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Joanne Xiu
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Journal Articles

Abstract P1-03-22: Comprehensive characterization of the androgen receptor in male breast cancer

Free
Priya Jayachandran, Sachin Kumar Deshmukh, Sharon Wu, Jennifer R. Ribeiro, Irene Kang, Joanne Xiu, Francesca Battaglin, Darcy V. Spicer, Daphne B. Stewart, Shivani Soni, Wu Zhang, Janice Lu, Karam Ashouri, Joshua Millstein, William Flood, Jose P. Leone, Dario Trapani, Maryam Lustberg, Stephanie L. Graff, George W. Sledge, Jr., Heinz-Josef Lenz, Evanthia T. Roussos Torres
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): P1-03-22.
https://doi.org/10.1158/1557-3265.SABCS24-P1-03-22
Published: 13 June 2025
View articletitled, Abstract P1-03-22: Comprehensive characterization of the androgen receptor in male breast cancer
Journal Articles

Abstract P1-05-21: Prognostic implications of oncogenetic pathway alterations in advanced male breast cancer

Free
Dario Trapani, Sachin Kumar Deshmukh, Sharon Wu, Joanne Xiu, Daniel L. Abravanel, Priya Jayachandran, Nancy U. Lin, Giuseppe Curigliano, Philip Spanheimer, Milan Radovich, Stephanie L. Graff, Maryam Lustberg, George W. Sledge, Jr, Sara M. Tolaney, Jose P. Leone
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): P1-05-21.
https://doi.org/10.1158/1557-3265.SABCS24-P1-05-21
Published: 13 June 2025
View articletitled, Abstract P1-05-21: Prognostic implications of oncogenetic pathway alterations in advanced male breast cancer
Journal Articles

Abstract PS13-09: Mechanisms of Resistance to Trastuzumab Deruxtecan in Breast Cancer Elucidated by Multi-omic Molecular Profiling

Free
George Sledge, Joanne Xiu, Reshma L. Mahtani, Ana C. Sandoval Leon, Matthew J. Oberley, Milan Radovich, David Spetzler
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): PS13-09.
https://doi.org/10.1158/1557-3265.SABCS24-PS13-09
Published: 13 June 2025
View articletitled, Abstract PS13-09: Mechanisms of Resistance to Trastuzumab Deruxtecan in Breast Cancer Elucidated by Multi-omic Molecular Profiling
Journal Articles

Abstract P3-01-25: Molecular and immunological characterization of HER2-low, HER2 ultra-low, and HER2-null male breast cancer

Free
Dario Trapani, Sachin Kumar Deshmukh, Sharon Wu, Joanne Xiu, Priya Jayachandran, Nancy U. Lin, Giuseppe Curigliano, Milan Radovich, Maryam Lustberg, Stephanie L. Graff, George W. Sledge, Jr, Sara M. Tolaney, Jose P. Leone
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): P3-01-25.
https://doi.org/10.1158/1557-3265.SABCS24-P3-01-25
Published: 13 June 2025
View articletitled, Abstract P3-01-25: Molecular and immunological characterization of HER2-low, HER2 ultra-low, and HER2-null male breast cancer
Journal Articles

Abstract PS17-02: Molecular and Immune Landscape of Metaplastic Triple Negative Breast Cancer Compared with Invasive Ductal Triple Negative Breast Cancer

Free
Pooja Advani, Sachin Kumar Deshmukh, Sharon Wu, Joanne Xiu, Jose P. Leone, Priya Jayachandran, Matthew Oberley, Maryam Lustberg, Stephanie L. Graff, George W. Sledge, Jr, Asher Chanan-Khan
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): PS17-02.
https://doi.org/10.1158/1557-3265.SABCS24-PS17-02
Published: 13 June 2025
View articletitled, Abstract PS17-02: Molecular and Immune Landscape of Metaplastic Triple Negative Breast Cancer Compared with Invasive Ductal Triple Negative Breast Cancer
Journal Articles

Abstract P1-01-16: Molecular landscape of HR+/HER2- male breast cancer (MaBC) compared with female breast cancer (FeBC)

Free
Dario Trapani, Sachin Kumar Deshmukh, Sharon Wu, Joanne Xiu, Pooja Advani, Daniel L. Abravanel, Nancy U. Lin, Giuseppe Curigliano, William Flood, Stephanie L. Graff, Maryam Lustberg, Philip Spanheimer, George W. Sledge, Jr, Sara M. Tolaney, Jose P. Leone
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): P1-01-16.
https://doi.org/10.1158/1557-3265.SABCS24-P1-01-16
Published: 13 June 2025
View articletitled, Abstract P1-01-16: Molecular landscape of HR+/HER2- male breast cancer (MaBC) compared with female breast cancer (FeBC)
Journal Articles

Distinct Molecular and Clinical Features of Specific Variants of KRAS Codon 12 in Pancreatic Adenocarcinoma

Open Access
Bach Ardalan, Aaron Ciner, Yasmine Baca, Andrew Hinton, Sourat Darabi, Anup Kasi, Emil Lou, Jose Ignacio Azqueta, Joanne Xiu, Jashodeep Datta, Anthony F. Shields, Andrew Aguirre, Harshabad Singh, Rachna T. Shroff, Michael J. Pishvaian, Sanjay Goel
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (6): 1082–1090.
https://doi.org/10.1158/1078-0432.CCR-24-3149
Published: 17 March 2025
View articletitled, Distinct Molecular and Clinical Features of Specific Variants of KRAS Codon 12 in Pancreatic Adenocarcinoma
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Includes: Supplementary data
Journal Articles

Clinical and Genomic Features of Classical and Basal Transcriptional Subtypes in Pancreatic Cancer

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Harshabad Singh, Joanne Xiu, Kevin S. Kapner, Chen Yuan, Raja R. Narayan, Matthew Oberley, Alex Farrell, Rishi Surana, Brandon M. Huffman, Kimberly Perez, James M. Cleary, Alexander C. Jordan, Andressa Dias Costa, Hannah L. Williams, Srivatsan Raghavan, Benjamin Weinberg, Michael J. Pishvaian, Rachna T. Shroff, Sanjay Goel, Stephanie K. Dougan, Jonathan A. Nowak, David Spetzler, George Sledge, Brian M. Wolpin, Andrew J. Aguirre
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (21): 4932–4942.
https://doi.org/10.1158/1078-0432.CCR-24-1164
Published: 01 November 2024
View articletitled, Clinical and Genomic Features of Classical and Basal Transcriptional Subtypes in Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Molecular Profiling and the Impact of Treatment on Outcomes in Adenoid Cystic Carcinoma Type I and II

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Glenn J. Hanna, Punita Grover, Andrew Elliott, Julie McGrath, Joanne Xiu, Ammar Sukari, Jennifer M. Johnson, Trisha Wise-Draper
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (10): 2225–2232.
https://doi.org/10.1158/1078-0432.CCR-23-3182
Published: 15 May 2024
View articletitled, Molecular Profiling and the Impact of Treatment on Outcomes in Adenoid Cystic Carcinoma Type I and II
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Includes: Supplementary data
Journal Articles

Differential Responses to Immune Checkpoint Inhibitors are Governed by Diverse Mismatch Repair Gene Alterations

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Moh'd M. Khushman, Michael D. Toboni, Joanne Xiu, Upender Manne, Alex Farrell, Emil Lou, Anthony F. Shields, Philip A. Philip, Mohamed E. Salem, Jim Abraham, David Spetzler, John Marshall, Priya Jayachandran, Michael J. Hall, Heinz-Josef Lenz, Ibrahim Halil Sahin, Andreas Seeber, Mathew A. Powell
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (9): 1906–1915.
https://doi.org/10.1158/1078-0432.CCR-23-3004
Published: 01 May 2024
View articletitled, Differential Responses to Immune Checkpoint Inhibitors are Governed by Diverse Mismatch Repair Gene Alterations
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Journal Articles

Advanced Age in Humans and Mouse Models of Glioblastoma Show Decreased Survival from Extratumoral Influence

Open Access
Margaret Johnson, April Bell, Kristen L. Lauing, Erik Ladomersky, Lijie Zhai, Manon Penco-Campillo, Yajas Shah, Elizabeth Mauer, Joanne Xiu, Theodore Nicolaides, Michael Drumm, Kathleen McCortney, Olivier Elemento, Miri Kim, Prashant Bommi, Justin T. Low, Ruba Memon, Jennifer Wu, Junfei Zhao, Xinlei Mi, Michael J. Glantz, Soma Sengupta, Brandyn Castro, Bakhtiar Yamini, Craig Horbinski, Darren J. Baker, Theresa L. Walunas, Gary E. Schiltz, Rimas V. Lukas, Derek A. Wainwright
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (23): 4973–4989.
https://doi.org/10.1158/1078-0432.CCR-23-0834
Published: 01 December 2023
View articletitled, Advanced Age in Humans and Mouse Models of Glioblastoma Show Decreased Survival from Extratumoral Influence
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Includes: Supplementary data
Journal Articles

Metastatic Prostate Cancers with BRCA2 versus ATM Mutations Exhibit Divergent Molecular Features and Clinical Outcomes

Available to Purchase
Justin Hwang, Xiaolei Shi, Andrew Elliott, Taylor E. Arnoff, Julie McGrath, Joanne Xiu, Phillip Walker, Hannah E. Bergom, Abderrahman Day, Shihab Ahmed, Sydney Tape, Allison Makovec, Atef Ali, Rami M. Shaker, Eamon Toye, Rachel Passow, John R. Lozada, Jinhua Wang, Emil Lou, Kent W. Mouw, Benedito A. Carneiro, Elisabeth I. Heath, Rana R. McKay, W. Michael Korn, Chadi Nabhan, Charles J. Ryan, Emmanuel S. Antonarakis
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (14): 2702–2713.
https://doi.org/10.1158/1078-0432.CCR-22-3394
Published: 14 July 2023
View articletitled, Metastatic Prostate Cancers with BRCA2 versus ATM Mutations Exhibit Divergent Molecular Features and Clinical Outcomes
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Includes: Supplementary data
Journal Articles

Multi-omic Characterization of Pancreatic Ductal Adenocarcinoma Relates CXCR4 mRNA Expression Levels to Potential Clinical Targets

Open Access
Florian Kocher, Alberto Puccini, Gerold Untergasser, Agnieszka Martowicz, Kai Zimmer, Andreas Pircher, Yasmine Baca, Joanne Xiu, Johannes Haybaeck, Piotr Tymoszuk, Richard M. Goldberg, Angelica Petrillo, Anthony F. Shields, Mohamed E. Salem, John L. Marshall, Michael Hall, W. Michael Korn, Chadi Nabhan, Francesca Battaglin, Heinz-Josef Lenz, Emil Lou, Su-Pin Choo, Chee-Keong Toh, Silvia Gasteiger, Renate Pichler, Dominik Wolf, Andreas Seeber
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (22): 4957–4967.
https://doi.org/10.1158/1078-0432.CCR-22-0275
Published: 14 November 2022
View articletitled, Multi-omic Characterization of Pancreatic Ductal Adenocarcinoma Relates CXCR4 mRNA Expression Levels to Potential Clinical Targets
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Includes: Supplementary data
Journal Articles

Molecular Characterization of KRAS Wild-type Tumors in Patients with Pancreatic Adenocarcinoma

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Philip A. Philip, Ibrahim Azar, Joanne Xiu, Michael J. Hall, Andrew Eugene Hendifar, Emil Lou, Jimmy J. Hwang, Jun Gong, Rebecca Feldman, Michelle Ellis, Phil Stafford, David Spetzler, Moh'd M. Khushman, Davendra Sohal, A. Craig Lockhart, Benjamin A. Weinberg, Wafik S. El-Deiry, John Marshall, Anthony F. Shields, W. Michael Korn
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (12): 2704–2714.
https://doi.org/10.1158/1078-0432.CCR-21-3581
Published: 13 June 2022
View articletitled, Molecular Characterization of KRAS Wild-type Tumors in Patients with Pancreatic Adenocarcinoma
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Includes: Supplementary data
Journal Articles

Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer

Open Access
Andreas Seeber, Francesca Battaglin, Kai Zimmer, Florian Kocher, Yasmine Baca, Joanne Xiu, Gilbert Spizzo, Veronica Novotny-Diermayr, Dietmar Rieder, Alberto Puccini, Jeff Swensen, Michelle Ellis, Richard M. Goldberg, Axel Grothey, Anthony F. Shields, John L. Marshall, Benjamin A. Weinberg, Paul E. Sackstein, Kiat Hon Lim, Gek San Tan, Chadi Nabhan, W. Michael Korn, Arno Amann, Zlatko Trajanoski, Martin D. Berger, Emil Lou, Dominik Wolf, Heinz-Josef Lenz
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (9): 1863–1870.
https://doi.org/10.1158/1078-0432.CCR-21-3018
Published: 02 May 2022
View articletitled, Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Association of TP53 and CDKN2A Mutation Profile with Tumor Mutation Burden in Head and Neck Cancer

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Alexander Y. Deneka, Yasmine Baca, Ilya G. Serebriiskii, Emmanuelle Nicolas, Mitchell I. Parker, Theodore T. Nguyen, Joanne Xiu, W. Michael Korn, Michael J. Demeure, Trisha Wise-Draper, Ammar Sukari, Barbara Burtness, Erica A. Golemis
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (9): 1925–1937.
https://doi.org/10.1158/1078-0432.CCR-21-4316
Published: 02 May 2022
View articletitled, Association of TP53 and CDKN2A Mutation Profile with Tumor Mutation Burden in Head and Neck Cancer
Open the PDF for Association of TP53 and CDKN2A Mutation Profile with Tumor Mutation Burden in Head and Neck Cancer in another window
Includes: Supplementary data
Journal Articles

Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer

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Jonathan M. Loree, Yucai Wang, Muddassir A. Syed, Alexey V. Sorokin, Oluwadara Coker, Joanne Xiu, Benjamin A. Weinberg, Ari M. Vanderwalde, Anteneh Tesfaye, Victoria M. Raymond, Benjamin Miron, Gabi Tarcic, Ori Zelichov, Russell R. Broaddus, Patrick Kwok Shing Ng, Kang Jin Jeong, Yiu Huen Tsang, Gordon B. Mills, Michael J. Overman, Axel Grothey, John L. Marshall, Scott Kopetz
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (16): 4587–4598.
https://doi.org/10.1158/1078-0432.CCR-21-0180
Published: 15 August 2021
View articletitled, Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer
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Includes: Supplementary data
Journal Articles

The Landscape of Alterations in DNA Damage Response Pathways in Colorectal Cancer

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Hiroyuki Arai, Andrew Elliott, Joanne Xiu, Jingyuan Wang, Francesca Battaglin, Natsuko Kawanishi, Shivani Soni, Wu Zhang, Joshua Millstein, Davendra Sohal, Richard M. Goldberg, Michael J. Hall, Aaron J. Scott, Moh'd Khushman, Jimmy J. Hwang, Emil Lou, Benjamin A. Weinberg, John L. Marshall, Albert C. Lockhart, Phillip Stafford, Jian Zhang, Roberto Moretto, Chiara Cremolini, W. Michael Korn, Heinz-Josef Lenz
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (11): 3234–3242.
https://doi.org/10.1158/1078-0432.CCR-20-3635
Published: 01 June 2021
View articletitled, The Landscape of Alterations in DNA Damage Response Pathways in Colorectal Cancer
Open the PDF for The Landscape of Alterations in DNA Damage Response Pathways in Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Clinical Validation of a Machine-learning–derived Signature Predictive of Outcomes from First-line Oxaliplatin-based Chemotherapy in Advanced Colorectal Cancer

Free
Jim P. Abraham, Daniel Magee, Chiara Cremolini, Carlotta Antoniotti, David D. Halbert, Joanne Xiu, Phillip Stafford, Donald A. Berry, Matthew J. Oberley, Anthony F. Shields, John L. Marshall, Mohamed E. Salem, Alfredo Falcone, Axel Grothey, Michael J. Hall, Alan P. Venook, Heinz-Josef Lenz, Anthony Helmstetter, W. Michael Korn, David B. Spetzler
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (4): 1174–1183.
https://doi.org/10.1158/1078-0432.CCR-20-3286
Published: 15 February 2021
View articletitled, Clinical Validation of a Machine-learning–derived Signature Predictive of Outcomes from First-line Oxaliplatin-based Chemotherapy in Advanced Colorectal Cancer
Open the PDF for Clinical Validation of a Machine-learning–derived Signature Predictive of Outcomes from First-line Oxaliplatin-based Chemotherapy in Advanced Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Comprehensive Genomic Profiling of Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs)

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Alberto Puccini, Kelsey Poorman, Mohamed E. Salem, Davide Soldato, Andreas Seeber, Richard M. Goldberg, Anthony F. Shields, Joanne Xiu, Francesca Battaglin, Martin D. Berger, Ryuma Tokunaga, Madiha Naseem, Afsaneh Barzi, Syma Iqbal, Wu Zhang, Shivani Soni, Jimmy J. Hwang, Philip A. Philip, Stefania Sciallero, W. Michael Korn, John L. Marshall, Heinz-Josef Lenz
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (22): 5943–5951.
https://doi.org/10.1158/1078-0432.CCR-20-1804
Published: 13 November 2020
View articletitled, Comprehensive Genomic Profiling of Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs)
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