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Journal Articles

Abstract A025: Tumor fraction (TF) is associated with real-world progression-free survival (rwPFS) in advanced non-small-cell lung cancer (aNSCLC) patients treated with chemotherapy (chemo)

Jing Wang, Sean Gordon, Errin Lagow, Tara Dinman, Carin Espenschied, Shile Zhang, Kimberly Banks
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (21_Supplement): A025.
https://doi.org/10.1158/1557-3265.LIQBIOP24-A025
Published: 13 November 2024
View article titled, Abstract A025: Tumor fraction (TF) is associated with real-world progression-free survival (rwPFS) in advanced non-small-cell lung cancer (aNSCLC) patients treated with chemotherapy (chemo)
Journal Articles

Abstract A033: Leveraging mass cytometry for phenotyping CTCs in SCLC liquid biopsies: Tracking therapy resistance at a personalized level

Loukia G Karacosta, Sayantan Bhattacharyya, Allison Stewart, Ashley Victorian, Ester F Lujan, Shafqat Ehsan, Subin Kim, Alberto Duarte, Runsheng Wang, Benedict Anchang, Jing Wang, Lauren Byers
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (21_Supplement): A033.
https://doi.org/10.1158/1557-3265.LIQBIOP24-A033
Published: 13 November 2024
View article titled, Abstract A033: Leveraging mass cytometry for phenotyping CTCs in SCLC liquid biopsies: Tracking therapy resistance at a personalized level
Journal Articles

Abstract PR005: Leveraging mass cytometry for phenotyping CTCs in SCLC liquid biopsies: Tracking therapy resistance at a personalized level

Loukia G Karacosta, Sayantan Bhattacharyya, Allison Stewart, Ashley Victorian, Ester F Lujan, Shafqat Ehsan, Subin Kim, Alberto Duarte, Runsheng Wang, Benedict Anchang, Jing Wang, Lauren Byers
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (21_Supplement): PR005.
https://doi.org/10.1158/1557-3265.LIQBIOP24-PR005
Published: 13 November 2024
View article titled, Abstract PR005: Leveraging mass cytometry for phenotyping CTCs in SCLC liquid biopsies: Tracking therapy resistance at a personalized level
Journal Articles

YAP1 Status Defines Two Intrinsic Subtypes of LCNEC with Distinct Molecular Features and Therapeutic Vulnerabilities

C. Allison Stewart, Lixia Diao, Yuanxin Xi, Runsheng Wang, Kavya Ramkumar, Alejandra G. Serrano, Azusa Tanimoto, B. Leticia Rodriguez, Benjamin B. Morris, Li Shen, Bingnan Zhang, Yan Yang, Samera H. Hamad, Robert J. Cardnell, Alberto Duarte, Jr, Moushumi Sahu, Veronica Y. Novegil, Bernard E. Weissman, Michael Frumovitz, Neda Kalhor, Luisa Solis Soto, Pedro da Rocha, Natalie Vokes, Don L. Gibbons, Jing Wang, John V. Heymach, Bonnie Glisson, Lauren Averett Byers, Carl M. Gay
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (20): 4743–4754.
https://doi.org/10.1158/1078-0432.CCR-24-0361
Published: 15 October 2024
View article titled, YAP1 Status Defines Two Intrinsic Subtypes of LCNEC with Distinct Molecular Features and Therapeutic Vulnerabilities
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Includes: Supplementary data
Journal Articles

Oral Estrogen Receptor PROTAC Vepdegestrant (ARV-471) Is Highly Efficacious as Monotherapy and in Combination with CDK4/6 or PI3K/mTOR Pathway Inhibitors in Preclinical ER+ Breast Cancer Models

Sheryl M. Gough, John J. Flanagan, Jessica Teh, Monica Andreoli, Emma Rousseau, Melissa Pannone, Mark Bookbinder, Ryan Willard, Kim Davenport, Elizabeth Bortolon, Gregory Cadelina, Debbie Gordon, Jennifer Pizzano, Jennifer Macaluso, Leofal Soto, John Corradi, Katherine Digianantonio, Ieva Drulyte, Alicia Morgan, Connor Quinn, Miklós Békés, Caterina Ferraro, Xin Chen, Gan Wang, Hanqing Dong, Jing Wang, David R. Langley, John Houston, Richard Gedrich, Ian C. Taylor
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (16): 3549–3563.
https://doi.org/10.1158/1078-0432.CCR-23-3465
Published: 15 August 2024
View article titled, Oral Estrogen Receptor PROTAC Vepdegestrant (ARV-471) Is Highly Efficacious as Monotherapy and in Combination with CDK4/6 or PI3K/mTOR Pathway Inhibitors in Preclinical ER<sup>+</sup> Breast Cancer Models
Open the PDF for Oral Estrogen Receptor PROTAC Vepdegestrant (ARV-471) Is Highly Efficacious as Monotherapy and in Combination with CDK4/6 or PI3K/mTOR Pathway Inhibitors in Preclinical ER<sup>+</sup> Breast Cancer Models in another window
Includes: Supplementary data
Journal Articles

Cadonilimab Combined with Chemotherapy with or without Bevacizumab as First-Line Treatment in Recurrent or Metastatic Cervical Cancer (COMPASSION-13): A Phase 2 Study

Hanmei Lou, Hongbing Cai, Xin Huang, Guiling Li, Li Wang, Fei Liu, Wenjing Qin, Ting Liu, Wei Liu, Zhongmin Maxwell Wang, Baiyong Li, Yu Xia, Jing Wang
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (8): 1501–1508.
https://doi.org/10.1158/1078-0432.CCR-23-3162
Published: 15 April 2024
View article titled, Cadonilimab Combined with Chemotherapy with or without Bevacizumab as First-Line Treatment in Recurrent or Metastatic Cervical Cancer (COMPASSION-13): A Phase 2 Study
Open the PDF for Cadonilimab Combined with Chemotherapy with or without Bevacizumab as First-Line Treatment in Recurrent or Metastatic Cervical Cancer (COMPASSION-13): A Phase 2 Study in another window
Includes: Supplementary data
Journal Articles

Efficacy and Quality-of-Life Following Involved Nodal Radiotherapy for Head and Neck Squamous Cell Carcinoma: The INRT-AIR Phase II Clinical Trial

David J. Sher, Dominic H. Moon, Dat Vo, Jing Wang, Liyuan Chen, Michael Dohopolski, Randall Hughes, Baran D. Sumer, Chul Ahn, Vladimir Avkshtol
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (17): 3284–3291.
https://doi.org/10.1158/1078-0432.CCR-23-0334
Published: 01 September 2023
View article titled, Efficacy and Quality-of-Life Following Involved Nodal Radiotherapy for Head and Neck Squamous Cell Carcinoma: The INRT-AIR Phase II Clinical Trial
Open the PDF for Efficacy and Quality-of-Life Following Involved Nodal Radiotherapy for Head and Neck Squamous Cell Carcinoma: The INRT-AIR Phase II Clinical Trial in another window
Includes: Supplementary data
Journal Articles

Targeting BCL2 Overcomes Resistance and Augments Response to Aurora Kinase B Inhibition by AZD2811 in Small Cell Lung Cancer

Kavya Ramkumar, Azusa Tanimoto, Carminia M. Della Corte, C. Allison Stewart, Qi Wang, Li Shen, Robert J. Cardnell, Jing Wang, Urszula M. Polanska, Courtney Andersen, Jamal Saeh, J. Elizabeth Pease, Jon Travers, Giulia Fabbri, Carl M. Gay, Jelena Urosevic, Lauren A. Byers
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (16): 3237–3249.
https://doi.org/10.1158/1078-0432.CCR-23-0375
Published: 15 August 2023
View article titled, Targeting BCL2 Overcomes Resistance and Augments Response to Aurora Kinase B Inhibition by AZD2811 in Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

IL6 Mediates Suppression of T- and NK-cell Function in EMT-associated TKI-resistant EGFR-mutant NSCLC

Sonia A. Patel, Monique B. Nilsson, Yan Yang, Xiuning Le, Hai T. Tran, Yasir Y. Elamin, Xiaoxing Yu, Fahao Zhang, Alissa Poteete, Xiaoyang Ren, Li Shen, Jing Wang, Seyed Javad Moghaddam, Tina Cascone, Michael Curran, Don L. Gibbons, John V. Heymach
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (7): 1292–1304.
https://doi.org/10.1158/1078-0432.CCR-22-3379
Published: 03 April 2023
View article titled, IL6 Mediates Suppression of T- and NK-cell Function in EMT-associated TKI-resistant EGFR-mutant NSCLC
Open the PDF for IL6 Mediates Suppression of T- and NK-cell Function in EMT-associated TKI-resistant EGFR-mutant NSCLC in another window
Includes: Supplementary data
Journal Articles

Dysregulation and Epigenetic Reprogramming of NRF2 Signaling Axis Promote Acquisition of Cisplatin Resistance and Metastasis in Head and Neck Squamous Cell Carcinoma

Abdullah A. Osman, Emre Arslan, Mason Bartels, Chieko Michikawa, Antje Lindemann, Katarzyna Tomczak, Wangjie Yu, Vlad Sandulache, Wencai Ma, Li Shen, Jing Wang, Anand K. Singh, Mitchell J. Frederick, Nakia D. Spencer, Jeffery Kovacs, Timothy Heffernan, William F. Symmans, Kunal Rai, Jeffrey N. Myers
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (7): 1344–1359.
https://doi.org/10.1158/1078-0432.CCR-22-2747
Published: 03 April 2023
View article titled, Dysregulation and Epigenetic Reprogramming of NRF2 Signaling Axis Promote Acquisition of Cisplatin Resistance and Metastasis in Head and Neck Squamous Cell Carcinoma
Open the PDF for Dysregulation and Epigenetic Reprogramming of NRF2 Signaling Axis Promote Acquisition of Cisplatin Resistance and Metastasis in Head and Neck Squamous Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

SHR-1701, a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, for Recurrent or Metastatic Cervical Cancer: A Clinical Expansion Cohort of a Phase I Study

Jifeng Feng, Dihong Tang, Jing Wang, Qi Zhou, Jin Peng, Hanmei Lou, Yuping Sun, Yunlang Cai, Hongmin Chen, Junqin Yang, Pan Liu, Linna Wang, Jianjun Zou
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (24): 5297–5305.
https://doi.org/10.1158/1078-0432.CCR-22-0346
Published: 15 December 2022
View article titled, SHR-1701, a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, for Recurrent or Metastatic Cervical Cancer: A Clinical Expansion Cohort of a Phase I Study
Open the PDF for SHR-1701, a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, for Recurrent or Metastatic Cervical Cancer: A Clinical Expansion Cohort of a Phase I Study in another window
Includes: Supplementary data
Journal Articles

Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus–Driven Cancers

Soma Ghosh, Tuhina Mazumdar, Wei Xu, Reid T. Powell, Clifford Stephan, Li Shen, Pooja A. Shah, Curtis R. Pickering, Jeffery N. Myers, Jing Wang, Mitchell J. Frederick, Faye M. Johnson
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (20): 4479–4493.
https://doi.org/10.1158/1078-0432.CCR-22-1627
Published: 14 October 2022
View article titled, Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus–Driven Cancers
Open the PDF for Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus–Driven Cancers in another window
Includes: Supplementary data
Journal Articles

Membrane-Anchored and Tumor-Targeted IL12 (attIL12)-PBMC Therapy for Osteosarcoma

Qing Yang, Jiemiao Hu, Zhiliang Jia, Qi Wang, Jing Wang, Long Hoang Dao, Wendong Zhang, Sheng Zhang, Xueqing Xia, Richard Gorlick, Shulin Li
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (17): 3862–3873.
https://doi.org/10.1158/1078-0432.CCR-22-0721
Published: 01 September 2022
View article titled, Membrane-Anchored and Tumor-Targeted IL12 (attIL12)-PBMC Therapy for Osteosarcoma
Open the PDF for Membrane-Anchored and Tumor-Targeted IL12 (attIL12)-PBMC Therapy for Osteosarcoma in another window
Includes: Supplementary data
Journal Articles

Induction Chemotherapy with or without Erlotinib in Patients with Head and Neck Squamous Cell Carcinoma Amenable for Surgical Resection

Xiuning Le, Frederico O. Gleber-Netto, M. Laura Rubin, Yun Qing, Robyn Du, Merrill Kies, George Blumenschein, Jr, Charles Lu, Faye M. Johnson, Diana Bell, Jeff Lewis, Jiexin Zhang, Lei Feng, Kaye Wilson, Kathrina Marcelo-Lewis, Jing Wang, Lawrence Ginsberg, Maura Gillison, J. Jack Lee, Funda Meric-Berstam, Gordon B. Mills, William N. William, Jr, Jeffrey N. Myers, Curtis R. Pickering
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (13): 2796–2806.
https://doi.org/10.1158/1078-0432.CCR-21-3239
Published: 01 July 2022
View article titled, Induction Chemotherapy with or without Erlotinib in Patients with Head and Neck Squamous Cell Carcinoma Amenable for Surgical Resection
Open the PDF for Induction Chemotherapy with or without Erlotinib in Patients with Head and Neck Squamous Cell Carcinoma Amenable for Surgical Resection in another window
Includes: Supplementary data
Journal Articles

Olaparib Maintenance Monotherapy in Asian Patients with Platinum-Sensitive Relapsed Ovarian Cancer: Phase III Trial (L-MOCA)

Qinglei Gao, Jianqing Zhu, Weidong Zhao, Yi Huang, Ruifang An, Hong Zheng, Pengpeng Qu, Li Wang, Qi Zhou, Danbo Wang, Ge Lou, Jing Wang, Ke Wang, John Low, Beihua Kong, Abdul Malik Rozita, Lim Chun Sen, Rutie Yin, Xing Xie, Jihong Liu, Wei Sun, Jingya Su, Chunyi Zhang, Rongyu Zang, Ding Ma
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (11): 2278–2285.
https://doi.org/10.1158/1078-0432.CCR-21-3023
Published: 01 June 2022
View article titled, Olaparib Maintenance Monotherapy in Asian Patients with Platinum-Sensitive Relapsed Ovarian Cancer: Phase III Trial (L-MOCA)
Open the PDF for Olaparib Maintenance Monotherapy in Asian Patients with Platinum-Sensitive Relapsed Ovarian Cancer: Phase III Trial (L-MOCA) in another window
Includes: Supplementary data
Journal Articles

Pamiparib Monotherapy for Patients with Germline BRCA1/2-Mutated Ovarian Cancer Previously Treated with at Least Two Lines of Chemotherapy: A Multicenter, Open-Label, Phase II Study

Xiaohua Wu, Jianqing Zhu, Jing Wang, Zhongqiu Lin, Rutie Yin, Wei Sun, Qi Zhou, Songling Zhang, Danbo Wang, Hong Shi, Yunong Gao, Yi Huang, Guiling Li, Xiuli Wang, Ying Cheng, Ge Lou, Qinglei Gao, Li Wang, Xiuping Du, Mei Pan, Xiyan Mu, Li Li, Miao Li, Song Mu, Beihua Kong
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (4): 653–661.
https://doi.org/10.1158/1078-0432.CCR-21-1186
Published: 15 February 2022
View article titled, Pamiparib Monotherapy for Patients with Germline <em>BRCA1/2</em>-Mutated Ovarian Cancer Previously Treated with at Least Two Lines of Chemotherapy: A Multicenter, Open-Label, Phase II Study
Open the PDF for Pamiparib Monotherapy for Patients with Germline <em>BRCA1/2</em>-Mutated Ovarian Cancer Previously Treated with at Least Two Lines of Chemotherapy: A Multicenter, Open-Label, Phase II Study in another window
Includes: Supplementary data
Journal Articles

Targeting Fc Receptor-Mediated Effects and the “Don't Eat Me” Signal with an Oncolytic Virus Expressing an Anti-CD47 Antibody to Treat Metastatic Ovarian Cancer

Lei Tian, Bo Xu, Kun-Yu Teng, Mihae Song, Zheng Zhu, Yuqing Chen, Jing Wang, Jianying Zhang, Mingye Feng, Balveen Kaur, Lorna Rodriguez, Michael A. Caligiuri, Jianhua Yu
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (1): 201–214.
https://doi.org/10.1158/1078-0432.CCR-21-1248
Published: 05 January 2022
View article titled, Targeting Fc Receptor-Mediated Effects and the “Don't Eat Me” Signal with an Oncolytic Virus Expressing an Anti-CD47 Antibody to Treat Metastatic Ovarian Cancer
Open the PDF for Targeting Fc Receptor-Mediated Effects and the “Don't Eat Me” Signal with an Oncolytic Virus Expressing an Anti-CD47 Antibody to Treat Metastatic Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

An Open-label, Multicenter, Single-arm, Phase II Study of Fluzoparib in Patients with Germline BRCA1/2 Mutation and Platinum-sensitive Recurrent Ovarian Cancer

Ning Li, Hualei Bu, Jihong Liu, Jianqing Zhu, Qi Zhou, Li Wang, Rutie Yin, Xiaohua Wu, Shuzhong Yao, Kangsheng Gu, Hui Zhang, Guiling Li, Hongming Pan, Qiang Wu, Ruifang An, Xinfeng Yang, Yaping Zhu, Xiaoping Wan, Wei Duan, Jianping Xiong, Hongyan Guo, Ge Lou, Jing Wang, Wenjing Hu, Xin Zhang, Yuanguang Meng, Ben Zhang, Yuting Wang, Quanren Wang, Lingying Wu
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (9): 2452–2458.
https://doi.org/10.1158/1078-0432.CCR-20-3546
Published: 01 May 2021
View article titled, An Open-label, Multicenter, Single-arm, Phase II Study of Fluzoparib in Patients with Germline <em>BRCA1/2</em> Mutation and Platinum-sensitive Recurrent Ovarian Cancer
Open the PDF for An Open-label, Multicenter, Single-arm, Phase II Study of Fluzoparib in Patients with Germline <em>BRCA1/2</em> Mutation and Platinum-sensitive Recurrent Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract B26: The natural history of ovarian high-grade serous carcinoma from time effects of ovulation inhibition and progesterone clearance of p53-defective lesions

Tang-Yuan Chu, Na-Yi Yuan Wu, Jing Wang
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13_Supplement): B26.
https://doi.org/10.1158/1557-3265.OVCA19-B26
Published: 01 July 2020
View article titled, Abstract B26: The natural history of ovarian high-grade serous carcinoma from time effects of ovulation inhibition and progesterone clearance of p53-defective lesions
Journal Articles

Abstract B14: Variations in the proteasome activity are associated with human papilloma virus (HPV) gene expression and patient survival in HPV+ oropharyngeal tumors

Frederico O. Gleber-Netto, Meng Gao, Li Shen, Jing Wang, Jeffrey N. Myers, Faye M. Johnson, Curtis R. Pickering
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (12_Supplement_2): B14.
https://doi.org/10.1158/1557-3265.AACRAHNS19-B14
Published: 15 June 2020
View article titled, Abstract B14: Variations in the proteasome activity are associated with human papilloma virus (HPV) gene expression and patient survival in HPV+ oropharyngeal tumors