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Jenny C. Chang
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Journal Articles

Abstract P2-06-06: The Role of iNOS Inhibition in Enhancing Chemotherapy Efficacy by Modulating the Tumor Microenvironment in Obese TNBC Models

Free
Ivonne Uzair, Jenying Deng, Sean Hynes, Karina Ortega-Martinez, Kai Sun, Wei Qian, Jianying Zhou, Polina Matre, Jenny C Chang
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): P2-06-06.
https://doi.org/10.1158/1557-3265.SABCS24-P2-06-06
Published: 13 June 2025
View articletitled, Abstract P2-06-06: The Role of iNOS Inhibition in Enhancing Chemotherapy Efficacy by Modulating the Tumor Microenvironment in Obese TNBC Models
Journal Articles

Abstract RF1-07: Multifactor analysis for pathologic complete response (pCR) in a chemotherapy-free regimen of durvalumab, trastuzumab, and pertuzumab (DTP Trial) in HER2-enriched early breast cancer

Free
Polly Niravath, Mailin Li, Jian Guan, Wei Qian, Fotis Nikolo, Jenying Deng, Xen Ping Hoi, Tiffany Sheu, Susan L Haley, Mary Schwartz, Sunil Mathur, Kai Sun, Hahn Mai, Keith S. Chan, Steven T. C. Wong, Aleix Prat, Jenny C Chang
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): RF1-07.
https://doi.org/10.1158/1557-3265.SABCS24-RF1-07
Published: 13 June 2025
View articletitled, Abstract RF1-07: Multifactor analysis for pathologic complete response (pCR) in a chemotherapy-free regimen of durvalumab, trastuzumab, and pertuzumab (DTP Trial) in HER2-enriched early breast cancer
Journal Articles

Abstract P3-02-28: A combination approach to target residual tumors via ferroptosis induction

Free
Zhiming Wang, Hala S. Hassanain, Erin He, Filza Anis, Nancy Azizian, Delaney K. Sullivan, Jenny C. Chang, Mark Pegram, Yulin Li
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): P3-02-28.
https://doi.org/10.1158/1557-3265.SABCS24-P3-02-28
Published: 13 June 2025
View articletitled, Abstract P3-02-28: A combination approach to target residual tumors via ferroptosis induction
Journal Articles

Abstract P3-06-25: Humanized patient-derived xenograft models of triple-negative breast cancer for analyzing the safety and effectiveness of mRNA lipid nanoparticle cancer vaccines

Free
Maria F. Chervo, Wei Qian, Karina A. Ortega-Martinez, Jianying Zhou, Raghav Shroff, Chiara Mancino, Liliana Guzman-Rojas, Francesca Taraballi, John P. Cooke, Jimmy D. Gollihar, Jenny C. Chang
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): P3-06-25.
https://doi.org/10.1158/1557-3265.SABCS24-P3-06-25
Published: 13 June 2025
View articletitled, Abstract P3-06-25: Humanized patient-derived xenograft models of triple-negative breast cancer for analyzing the safety and effectiveness of mRNA lipid nanoparticle cancer vaccines
Journal Articles

Targeting Nitric Oxide: Say NO to Metastasis

Open Access
Tejaswini P. Reddy, Sharon A. Glynn, Timothy R. Billiar, David A. Wink, Jenny C. Chang
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (10): 1855–1868.
https://doi.org/10.1158/1078-0432.CCR-22-2791
Published: 15 May 2023
View articletitled, Targeting Nitric Oxide: Say NO to Metastasis
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Journal Articles

A Phase 2 Trial of Enhancing Immune Checkpoint Blockade by Stereotactic Radiation and In Situ Virus Gene Therapy in Metastatic Triple-Negative Breast Cancer

Open Access
Kai Sun, Yitian Xu, Licheng Zhang, Polly Niravath, Jorge Darcourt, Tejal Patel, Bin S. Teh, Andrew M. Farach, Carlo Guerrero, Sunil Mathur, Mark A. Sultenfuss, Nakul Gupta, Mary R. Schwartz, Susan L. Haley, Sindhu Nair, Xiaoxian Li, Thi Truc Anh Nguyen, Joseph D. Butner, Joe Ensor, Jaime A. Mejia, Zhuyong Mei, E. Brian Butler, Shu-hsia Chen, Eric H. Bernicker, Jenny C. Chang
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (20): 4392–4401.
https://doi.org/10.1158/1078-0432.CCR-22-0622
Published: 14 October 2022
View articletitled, A Phase 2 Trial of Enhancing Immune Checkpoint Blockade by Stereotactic Radiation and In Situ Virus Gene Therapy in Metastatic Triple-Negative Breast Cancer
Open the PDF for A Phase 2 Trial of Enhancing Immune Checkpoint Blockade by Stereotactic Radiation and In Situ Virus Gene Therapy in Metastatic Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Activating Transcription Factor 4 Modulates TGFβ-Induced Aggressiveness in Triple-Negative Breast Cancer via SMAD2/3/4 and mTORC2 Signaling

Free
Adrián González-González, Esperanza Muñoz-Muela, Juan A. Marchal, Francisca E. Cara, Maria P. Molina, Marina Cruz-Lozano, Gema Jiménez, Akanksha Verma, Alberto Ramírez, Wei Qian, Wen Chen, Anthony J. Kozielski, Olivier Elemento, María D. Martín-Salvago, Rafael J. Luque, Carmen Rosa-Garrido, David Landeira, María Quintana-Romero, Roberto R. Rosato, Maria A. García, Cesar L. Ramirez-Tortosa, Hanna Kim, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Anil K. Sood, Jose A. Lorente, Pedro Sánchez-Rovira, Jenny C. Chang, Sergio Granados-Principal
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (22): 5697–5709.
https://doi.org/10.1158/1078-0432.CCR-17-3125
Published: 15 November 2018
View articletitled, Activating Transcription Factor 4 Modulates TGFβ-Induced Aggressiveness in Triple-Negative Breast Cancer via SMAD2/3/4 and mTORC2 Signaling
Open the PDF for Activating Transcription Factor 4 Modulates TGFβ-Induced Aggressiveness in Triple-Negative Breast Cancer via SMAD2/3/4 and mTORC2 Signaling in another window
Includes: Supplementary data
Journal Articles

Pharmacological Inhibition of NOS Activates ASK1/JNK Pathway Augmenting Docetaxel-Mediated Apoptosis in Triple-Negative Breast Cancer

Free
Daniel Dávila-González, Dong Soon Choi, Roberto R. Rosato, Sergio M. Granados-Principal, John G. Kuhn, Wen-Feng Li, Wei Qian, Wen Chen, Anthony J. Kozielski, Helen Wong, Bhuvanesh Dave, Jenny C. Chang
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (5): 1152–1162.
https://doi.org/10.1158/1078-0432.CCR-17-1437
Published: 28 February 2018
View articletitled, Pharmacological Inhibition of NOS Activates ASK1/JNK Pathway Augmenting Docetaxel-Mediated Apoptosis in Triple-Negative Breast Cancer
Open the PDF for Pharmacological Inhibition of NOS Activates ASK1/JNK Pathway Augmenting Docetaxel-Mediated Apoptosis in Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

A Randomized Phase II Neoadjuvant Study of Cisplatin, Paclitaxel With or Without Everolimus in Patients with Stage II/III Triple-Negative Breast Cancer (TNBC): Responses and Long-term Outcome Correlated with Increased Frequency of DNA Damage Response Gene Mutations, TNBC Subtype, AR Status, and Ki67

Free
Bojana Jovanović, Ingrid A. Mayer, Erica L. Mayer, Vandana G. Abramson, Aditya Bardia, Melinda E. Sanders, M. Gabriela Kuba, Monica V. Estrada, J. Scott Beeler, Timothy M. Shaver, Kimberly C. Johnson, Violeta Sanchez, Jennifer M. Rosenbluth, Patrick M. Dillon, Andres Forero-Torres, Jenny C. Chang, Ingrid M. Meszoely, Ana M. Grau, Brian D. Lehmann, Yu Shyr, Quanhu Sheng, Sheau-Chiann Chen, Carlos L. Arteaga, Jennifer A. Pietenpol
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (15): 4035–4045.
https://doi.org/10.1158/1078-0432.CCR-16-3055
Published: 01 August 2017
View articletitled, A Randomized Phase II Neoadjuvant Study of Cisplatin, Paclitaxel With or Without Everolimus in Patients with Stage II/III Triple-Negative Breast Cancer (TNBC): Responses and Long-term Outcome Correlated with Increased Frequency of DNA Damage Response Gene Mutations, TNBC Subtype, AR Status, and Ki67
Open the PDF for A Randomized Phase II Neoadjuvant Study of Cisplatin, Paclitaxel With or Without Everolimus in Patients with Stage II/III Triple-Negative Breast Cancer (TNBC): Responses and Long-term Outcome Correlated with Increased Frequency of DNA Damage Response Gene Mutations, TNBC Subtype, AR Status, and Ki67 in another window
Includes: Supplementary data
Journal Articles

Upregulation of ER Signaling as an Adaptive Mechanism of Cell Survival in HER2-Positive Breast Tumors Treated with Anti-HER2 Therapy

Free
Mario Giuliano, Huizhong Hu, Yen-Chao Wang, Xiaoyong Fu, Agostina Nardone, Sabrina Herrera, Sufeng Mao, Alejandro Contreras, Carolina Gutierrez, Tao Wang, Susan G. Hilsenbeck, Carmine De Angelis, Nicholas J. Wang, Laura M. Heiser, Joe W. Gray, Sara Lopez-Tarruella, Anne C. Pavlick, Meghana V. Trivedi, Gary C. Chamness, Jenny C. Chang, C. Kent Osborne, Mothaffar F. Rimawi, Rachel Schiff
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (17): 3995–4003.
https://doi.org/10.1158/1078-0432.CCR-14-2728
Published: 31 August 2015
View articletitled, Upregulation of ER Signaling as an Adaptive Mechanism of Cell Survival in HER2-Positive Breast Tumors Treated with Anti-HER2 Therapy
Open the PDF for Upregulation of ER Signaling as an Adaptive Mechanism of Cell Survival in HER2-Positive Breast Tumors Treated with Anti-HER2 Therapy in another window
Includes: Supplementary data
Journal Articles

Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer

Free
Matthew D. Burstein, Anna Tsimelzon, Graham M. Poage, Kyle R. Covington, Alejandro Contreras, Suzanne A.W. Fuqua, Michelle I Savage, C. Kent Osborne, Susan G. Hilsenbeck, Jenny C. Chang, Gordon B. Mills, Ching C. Lau, Powel H. Brown
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (7): 1688–1698.
https://doi.org/10.1158/1078-0432.CCR-14-0432
Published: 31 March 2015
View articletitled, Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer
Open the PDF for Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Identification of Prognosis-Relevant Subgroups in Patients with Chemoresistant Triple-Negative Breast Cancer

Free
Ke-Da Yu, Rui Zhu, Ming Zhan, Angel A. Rodriguez, Wei Yang, Stephen Wong, Andreas Makris, Brian D. Lehmann, Xi Chen, Ingrid Mayer, Jennifer A. Pietenpol, Zhi-Ming Shao, W. Fraser Symmans, Jenny C. Chang
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (10): 2723–2733.
https://doi.org/10.1158/1078-0432.CCR-12-2986
Published: 12 May 2013
View articletitled, Identification of Prognosis-Relevant Subgroups in Patients with Chemoresistant Triple-Negative Breast Cancer
Open the PDF for Identification of Prognosis-Relevant Subgroups in Patients with Chemoresistant Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Preclinical and Clinical Studies of Gamma Secretase Inhibitors with Docetaxel on Human Breast Tumors

Free
Anne F. Schott, Melissa D. Landis, Gabriela Dontu, Kent A. Griffith, Rachel M. Layman, Ian Krop, Lacey A. Paskett, Helen Wong, Lacey E. Dobrolecki, Michael T. Lewis, Amber M. Froehlich, Jaya Paranilam, Daniel F. Hayes, Max S. Wicha, Jenny C. Chang
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (6): 1512–1524.
https://doi.org/10.1158/1078-0432.CCR-11-3326
Published: 14 March 2013
View articletitled, Preclinical and Clinical Studies of Gamma Secretase Inhibitors with Docetaxel on Human Breast Tumors
Open the PDF for Preclinical and Clinical Studies of Gamma Secretase Inhibitors with Docetaxel on Human Breast Tumors in another window
Includes: Supplementary data
Journal Articles

High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti–IGF-IR Therapy

Free
Beate C. Litzenburger, Chad J. Creighton, Anna Tsimelzon, Bonita T. Chan, Susan G. Hilsenbeck, Tao Wang, Joan M. Carboni, Marco M. Gottardis, Fei Huang, Jenny C. Chang, Michael T. Lewis, Mothaffar F. Rimawi, Adrian V. Lee
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (8): 2314–2327.
https://doi.org/10.1158/1078-0432.CCR-10-1903
Published: 14 April 2011
View articletitled, High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti–IGF-IR Therapy
Open the PDF for High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti–IGF-IR Therapy in another window
Includes: Supplementary data
Journal Articles

HER2 Inhibition: From Discovery to Clinical Practice

Free
Jenny C. Chang
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (1): 1–3.
https://doi.org/10.1158/1078-0432.CCR-06-2405
Published: 02 January 2007
View articletitled, HER2 Inhibition: From Discovery to Clinical Practice
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Journal Articles

Molecular Heterogeneity of Inflammatory Breast Cancer: A Hyperproliferative Phenotype

Free
Dang M. Nguyen, Kathy Sam, Anna Tsimelzon, Xiaoxian Li, Helen Wong, Syed Mohsin, Gary M. Clark, Susan G. Hilsenbeck, Richard M. Elledge, D. Craig Allred, Peter O'Connell, Jenny C. Chang
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (17): 5047–5054.
https://doi.org/10.1158/1078-0432.CCR-05-2248
Published: 01 September 2006
View articletitled, Molecular Heterogeneity of Inflammatory Breast Cancer: A Hyperproliferative Phenotype
Open the PDF for Molecular Heterogeneity of Inflammatory Breast Cancer: A Hyperproliferative Phenotype in another window