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Jessica N. McAlpine
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Journal Articles

Targeted and Shallow Whole-Genome Sequencing Identifies Therapeutic Opportunities in p53abn Endometrial Cancers

Amy Jamieson, Juliana Sobral de Barros, Dawn R. Cochrane, J. Maxwell Douglas, Sameer Shankar, Branden J. Lynch, Samuel Leung, Spencer Martin, Janine Senz, Amy Lum, Yvette Drew, C. Blake Gilks, David G. Huntsman, Jessica N. McAlpine
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (11): 2461–2474.
https://doi.org/10.1158/1078-0432.CCR-23-3689
Published: 03 June 2024
View article titled, Targeted and Shallow Whole-Genome Sequencing Identifies Therapeutic Opportunities in p53abn Endometrial Cancers
Open the PDF for Targeted and Shallow Whole-Genome Sequencing Identifies Therapeutic Opportunities in p53abn Endometrial Cancers in another window
Includes: Supplementary data
Journal Articles

Abstract PR002: Proteomic profiling of endometrial carcinomas

Dawn R. Cochrane, Gian Luca Negri, Jutta Huvila, Juliana Sobral de Barros, Forouh Kalantari, Nissreen Mohammad, David Farnell, Emily Thompson, Amy Lum, Sandra E. Spencer, Amy Jamieson, Samuel Leung, Derek Chiu, Martin Koebel, Stefan Kommoss, Friedrich Kommoss, Blake Gilks, Lien Hoang, David Huntsman, Gregg B. Morin, Jessica N. McAlpine
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (5_Supplement): PR002.
https://doi.org/10.1158/1557-3265.ENDO24-PR002
Published: 01 March 2024
View article titled, Abstract PR002: Proteomic profiling of endometrial carcinomas
Journal Articles

Abstract B012: Application of shallow whole genome sequencing to identify therapeutic opportunities in p53abn endometrial cancers

Amy Jamieson, Juliana Sobral de Barros, Dawn R. Cochrane, Maxwell Douglas, Sameer Shankar, Samuel Leung, Branden Lynch, Janine Senz, Blake Gilks, David G. Huntsman, Jessica N. McAlpine
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (5_Supplement): B012.
https://doi.org/10.1158/1557-3265.ENDO24-B012
Published: 01 March 2024
View article titled, Abstract B012: Application of shallow whole genome sequencing to identify therapeutic opportunities in p53abn endometrial cancers
Journal Articles

Abstract B031: High risk no specific molecular profile (HR-NSMP) endometrial cancer can be stratified into three subgroups based on tumor grade and estrogen receptor status with differing clinicopathologic characteristics and outcomes

Andrea Neilson, Amy Jamieson, Derek Chiu, Samuel Leung, Amy Lum, Jennifer Pors, Stefan Kommoss, Aline Talhouk, David G. Huntsman, Naveena Singh, C. Blake Gilks, Jessica N. McAlpine
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (5_Supplement): B031.
https://doi.org/10.1158/1557-3265.ENDO24-B031
Published: 01 March 2024
View article titled, Abstract B031: High risk no specific molecular profile (HR-NSMP) endometrial cancer can be stratified into three subgroups based on tumor grade and estrogen receptor status with differing clinicopathologic characteristics and outcomes
Journal Articles

Abstract B026: Substratification of mismatch repair deficient (MMRd) endometrial cancers can provide prognostic and predictive refinement

Amy Jamieson, Jennifer Pors, Samuel Leung, Derek Chiu, Stefan Kommoss, Aline Talhouk, David G. Huntsman, Naveena Singh, Blake Gilks, Jessica N. McAlpine
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (5_Supplement): B026.
https://doi.org/10.1158/1557-3265.ENDO24-B026
Published: 01 March 2024
View article titled, Abstract B026: Substratification of mismatch repair deficient (MMRd) endometrial cancers can provide prognostic and predictive refinement
Journal Articles

Clinical Behavior and Molecular Landscape of Stage I p53-Abnormal Low-Grade Endometrioid Endometrial Carcinomas

Amy Jamieson, Lisa Vermij, Claire J.H. Kramer, Jan J. Jobsen, Ina Jürgemlienk-Schulz, Ludy Lutgens, Jan Willem Mens, Marie A.D. Haverkort, Annerie Slot, Remi A. Nout, Jan Oosting, Joseph Carlson, Brooke E. Howitt, Philip P.C. Ip, Sigurd F. Lax, W. Glenn McCluggage, Naveena Singh, Jessica N. McAlpine, Carien L. Creutzberg, Nanda Horeweg, C. Blake Gilks, Tjalling Bosse
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (23): 4949–4957.
https://doi.org/10.1158/1078-0432.CCR-23-1397
Published: 01 December 2023
View article titled, Clinical Behavior and Molecular Landscape of Stage I p53-Abnormal Low-Grade Endometrioid Endometrial Carcinomas
Open the PDF for Clinical Behavior and Molecular Landscape of Stage I p53-Abnormal Low-Grade Endometrioid Endometrial Carcinomas in another window
Includes: Supplementary data
Journal Articles

The Prognostic Effect of Immune Cell Infiltration Depends on Molecular Subtype in Endometrioid Ovarian Carcinomas

Karolin Heinze, Evan S. Cairns, Shelby Thornton, Bronwyn Harris, Katy Milne, Marcel Grube, Charlotte Meyer, Anthony N. Karnezis, Sian Fereday, Dale W. Garsed, Samuel C.Y. Leung, Derek S. Chiu, Malak Moubarak, Philipp Harter, Florian Heitz, Jessica N. McAlpine, Anna DeFazio, David D.L. Bowtell, Ellen L. Goode, Malcolm Pike, Susan J. Ramus, C. Leigh Pearce, Annette Staebler, Martin Köbel, Stefan Kommoss, Aline Talhouk, Brad H. Nelson, Michael S. Anglesio
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (17): 3471–3483.
https://doi.org/10.1158/1078-0432.CCR-22-3815
Published: 01 September 2023
View article titled, The Prognostic Effect of Immune Cell Infiltration Depends on Molecular Subtype in Endometrioid Ovarian Carcinomas
Open the PDF for The Prognostic Effect of Immune Cell Infiltration Depends on Molecular Subtype in Endometrioid Ovarian Carcinomas in another window
Includes: Supplementary data
Journal Articles

Abstract PR002: Global proteomic profiling of endometrial carcinomas identify prognostic markers

Dawn R. Cochrane, Gian Negri, Jutta Huvila, David A. Farnell, Emily Thompson, Winnie Yang, Genny Trigo-Gonzales, Amy Lum, Sandra Spencer, Ryan Riley, Samuel Leung, Christine Chow, Jamie Lim, Martin Koebel, Stefan Kommoss, Friedrich Kommoss, Lien Hoang, David G. Huntsman, Gregg Morin, Jessica N. McAlpine
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (3_Supplement): PR002.
https://doi.org/10.1158/1557-3265.ENDOMET20-PR002
Published: 01 February 2021
View article titled, Abstract PR002: Global proteomic profiling of endometrial carcinomas identify prognostic markers
Journal Articles

Abstract IA017: Molecular classification and stratification: Diving deeper

Jessica N. McAlpine
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (3_Supplement): IA017.
https://doi.org/10.1158/1557-3265.ENDOMET20-IA017
Published: 01 February 2021
View article titled, Abstract IA017: Molecular classification and stratification: Diving deeper
Journal Articles

Endometrial Cancer Molecular Risk Stratification is Equally Prognostic for Endometrioid Ovarian Carcinoma

Pauline Krämer, Aline Talhouk, Mary Anne Brett, Derek S. Chiu, Evan S. Cairns, Daniëlla A. Scheunhage, Rory F.L. Hammond, David Farnell, Tayyebeh M. Nazeran, Marcel Grube, Zhouchunyang Xia, Janine Senz, Samuel Leung, Lukas Feil, Jana Pasternak, Katherine Dixon, Andreas Hartkopf, Bernhard Krämer, Sara Brucker, Florian Heitz, Andreas du Bois, Philipp Harter, Felix K.F. Kommoss, Hans-Peter Sinn, Sabine Heublein, Friedrich Kommoss, Hans-Walter Vollert, Ranjit Manchanda, Cornelis D. de Kroon, Hans W. Nijman, Marco de Bruyn, Emily F. Thompson, Ali Bashashati, Jessica N. McAlpine, Naveena Singh, Anna V. Tinker, Annette Staebler, Tjalling Bosse, Stefan Kommoss, Martin Köbel, Michael S. Anglesio
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (20): 5400–5410.
https://doi.org/10.1158/1078-0432.CCR-20-1268
Published: 15 October 2020
View article titled, Endometrial Cancer Molecular Risk Stratification is Equally Prognostic for Endometrioid Ovarian Carcinoma
Open the PDF for Endometrial Cancer Molecular Risk Stratification is Equally Prognostic for Endometrioid Ovarian Carcinoma in another window
Includes: Supplementary data
Journal Articles

FGFR2c Mesenchymal Isoform Expression Is Associated with Poor Prognosis and Further Refines Risk Stratification within Endometrial Cancer Molecular Subtypes

Asmerom T. Sengal, Ann-Marie Patch, Cameron E. Snell, Deborah S. Smith, Samuel C.Y. Leung, Aline Talhouk, Elizabeth D. Williams, Jessica N. McAlpine, Pamela M. Pollock
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (17): 4569–4580.
https://doi.org/10.1158/1078-0432.CCR-19-4088
Published: 01 September 2020
View article titled, FGFR2c Mesenchymal Isoform Expression Is Associated with Poor Prognosis and Further Refines Risk Stratification within Endometrial Cancer Molecular Subtypes
Open the PDF for FGFR2c Mesenchymal Isoform Expression Is Associated with Poor Prognosis and Further Refines Risk Stratification within Endometrial Cancer Molecular Subtypes in another window
Includes: Supplementary data
Journal Articles

Arginine Depletion Therapy with ADI-PEG20 Limits Tumor Growth in Argininosuccinate Synthase–Deficient Ovarian Cancer, Including Small-Cell Carcinoma of the Ovary, Hypercalcemic Type

Jennifer X. Ji, Dawn R. Cochrane, Basile Tessier-Cloutier, Shary Yutin Chen, Germain Ho, Khyatiben V. Pathak, Isabel N. Alcazar, David Farnell, Samuel Leung, Angela Cheng, Christine Chow, Shane Colborne, Gian Luca Negri, Friedrich Kommoss, Anthony Karnezis, Gregg B. Morin, Jessica N. McAlpine, C. Blake Gilks, Bernard E. Weissman, Jeffrey M. Trent, Lynn Hoang, Patrick Pirrotte, Yemin Wang, David G. Huntsman
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (16): 4402–4413.
https://doi.org/10.1158/1078-0432.CCR-19-1905
Published: 14 August 2020
View article titled, Arginine Depletion Therapy with ADI-PEG20 Limits Tumor Growth in Argininosuccinate Synthase–Deficient Ovarian Cancer, Including Small-Cell Carcinoma of the Ovary, Hypercalcemic Type
Open the PDF for Arginine Depletion Therapy with ADI-PEG20 Limits Tumor Growth in Argininosuccinate Synthase–Deficient Ovarian Cancer, Including Small-Cell Carcinoma of the Ovary, Hypercalcemic Type in another window
Includes: Supplementary data
Journal Articles

Abstract B09: Single-cell RNA sequencing of normal endometrial organoids uncovers novel cell-type markers for prognostication of primary tumor samples

Dawn R. Cochrane, Kieran R. Campbell, Kendall Greening, Germain C. Ho, James Hopkins, Minh Bui, Vassilena Sharlandjieva, Daniel Lai, Maya DeGrood, Evan W. Gibbard, Samuel Leung, Angela S. Cheng, Jamie L.P. Lim, Samantha Neilson, David Farnell, Friedrich Kommoss, Jessica N. McAlpine, Sohrab P. Shah, David G. Huntsman
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13_Supplement): B09.
https://doi.org/10.1158/1557-3265.OVCA19-B09
Published: 01 July 2020
View article titled, Abstract B09: Single-cell RNA sequencing of normal endometrial organoids uncovers novel cell-type markers for prognostication of primary tumor samples
Journal Articles

Abstract GMM-030: MODELS AND ANALYTIC TECHNIQUES OF MULLERIAN TISSUE-DERIVED ORGANOIDS

Germain C. Ho, Dawn R. Cochrane, Evan W. Gibbard, Kieran Campbell, Basile Tessier-Cloutier, Kendall Greening, Forouh Kalantari, Genny Trigo-Gonzalez, Yemin Wang, Jessica N. McAlpine, Sohrab P. Shah, David G. Huntsman
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (22_Supplement): GMM-030.
https://doi.org/10.1158/1557-3265.OVCASYMP18-GMM-030
Published: 15 November 2019
View article titled, Abstract GMM-030: MODELS AND ANALYTIC TECHNIQUES OF MULLERIAN TISSUE-DERIVED ORGANOIDS
Journal Articles

Abstract GMM-020: CELL OF ORIGIN, MUTATION AND MICROENVIRONMENT: MODELING EARLY EVENTS OF ENDOMETRIOSIS ASSOCIATED CANCERS

Dawn R Cochrane, Basile Tessier-Cloutier, Germain Ho, Kieran Campbell, Evan Gibbard, Katherine M Lawrence, Tayyebeh Nazeran, Anthony N. Karnezis, Clara Salamanca, Angela S Cheng, Jessica N McAlpine, Sohrab Shah, Lien N Hoang, C Blake Gilks, David G Huntsman
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (22_Supplement): GMM-020.
https://doi.org/10.1158/1557-3265.OVCASYMP18-GMM-020
Published: 15 November 2019
View article titled, Abstract GMM-020: CELL OF ORIGIN, MUTATION AND MICROENVIRONMENT: MODELING EARLY EVENTS OF ENDOMETRIOSIS ASSOCIATED CANCERS
Journal Articles

Molecular Subtype Not Immune Response Drives Outcomes in Endometrial Carcinoma

Aline Talhouk, Heather Derocher, Pascal Schmidt, Samuel Leung, Katy Milne, C. Blake Gilks, Michael S. Anglesio, Brad H. Nelson, Jessica N. McAlpine
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (8): 2537–2548.
https://doi.org/10.1158/1078-0432.CCR-18-3241
Published: 15 April 2019
View article titled, Molecular Subtype Not Immune Response Drives Outcomes in Endometrial Carcinoma
Open the PDF for Molecular Subtype Not Immune Response Drives Outcomes in Endometrial Carcinoma in another window
Includes: Supplementary data
Journal Articles

Endometrial Carcinomas with POLE Exonuclease Domain Mutations Have a Favorable Prognosis

Melissa K. McConechy, Aline Talhouk, Samuel Leung, Derek Chiu, Winnie Yang, Janine Senz, Linda J. Reha-Krantz, Cheng-Han Lee, David G. Huntsman, C. Blake Gilks, Jessica N. McAlpine
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (12): 2865–2873.
https://doi.org/10.1158/1078-0432.CCR-15-2233
Published: 14 June 2016
View article titled, Endometrial Carcinomas with <em>POLE</em> Exonuclease Domain Mutations Have a Favorable Prognosis
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Includes: Supplementary data
Journal Articles

Abstract B10: FOXL2 402C>G mutation can be identified in the circulating tumor DNA of patients with adult-type granulosa cell tumor.

Anniina Färkkilä, Melissa K. McConechy, Winnie Yang, Aline Talhouk, Ying Ng, Ryan Morin, Annika Riska, Jessica N. McAlpine, Leila Unkila-Kallio, Mikko Anttonen, David G. Huntsman
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (2_Supplement): B10.
https://doi.org/10.1158/1557-3265.OVCA15-B10
Published: 15 January 2016
View article titled, Abstract B10: FOXL2 402C&gt;G mutation can be identified in the circulating tumor DNA of patients with adult-type granulosa cell tumor.
Journal Articles

Profiling EGFR isoforms in ovarian cancer demonstrates that EGFR and sEGFR have prognostic significance: Implications for EGFR isoforms as cancer biomarkers.

Andre T. Baron, Jessica N. McAlpine, Jason Wilken, Mi-Ok Kim, Kimberly Kimbler, Trace Christensen, Wenxin Zheng, Maritza Martel, Fattaneh A. Tavassoli, Nita J. Maihle
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (19_Supplement): A58.
Published: 15 August 2014
View article titled, Profiling EGFR isoforms in ovarian cancer demonstrates that EGFR and sEGFR have prognostic significance: Implications for EGFR isoforms as cancer biomarkers.
Journal Articles

Abstract A18: Defining ovarian mucinous tumors: Cancer genes and heterogeneity

Michael S. Anglesio, Robertson Mackenzie, Stefan Kommoss, Boris J. Winterhoff, Benjamin Kipp, Jaoquin Garcia, Jesse S. Voss, Kevin Halling, Sarah Kerr, Janine Senz, Winnie Yang, Magnus von Knebel Doeberitz, Elena-Sophie Prigge, Miriam Reuschenbach, Anna V. Tinker, Blake Gilks, Jamie N. Bakkum-Gamez, David G. Huntsman, Jessica N. McAlpine
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (19_Supplement): A18.
https://doi.org/10.1158/1078-0432.OVCA13-A18
Published: 13 May 2014
View article titled, Abstract A18: Defining ovarian mucinous tumors: Cancer genes and heterogeneity