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John H. Sampson
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Journal Articles

Glioblastoma Clinical Trials: Current Landscape and Opportunities for Improvement

Stephen J. Bagley, Shawn Kothari, Rifaquat Rahman, Eudocia Q. Lee, Gavin P. Dunn, Evanthia Galanis, Susan M. Chang, Louis Burt Nabors, Manmeet S. Ahluwalia, Roger Stupp, Minesh P. Mehta, David A. Reardon, Stuart A. Grossman, Erik P. Sulman, John H. Sampson, Simon Khagi, Michael Weller, Timothy F. Cloughesy, Patrick Y. Wen, Mustafa Khasraw
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (4): 594–602.
https://doi.org/10.1158/1078-0432.CCR-21-2750
Published: 15 February 2022
View article titled, Glioblastoma Clinical Trials: Current Landscape and Opportunities for Improvement
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Journal Articles

Designing Clinical Trials for Combination Immunotherapy: A Framework for Glioblastoma

Kirit Singh, Kristen A. Batich, Patrick Y. Wen, Aaron C. Tan, Stephen J. Bagley, Michael Lim, Michael Platten, Howard Colman, David M. Ashley, Susan M. Chang, Rifaquat Rahman, Evanthia Galanis, Alireza Mansouri, Vinay K. Puduvalli, David A. Reardon, Solmaz Sahebjam, John H. Sampson, John Simes, Donald A. Berry, Gelareh Zadeh, Tim F. Cloughesy, Minesh P. Mehta, Steven Piantadosi, Michael Weller, Amy B. Heimberger, Mustafa Khasraw
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (4): 585–593.
https://doi.org/10.1158/1078-0432.CCR-21-2681
Published: 15 February 2022
View article titled, Designing Clinical Trials for Combination Immunotherapy: A Framework for Glioblastoma
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Journal Articles

Once, Twice, Three Times a Finding: Reproducibility of Dendritic Cell Vaccine Trials Targeting Cytomegalovirus in Glioblastoma

Kristen A. Batich, Duane A. Mitchell, Patrick Healy, James E. Herndon, II, John H. Sampson
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (20): 5297–5303.
https://doi.org/10.1158/1078-0432.CCR-20-1082
Published: 15 October 2020
View article titled, Once, Twice, Three Times a Finding: Reproducibility of Dendritic Cell Vaccine Trials Targeting Cytomegalovirus in Glioblastoma
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Journal Articles

PD-1 Inhibitors: Do they have a Future in the Treatment of Glioblastoma?

Mustafa Khasraw, David A. Reardon, Michael Weller, John H. Sampson
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (20): 5287–5296.
https://doi.org/10.1158/1078-0432.CCR-20-1135
Published: 15 October 2020
View article titled, PD-1 Inhibitors: Do they have a Future in the Treatment of Glioblastoma?
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Journal Articles

Rindopepimut with Bevacizumab for Patients with Relapsed EGFRvIII-Expressing Glioblastoma (ReACT): Results of a Double-Blind Randomized Phase II Trial

David A. Reardon, Annick Desjardins, James J. Vredenburgh, Donald M. O'Rourke, David D. Tran, Karen L. Fink, Louis B. Nabors, Gordon Li, Daniela A. Bota, Rimas V. Lukas, Lynn S. Ashby, J. Paul Duic, Maciej M. Mrugala, Scott Cruickshank, Laura Vitale, Yi He, Jennifer A. Green, Michael J. Yellin, Christopher D. Turner, Tibor Keler, Thomas A. Davis, John H. Sampson
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (7): 1586–1594.
https://doi.org/10.1158/1078-0432.CCR-18-1140
Published: 01 April 2020
View article titled, Rindopepimut with Bevacizumab for Patients with Relapsed EGFRvIII-Expressing Glioblastoma (ReACT): Results of a Double-Blind Randomized Phase II Trial
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Includes: Supplementary data
Journal Articles

The Evolving Modern Management of Brain Metastasis

Peter E. Fecci, Cosette D. Champion, Jacob Hoj, Courtney M. McKernan, C. Rory Goodwin, John P. Kirkpatrick, Carey K. Anders, Ann Marie Pendergast, John H. Sampson
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (22): 6570–6580.
https://doi.org/10.1158/1078-0432.CCR-18-1624
Published: 15 November 2019
View article titled, The Evolving Modern Management of Brain Metastasis
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Journal Articles

Brain Tumor Microenvironment and Host State: Implications for Immunotherapy

William Tomaszewski, Luis Sanchez-Perez, Thomas F. Gajewski, John H. Sampson
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (14): 4202–4210.
https://doi.org/10.1158/1078-0432.CCR-18-1627
Published: 15 July 2019
View article titled, Brain Tumor Microenvironment and Host State: Implications for Immunotherapy
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Journal Articles

Immunotherapy for Glioblastoma: Adoptive T-cell Strategies

Bryan D. Choi, Marcela V. Maus, Carl H. June, John H. Sampson
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (7): 2042–2048.
https://doi.org/10.1158/1078-0432.CCR-18-1625
Published: 01 April 2019
View article titled, Immunotherapy for Glioblastoma: Adoptive T-cell Strategies
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Journal Articles

Preventing Lck Activation in CAR T Cells Confers Treg Resistance but Requires 4-1BB Signaling for Them to Persist and Treat Solid Tumors in Nonlymphodepleted Hosts

Carter M. Suryadevara, Rupen Desai, S. Harrison Farber, Bryan D. Choi, Adam M. Swartz, Steven H. Shen, Patrick C. Gedeon, David J. Snyder, James E. Herndon, II, Patrick Healy, Elizabeth A. Reap, Gary E. Archer, Peter E. Fecci, John H. Sampson, Luis Sanchez-Perez
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (1): 358–368.
https://doi.org/10.1158/1078-0432.CCR-18-1211
Published: 03 January 2019
View article titled, Preventing Lck Activation in CAR T Cells Confers Treg Resistance but Requires 4-1BB Signaling for Them to Persist and Treat Solid Tumors in Nonlymphodepleted Hosts
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Journal Articles

A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma

Patrick C. Gedeon, Teilo H. Schaller, Satish K. Chitneni, Bryan D. Choi, Chien-Tsun Kuan, Carter M. Suryadevara, David J. Snyder, Robert J. Schmittling, Scott E. Szafranski, Xiuyu Cui, Patrick N. Healy, James E. Herndon, II, Roger E. McLendon, Stephen T. Keir, Gary E. Archer, Elizabeth A. Reap, Luis Sanchez-Perez, Darell D. Bigner, John H. Sampson
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (15): 3611–3631.
https://doi.org/10.1158/1078-0432.CCR-17-0126
Published: 31 July 2018
View article titled, A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma
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Includes: Supplementary data
Journal Articles

Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted Vaccination

Kristen A. Batich, Elizabeth A. Reap, Gary E. Archer, Luis Sanchez-Perez, Smita K. Nair, Robert J. Schmittling, Pam Norberg, Weihua Xie, James E. Herndon, II, Patrick Healy, Roger E. McLendon, Allan H. Friedman, Henry S. Friedman, Darell Bigner, Gordana Vlahovic, Duane A. Mitchell, John H. Sampson
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (8): 1898–1909.
https://doi.org/10.1158/1078-0432.CCR-16-2057
Published: 13 April 2017
View article titled, Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted Vaccination
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Includes: Supplementary data
Journal Articles

Immunotherapy Gone Viral: Bortezomib and oHSV Enhance Antitumor NK-Cell Activity

Carter M. Suryadevara, Katherine A. Riccione, John H. Sampson
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (21): 5164–5166.
https://doi.org/10.1158/1078-0432.CCR-16-1666
Published: 31 October 2016
View article titled, Immunotherapy Gone Viral: Bortezomib and oHSV Enhance Antitumor NK-Cell Activity
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Journal Articles

Differential Immune Microenvironments and Response to Immune Checkpoint Blockade among Molecular Subtypes of Murine Medulloblastoma

Christina D. Pham, Catherine Flores, Changlin Yang, Elaine M. Pinheiro, Jennifer H. Yearley, Elias J. Sayour, Yanxin Pei, Colin Moore, Roger E. McLendon, Jianping Huang, John H. Sampson, Robert Wechsler-Reya, Duane A. Mitchell
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (3): 582–595.
https://doi.org/10.1158/1078-0432.CCR-15-0713
Published: 31 January 2016
View article titled, Differential Immune Microenvironments and Response to Immune Checkpoint Blockade among Molecular Subtypes of Murine Medulloblastoma
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Includes: Supplementary data
Journal Articles

Immunotherapy for Primary Brain Tumors: No Longer a Matter of Privilege

Peter E. Fecci, Amy B. Heimberger, John H. Sampson
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (22): 5620–5629.
https://doi.org/10.1158/1078-0432.CCR-14-0832
Published: 13 November 2014
View article titled, Immunotherapy for Primary Brain Tumors: No Longer a Matter of Privilege
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Journal Articles

Recognition and Killing of Autologous, Primary Glioblastoma Tumor Cells by Human Cytomegalovirus pp65-Specific Cytotoxic T Cells

Smita K. Nair, Gabriel De Leon, David Boczkowski, Robert Schmittling, Weihua Xie, Janet Staats, Rebecca Liu, Laura A. Johnson, Kent Weinhold, Gary E. Archer, John H. Sampson, Duane A. Mitchell
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (10): 2684–2694.
https://doi.org/10.1158/1078-0432.CCR-13-3268
Published: 14 May 2014
View article titled, Recognition and Killing of Autologous, Primary Glioblastoma Tumor Cells by Human Cytomegalovirus pp65-Specific Cytotoxic T Cells
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Includes: Supplementary data
Journal Articles

EGFRvIII mCAR-Modified T-Cell Therapy Cures Mice with Established Intracerebral Glioma and Generates Host Immunity against Tumor-Antigen Loss

John H. Sampson, Bryan D. Choi, Luis Sanchez-Perez, Carter M. Suryadevara, David J. Snyder, Catherine T. Flores, Robert J. Schmittling, Smita K. Nair, Elizabeth A. Reap, Pamela K. Norberg, James E. Herndon, II, Chien-Tsun Kuan, Richard A. Morgan, Steven A. Rosenberg, Laura A. Johnson
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (4): 972–984.
https://doi.org/10.1158/1078-0432.CCR-13-0709
Published: 16 February 2014
View article titled, EGFRvIII mCAR-Modified T-Cell Therapy Cures Mice with Established Intracerebral Glioma and Generates Host Immunity against Tumor-Antigen Loss
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Journal Articles

Regulatory T Cells Move in When Gliomas Say “I DO”

Bryan D. Choi, Peter E. Fecci, John H. Sampson
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (22): 6086–6088.
https://doi.org/10.1158/1078-0432.CCR-12-2801
Published: 14 November 2012
View article titled, Regulatory T Cells Move in When Gliomas Say “I DO”
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Includes: Supplementary data
Journal Articles

Is Cytomegalovirus a Therapeutic Target in Glioblastoma?

John H. Sampson, Duane A. Mitchell
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (14): 4619–4621.
https://doi.org/10.1158/1078-0432.CCR-11-0992
Published: 17 July 2011
View article titled, Is Cytomegalovirus a Therapeutic Target in Glioblastoma?
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Journal Articles

The Addition of Bevacizumab to Standard Radiation Therapy and Temozolomide Followed by Bevacizumab, Temozolomide, and Irinotecan for Newly Diagnosed Glioblastoma

James J. Vredenburgh, Annick Desjardins, David A. Reardon, Katherine B. Peters, James E. Herndon, II, Jennifer Marcello, John P. Kirkpatrick, John H. Sampson, Leighann Bailey, Stevie Threatt, Allan H. Friedman, Darell D. Bigner, Henry S. Friedman
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (12): 4119–4124.
https://doi.org/10.1158/1078-0432.CCR-11-0120
Published: 15 June 2011
View article titled, The Addition of Bevacizumab to Standard Radiation Therapy and Temozolomide Followed by Bevacizumab, Temozolomide, and Irinotecan for Newly Diagnosed Glioblastoma
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Journal Articles

Phase II Trial of Gliadel plus O6-Benzylguanine in Adults with Recurrent Glioblastoma Multiforme

Jennifer A. Quinn, Sara Xiaoyin Jiang, James Carter, David A. Reardon, Annick Desjardins, James J. Vredenburgh, Jeremy N. Rich, Sridharan Gururangan, Allan H. Friedman, Darell D. Bigner, John H. Sampson, Roger E. McLendon, James E. Herndon, II, Stevie Threatt, Henry S. Friedman
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (3): 1064–1068.
https://doi.org/10.1158/1078-0432.CCR-08-2130
Published: 02 February 2009
View article titled, Phase II Trial of Gliadel plus <em>O</em><sup>6</sup>-Benzylguanine in Adults with Recurrent Glioblastoma Multiforme
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