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Jose Luis Perez-Gracia
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Journal Articles

A Phase I Dose Escalation and Cohort Expansion Study of CB307, a Trispecific Humabody against PSMA, CD137, and Albumin in Patients with PSMA-Positive Solid Tumors

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Johann S. de Bono, Anja Williams, Ignacio Melero, Anuradha Jayaram, Jessica E. Hawley, Bernard Doger de Speville, Irene Moreno, Daniel Castellano, Òscar Reig, Daan G. Knapen, Georgia Anguera, Julia Martinez, Eelke Gort, Maja de Jonge, Jose Luis Alonso-Romero, Valentina Boni, Jose Luis Perez-Gracia, Alejandro Falcon, Derk Jan de Groot, Andrew J. Pierce, Andrew J. Leishman, Peter Lloyd, Phillip D. Bartlett, Philip Bland-Ward, Albert Chau, Minjung Song, Kevin Duffy, Kenji Hashimoto, Elisabeth de Vries
Journal: Clinical Cancer Research
Clin Cancer Res OF1–OF12.
https://doi.org/10.1158/1078-0432.CCR-24-3581
Published: 14 April 2025
View articletitled, A Phase I Dose Escalation and Cohort Expansion Study of CB307, a Trispecific Humabody against PSMA, CD137, and Albumin in Patients with PSMA-Positive Solid Tumors
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Includes: Supplementary data
Journal Articles

Targeting T-Cell Costimulation to the Surface of Tumor Cells

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Iñaki Eguren-Santamaría, Miguel F. Sanmamed, Paula Molero-Glez, Jose Luis Perez-Gracia, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (2): 231–233.
https://doi.org/10.1158/1078-0432.CCR-24-3003
Published: 17 January 2025
View articletitled, Targeting T-Cell Costimulation to the Surface of Tumor Cells
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Journal Articles

Obinutuzumab Pretreatment as a Novel Approach to Mitigate Formation of Anti-Drug Antibodies Against Cergutuzumab Amunaleukin in Patients with Solid Tumors

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Solange Peters, Eric Angevin, Teresa Alonso-Gordoa, Kristoffer Rohrberg, Ignacio Melero, Begoña Mellado, Jose-Luis Perez-Gracia, Josep Tabernero, Celine Adessi, Christophe Boetsch, Carl Watson, Joseph Dal Porto, David Dejardin, Christopher Del Nagro, Valeria Nicolini, Stefan Evers, Christian Klein, Barbara Leutgeb, Pavel Pisa, Eva Rossmann, José Saro, Pablo Umana, Jehad Charo, Volker Teichgräber, Neeltje Steeghs
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (8): 1630–1641.
https://doi.org/10.1158/1078-0432.CCR-23-2658
Published: 15 April 2024
View articletitled, Obinutuzumab Pretreatment as a Novel Approach to Mitigate Formation of Anti-Drug Antibodies Against Cergutuzumab Amunaleukin in Patients with Solid Tumors
Open the PDF for Obinutuzumab Pretreatment as a Novel Approach to Mitigate Formation of Anti-Drug Antibodies Against Cergutuzumab Amunaleukin in Patients with Solid Tumors in another window
Includes: Supplementary data
Journal Articles

A Phase Ib, Open-label Study Evaluating the Safety and Efficacy of Ipatasertib plus Rucaparib in Patients with Metastatic Castration-resistant Prostate Cancer

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David Pook, Daniel M. Geynisman, Joan Carles, Filippo de Braud, Anthony M. Joshua, José Luis Pérez-Gracia, Casilda Llácer Pérez, Sang Joon Shin, Bruno Fang, Minal Barve, Marco Maruzzo, Sergio Bracarda, Miso Kim, Yannick Kerloeguen, Jorge Daniel Gallo, Sophia L. Maund, Adam Harris, Kuan-Chieh Huang, Victor Poon, Dhruvitkumar S. Sutaria, Howard Gurney
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (17): 3292–3300.
https://doi.org/10.1158/1078-0432.CCR-22-2585
Published: 01 September 2023
View articletitled, A Phase Ib, Open-label Study Evaluating the Safety and Efficacy of Ipatasertib plus Rucaparib in Patients with Metastatic Castration-resistant Prostate Cancer
Open the PDF for A Phase Ib, Open-label Study Evaluating the Safety and Efficacy of Ipatasertib plus Rucaparib in Patients with Metastatic Castration-resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non–Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis

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Ila Datar, Miguel F. Sanmamed, Jun Wang, Brian S. Henick, Jungmin Choi, Ti Badri, Weilai Dong, Nikita Mani, Maria Toki, Luis D. Mejías, Maria D. Lozano, Jose Luis Perez-Gracia, Vamsidhar Velcheti, Matthew D. Hellmann, Justin F. Gainor, Kristen McEachern, David Jenkins, Konstantinos Syrigos, Katerina Politi, Scott Gettinger, David L. Rimm, Roy S. Herbst, Ignacio Melero, Lieping Chen, Kurt A. Schalper
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (15): 4663–4673.
https://doi.org/10.1158/1078-0432.CCR-18-4142
Published: 01 August 2019
View articletitled, Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non–Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis
Open the PDF for Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non–Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis in another window
Includes: Supplementary data
Journal Articles

Immunotherapy Combinations and Sequences in Urothelial Cancer: Facts and Hopes

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Alejo Rodriguez-Vida, Jose Luis Perez-Gracia, Joaquim Bellmunt
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (24): 6115–6124.
https://doi.org/10.1158/1078-0432.CCR-17-3108
Published: 13 December 2018
View articletitled, Immunotherapy Combinations and Sequences in Urothelial Cancer: Facts and Hopes
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Journal Articles

Immunomodulatory Activity of Nivolumab in Metastatic Renal Cell Carcinoma

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Toni K. Choueiri, Mayer N. Fishman, Bernard Escudier, David F. McDermott, Charles G. Drake, Harriet Kluger, Walter M. Stadler, Jose Luis Perez-Gracia, Douglas G. McNeel, Brendan Curti, Michael R. Harrison, Elizabeth R. Plimack, Leonard Appleman, Lawrence Fong, Laurence Albiges, Lewis Cohen, Tina C. Young, Scott D. Chasalow, Petra Ross-Macdonald, Shivani Srivastava, Maria Jure-Kunkel, John F. Kurland, Jason S. Simon, Mario Sznol
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (22): 5461–5471.
https://doi.org/10.1158/1078-0432.CCR-15-2839
Published: 14 November 2016
View articletitled, Immunomodulatory Activity of Nivolumab in Metastatic Renal Cell Carcinoma
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Includes: Supplementary data
Journal Articles

Serum Interleukin-8 Reflects Tumor Burden and Treatment Response across Malignancies of Multiple Tissue Origins

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Miguel F. Sanmamed, Omar Carranza-Rua, Carlos Alfaro, Carmen Oñate, Salvador Martín-Algarra, Guiomar Perez, Sara F. Landazuri, Álvaro Gonzalez, Stefanie Gross, Inmaculada Rodriguez, Cecilia Muñoz-Calleja, María Rodríguez-Ruiz, Bruno Sangro, José M. López-Picazo, Manglio Rizzo, Guillermo Mazzolini, Juan I. Pascual, Maria Pilar Andueza, Jose Luis Perez-Gracia, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (22): 5697–5707.
https://doi.org/10.1158/1078-0432.CCR-13-3203
Published: 13 November 2014
View articletitled, Serum Interleukin-8 Reflects Tumor Burden and Treatment Response across Malignancies of Multiple Tissue Origins
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Includes: Supplementary data
Journal Articles

Direct Effects of Type I Interferons on Cells of the Immune System

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Sandra Hervas-Stubbs, Jose Luis Perez-Gracia, Ana Rouzaut, Miguel F. Sanmamed, Agnes Le Bon, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (9): 2619–2627.
https://doi.org/10.1158/1078-0432.CCR-10-1114
Published: 01 May 2011
View articletitled, Direct Effects of Type I Interferons on Cells of the Immune System
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