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Joseph E. Tomaszewski
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Journal Articles

Pharmacodynamic Response of the MET/HGF Receptor to Small-Molecule Tyrosine Kinase Inhibitors Examined with Validated, Fit-for-Clinic Immunoassays

Free
Apurva K. Srivastava, Melinda G. Hollingshead, Jennifer Weiner, Tony Navas, Yvonne A. Evrard, Sonny A. Khin, Jiuping Jay Ji, Yiping Zhang, Suzanne Borgel, Thomas D. Pfister, Robert J. Kinders, Donald P. Bottaro, W. Marston Linehan, Joseph E. Tomaszewski, James H. Doroshow, Ralph E. Parchment
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (14): 3683–3694.
https://doi.org/10.1158/1078-0432.CCR-15-2323
Published: 14 July 2016
View articletitled, Pharmacodynamic Response of the MET/HGF Receptor to Small-Molecule Tyrosine Kinase Inhibitors Examined with Validated, Fit-for-Clinic Immunoassays
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Includes: Supplementary data
Journal Articles

Effect of a Smac Mimetic (TL32711, Birinapant) on the Apoptotic Program and Apoptosis Biomarkers Examined with Validated Multiplex Immunoassays Fit for Clinical Use

Free
Apurva K. Srivastava, Soumya Jaganathan, Laurie Stephen, Melinda G. Hollingshead, Adam Layhee, Eric Damour, Jeevan Prasaad Govindharajulu, Jennifer Donohue, Dominic Esposito, James P. Mapes, Robert J. Kinders, Naoko Takebe, Joseph E. Tomaszewski, Shivaani Kummar, James H. Doroshow, Ralph E. Parchment
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (4): 1000–1010.
https://doi.org/10.1158/1078-0432.CCR-14-3156
Published: 14 February 2016
View articletitled, Effect of a Smac Mimetic (TL32711, Birinapant) on the Apoptotic Program and Apoptosis Biomarkers Examined with Validated Multiplex Immunoassays Fit for Clinical Use
Open the PDF for Effect of a Smac Mimetic (TL32711, Birinapant) on the Apoptotic Program and Apoptosis Biomarkers Examined with Validated Multiplex Immunoassays Fit for Clinical Use in another window
Includes: Supplementary data
Journal Articles

Developing Safety Criteria for Introducing New Agents into Neoadjuvant Trials

Free
Angela DeMichele, Donald A. Berry, JoAnne Zujewski, Sally Hunsberger, Larry Rubinstein, Joseph E. Tomaszewski, Gary Kelloff, Jane Perlmutter, Meredith Buxton, Julia Lyandres, Kathy S. Albain, Chris Benz, A. Jo Chien, Paul Haluska, Brian Leyland-Jones, Minetta C. Liu, Pamela Munster, Olufunmilayo Olopade, John W. Park, Barbara A. Parker, Lajos Pusztai, Debu Tripathy, Hope Rugo, Douglas Yee, Laura Esserman
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (11): 2817–2823.
https://doi.org/10.1158/1078-0432.CCR-12-2620
Published: 30 May 2013
View articletitled, Developing Safety Criteria for Introducing New Agents into Neoadjuvant Trials
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Journal Articles

A Phase I Study of Veliparib in Combination with Metronomic Cyclophosphamide in Adults with Refractory Solid Tumors and Lymphomas

Free
Shivaani Kummar, Jiuping Ji, Robert Morgan, Heinz-Josef Lenz, Shannon L. Puhalla, Chandra P. Belani, David R. Gandara, Deborah Allen, Brian Kiesel, Jan H. Beumer, Edward M. Newman, Larry Rubinstein, Alice Chen, Yiping Zhang, Lihua Wang, Robert J. Kinders, Ralph E. Parchment, Joseph E. Tomaszewski, James H. Doroshow
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (6): 1726–1734.
https://doi.org/10.1158/1078-0432.CCR-11-2821
Published: 14 March 2012
View articletitled, A Phase I Study of Veliparib in Combination with Metronomic Cyclophosphamide in Adults with Refractory Solid Tumors and Lymphomas
Open the PDF for A Phase I Study of Veliparib in Combination with Metronomic Cyclophosphamide in Adults with Refractory Solid Tumors and Lymphomas in another window
Includes: Supplementary data
Journal Articles

Monitoring Drug-Induced γH2AX as a Pharmacodynamic Biomarker in Individual Circulating Tumor Cells

Free
Lihua H. Wang, Thomas D. Pfister, Ralph E. Parchment, Shivaani Kummar, Larry Rubinstein, Yvonne A. Evrard, Martin E. Gutierrez, Anthony J. Murgo, Joseph E. Tomaszewski, James H. Doroshow, Robert J. Kinders
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (3): 1073–1084.
https://doi.org/10.1158/1078-0432.CCR-09-2799
Published: 01 February 2010
View articletitled, Monitoring Drug-Induced γH2AX as a Pharmacodynamic Biomarker in Individual Circulating Tumor Cells
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Includes: Supplementary data
Journal Articles

Preclinical Modeling of a Phase 0 Clinical Trial: Qualification of a Pharmacodynamic Assay of Poly (ADP-Ribose) Polymerase in Tumor Biopsies of Mouse Xenografts

Free
Robert J. Kinders, Melinda Hollingshead, Sonny Khin, Larry Rubinstein, Joseph E. Tomaszewski, James H. Doroshow, Ralph E. Parchment, the National Cancer Institute Phase 0 Clinical Trials Team
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (21): 6877–6885.
https://doi.org/10.1158/1078-0432.CCR-08-0214
Published: 03 November 2008
View articletitled, Preclinical Modeling of a Phase 0 Clinical Trial: Qualification of a Pharmacodynamic Assay of Poly (ADP-Ribose) Polymerase in Tumor Biopsies of Mouse Xenografts
Open the PDF for Preclinical Modeling of a Phase 0 Clinical Trial: Qualification of a Pharmacodynamic Assay of Poly (ADP-Ribose) Polymerase in Tumor Biopsies of Mouse Xenografts in another window
Includes: Supplementary data
Journal Articles

Tissue-Based Research in Kidney Cancer: Current Challenges and Future Directions

Free
Sabina Signoretti, Gennady Bratslavsky, Frederick M. Waldman, Victor E. Reuter, John Haaga, Maria Merino, George V. Thomas, Michael R. Pins, Towia Libermann, John Gillespie, Joseph E. Tomaszewski, Carolyn C. Compton, Andrew Hruszkewycz, W. Marston Linehan, Michael B. Atkins
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (12): 3699–3705.
https://doi.org/10.1158/1078-0432.CCR-07-4733
Published: 16 June 2008
View articletitled, Tissue-Based Research in Kidney Cancer: Current Challenges and Future Directions
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Journal Articles

Designing Phase 0 Cancer Clinical Trials

Free
Anthony J. Murgo, Shivaani Kummar, Larry Rubinstein, Martin Gutierrez, Jerry Collins, Robert Kinders, Ralph E. Parchment, Jiuping Ji, Seth M. Steinberg, Sherry X. Yang, Melinda Hollingshead, Alice Chen, Lee Helman, Robert Wiltrout, Joseph E. Tomaszewski, James H. Doroshow
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (12): 3675–3682.
https://doi.org/10.1158/1078-0432.CCR-07-4560
Published: 16 June 2008
View articletitled, Designing Phase 0 Cancer Clinical Trials
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