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Karel Helman
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Journal Articles

Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells

Elizabeth A. Lemm, Beatriz Valle-Argos, Lindsay D. Smith, Johanna Richter, Yohannes Gebreselassie, Matthew J. Carter, Jana Karolova, Michael Svaton, Karel Helman, Nicola J. Weston-Bell, Laura Karydis, Chris T. Williamson, Georg Lenz, Jeremy Pettigrew, Curtis Harwig, Freda K. Stevenson, Mark Cragg, Francesco Forconi, Andrew J. Steele, Jennifer Cross, Lloyd Mackenzie, Pavel Klener, Graham Packham
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (7): 1700–1711.
https://doi.org/10.1158/1078-0432.CCR-19-2202
Published: 01 April 2020
View article titled, Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells
Open the PDF for Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells in another window
Includes: Supplementary data
Journal Articles

Cotargeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal In Vivo in Relapsed Mantle Cell Lymphoma

Dana Prukova, Ladislav Andera, Zuzana Nahacka, Jana Karolova, Michael Svaton, Magdalena Klanova, Ondrej Havranek, Jan Soukup, Karla Svobodova, Zuzana Zemanova, Diana Tuskova, Eva Pokorna, Karel Helman, Kristina Forsterova, Mariana Pacheco-Blanco, Petra Vockova, Adela Berkova, Eva Fronkova, Marek Trneny, Pavel Klener
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (14): 4455–4465.
https://doi.org/10.1158/1078-0432.CCR-18-3275
Published: 15 July 2019
View article titled, Cotargeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal <em>In Vivo</em> in Relapsed Mantle Cell Lymphoma
Open the PDF for Cotargeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal <em>In Vivo</em> in Relapsed Mantle Cell Lymphoma in another window
Includes: Supplementary data
Journal Articles

Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma

Magdalena Klanova, Ladislav Andera, Jan Brazina, Jan Svadlenka, Simona Benesova, Jan Soukup, Dana Prukova, Dana Vejmelkova, Radek Jaksa, Karel Helman, Petra Vockova, Lucie Lateckova, Jan Molinsky, Bokang Calvin Lenyeletse Maswabi, Mahmudul Alam, Roman Kodet, Robert Pytlik, Marek Trneny, Pavel Klener
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (5): 1138–1149.
https://doi.org/10.1158/1078-0432.CCR-15-1191
Published: 29 February 2016
View article titled, Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma
Open the PDF for Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma in another window
Includes: Supplementary data