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John Lyons
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Journal Articles

An Effective Epigenetic-PARP Inhibitor Combination Therapy for Breast and Ovarian Cancers Independent of BRCA Mutations

Nicholas Pulliam, Fang Fang, Ali R. Ozes, Jessica Tang, Adeoluwa Adewuyi, Harold Keer, John Lyons, Stephen B. Baylin, Daniela Matei, Harikrishna Nakshatri, Feyruz V. Rassool, Kathy D. Miller, Kenneth P. Nephew
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (13): 3163–3175.
DOI: https://doi.org/10.1158/1078-0432.CCR-18-0204
Published: 01 July 2018
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Includes: Supplementary data
Journal Articles

First-in-Human Phase I Dose Escalation Study of a Second-Generation Non-Ansamycin HSP90 Inhibitor, AT13387, in Patients with Advanced Solid Tumors

Geoffrey I. Shapiro, Eunice Kwak, Bruce J. Dezube, Murray Yule, John Ayrton, John Lyons, Daruka Mahadevan
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2015) 21 (1): 87–97.
DOI: https://doi.org/10.1158/1078-0432.CCR-14-0979
Published: 05 January 2015
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Includes: Supplementary data
Journal Articles

The Novel, Small-Molecule DNA Methylation Inhibitor SGI-110 as an Ovarian Cancer Chemosensitizer

Fang Fang, Joanne Munck, Jessica Tang, Pietro Taverna, Yinu Wang, David F.B. Miller, Jay Pilrose, Gavin Choy, Mohammad Azab, Katherine S. Pawelczak, Pamela VanderVere-Carozza, Michael Wagner, John Lyons, Daniela Matei, John J. Turchi, Kenneth P. Nephew
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (24): 6504–6516.
DOI: https://doi.org/10.1158/1078-0432.CCR-14-1553
Published: 14 December 2014
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Includes: Supplementary data
Journal Articles

Biomarker identification for AT9283 a multi-targeted kinase inhibitor with Aurora A and B activities from pre-clinical models to clinical trials.

John Lyons, Matt Squires, Murray Yule, Victoria Lock, Jayne Curry, Matthias Reule, Neil Thompson
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (15_Supplement): B15.
Published: 15 August 2014
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Journal Articles

Abstract IA17: Targeting the methylome for epigenetic resensitization of ovarian cancer

Kenneth P. Nephew, Daniela Matei, Pietro Taverna, Fang Fang, Jessica Tang, Gavin Choy, John Lyons, Mohammad Azab, Jay Pilrose, John Turchi
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (19_Supplement): IA17.
DOI: https://doi.org/10.1158/1078-0432.OVCA13-IA17
Published: 13 May 2014
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Journal Articles

Abstract B19: The HSP90 inhibitor, AT13387, is effective against multiple mechanisms of kinase inhibitor resistance

Ana Rodriguez-Lopez, Tomoko Smyth, Rachel McMenamin, John Lyons, Neil Thompson, Victoria Lock, Pietro Taverna, Robert Corringham, Nicola Wallis
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (10_Supplement): B19.
DOI: https://doi.org/10.1158/1078-0432.MECHRES-B19
Published: 04 March 2013
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