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Jennifer J. Knox
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Journal Articles

hENT1 as a Predictive Biomarker in PDAC—Response

Sheron Perera, Gun Ho Jang, Robert Grant, Faiyaz Notta, Barbara Grunwald, Steven Gallinger, Jennifer J. Knox, Grainne M. O'Kane
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (15): 2945–2948.
https://doi.org/10.1158/1078-0432.CCR-23-0887
Published: 01 August 2023
View article titled, hENT1 as a Predictive Biomarker in PDAC—Response
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Journal Articles

hENT1 Expression Predicts Response to Gemcitabine and Nab-Paclitaxel in Advanced Pancreatic Ductal Adenocarcinoma

Sheron Perera, Gun Ho Jang, Yifan Wang, Deirdre Kelly, Michael Allen, Amy Zhang, Robert E. Denroche, Anna Dodd, Stephanie Ramotar, Shawn Hutchinson, Mustapha Tehfe, Ravi Ramjeesingh, James Biagi, Bernard Lam, Julie Wilson, Sandra E. Fischer, George Zogopoulos, Faiyaz Notta, Steven Gallinger, Robert C. Grant, Jennifer J. Knox, Grainne M. O'Kane
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (23): 5115–5120.
https://doi.org/10.1158/1078-0432.CCR-22-2576
Published: 01 December 2022
View article titled, hENT1 Expression Predicts Response to Gemcitabine and Nab-Paclitaxel in Advanced Pancreatic Ductal Adenocarcinoma
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Includes: Supplementary data
Journal Articles

Correction: GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer

Grainne M. O'Kane, Barbara T. Grünwald, Gun-Ho Jang, Mehdi Masoomian, Sarah Picardo, Robert C. Grant, Robert E. Denroche, Amy Zhang, Yifan Wang, Jessica K. Miller, Bernard Lam, Paul M. Krzyzanowski, Ilinca M. Lungu, John M.S. Bartlett, Melanie Peralta, Foram Vyas, Rama Khokha, James Biagi, Dianne Chadwick, Stephanie Ramotar, Shawn Hutchinson, Anna Dodd, Julie M. Wilson, Faiyaz Notta, George Zogopoulos, Steven Gallinger, Jennifer J. Knox, Sandra E. Fischer
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (12): 2715.
https://doi.org/10.1158/1078-0432.CCR-22-1272
Published: 13 June 2022
View article titled, Correction: GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer
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Journal Articles

Pembrolizumab Monotherapy for Previously Untreated Advanced Hepatocellular Carcinoma: Data from the Open-Label, Phase II KEYNOTE-224 Trial

Gontran Verset, Ivan Borbath, Mark Karwal, Chris Verslype, Hans Van Vlierberghe, Adel Kardosh, Vittorina Zagonel, Per Stal, Debashis Sarker, Daniel H. Palmer, Arndt Vogel, Julien Edeline, Stephane Cattan, Masatoshi Kudo, Ann-Lii Cheng, Sadahisa Ogasawara, Bruno Daniele, Stephen L. Chan, Jennifer J. Knox, Shukui Qin, Abby B. Siegel, Michael Chisamore, Ken Hatogai, Anran Wang, Richard S. Finn, Andrew X. Zhu
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (12): 2547–2554.
https://doi.org/10.1158/1078-0432.CCR-21-3807
Published: 13 June 2022
View article titled, Pembrolizumab Monotherapy for Previously Untreated Advanced Hepatocellular Carcinoma: Data from the Open-Label, Phase II KEYNOTE-224 Trial
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Includes: Supplementary data
Journal Articles

Subtype-Discordant Pancreatic Ductal Adenocarcinoma Tumors Show Intermediate Clinical and Molecular Characteristics

James T. Topham, Joanna M. Karasinska, Michael K.C. Lee, Veronika Csizmok, Laura M. Williamson, Gun Ho Jang, Robert E. Denroche, Erica S. Tsang, Steve E. Kalloger, Hui-li Wong, Grainne M. O'Kane, Richard A. Moore, Andrew J. Mungall, Faiyaz Notta, Jonathan M. Loree, Julie M. Wilson, Oliver Bathe, Patricia A. Tang, Rachel Goodwin, Jennifer J. Knox, Steven Gallinger, Janessa Laskin, Marco A. Marra, Steven J.M. Jones, Daniel J. Renouf, David F. Schaeffer
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (1): 150–157.
https://doi.org/10.1158/1078-0432.CCR-20-2831
Published: 04 January 2021
View article titled, Subtype-Discordant Pancreatic Ductal Adenocarcinoma Tumors Show Intermediate Clinical and Molecular Characteristics
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Includes: Supplementary data
Journal Articles

Delving into Early-onset Pancreatic Ductal Adenocarcinoma: How Does Age Fit In?

Erica S. Tsang, James T. Topham, Joanna M. Karasinska, Michael K.C. Lee, Laura M. Williamson, Shehara Mendis, Robert E. Denroche, Gun Ho Jang, Steve E. Kalloger, Richard A. Moore, Andrew J. Mungall, Oliver F. Bathe, Patricia A. Tang, Faiyaz Notta, Julie M. Wilson, Janessa Laskin, Grainne M. O'Kane, Jennifer J. Knox, Rachel A. Goodwin, Jonathan M. Loree, Steven J.M. Jones, Marco A. Marra, Steven Gallinger, David F. Schaeffer, Daniel J. Renouf
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (1): 246–254.
https://doi.org/10.1158/1078-0432.CCR-20-1042
Published: 04 January 2021
View article titled, Delving into Early-onset Pancreatic Ductal Adenocarcinoma: How Does Age Fit In?
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Includes: Supplementary data
Journal Articles

A Preclinical Trial and Molecularly Annotated Patient Cohort Identify Predictive Biomarkers in Homologous Recombination–deficient Pancreatic Cancer

Yifan Wang, Jin Yong Patrick Park, Alain Pacis, Robert E. Denroche, Gun Ho Jang, Amy Zhang, Adeline Cuggia, Celine Domecq, Jean Monlong, Maria Raitses-Gurevich, Robert C. Grant, Ayelet Borgida, Spring Holter, Chani Stossel, Simeng Bu, Mehdi Masoomian, Ilinca M. Lungu, John M.S. Bartlett, Julie M. Wilson, Zu-Hua Gao, Yasser Riazalhosseini, Jamil Asselah, Nathaniel Bouganim, Tatiana Cabrera, Louis-Martin Boucher, David Valenti, James Biagi, Celia M.T. Greenwood, Paz Polak, William D. Foulkes, Talia Golan, Grainne M. O'Kane, Sandra E. Fischer, Jennifer J. Knox, Steven Gallinger, George Zogopoulos
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (20): 5462–5476.
https://doi.org/10.1158/1078-0432.CCR-20-1439
Published: 15 October 2020
View article titled, A Preclinical Trial and Molecularly Annotated Patient Cohort Identify Predictive Biomarkers in Homologous Recombination–deficient Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer

Grainne M. O’Kane, Barbara T. Grünwald, Gun-Ho Jang, Mehdi Masoomian, Sarah Picardo, Robert C. Grant, Robert E. Denroche, Amy Zhang, Yifan Wang, Jessica K. Miller, Bernard Lam, Paul M. Krzyzanowski, Ilinca M. Lungu, John M.S. Bartlett, Melanie Peralta, Foram Vyas, Rama Khokha, James Biagi, Dianne Chadwick, Stephanie Ramotar, Shawn Hutchinson, Anna Dodd, Julie M. Wilson, Faiyaz Notta, George Zogopoulos, Steven Gallinger, Jennifer J. Knox, Sandra E. Fischer
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (18): 4901–4910.
https://doi.org/10.1158/1078-0432.CCR-19-3724
Published: 01 September 2020
View article titled, GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

A Four-Chemokine Signature Is Associated with a T-cell–Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer

Joan M. Romero, Barbara Grünwald, Gun-Ho Jang, Prashant P. Bavi, Aaditeya Jhaveri, Mehdi Masoomian, Sandra E. Fischer, Amy Zhang, Robert E. Denroche, Ilinca M. Lungu, Angela De Luca, John M.S. Bartlett, Jing Xu, Niandong Li, Sharon Dhaliwal, Sheng-Ben Liang, Dianne Chadwick, Foram Vyas, Peter Bronsert, Rama Khokha, Tracy L. McGaha, Faiyaz Notta, Pamela S. Ohashi, Susan J. Done, Grainne M. O'Kane, Julie M. Wilson, Jennifer J. Knox, Ashton Connor, Yifan Wang, George Zogopoulos, Steven Gallinger
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (8): 1997–2010.
https://doi.org/10.1158/1078-0432.CCR-19-2803
Published: 15 April 2020
View article titled, A Four-Chemokine Signature Is Associated with a T-cell–Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Altered Gene Expression along the Glycolysis–Cholesterol Synthesis Axis Is Associated with Outcome in Pancreatic Cancer

Joanna M. Karasinska, James T. Topham, Steve E. Kalloger, Gun Ho Jang, Robert E. Denroche, Luka Culibrk, Laura M. Williamson, Hui-Li Wong, Michael K.C. Lee, Grainne M. O'Kane, Richard A. Moore, Andrew J. Mungall, Malcolm J. Moore, Cassia Warren, Andrew Metcalfe, Faiyaz Notta, Jennifer J. Knox, Steven Gallinger, Janessa Laskin, Marco A. Marra, Steven J.M. Jones, Daniel J. Renouf, David F. Schaeffer
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (1): 135–146.
https://doi.org/10.1158/1078-0432.CCR-19-1543
Published: 03 January 2020
View article titled, Altered Gene Expression along the Glycolysis–Cholesterol Synthesis Axis Is Associated with Outcome in Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

NRG1 Gene Fusions Are Recurrent, Clinically Actionable Gene Rearrangements in KRAS Wild-Type Pancreatic Ductal Adenocarcinoma

Martin R. Jones, Laura M. Williamson, James T. Topham, Michael K.C. Lee, Angela Goytain, Julie Ho, Robert E. Denroche, GunHo Jang, Erin Pleasance, Yaoquing Shen, Joanna M. Karasinska, John P. McGhie, Sharlene Gill, Howard J. Lim, Malcolm J. Moore, Hui-li Wong, Tony Ng, Stephen Yip, Wei Zhang, Sara Sadeghi, Carolyn Reisle, Andrew J. Mungall, Karen L. Mungall, Richard A. Moore, Yussanne Ma, Jennifer J. Knox, Steven Gallinger, Janessa Laskin, Marco A. Marra, David F. Schaeffer, Steven J.M. Jones, Daniel J. Renouf
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (15): 4674–4681.
https://doi.org/10.1158/1078-0432.CCR-19-0191
Published: 01 August 2019
View article titled, <em>NRG1</em> Gene Fusions Are Recurrent, Clinically Actionable Gene Rearrangements in <em>KRAS</em> Wild-Type Pancreatic Ductal Adenocarcinoma
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Includes: Supplementary data
Journal Articles

Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial

Kyaw L. Aung, Sandra E. Fischer, Robert E. Denroche, Gun-Ho Jang, Anna Dodd, Sean Creighton, Bernadette Southwood, Sheng-Ben Liang, Dianne Chadwick, Amy Zhang, Grainne M. O'Kane, Hamzeh Albaba, Shari Moura, Robert C. Grant, Jessica K. Miller, Faridah Mbabaali, Danielle Pasternack, Ilinca M. Lungu, John M.S. Bartlett, Sangeet Ghai, Mathieu Lemire, Spring Holter, Ashton A. Connor, Richard A. Moffitt, Jen Jen Yeh, Lee Timms, Paul M. Krzyzanowski, Neesha Dhani, David Hedley, Faiyaz Notta, Julie M. Wilson, Malcolm J. Moore, Steven Gallinger, Jennifer J. Knox
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (6): 1344–1354.
https://doi.org/10.1158/1078-0432.CCR-17-2994
Published: 14 March 2018
View article titled, Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial
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Includes: Supplementary data
Journal Articles

Sequence Dependence of MEK Inhibitor AZD6244 Combined with Gemcitabine for the Treatment of Biliary Cancer

Junyao Xu, Jennifer J. Knox, Emin Ibrahimov, Eric Chen, Stefano Serra, Ming Tsao, Pinjiang Cao, Douglass Vines, David E. Green, Cristiane Metran-Nascente, Mairead G. McNamara, David W. Hedley
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (1): 118–127.
https://doi.org/10.1158/1078-0432.CCR-12-2557
Published: 02 January 2013
View article titled, Sequence Dependence of MEK Inhibitor AZD6244 Combined with Gemcitabine for the Treatment of Biliary Cancer
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Includes: Supplementary data