Measurements of Tumor Cell Autophagy Predict Invasiveness, Resistance to Chemotherapy, and Survival in Melanoma
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Includes: Supplementary data
Journal Articles

Phase II Trial of Temozolomide and Sorafenib in Advanced Melanoma Patients with or without Brain Metastases

Ravi K. Amaravadi, Lynn M. Schuchter, David F. McDermott, Amy Kramer, Lydia Giles, Kristi Gramlich, Mary Carberry, Andrea B. Troxel, Richard Letrero, Katherine L. Nathanson, Michael B. Atkins, Peter J. O'Dwyer, Keith T. Flaherty
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (24): 7711–7718.
https://doi.org/10.1158/1078-0432.CCR-09-2074
Published: 14 December 2009
View article titled, Phase II Trial of Temozolomide and Sorafenib in Advanced Melanoma Patients with or without Brain Metastases
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Journal Articles

Expression of Sorafenib Targets in Melanoma Patients Treated with Carboplatin, Paclitaxel and Sorafenib

Lucia Jilaveanu, Christopher Zito, Sandra J. Lee, Katherine L. Nathanson, Robert L. Camp, David L. Rimm, Keith T. Flaherty, Harriet M. Kluger
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (3): 1076–1085.
https://doi.org/10.1158/1078-0432.CCR-08-2280
Published: 02 February 2009
View article titled, Expression of Sorafenib Targets in Melanoma Patients Treated with Carboplatin, Paclitaxel and Sorafenib
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Includes: Supplementary data
Journal Articles

The Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibitor AZD6244 (ARRY-142886) Induces Growth Arrest in Melanoma Cells and Tumor Regression When Combined with Docetaxel

Nikolas K. Haass, Katrin Sproesser, Thiennga K. Nguyen, Rooha Contractor, C. Angelica Medina, Katherine L. Nathanson, Meenhard Herlyn, Keiran S.M. Smalley
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (1): 230–239.
https://doi.org/10.1158/1078-0432.CCR-07-1440
Published: 02 January 2008
View article titled, The Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibitor AZD6244 (ARRY-142886) Induces Growth Arrest in Melanoma Cells and Tumor Regression When Combined with Docetaxel
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Includes: Supplementary data