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Judith E. Karp
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Journal Articles

Exposure–Response of Veliparib to Inform Phase II Trial Design in Refractory or Relapsed Patients with Hematological Malignancies

Shailly Mehrotra, Mathangi Gopalakrishnan, Jogarao Gobburu, Jiuping Ji, Jacqueline M. Greer, Richard Piekarz, Judith E. Karp, Keith W. Pratz, Michelle A. Rudek
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (21): 6421–6429.
https://doi.org/10.1158/1078-0432.CCR-17-0143
Published: 31 October 2017
View article titled, Exposure–Response of Veliparib to Inform Phase II Trial Design in Refractory or Relapsed Patients with Hematological Malignancies
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Includes: Supplementary data
Journal Articles

Exposure–Response Analysis of Alvocidib (Flavopiridol) Treatment by Bolus or Hybrid Administration in Newly Diagnosed or Relapsed/Refractory Acute Leukemia Patients

Carl LaCerte, Vijay Ivaturi, Joga Gobburu, Jacqueline M. Greer, L. Austin Doyle, John J. Wright, Judith E. Karp, Michelle A. Rudek
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (14): 3592–3600.
https://doi.org/10.1158/1078-0432.CCR-16-2629
Published: 13 July 2017
View article titled, Exposure–Response Analysis of Alvocidib (Flavopiridol) Treatment by Bolus or Hybrid Administration in Newly Diagnosed or Relapsed/Refractory Acute Leukemia Patients
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Includes: Supplementary data
Journal Articles

A Phase I Study of Topotecan, Carboplatin and the PARP Inhibitor Veliparib in Acute Leukemias, Aggressive Myeloproliferative Neoplasms, and Chronic Myelomonocytic Leukemia

Keith W. Pratz, Michelle A. Rudek, Ivana Gojo, Mark R. Litzow, Michael A. McDevitt, Jiuping Ji, Larry M. Karnitz, James G. Herman, Robert J. Kinders, B. Douglas Smith, Steven D. Gore, Hetty E. Carraway, Margaret M. Showel, Douglas E. Gladstone, Mark J. Levis, Hua-Ling Tsai, Gary Rosner, Alice Chen, Scott H. Kaufmann, Judith E. Karp
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (4): 899–907.
https://doi.org/10.1158/1078-0432.CCR-16-1274
Published: 14 February 2017
View article titled, A Phase I Study of Topotecan, Carboplatin and the PARP Inhibitor Veliparib in Acute Leukemias, Aggressive Myeloproliferative Neoplasms, and Chronic Myelomonocytic Leukemia
Open the PDF for A Phase I Study of Topotecan, Carboplatin and the PARP Inhibitor Veliparib in Acute Leukemias, Aggressive Myeloproliferative Neoplasms, and Chronic Myelomonocytic Leukemia in another window
Includes: Supplementary data
Journal Articles

A Phase 1 Study of the PARP Inhibitor Veliparib in Combination with Temozolomide in Acute Myeloid Leukemia

Ivana Gojo, Jan H. Beumer, Keith W. Pratz, Michael A. McDevitt, Maria R. Baer, Amanda L. Blackford, B. Douglas Smith, Steven D. Gore, Hetty E. Carraway, Margaret M. Showel, Mark J. Levis, Amy E. Dezern, Douglas E. Gladstone, Jiuping Jay Ji, Lihua Wang, Robert J. Kinders, Marie Pouquet, Ismail Ali-Walbi, Michelle A. Rudek, Weijie Poh, James G. Herman, Larry M. Karnitz, Scott H. Kaufmann, Alice Chen, Judith E. Karp
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (3): 697–706.
https://doi.org/10.1158/1078-0432.CCR-16-0984
Published: 31 January 2017
View article titled, A Phase 1 Study of the PARP Inhibitor Veliparib in Combination with Temozolomide in Acute Myeloid Leukemia
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Includes: Supplementary data
Journal Articles

Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms

Keith W. Pratz, Brian D. Koh, Anand G. Patel, Karen S. Flatten, Weijie Poh, James G. Herman, Robert Dilley, Maria I. Harrell, B. Douglas Smith, Judith E. Karp, Elizabeth M. Swisher, Michael A. McDevitt, Scott H. Kaufmann
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (15): 3894–3902.
https://doi.org/10.1158/1078-0432.CCR-15-2351
Published: 31 July 2016
View article titled, Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms
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Includes: Supplementary data
Journal Articles

New Strategies in Acute Myelogenous Leukemia: Leukemogenesis and Personalized Medicine

Ivana Gojo, Judith E. Karp
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (24): 6233–6241.
https://doi.org/10.1158/1078-0432.CCR-14-0900
Published: 14 December 2014
View article titled, New Strategies in Acute Myelogenous Leukemia: Leukemogenesis and Personalized Medicine
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Journal Articles

Phase I and Pharmacologic Trial of Cytosine Arabinoside with the Selective Checkpoint 1 Inhibitor Sch 900776 in Refractory Acute Leukemias

Judith E. Karp, Brian M. Thomas, Jacqueline M. Greer, Christopher Sorge, Steven D. Gore, Keith W. Pratz, B. Douglas Smith, Karen S. Flatten, Kevin Peterson, Paula Schneider, Karen Mackey, Tomoko Freshwater, Mark J. Levis, Michael A. McDevitt, Hetty E. Carraway, Douglas E. Gladstone, Margaret M. Showel, Sabine Loechner, David A. Parry, Jo Ann Horowitz, Randi Isaacs, Scott H. Kaufmann
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (24): 6723–6731.
https://doi.org/10.1158/1078-0432.CCR-12-2442
Published: 16 December 2012
View article titled, Phase I and Pharmacologic Trial of Cytosine Arabinoside with the Selective Checkpoint 1 Inhibitor Sch 900776 in Refractory Acute Leukemias
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Journal Articles

Effects of Selective Checkpoint Kinase 1 Inhibition on Cytarabine Cytotoxicity in Acute Myelogenous Leukemia Cells In Vitro

Erin L. Schenk, Brian D. Koh, Karen S. Flatten, Kevin L. Peterson, David Parry, Allan D. Hess, B. Douglas Smith, Judith E. Karp, Larry M. Karnitz, Scott H. Kaufmann
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (19): 5364–5373.
https://doi.org/10.1158/1078-0432.CCR-12-0961
Published: 30 September 2012
View article titled, Effects of Selective Checkpoint Kinase 1 Inhibition on Cytarabine Cytotoxicity in Acute Myelogenous Leukemia Cells <em>In Vitro</em>
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Includes: Supplementary data
Journal Articles

Phase II Trial of Tipifarnib as Maintenance Therapy in First Complete Remission in Adults with Acute Myelogenous Leukemia and Poor-Risk Features

Judith E. Karp, B. Douglas Smith, Ivana Gojo, Jeffrey E. Lancet, Jacqueline Greer, Maureen Klein, Larry Morris, Mark J. Levis, Steven D. Gore, John J. Wright, Elizabeth Garrett-Mayer
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (10): 3077–3082.
https://doi.org/10.1158/1078-0432.CCR-07-4743
Published: 15 May 2008
View article titled, Phase II Trial of Tipifarnib as Maintenance Therapy in First Complete Remission in Adults with Acute Myelogenous Leukemia and Poor-Risk Features
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Journal Articles

Sequential Flavopiridol, Cytosine Arabinoside, and Mitoxantrone: A Phase II Trial in Adults with Poor-Risk Acute Myelogenous Leukemia

Judith E. Karp, B. Douglas Smith, Mark J. Levis, Steven D. Gore, Jacqueline Greer, Catherine Hattenburg, Janet Briel, Richard J. Jones, John J. Wright, A. Dimitri Colevas
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (15): 4467–4473.
https://doi.org/10.1158/1078-0432.CCR-07-0381
Published: 01 August 2007
View article titled, Sequential Flavopiridol, Cytosine Arabinoside, and Mitoxantrone: A Phase II Trial in Adults with Poor-Risk Acute Myelogenous Leukemia
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Journal Articles

Phase I and Pharmacokinetic Study of Flavopiridol followed by 1-β-d-Arabinofuranosylcytosine and Mitoxantrone in Relapsed and Refractory Adult Acute Leukemias

Judith E. Karp, Antonino Passaniti, Ivana Gojo, Scott Kaufmann, Keith Bible, Tushar S. Garimella, Jacqueline Greer, Janet Briel, B. Douglas Smith, Steven D. Gore, Michael L. Tidwell, Douglas D. Ross, John J. Wright, A. Dimitrios Colevas, Kenneth S. Bauer
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (23): 8403–8412.
https://doi.org/10.1158/1078-0432.CCR-05-1201
Published: 01 December 2005
View article titled, Phase I and Pharmacokinetic Study of Flavopiridol followed by 1-β-<sc>d</sc>-Arabinofuranosylcytosine and Mitoxantrone in Relapsed and Refractory Adult Acute Leukemias
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Journal Articles

Phase I and Pharmacologic Study of Infusional Topotecan and Carboplatin in Relapsed and Refractory Acute Leukemia

Scott H. Kaufmann, Judith E. Karp, Louis Letendre, Timothy J. Kottke, Stephanie Safgren, Jackie Greer, Ivana Gojo, Pamela Atherton, Phyllis A. Svingen, David A. Loegering, Mark R. Litzow, Jeff A. Sloan, Joel M. Reid, Matthew M. Ames, Alex A. Adjei, Charles Erlichman
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (18): 6641–6649.
https://doi.org/10.1158/1078-0432.CCR-05-0817
Published: 15 September 2005
View article titled, Phase I and Pharmacologic Study of Infusional Topotecan and Carboplatin in Relapsed and Refractory Acute Leukemia
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Journal Articles

Targeting Vascular Endothelial Growth Factor for Relapsed and Refractory Adult Acute Myelogenous Leukemias: Therapy with Sequential 1-β-d-Arabinofuranosylcytosine, Mitoxantrone, and Bevacizumab

Judith E. Karp, Ivana Gojo, Roberto Pili, Christopher D. Gocke, Jacqueline Greer, Chuanfa Guo, David Qian, Lawrence Morris, Michael Tidwell, Helen Chen, James Zwiebel
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (11): 3577–3585.
https://doi.org/10.1158/1078-0432.CCR-03-0627
Published: 01 June 2004
View article titled, Targeting Vascular Endothelial Growth Factor for Relapsed and Refractory Adult Acute Myelogenous Leukemias: <subtitle>Therapy with Sequential 1-β-<sc>d</sc>-Arabinofuranosylcytosine, Mitoxantrone, and Bevacizumab</subtitle>
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Journal Articles

Quantitative Analysis of Breast Cancer Resistance Protein and Cellular Resistance to Flavopiridol in Acute Leukemia Patients

Takeo Nakanishi, Judith E. Karp, Ming Tan, L. Austin Doyle, Todd Peters, Weidong Yang, David Wei, Douglas D. Ross
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (9): 3320–3328.
Published: 05 September 2003
View article titled, Quantitative Analysis of Breast Cancer Resistance Protein and Cellular Resistance to Flavopiridol in Acute Leukemia Patients
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Journal Articles

Timed Sequential Therapy of Acute Leukemia with Flavopiridol: In Vitro Model for a Phase I Clinical Trial

Judith E. Karp, Douglas D. Ross, Weidong Yang, Michael L. Tidwell, Yuetong Wei, Jacqueline Greer, Dean L. Mann, Takeo Nakanishi, John J. Wright, A. Dmitri Colevas
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (1): 307–315.
Published: 01 January 2003
View article titled, Timed Sequential Therapy of Acute Leukemia with Flavopiridol: <subtitle> <em>In Vitro</em> Model for a Phase I Clinical Trial</subtitle>
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