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John Lewicki
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Journal Articles

Abstract A42: Using a PDX tumor bank to screen for cancer stem cell therapies

James Evans, Chun Zhang, Angie InKyung Park, Alayne Brunner, Min Wang, Cristina Dee-Hoskins, Roger Lopez, Xiaomei Song, Kellie Pickell, Wan-Cheng Yen, Marcus Fischer, Raymond Tam, Gilbert O'Young, Jakob Dupont, Lei Zhou, Austin Gurney, John Lewicki, Tim Hoey, Ann M. Kapoun, Belinda Cancilla
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16_Supplement): A42.
https://doi.org/10.1158/1557-3265.PDX16-A42
Published: 15 August 2016
View article titled, Abstract A42: Using a PDX tumor bank to screen for cancer stem cell therapies
Journal Articles

Abstract A41: Use of patient-derived tumor xenografts (PDX) for discovery and development of an anti-Notch2/3 monoclonal antibody targeting cancer stem cells

Marcus M. Fischer, Wan-Ching Yen, Fumiko Axelrod, Christopher Bond, Jennifer Cain, Belinda Cancilla, Randall Henner, Rene Meisner, Aaron Sato, Jalpa Shaw, Tracy Tang, Breanna Wallace, Min Wang, Chun Zhang, Ann Kapoun, Lei Zhou, Jakob Dupont, John Lewicki, Austin Gurney, Tim Hoey
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16_Supplement): A41.
https://doi.org/10.1158/1557-3265.PDX16-A41
Published: 15 August 2016
View article titled, Abstract A41: Use of patient-derived tumor xenografts (PDX) for discovery and development of an anti-Notch2/3 monoclonal antibody targeting cancer stem cells
Journal Articles

Abstract A29: Discovery and preclinical to clinical evaluation of biomarkers for Anti-DLL4, a monoclonal antibody targeting cancer stem cells

Ann M. Kapoun, Min Wang, Gilbert O'Young, Lucia Beviglia, Yu-Wang Liu, Pete Yeung, Marcus Fischer, Dave Smith, John Lewicki, Tim Hoey
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (14_Supplement): A29.
https://doi.org/10.1158/1078-0432.TCMUSA10-A29
Published: 02 February 2016
View article titled, Abstract A29: Discovery and preclinical to clinical evaluation of biomarkers for Anti-DLL4, a monoclonal antibody targeting cancer stem cells
Journal Articles

Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency

Wan-Ching Yen, Marcus M. Fischer, Fumiko Axelrod, Christopher Bond, Jennifer Cain, Belinda Cancilla, William R. Henner, Rene Meisner, Aaron Sato, Jalpa Shah, Tracy Tang, Breanna Wallace, Min Wang, Chun Zhang, Ann M. Kapoun, John Lewicki, Austin Gurney, Timothy Hoey
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2015) 21 (9): 2084–2095.
https://doi.org/10.1158/1078-0432.CCR-14-2808
Published: 30 April 2015
View article titled, Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency
Open the PDF for Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency in another window
Includes: Supplementary data
Journal Articles

Abstract A33: Combined therapy of a novel anti-NOTCH2/3 antibody with paclitaxel inhibits tumor growth in a patient-derived breast tumor xenograft

Jie Wei, Jennifer Cain, Jalpa Shah, Breanna Wallace, Tracy Tang, Min Wang, Christopher Murriel, Cancilla Belinda, Austin Gurney, Aaron Sato, John Lewicki, Ann Kapoun, Tim Hoey
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (4_Supplement): A33.
https://doi.org/10.1158/1557-3265.PMS14-A33
Published: 13 February 2015
View article titled, Abstract A33: Combined therapy of a novel anti-NOTCH2/3 antibody with paclitaxel inhibits tumor growth in a patient-derived breast tumor xenograft
Journal Articles

Anti-DLL4 Has Broad Spectrum Activity in Pancreatic Cancer Dependent on Targeting DLL4-Notch Signaling in Both Tumor and Vasculature Cells

Wan-Ching Yen, Marcus M. Fischer, Mark Hynes, Jingjiang Wu, Edward Kim, Lucia Beviglia, V. Pete Yeung, Xiaomei Song, Ann M. Kapoun, John Lewicki, Austin Gurney, Diane M. Simeone, Timothy Hoey
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (19): 5374–5386.
https://doi.org/10.1158/1078-0432.CCR-12-0736
Published: 30 September 2012
View article titled, Anti-DLL4 Has Broad Spectrum Activity in Pancreatic Cancer Dependent on Targeting DLL4-Notch Signaling in Both Tumor and Vasculature Cells
Open the PDF for Anti-DLL4 Has Broad Spectrum Activity in Pancreatic Cancer Dependent on Targeting DLL4-Notch Signaling in Both Tumor and Vasculature Cells in another window
Includes: Supplementary data