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Karen H. Lu
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Journal Articles

Long-Term Follow-up of Levonorgestrel Intrauterine Device for Atypical Hyperplasia and Early Endometrial Cancer Reveals Relapse Characterized by Immune Exhaustion

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Mikayla B. Bowen, Brenda Melendez, Qian Zhang, Richard K. Yang, Bryan M. Fellman, Barrett C. Lawson, Naomi N. Adjei, Joseph Celestino, Khalida M. Wani, Bhavana Singh, Diana L. Urbauer, Alexander J. Lazar, Karen H. Lu, Jennifer A. Wargo, Shannon N. Westin, Melinda S. Yates
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (22): 5073–5082.
https://doi.org/10.1158/1078-0432.CCR-24-0362
Published: 15 November 2024
View articletitled, Long-Term Follow-up of Levonorgestrel Intrauterine Device for Atypical Hyperplasia and Early Endometrial Cancer Reveals Relapse Characterized by Immune Exhaustion
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Includes: Supplementary data
Journal Articles

Clinical and Genomic Landscape of RAS Mutations in Gynecologic Cancers

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Ji Son, Yingao Zhang, Heather Lin, Oriol Mirallas, Pablo Alvarez Ballesteros, Mirella Nardo, Natalie Clark, R. Tyler Hillman, Erick Campbell, Vijaykumar Holla, Amber M. Johnson, Amadeo B. Biter, Ying Yuan, Lauren P. Cobb, David M. Gershenson, Amir A. Jazaeri, Karen H. Lu, Pamela T. Soliman, Shannon N. Westin, Elizabeth D. Euscher, Barrett C. Lawson, Richard K. Yang, Funda Meric-Bernstam, David S. Hong
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (14): 2986–2995.
https://doi.org/10.1158/1078-0432.CCR-23-2819
Published: 15 July 2024
View articletitled, Clinical and Genomic Landscape of RAS Mutations in Gynecologic Cancers
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Includes: Supplementary data
Journal Articles

Phase Ib Dose Expansion and Translational Analyses of Olaparib in Combination with Capivasertib in Recurrent Endometrial, Triple-Negative Breast, and Ovarian Cancer

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Shannon N. Westin, Marilyne Labrie, Jennifer K. Litton, Aurora Blucher, Yong Fang, Christopher P. Vellano, Joseph R. Marszalek, Ningping Feng, XiaoYan Ma, Allison Creason, Bryan Fellman, Ying Yuan, Sanghoon Lee, Tae-Beom Kim, Jinsong Liu, Anca Chelariu-Raicu, Tsun Hsuan Chen, Nashwa Kabil, Pamela T. Soliman, Michael Frumovitz, Katheleen M. Schmeler, Amir Jazaeri, Karen H. Lu, Rashmi Murthy, Larissa A. Meyer, Charlotte C. Sun, Anil K. Sood, Robert L. Coleman, Gordon B. Mills
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (23): 6354–6365.
https://doi.org/10.1158/1078-0432.CCR-21-1656
Published: 01 December 2021
View articletitled, Phase Ib Dose Expansion and Translational Analyses of Olaparib in Combination with Capivasertib in Recurrent Endometrial, Triple-Negative Breast, and Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Abstract PO011: Spatial immune cell and transcriptome profiling uncover differential cellular and molecular signatures in primary and metastatic tumor sites in patients with advanced uterine serous cancer

Free
Li Zhang, Angela Rynne-Vidal, Karen H. Lu, Samuel C. Mok
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (3_Supplement): PO011.
https://doi.org/10.1158/1557-3265.ENDOMET20-PO011
Published: 01 February 2021
View articletitled, Abstract PO011: Spatial immune cell and transcriptome profiling uncover differential cellular and molecular signatures in primary and metastatic tumor sites in patients with advanced uterine serous cancer
Journal Articles

Abstract PO049: Compartment-specific profiling for evaluation of disrupted signaling in early stage, low-grade endometrial cancer

Free
Qian Zhang, Xiaoping Su, Joseph Celestino, Ying Yuan, Samuel C. Mok, Karen H. Lu, Melinda S. Yates
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (3_Supplement): PO049.
https://doi.org/10.1158/1557-3265.ENDOMET20-PO049
Published: 01 February 2021
View articletitled, Abstract PO049: Compartment-specific profiling for evaluation of disrupted signaling in early stage, low-grade endometrial cancer
Journal Articles

Abstract PO015: The impact of the tumor immune microenvironment on response to pembrolizumab in patients with microsatellite instability-high endometrial cancer

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Jeffrey A. How, Minghao Dao, Elizabeth Euscher, Melinda Yates, Weiyi Peng, Shrina D. Patel, Karen H. Lu, Patrick Hwu, Linghua Wang, Amir A. Jazaeri
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (3_Supplement): PO015.
https://doi.org/10.1158/1557-3265.ENDOMET20-PO015
Published: 01 February 2021
View articletitled, Abstract PO015: The impact of the tumor immune microenvironment on response to pembrolizumab in patients with microsatellite instability-high endometrial cancer
Journal Articles

Abstract IA11: Women at high risk for ovarian cancer: Novel strategies for identification and prevention

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Karen H. Lu
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13_Supplement): IA11.
https://doi.org/10.1158/1557-3265.OVCA19-IA11
Published: 01 July 2020
View articletitled, Abstract IA11: Women at high risk for ovarian cancer: Novel strategies for identification and prevention
Journal Articles

Abstract B43: A serum protein biomarker signature for the detection of early stages of ovarian cancer

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Amy P. Skubitz, Kristin L. Boylan, Timothy K. Starr, Xuan Pu, Qing Cao, Kate Geschwind, Robert C. Bast, Jr., Karen H. Lu, Joseph Celestino, Ashley J. Petersen
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13_Supplement): B43.
https://doi.org/10.1158/1557-3265.OVCA19-B43
Published: 01 July 2020
View articletitled, Abstract B43: A serum protein biomarker signature for the detection of early stages of ovarian cancer
Journal Articles

Everolimus, Letrozole, and Metformin in Women with Advanced or Recurrent Endometrioid Endometrial Cancer: A Multi-Center, Single Arm, Phase II Study

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Pamela T. Soliman, Shannon N. Westin, David A. Iglesias, Bryan M. Fellman, Ying Yuan, Qian Zhang, Melinda S. Yates, Russell R. Broaddus, Brian M. Slomovitz, Karen H. Lu, Robert L. Coleman
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (3): 581–587.
https://doi.org/10.1158/1078-0432.CCR-19-0471
Published: 03 February 2020
View articletitled, Everolimus, Letrozole, and Metformin in Women with Advanced or Recurrent Endometrioid Endometrial Cancer: A Multi-Center, Single Arm, Phase II Study
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Includes: Supplementary data
Journal Articles

Abstract AP08: DEVELOPMENT OF A MULTI-PROTEIN CLASSIFIER FOR OVARIAN CANCER DETECTION BY SIMULTANEOUS MEASUREMENT OF 92 SERUM PROTEINS ON PROSEEK MULTIPLEX ONCOLOGY II PLATES

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Amy P.N. Skubitz, Kristin L.M. Boylan, Kate Geschwind, Qing Cao, Timothy K. Starr, Melissa A. Geller, Joseph Celestino, Robert C. Bast, Jr., Karen H. Lu, Joseph S. Koopmeiners
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (22_Supplement): AP08.
https://doi.org/10.1158/1557-3265.OVCASYMP18-AP08
Published: 15 November 2019
View articletitled, Abstract AP08: DEVELOPMENT OF A MULTI-PROTEIN CLASSIFIER FOR OVARIAN CANCER DETECTION BY SIMULTANEOUS MEASUREMENT OF 92 SERUM PROTEINS ON PROSEEK MULTIPLEX ONCOLOGY II PLATES
Journal Articles

Abstract B20: Simultaneous measurement of 92 serum protein biomarkers for the development of a multiprotein classifier for ovarian cancer detection

Free
Amy P.N. Skubitz, Kristin L.M. Boylan, Kate Geschwind, Qing Cao, Timothy K. Starr, Melissa A. Geller, Robert C. Bast, Jr., Karen H. Lu, Joseph S. Koopmeiners
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (15_Supplement): B20.
https://doi.org/10.1158/1557-3265.OVCA17-B20
Published: 01 August 2018
View articletitled, Abstract B20: Simultaneous measurement of 92 serum protein biomarkers for the development of a multiprotein classifier for ovarian cancer detection
Journal Articles

Elevation of TP53 Autoantibody Before CA125 in Preclinical Invasive Epithelial Ovarian Cancer

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Wei-Lei Yang, Aleksandra Gentry-Maharaj, Archana Simmons, Andy Ryan, Evangelia Ourania Fourkala, Zhen Lu, Keith A. Baggerly, Yang Zhao, Karen H. Lu, David Bowtell, Ian Jacobs, Steven J. Skates, Wei-Wu He, Usha Menon, Robert C. Bast, Jr
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (19): 5912–5922.
https://doi.org/10.1158/1078-0432.CCR-17-0284
Published: 01 October 2017
View articletitled, Elevation of TP53 Autoantibody Before CA125 in Preclinical Invasive Epithelial Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Immune Microenvironment in Microsatellite-Instable Endometrial Cancers: Hereditary or Sporadic Origin Matters

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Janelle B. Pakish, Qian Zhang, Zhongyuan Chen, Han Liang, Gary B. Chisholm, Ying Yuan, Samuel C. Mok, Russell R. Broaddus, Karen H. Lu, Melinda S. Yates
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (15): 4473–4481.
https://doi.org/10.1158/1078-0432.CCR-16-2655
Published: 01 August 2017
View articletitled, Immune Microenvironment in Microsatellite-Instable Endometrial Cancers: Hereditary or Sporadic Origin Matters
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Includes: Supplementary data
Journal Articles

Early Detection of Ovarian Cancer using the Risk of Ovarian Cancer Algorithm with Frequent CA125 Testing in Women at Increased Familial Risk – Combined Results from Two Screening Trials

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Steven J. Skates, Mark H. Greene, Saundra S. Buys, Phuong L. Mai, Powel Brown, Marion Piedmonte, Gustavo Rodriguez, John O. Schorge, Mark Sherman, Mary B. Daly, Thomas Rutherford, Wendy R. Brewster, David M. O'Malley, Edward Partridge, John Boggess, Charles W. Drescher, Claudine Isaacs, Andrew Berchuck, Susan Domchek, Susan A. Davidson, Robert Edwards, Steven A. Elg, Katie Wakeley, Kelly-Anne Phillips, Deborah Armstrong, Ira Horowitz, Carol J. Fabian, Joan Walker, Patrick M. Sluss, William Welch, Lori Minasian, Nora K. Horick, Carol H. Kasten, Susan Nayfield, David Alberts, Dianne M. Finkelstein, Karen H. Lu
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (14): 3628–3637.
https://doi.org/10.1158/1078-0432.CCR-15-2750
Published: 13 July 2017
View articletitled, Early Detection of Ovarian Cancer using the Risk of Ovarian Cancer Algorithm with Frequent CA125 Testing in Women at Increased Familial Risk – Combined Results from Two Screening Trials
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Includes: Supplementary data
Journal Articles

Abstract B73: Human omental-derived adipose stem cells: Modulator of ovarian cancer proliferation, migration and chemoresistance

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Aleksandra Nowicka, Travis Solley, Frank C. Marini, Hadley J. Sharp, Russell R. Broaddus, Kolonin G. Mikhail, Samuel C. Mok, Wendy A. Woodward, Karen H. Lu, Ann H. Klopp
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (19_Supplement): B73.
https://doi.org/10.1158/1078-0432.OVCA13-B73
Published: 13 May 2014
View articletitled, Abstract B73: Human omental-derived adipose stem cells: Modulator of ovarian cancer proliferation, migration and chemoresistance
Journal Articles

Loss of Tuberous Sclerosis Complex-2 Function and Activation of Mammalian Target of Rapamycin Signaling in Endometrial Carcinoma

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Karen H. Lu, Weiguo Wu, Bhuvanesh Dave, Brian M. Slomovitz, Thomas W. Burke, Mark F. Munsell, Russell R. Broaddus, Cheryl Lyn Walker
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (9): 2543–2550.
https://doi.org/10.1158/1078-0432.CCR-07-0321
Published: 01 May 2008
View articletitled, Loss of Tuberous Sclerosis Complex-2 Function and Activation of Mammalian Target of Rapamycin Signaling in Endometrial Carcinoma
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Includes: Supplementary data
Journal Articles

Progress in Chemoprevention Drug Development: The Promise of Molecular Biomarkers for Prevention of Intraepithelial Neoplasia and Cancer—A Plan to Move Forward

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Gary J. Kelloff, Scott M. Lippman, Andrew J. Dannenberg, Caroline C. Sigman, Homer L. Pearce, Brian J. Reid, Eva Szabo, V. Craig Jordan, Margaret R. Spitz, Gordon B. Mills, Vali A. Papadimitrakopoulou, Reuben Lotan, Bharat B. Aggarwal, Robert S. Bresalier, Jeri Kim, Banu Arun, Karen H. Lu, Melanie E. Thomas, Helen E. Rhodes, Molly A. Brewer, Michele Follen, Dong M. Shin, Howard L. Parnes, Jill M. Siegfried, Alison A. Evans, William J. Blot, Wong-Ho Chow, Patricia L. Blount, Carlo C. Maley, Kenneth K. Wang, Stephen Lam, J. Jack Lee, Steven M. Dubinett, Paul F. Engstrom, Frank L. Meyskens, Jr., Joyce O'Shaughnessy, Ernest T. Hawk, Bernard Levin, William G. Nelson, Waun Ki Hong, for the AACR Task Force on Cancer Prevention
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (12): 3661–3697.
https://doi.org/10.1158/1078-0432.CCR-06-1104
Published: 15 June 2006
View articletitled, Progress in Chemoprevention Drug Development: The Promise of Molecular Biomarkers for Prevention of Intraepithelial Neoplasia and Cancer—A Plan to Move Forward
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Journal Articles

Patterns of Gene Expression in Different Histotypes of Epithelial Ovarian Cancer Correlate with Those in Normal Fallopian Tube, Endometrium, and Colon

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Rebecca T. Marquez, Keith A. Baggerly, Andrea P. Patterson, Jinsong Liu, Russell Broaddus, Michael Frumovitz, Edward N. Atkinson, David I. Smith, Lynn Hartmann, David Fishman, Andrew Berchuck, Regina Whitaker, David M. Gershenson, Gordon B. Mills, Robert C. Bast, Jr., Karen H. Lu
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (17): 6116–6126.
https://doi.org/10.1158/1078-0432.CCR-04-2509
Published: 06 September 2005
View articletitled, Patterns of Gene Expression in Different Histotypes of Epithelial Ovarian Cancer Correlate with Those in Normal Fallopian Tube, Endometrium, and Colon
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Journal Articles

Methylation and Messenger RNA Expression of p15INK4b but Not p16INK4a Are Independent Risk Factors for Ovarian Cancer

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Zhensheng Liu, Li-E Wang, Luo Wang, Karen H. Lu, Gordon B. Mills, Melissa L. Bondy, Qingyi Wei
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (13): 4968–4976.
https://doi.org/10.1158/1078-0432.CCR-04-2293
Published: 06 July 2005
View articletitled, Methylation and Messenger RNA Expression of p15INK4b but Not p16INK4a Are Independent Risk Factors for Ovarian Cancer
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Journal Articles

Gene Expression Profiles Predict Early Relapse in Ovarian Cancer after Platinum-Paclitaxel Chemotherapy

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Lynn C. Hartmann, Karen H. Lu, Gerald P. Linette, William A. Cliby, Kimberly R. Kalli, David Gershenson, Robert C. Bast, James Stec, Natalia Iartchouk, David I. Smith, Jeffrey S. Ross, Sebastian Hoersch, Viji Shridhar, James Lillie, Scott H. Kaufmann, Edwin A. Clark, Andrew I. Damokosh
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (6): 2149–2155.
https://doi.org/10.1158/1078-0432.CCR-04-1673
Published: 23 March 2005
View articletitled, Gene Expression Profiles Predict Early Relapse in Ovarian Cancer after Platinum-Paclitaxel Chemotherapy
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