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Jennifer R. Grandis
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Journal Articles

Response to Neoadjuvant Targeted Therapy in Operable Head and Neck Cancer Confers Survival Benefit

Marco A. Mascarella, Tolani F. Olonisakin, Purva Rumde, Varun Vendra, Melonie A. Nance, Seungwon Kim, Mark W. Kubik, Shaum S. Sridharan, Robert L. Ferris, Moon J. Fenton, Daniel R. Clayburgh, James P. Ohr, Sonali C. Joyce, Malabika Sen, James G. Herman, Jennifer R. Grandis, Dan P. Zandberg, Umamaheswar Duvvuri
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (4): 723–730.
https://doi.org/10.1158/1078-0432.CCR-22-1768
Published: 16 February 2023
View article titled, Response to Neoadjuvant Targeted Therapy in Operable Head and Neck Cancer Confers Survival Benefit
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Includes: Supplementary data
Journal Articles

STAT3 Activation as a Predictive Biomarker for Ruxolitinib Response in Head and Neck Cancer

Zoya Qureshy, Hua Li, Yan Zeng, Jose Rivera, Ning Cheng, Christopher N. Peterson, Mi-Ok Kim, William R. Ryan, Patrick K. Ha, Julie E. Bauman, Steven J. Wang, Steven R. Long, Daniel E. Johnson, Jennifer R. Grandis
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (21): 4737–4746.
https://doi.org/10.1158/1078-0432.CCR-22-0744
Published: 01 November 2022
View article titled, STAT3 Activation as a Predictive Biomarker for Ruxolitinib Response in Head and Neck Cancer
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Includes: Supplementary data
Journal Articles

Treatment of Fanconi Anemia–Associated Head and Neck Cancer: Opportunities to Improve Outcomes

Rex H. Lee, Hyunseok Kang, Sue S. Yom, Agata Smogorzewska, Daniel E. Johnson, Jennifer R. Grandis
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (19): 5168–5187.
https://doi.org/10.1158/1078-0432.CCR-21-1259
Published: 01 October 2021
View article titled, Treatment of Fanconi Anemia–Associated Head and Neck Cancer: Opportunities to Improve Outcomes
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Journal Articles

Correction: Human Papillomavirus Regulates HER3 Expression in Head and Neck Cancer: Implications for Targeted HER3 Therapy in HPV+ Patients

Toni M. Brand, Stefan Hartmann, Neil E. Bhola, Noah D. Peyser, Hua Li, Yan Zeng, Erin Isaacson Wechsler, Max V. Ranall, Sourav Bandyopadhyay, Umamaheswar Duvvuri, Theresa M. LaVallee, Richard C.K. Jordan, Daniel E. Johnson, Jennifer R. Grandis
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (14): 4129.
https://doi.org/10.1158/1078-0432.CCR-21-2141
Published: 15 July 2021
View article titled, Correction: Human Papillomavirus Regulates HER3 Expression in Head and Neck Cancer: Implications for Targeted HER3 Therapy in HPV<sup>+</sup> Patients
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Journal Articles

Molecular and Clinical Activity of CDX-3379, an Anti-ErbB3 Monoclonal Antibody, in Head and Neck Squamous Cell Carcinoma Patients

Umamaheswar Duvvuri, Jonathan George, Seungwon Kim, Diego Alvarado, Veronique M. Neumeister, Ahmed Chenna, Richard Gedrich, Thomas Hawthorne, Theresa LaVallee, Jennifer R. Grandis, Julie E. Bauman
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (19): 5752–5758.
https://doi.org/10.1158/1078-0432.CCR-18-3453
Published: 01 October 2019
View article titled, Molecular and Clinical Activity of CDX-3379, an Anti-ErbB3 Monoclonal Antibody, in Head and Neck Squamous Cell Carcinoma Patients
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Includes: Supplementary data
Journal Articles

The RARS–MAD1L1 Fusion Gene Induces Cancer Stem Cell–like Properties and Therapeutic Resistance in Nasopharyngeal Carcinoma

Qian Zhong, Zhi-Hua Liu, Zhi-Rui Lin, Ze-Dong Hu, Li Yuan, Yan-min Liu, Ai-Jun Zhou, Li-Hua Xu, Li-Juan Hu, Zi-Feng Wang, Xin-Yuan Guan, Jia-Jie Hao, Vivian W.Y. Lui, Ling Guo, Hai-Qiang Mai, Ming-Yuan Chen, Fei Han, Yun-Fei Xia, Jennifer R. Grandis, Xing Zhang, Mu-Sheng Zeng
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (3): 659–673.
https://doi.org/10.1158/1078-0432.CCR-17-0352
Published: 31 January 2018
View article titled, The <em>RARS–MAD1L1</em> Fusion Gene Induces Cancer Stem Cell–like Properties and Therapeutic Resistance in Nasopharyngeal Carcinoma
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Includes: Supplementary data
Journal Articles

Abstract PR04: HER3 crosstalk with HPV16-E6E7 is a feedback resistance mechanism to PI3K-targeted therapies in head and neck cancer

Toni M. Brand, Stefan Hartmann, Neil E. Bhola, Hua Li, Yan Zeng, Rachel O'Keefe, Max V. Ranall, Sourav Bandyopadhyay, Margaret Soucheray, Danielle L. Swaney, Nevan Krogan, Carolyn Kemp, Umamaheswar Duvvuri, Daniel E. Johnson, Michelle A. Ozbun, Julie E. Bauman, Jennifer R. Grandis
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (23_Supplement): PR04.
https://doi.org/10.1158/1557-3265.AACRAHNS17-PR04
Published: 30 November 2017
View article titled, Abstract PR04: HER3 crosstalk with HPV16-E6E7 is a feedback resistance mechanism to PI3K-targeted therapies in head and neck cancer
Journal Articles

Abstract IA09: Comprehensive genomic characterization of head and neck squamous cell carcinomas

Jennifer R. Grandis
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (23_Supplement): IA09.
https://doi.org/10.1158/1557-3265.AACRAHNS17-IA09
Published: 30 November 2017
View article titled, Abstract IA09: Comprehensive genomic characterization of head and neck squamous cell carcinomas
Journal Articles

Human Papillomavirus Regulates HER3 Expression in Head and Neck Cancer: Implications for Targeted HER3 Therapy in HPV+ Patients

Toni M. Brand, Stefan Hartmann, Neil E. Bhola, Noah D. Peyser, Hua Li, Yan Zeng, Erin Isaacson Wechsler, Max V. Ranall, Sourav Bandyopadhyay, Umamaheswar Duvvuri, Theresa M. LaVallee, Richard C.K. Jordan, Daniel E. Johnson, Jennifer R. Grandis
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (12): 3072–3083.
https://doi.org/10.1158/1078-0432.CCR-16-2203
Published: 14 June 2017
View article titled, Human Papillomavirus Regulates HER3 Expression in Head and Neck Cancer: Implications for Targeted HER3 Therapy in HPV<sup>+</sup> Patients
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Includes: Supplementary data
Journal Articles

New Strategies in Esophageal Carcinoma: Translational Insights from Signaling Pathways and Immune Checkpoints

Victoria E. Wang, Jennifer R. Grandis, Andrew H. Ko
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (17): 4283–4290.
https://doi.org/10.1158/1078-0432.CCR-16-0292
Published: 31 August 2016
View article titled, New Strategies in Esophageal Carcinoma: Translational Insights from Signaling Pathways and Immune Checkpoints
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Journal Articles

HGF/Met Signaling in Head and Neck Cancer: Impact on the Tumor Microenvironment

Stefan Hartmann, Neil E. Bhola, Jennifer R. Grandis
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16): 4005–4013.
https://doi.org/10.1158/1078-0432.CCR-16-0951
Published: 14 August 2016
View article titled, HGF/Met Signaling in Head and Neck Cancer: Impact on the Tumor Microenvironment
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Journal Articles

Increased Expression of HER2, HER3, and HER2:HER3 Heterodimers in HPV-Positive HNSCC Using a Novel Proximity-Based Assay: Implications for Targeted Therapies

Netanya I. Pollock, Lin Wang, Gerald Wallweber, William E. Gooding, Weidong Huang, Ahmed Chenna, John Winslow, Malabika Sen, Kara A. DeGrave, Hua Li, Yan Zeng, Jennifer R. Grandis
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (20): 4597–4606.
https://doi.org/10.1158/1078-0432.CCR-14-3338
Published: 14 October 2015
View article titled, Increased Expression of HER2, HER3, and HER2:HER3 Heterodimers in HPV-Positive HNSCC Using a Novel Proximity-Based Assay: Implications for Targeted Therapies
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Includes: Supplementary data
Journal Articles

Abstract B39: Generation of head and neck cancer patient-derived xenografts with in vivo acquired cetuximab resistance

Pei Zhou, Hua Li, Sarah Wheeler, Jennifer R. Grandis, Laura A. Stabile, Ann Marie Egloff
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (4_Supplement): B39.
https://doi.org/10.1158/1557-3265.PMS14-B39
Published: 13 February 2015
View article titled, Abstract B39: Generation of head and neck cancer patient-derived xenografts with in vivo acquired cetuximab resistance
Journal Articles

HER2 as a Therapeutic Target in Head and Neck Squamous Cell Carcinoma

Netanya I. Pollock, Jennifer R. Grandis
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (3): 526–533.
https://doi.org/10.1158/1078-0432.CCR-14-1432
Published: 01 February 2015
View article titled, HER2 as a Therapeutic Target in Head and Neck Squamous Cell Carcinoma
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Journal Articles

Phase II Study of Cetuximab in Combination with Cisplatin and Radiation in Unresectable, Locally Advanced Head and Neck Squamous Cell Carcinoma: Eastern Cooperative Oncology Group Trial E3303

Ann Marie Egloff, Ju-Whei Lee, Corey J. Langer, Harry Quon, Alec Vaezi, Jennifer R. Grandis, Raja R. Seethala, Lin Wang, Dong M. Shin, Athanassios Argiris, Donghua Yang, Ranee Mehra, John Andrew Ridge, Urjeet A. Patel, Barbara A. Burtness, Arlene A. Forastiere
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (19): 5041–5051.
https://doi.org/10.1158/1078-0432.CCR-14-0051
Published: 30 September 2014
View article titled, Phase II Study of Cetuximab in Combination with Cisplatin and Radiation in Unresectable, Locally Advanced Head and Neck Squamous Cell Carcinoma: Eastern Cooperative Oncology Group Trial E3303
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Includes: Supplementary data
Journal Articles

Erlotinib, Erlotinib–Sulindac versus Placebo: A Randomized, Double-Blind, Placebo-Controlled Window Trial in Operable Head and Neck Cancer

Neil D. Gross, Julie E. Bauman, William E. Gooding, William Denq, Sufi M. Thomas, Lin Wang, Simion Chiosea, Brian L. Hood, Melanie S. Flint, Mai Sun, Thomas P. Conrads, Robert L. Ferris, Jonas T. Johnson, Seungwon Kim, Athanassios Argiris, Lori Wirth, Marina N. Nikiforova, Jill M. Siegfried, Jennifer R. Grandis
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (12): 3289–3298.
https://doi.org/10.1158/1078-0432.CCR-13-3360
Published: 12 June 2014
View article titled, Erlotinib, Erlotinib–Sulindac versus Placebo: A Randomized, Double-Blind, Placebo-Controlled Window Trial in Operable Head and Neck Cancer
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Includes: Supplementary data
Journal Articles

Chemoprevention of Head and Neck Cancer by Simultaneous Blocking of Epidermal Growth Factor Receptor and Cyclooxygenase-2 Signaling Pathways: Preclinical and Clinical Studies

Dong M. Shin, Hongzheng Zhang, Nabil F. Saba, Amy Y. Chen, Sreenivas Nannapaneni, A.R.M. Ruhul Amin, Susan Müller, Melinda Lewis, Gabriel Sica, Scott Kono, Johann C. Brandes, William J. Grist, Rachel Moreno-Williams, Jonathan J. Beitler, Sufi M. Thomas, Zhengjia Chen, Hyung Ju C. Shin, Jennifer R. Grandis, Fadlo R. Khuri, Zhuo Georgia Chen
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (5): 1244–1256.
https://doi.org/10.1158/1078-0432.CCR-12-3149
Published: 03 March 2013
View article titled, Chemoprevention of Head and Neck Cancer by Simultaneous Blocking of Epidermal Growth Factor Receptor and Cyclooxygenase-2 Signaling Pathways: Preclinical and Clinical Studies
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Includes: Supplementary data
Journal Articles

c-Src Activation Mediates Erlotinib Resistance in Head and Neck Cancer by Stimulating c-Met

Laura P. Stabile, Guoqing He, Vivian Wai Yan Lui, Sufi M. Thomas, Cassandra Henry, Christopher T. Gubish, Sonali Joyce, Kelly M. Quesnelle, Jill M. Siegfried, Jennifer R. Grandis
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (2): 380–392.
https://doi.org/10.1158/1078-0432.CCR-12-1555
Published: 16 January 2013
View article titled, c-Src Activation Mediates Erlotinib Resistance in Head and Neck Cancer by Stimulating c-Met
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Includes: Supplementary data
Journal Articles

Carfilzomib and ONX 0912 Inhibit Cell Survival and Tumor Growth of Head and Neck Cancer and Their Activities Are Enhanced by Suppression of Mcl-1 or Autophagy

Yan Zang, Sufi M. Thomas, Elena T. Chan, Christopher J. Kirk, Maria L. Freilino, Hannah M. DeLancey, Jennifer R. Grandis, Changyou Li, Daniel E. Johnson
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (20): 5639–5649.
https://doi.org/10.1158/1078-0432.CCR-12-1213
Published: 14 October 2012
View article titled, Carfilzomib and ONX 0912 Inhibit Cell Survival and Tumor Growth of Head and Neck Cancer and Their Activities Are Enhanced by Suppression of Mcl-1 or Autophagy
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Includes: Supplementary data
Journal Articles

Molecular Pathways: Context-Dependent Approaches to Notch Targeting as Cancer Therapy

Ann Marie Egloff, Jennifer R. Grandis
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (19): 5188–5195.
https://doi.org/10.1158/1078-0432.CCR-11-2258
Published: 30 September 2012
View article titled, Molecular Pathways: Context-Dependent Approaches to Notch Targeting as Cancer Therapy
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