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John L. Marshall
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Journal Articles

Multi-omic Characterization of Pancreatic Ductal Adenocarcinoma Relates CXCR4 mRNA Expression Levels to Potential Clinical Targets

Florian Kocher, Alberto Puccini, Gerold Untergasser, Agnieszka Martowicz, Kai Zimmer, Andreas Pircher, Yasmine Baca, Joanne Xiu, Johannes Haybaeck, Piotr Tymoszuk, Richard M. Goldberg, Angelica Petrillo, Anthony F. Shields, Mohamed E. Salem, John L. Marshall, Michael Hall, W. Michael Korn, Chadi Nabhan, Francesca Battaglin, Heinz-Josef Lenz, Emil Lou, Su-Pin Choo, Chee-Keong Toh, Silvia Gasteiger, Renate Pichler, Dominik Wolf, Andreas Seeber
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (22): 4957–4967.
https://doi.org/10.1158/1078-0432.CCR-22-0275
Published: 14 November 2022
View article titled, Multi-omic Characterization of Pancreatic Ductal Adenocarcinoma Relates <em>CXCR4</em> mRNA Expression Levels to Potential Clinical Targets
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Includes: Supplementary data
Journal Articles

Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer

Andreas Seeber, Francesca Battaglin, Kai Zimmer, Florian Kocher, Yasmine Baca, Joanne Xiu, Gilbert Spizzo, Veronica Novotny-Diermayr, Dietmar Rieder, Alberto Puccini, Jeff Swensen, Michelle Ellis, Richard M. Goldberg, Axel Grothey, Anthony F. Shields, John L. Marshall, Benjamin A. Weinberg, Paul E. Sackstein, Kiat Hon Lim, Gek San Tan, Chadi Nabhan, W. Michael Korn, Arno Amann, Zlatko Trajanoski, Martin D. Berger, Emil Lou, Dominik Wolf, Heinz-Josef Lenz
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (9): 1863–1870.
https://doi.org/10.1158/1078-0432.CCR-21-3018
Published: 02 May 2022
View article titled, Comprehensive Analysis of R-Spondin Fusions and <em>RNF43</em> Mutations Implicate Novel Therapeutic Options in Colorectal Cancer
Open the PDF for Comprehensive Analysis of R-Spondin Fusions and <em>RNF43</em> Mutations Implicate Novel Therapeutic Options in Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer

Jonathan M. Loree, Yucai Wang, Muddassir A. Syed, Alexey V. Sorokin, Oluwadara Coker, Joanne Xiu, Benjamin A. Weinberg, Ari M. Vanderwalde, Anteneh Tesfaye, Victoria M. Raymond, Benjamin Miron, Gabi Tarcic, Ori Zelichov, Russell R. Broaddus, Patrick Kwok Shing Ng, Kang Jin Jeong, Yiu Huen Tsang, Gordon B. Mills, Michael J. Overman, Axel Grothey, John L. Marshall, Scott Kopetz
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (16): 4587–4598.
https://doi.org/10.1158/1078-0432.CCR-21-0180
Published: 15 August 2021
View article titled, Clinical and Functional Characterization of Atypical <em>KRAS</em>/<em>NRAS</em> Mutations in Metastatic Colorectal Cancer
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Includes: Supplementary data
Journal Articles

The Landscape of Alterations in DNA Damage Response Pathways in Colorectal Cancer

Hiroyuki Arai, Andrew Elliott, Joanne Xiu, Jingyuan Wang, Francesca Battaglin, Natsuko Kawanishi, Shivani Soni, Wu Zhang, Joshua Millstein, Davendra Sohal, Richard M. Goldberg, Michael J. Hall, Aaron J. Scott, Moh'd Khushman, Jimmy J. Hwang, Emil Lou, Benjamin A. Weinberg, John L. Marshall, Albert C. Lockhart, Phillip Stafford, Jian Zhang, Roberto Moretto, Chiara Cremolini, W. Michael Korn, Heinz-Josef Lenz
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (11): 3234–3242.
https://doi.org/10.1158/1078-0432.CCR-20-3635
Published: 01 June 2021
View article titled, The Landscape of Alterations in DNA Damage Response Pathways in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Clinical Validation of a Machine-learning–derived Signature Predictive of Outcomes from First-line Oxaliplatin-based Chemotherapy in Advanced Colorectal Cancer

Jim P. Abraham, Daniel Magee, Chiara Cremolini, Carlotta Antoniotti, David D. Halbert, Joanne Xiu, Phillip Stafford, Donald A. Berry, Matthew J. Oberley, Anthony F. Shields, John L. Marshall, Mohamed E. Salem, Alfredo Falcone, Axel Grothey, Michael J. Hall, Alan P. Venook, Heinz-Josef Lenz, Anthony Helmstetter, W. Michael Korn, David B. Spetzler
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (4): 1174–1183.
https://doi.org/10.1158/1078-0432.CCR-20-3286
Published: 15 February 2021
View article titled, Clinical Validation of a Machine-learning–derived Signature Predictive of Outcomes from First-line Oxaliplatin-based Chemotherapy in Advanced Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Comprehensive Genomic Profiling of Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs)

Alberto Puccini, Kelsey Poorman, Mohamed E. Salem, Davide Soldato, Andreas Seeber, Richard M. Goldberg, Anthony F. Shields, Joanne Xiu, Francesca Battaglin, Martin D. Berger, Ryuma Tokunaga, Madiha Naseem, Afsaneh Barzi, Syma Iqbal, Wu Zhang, Shivani Soni, Jimmy J. Hwang, Philip A. Philip, Stefania Sciallero, W. Michael Korn, John L. Marshall, Heinz-Josef Lenz
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (22): 5943–5951.
https://doi.org/10.1158/1078-0432.CCR-20-1804
Published: 13 November 2020
View article titled, Comprehensive Genomic Profiling of Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs)
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Journal Articles

A Phase I/II Study of Veliparib (ABT-888) in Combination with 5-Fluorouracil and Oxaliplatin in Patients with Metastatic Pancreatic Cancer

Michael J. Pishvaian, Hongkun Wang, Aiwu Ruth He, Jimmy J. Hwang, Brandon G. Smaglo, Sunnie S. Kim, Benjamin A. Weinberg, Louis M. Weiner, John L. Marshall, Jonathan R. Brody
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (19): 5092–5101.
https://doi.org/10.1158/1078-0432.CCR-20-1301
Published: 01 October 2020
View article titled, A Phase I/II Study of Veliparib (ABT-888) in Combination with 5-Fluorouracil and Oxaliplatin in Patients with Metastatic Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Molecular Profiling of Appendiceal Adenocarcinoma and Comparison with Right-sided and Left-sided Colorectal Cancer

Ryuma Tokunaga, Joanne Xiu, Curtis Johnston, Richard M. Goldberg, Philip A. Philip, Andreas Seeber, Madiha Naseem, Jae Ho Lo, Hiroyuki Arai, Francesca Battaglin, Alberto Puccini, Martin D. Berger, Shivani Soni, Wu Zhang, Jimmy J. Hwang, Anthony F. Shields, John L. Marshall, Hideo Baba, W. Michael Korn, Heinz-Josef Lenz
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (10): 3096–3103.
https://doi.org/10.1158/1078-0432.CCR-18-3388
Published: 15 May 2019
View article titled, Molecular Profiling of Appendiceal Adenocarcinoma and Comparison with Right-sided and Left-sided Colorectal Cancer
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Includes: Supplementary data
Journal Articles

A Randomized, Double-Blind, Placebo-Controlled Phase II Study of the Efficacy and Safety of Monotherapy Ontuxizumab (MORAb-004) Plus Best Supportive Care in Patients with Chemorefractory Metastatic Colorectal Cancer

Axel Grothey, Jonathan R. Strosberg, Lindsay A. Renfro, Herbert I. Hurwitz, John L. Marshall, Howard Safran, Michael J. Guarino, George P. Kim, J.R. Hecht, Susan C. Weil, John Heyburn, Wenquan Wang, Charles Schweizer, Daniel J. O'Shannessy, Luis Alberto Diaz, Jr
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (2): 316–325.
https://doi.org/10.1158/1078-0432.CCR-17-1558
Published: 15 January 2018
View article titled, A Randomized, Double-Blind, Placebo-Controlled Phase II Study of the Efficacy and Safety of Monotherapy Ontuxizumab (MORAb-004) Plus Best Supportive Care in Patients with Chemorefractory Metastatic Colorectal Cancer
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Journal Articles

Phase I Dose Finding Studies of Obatoclax (GX15-070), a Small Molecule Pan-BCL-2 Family Antagonist, in Patients with Advanced Solid Tumors or Lymphoma

Jimmy J. Hwang, John Kuruvilla, David Mendelson, Michael J. Pishvaian, J.F. Deeken, Lillian L. Siu, Mark S. Berger, Jean Viallet, John L. Marshall
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (15): 4038–4045.
https://doi.org/10.1158/1078-0432.CCR-10-0822
Published: 28 July 2010
View article titled, Phase I Dose Finding Studies of Obatoclax (GX15-070), a Small Molecule Pan-BCL-2 Family Antagonist, in Patients with Advanced Solid Tumors or Lymphoma
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Includes: Supplementary data
Journal Articles

Delivery of a Liposomal c-raf-1 Antisense Oligonucleotide by Weekly Bolus Dosing in Patients with Advanced Solid Tumors: A Phase I Study

Charles M. Rudin, John L. Marshall, Chao Hui Huang, Hedy L. Kindler, Chuanbo Zhang, Deepak Kumar, Prafulla C. Gokhale, Joyce Steinberg, Steve Wanaski, Usha N. Kasid, Mark J. Ratain
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (21): 7244–7251.
https://doi.org/10.1158/1078-0432.CCR-04-0642
Published: 08 November 2004
View article titled, Delivery of a Liposomal <em>c-raf-1</em> Antisense Oligonucleotide by Weekly Bolus Dosing in Patients with Advanced Solid Tumors: <subtitle>A Phase I Study</subtitle>
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Journal Articles

A Phase I and Pharmacokinetic Study of Squalamine, a Novel Antiangiogenic Agent, in Patients with Advanced Cancers

Pankaj Bhargava, John L. Marshall, William Dahut, Naiyer Rizvi, Nina Trocky, Jon I. Williams, Howard Hait, Sharon Song, Kenneth J. Holroyd, Michael J. Hawkins
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (12): 3912–3919.
Published: 01 December 2001
View article titled, A Phase I and Pharmacokinetic Study of Squalamine, a Novel Antiangiogenic Agent, in Patients with Advanced Cancers
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Journal Articles

A Safety and Pharmacokinetic Study of a Mixed-Backbone Oligonucleotide (GEM231) Targeting the Type I Protein Kinase A by Two-hour Infusions in Patients with Refractory Solid Tumors

Helen X. Chen, John L. Marshall, Elizabeth Ness, R. Russell Martin, Barry Dvorchik, Naiyer Rizvi, Judith Marquis, Margo McKinlay, William Dahut, Michael J. Hawkins
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (4): 1259–1266.
Published: 01 April 2000
View article titled, A Safety and Pharmacokinetic Study of a Mixed-Backbone Oligonucleotide (GEM231) Targeting the Type I Protein Kinase A by Two-hour Infusions in Patients with Refractory Solid Tumors
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Journal Articles

A Phase I and Pharmacokinetic Study of TNP-470 Administered Weekly to Patients with Advanced Cancer

Pankaj Bhargava, John L. Marshall, Naiyer Rizvi, William Dahut, Joseph Yoe, Manuela Figuera, Kim Phipps, Voon S. Ong, Allen Kato, Michael J. Hawkins
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (8): 1989–1995.
Published: 01 August 1999
View article titled, A Phase I and Pharmacokinetic Study of TNP-470 Administered Weekly to Patients with Advanced Cancer
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Journal Articles

A Phase I Study of LGD1069 in Adults with Advanced Cancer

Naiyer A. Rizvi, John L. Marshall, William Dahut, Elizabeth Ness, Joseph A. Truglia, Gordon Loewen, George M. Gill, Edgar H. Ulm, Rita Geiser, Dinah Jaunakais, Michael J. Hawkins
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (7): 1658–1664.
Published: 01 July 1999
View article titled, A Phase I Study of LGD1069 in Adults with Advanced Cancer
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