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Jonathan D. Licht
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Journal Articles

DNMT3A Harboring Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks

Kartika Venugopal, Yang Feng, Pawel Nowialis, Huanzhou Xu, Daniil E. Shabashvili, Cassandra M. Berntsen, Prabhjot Kaur, Kathryn I. Krajcik, Christina Taragjini, Zachary Zaroogian, Heidi L. Casellas Román, Luisa M. Posada, Chamara Gunaratne, Jianping Li, Daphné Dupéré-Richer, Richard L. Bennett, Santhi Pondugula, Alberto Riva, Christopher R. Cogle, Rene Opavsky, Brian K. Law, Sumita Bhaduri-McIntosh, Stefan Kubicek, Philipp B. Staber, Jonathan D. Licht, Jonathan E. Bird, Olga A. Guryanova
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (4): 756–769.
https://doi.org/10.1158/1078-0432.CCR-21-2863
Published: 15 February 2022
View article titled, DNMT3A Harboring Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks
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Includes: Supplementary data
Journal Articles

HDAC Inhibition Enhances the In Vivo Efficacy of MEK Inhibitor Therapy in Uveal Melanoma

Fernanda Faião-Flores, Michael F. Emmons, Michael A. Durante, Fumi Kinose, Biswarup Saha, Bin Fang, John M. Koomen, Srikumar P. Chellappan, Silvya Stuchi Maria-Engler, Uwe Rix, Jonathan D. Licht, J. William Harbour, Keiran S.M. Smalley
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (18): 5686–5701.
https://doi.org/10.1158/1078-0432.CCR-18-3382
Published: 13 September 2019
View article titled, HDAC Inhibition Enhances the <em>In Vivo</em> Efficacy of MEK Inhibitor Therapy in Uveal Melanoma
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Includes: Supplementary data
Journal Articles

Abstract 12: KMD6A/UTX loss enhances the malignant phenotype of multiple myeloma and sensitizes cells to EZH2 inhibition

Daphne Dupere-Richer, Teresa Ezponda, Christine Will, Eliza Caroline Small, Nobish Varghese, Patel Tej, Xiaoxiao Huang, Zheng Yupeng, Giovanni Tonon, Neil Kelleher, Jonathan Keats, Jonathan D. Licht
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (24_Supplement): 12.
https://doi.org/10.1158/1557-3265.HEMMAL17-12
Published: 14 December 2017
View article titled, Abstract 12: KMD6A/UTX loss enhances the malignant phenotype of multiple myeloma and sensitizes cells to EZH2 inhibition
Journal Articles

Abstract IA27: Deregulation and oncogenic functions of the NSD2/MMSET histone methyl transferase in hematologic malignancies

Jonathan D. Licht
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (24_Supplement): IA27.
https://doi.org/10.1158/1557-3265.HEMMAL17-IA27
Published: 14 December 2017
View article titled, Abstract IA27: Deregulation and oncogenic functions of the NSD2/MMSET histone methyl transferase in hematologic malignancies
Journal Articles

Abstract IA26: Aberrant histone methylation in multiple myeloma.

Jonathan D. Licht
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (17_Supplement): IA26.
https://doi.org/10.1158/1557-3265.HEMMAL14-IA26
Published: 19 August 2015
View article titled, Abstract IA26: Aberrant histone methylation in multiple myeloma.
Journal Articles

Abstract B32: Loss of the histone demethylase UTX alters the gene expression prolife and contributes to the malignant phenotype of multiple myeloma cells.

Teresa Ezponda, Relja Popovic, Yupeng Zheng, Behnam Nabet, Christine Will, Eliza Small, Manuela Occhionorelli, Giovanni Tonon, Jonathan Keats, Neil Kelleher, Jonathan D. Licht
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (17_Supplement): B32.
https://doi.org/10.1158/1557-3265.HEMMAL14-B32
Published: 19 August 2015
View article titled, Abstract B32: Loss of the histone demethylase UTX alters the gene expression prolife and contributes to the malignant phenotype of multiple myeloma cells.
Journal Articles

Molecular Pathways: Deregulation of Histone H3 Lysine 27 Methylation in Cancer—Different Paths, Same Destination

Teresa Ezponda, Jonathan D. Licht
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (19): 5001–5008.
https://doi.org/10.1158/1078-0432.CCR-13-2499
Published: 30 September 2014
View article titled, Molecular Pathways: Deregulation of Histone H3 Lysine 27 Methylation in Cancer—Different Paths, Same Destination
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Journal Articles

Ponatinib—A Step Forward in Overcoming Resistance in Chronic Myeloid Leukemia

Olga Frankfurt, Jonathan D. Licht
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (21): 5828–5834.
https://doi.org/10.1158/1078-0432.CCR-13-0258
Published: 31 October 2013
View article titled, Ponatinib—A Step Forward in Overcoming Resistance in Chronic Myeloid Leukemia
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Journal Articles

New Strategies in Acute Myeloid Leukemia: Redefining Prognostic Markers to Guide Therapy

Irum Khan, Jessica K. Altman, Jonathan D. Licht
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (19): 5163–5171.
https://doi.org/10.1158/1078-0432.CCR-12-0313
Published: 30 September 2012
View article titled, New Strategies in Acute Myeloid Leukemia: Redefining Prognostic Markers to Guide Therapy
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Journal Articles

Transcriptional Profiling of Polycythemia Vera Identifies Gene Expression Patterns Both Dependent and Independent from the Action of JAK2V617F

Windy Berkofsky-Fessler, Monica Buzzai, Marianne K-H. Kim, Steven Fruchtman, Vesna Najfeld, Dong-Joon Min, Fabricio F. Costa, Jared M. Bischof, Marcelo B. Soares, Melanie Jane McConnell, Weijia Zhang, Ross Levine, D. Gary Gilliland, Raffaele Calogero, Jonathan D. Licht
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (17): 4339–4352.
https://doi.org/10.1158/1078-0432.CCR-10-1092
Published: 31 August 2010
View article titled, Transcriptional Profiling of Polycythemia Vera Identifies Gene Expression Patterns Both Dependent and Independent from the Action of JAK2V617F
Open the PDF for Transcriptional Profiling of Polycythemia Vera Identifies Gene Expression Patterns Both Dependent and Independent from the Action of JAK2V617F in another window
Includes: Supplementary data