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Karel Pacak
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Journal Articles

A Phase II Trial of Guadecitabine in Children and Adults with SDH-Deficient GIST, Pheochromocytoma, Paraganglioma, and HLRCC-Associated Renal Cell Carcinoma

John A. Ligon, R. Taylor Sundby, Mary F. Wedekind, Fernanda I. Arnaldez, Jaydira Del Rivero, Lori Wiener, Ramaprasad Srinivasan, Melissa Spencer, Amanda Carbonell, Haiyan Lei, John Shern, Seth M. Steinberg, William D. Figg, Cody J. Peer, Sara Zimmerman, Josquin Moraly, Xia Xu, Stephen Fox, King Chan, Michael I. Barbato, Thorkell Andresson, Naomi Taylor, Karel Pacak, J. Keith Killian, Eva Dombi, W. Marston Linehan, Markku Miettinen, Richard Piekarz, Lee J. Helman, Paul Meltzer, Brigitte Widemann, John Glod
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (2): 341–348.
https://doi.org/10.1158/1078-0432.CCR-22-2168
Published: 17 January 2023
View article titled, A Phase II Trial of Guadecitabine in Children and Adults with SDH-Deficient GIST, Pheochromocytoma, Paraganglioma, and HLRCC-Associated Renal Cell Carcinoma
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Includes: Supplementary data
Journal Articles

High-Specific-Activity-131I-MIBG versus 177Lu-DOTATATE Targeted Radionuclide Therapy for Metastatic Pheochromocytoma and Paraganglioma

Abhishek Jha, David Taïeb, Jorge A. Carrasquillo, Daniel A. Pryma, Mayank Patel, Corina Millo, Wouter W. de Herder, Jaydira Del Rivero, Joakim Crona, Barry L. Shulkin, Irene Virgolini, Alice P. Chen, Bhagwant R. Mittal, Sandip Basu, Joseph S. Dillon, Thomas A. Hope, Carina Mari Aparici, Andrei H. Iagaru, Rodney J. Hicks, Anca M. Avram, Jonathan R. Strosberg, Ali Cahid Civelek, Frank I. Lin, Neeta Pandit-Taskar, Karel Pacak
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (11): 2989–2995.
https://doi.org/10.1158/1078-0432.CCR-20-3703
Published: 01 June 2021
View article titled, High-Specific-Activity-<sup>131</sup>I-MIBG versus <sup>177</sup>Lu-DOTATATE Targeted Radionuclide Therapy for Metastatic Pheochromocytoma and Paraganglioma
Open the PDF for High-Specific-Activity-<sup>131</sup>I-MIBG versus <sup>177</sup>Lu-DOTATATE Targeted Radionuclide Therapy for Metastatic Pheochromocytoma and Paraganglioma in another window
Journal Articles

Therapeutic Targeting of SDHB-Mutated Pheochromocytoma/Paraganglioma with Pharmacologic Ascorbic Acid

Yang Liu, Ying Pang, Boqun Zhu, Ondrej Uher, Veronika Caisova, Thanh-Truc Huynh, David Taieb, Katerina Hadrava Vanova, Hans Kumar Ghayee, Jiri Neuzil, Mark Levine, Chunzhang Yang, Karel Pacak
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (14): 3868–3880.
https://doi.org/10.1158/1078-0432.CCR-19-2335
Published: 15 July 2020
View article titled, Therapeutic Targeting of <em>SDHB</em>-Mutated Pheochromocytoma/Paraganglioma with Pharmacologic Ascorbic Acid
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Includes: Supplementary data
Journal Articles

Targeting NAD+/PARP DNA Repair Pathway as a Novel Therapeutic Approach to SDHB-Mutated Cluster I Pheochromocytoma and Paraganglioma

Ying Pang, Yanxin Lu, Veronika Caisova, Yang Liu, Petra Bullova, Thanh-Truc Huynh, Yiqiang Zhou, Di Yu, Zdenek Frysak, Igor Hartmann, David Taïeb, Karel Pacak, Chunzhang Yang
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (14): 3423–3432.
https://doi.org/10.1158/1078-0432.CCR-17-3406
Published: 15 July 2018
View article titled, Targeting NAD<sup>+</sup>/PARP DNA Repair Pathway as a Novel Therapeutic Approach to <em>SDHB</em>-Mutated Cluster I Pheochromocytoma and Paraganglioma
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Includes: Supplementary data
Journal Articles

Pheochromocytoma: The First Metabolic Endocrine Cancer

Ivana Jochmanova, Karel Pacak
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (20): 5001–5011.
https://doi.org/10.1158/1078-0432.CCR-16-0606
Published: 13 October 2016
View article titled, Pheochromocytoma: The First Metabolic Endocrine Cancer
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Includes: Supplementary data
Journal Articles

Superiority of [68Ga]-DOTATATE PET/CT to Other Functional Imaging Modalities in the Localization of SDHB-Associated Metastatic Pheochromocytoma and Paraganglioma

Ingo Janssen, Elise M. Blanchet, Karen Adams, Clara C. Chen, Corina M. Millo, Peter Herscovitch, David Taieb, Electron Kebebew, Hendrik Lehnert, Antonio T. Fojo, Karel Pacak
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (17): 3888–3895.
https://doi.org/10.1158/1078-0432.CCR-14-2751
Published: 31 August 2015
View article titled, Superiority of [<sup>68</sup>Ga]-DOTATATE PET/CT to Other Functional Imaging Modalities in the Localization of <em>SDHB</em>-Associated Metastatic Pheochromocytoma and Paraganglioma
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Includes: Supplementary data
Journal Articles

Genotype-Specific Abnormalities in Mitochondrial Function Associate with Distinct Profiles of Energy Metabolism and Catecholamine Content in Pheochromocytoma and Paraganglioma

Jyotsna U. Rao, Udo F.H. Engelke, Richard J.T. Rodenburg, Ron A. Wevers, Karel Pacak, Graeme Eisenhofer, Nan Qin, Benno Kusters, Angelina G. Goudswaard, Jacques W.M. Lenders, Ad R.M.M. Hermus, Arjen R. Mensenkamp, Henricus P.M. Kunst, Fred C.G.J. Sweep, Henri J.L.M. Timmers
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (14): 3787–3795.
https://doi.org/10.1158/1078-0432.CCR-12-3922
Published: 15 July 2013
View article titled, Genotype-Specific Abnormalities in Mitochondrial Function Associate with Distinct Profiles of Energy Metabolism and Catecholamine Content in Pheochromocytoma and Paraganglioma
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Includes: Supplementary data
Journal Articles

MAX Mutations Cause Hereditary and Sporadic Pheochromocytoma and Paraganglioma

Nelly Burnichon, Alberto Cascón, Francesca Schiavi, Nicole Paes Morales, Iñaki Comino-Méndez, Nasséra Abermil, Lucía Inglada-Pérez, Aguirre A. de Cubas, Laurence Amar, Marta Barontini, Sandra Bernaldo de Quirós, Jérôme Bertherat, Yves-Jean Bignon, Marinus J. Blok, Sara Bobisse, Salud Borrego, Maurizio Castellano, Philippe Chanson, María-Dolores Chiara, Eleonora P.M. Corssmit, Mara Giacchè, Ronald R. de Krijger, Tonino Ercolino, Xavier Girerd, Encarna B. Gómez-García, Álvaro Gómez-Graña, Isabelle Guilhem, Frederik J. Hes, Emiliano Honrado, Esther Korpershoek, Jacques W.M. Lenders, Rocío Letón, Arjen R. Mensenkamp, Anna Merlo, Luigi Mori, Arnaud Murat, Peggy Pierre, Pierre-François Plouin, Tamara Prodanov, Miguel Quesada-Charneco, Nan Qin, Elena Rapizzi, Victoria Raymond, Nicole Reisch, Giovanna Roncador, Macarena Ruiz-Ferrer, Frank Schillo, Alexander P.A. Stegmann, Carlos Suarez, Elisa Taschin, Henri J.L.M. Timmers, Carli M.J. Tops, Miguel Urioste, Felix Beuschlein, Karel Pacak, Massimo Mannelli, Patricia L. M. Dahia, Giuseppe Opocher, Graeme Eisenhofer, Anne-Paule Gimenez-Roqueplo, Mercedes Robledo
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (10): 2828–2837.
https://doi.org/10.1158/1078-0432.CCR-12-0160
Published: 14 May 2012
View article titled, <em>MAX</em> Mutations Cause Hereditary and Sporadic Pheochromocytoma and Paraganglioma
Open the PDF for <em>MAX</em> Mutations Cause Hereditary and Sporadic Pheochromocytoma and Paraganglioma in another window
Includes: Supplementary data