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Jeffrey Schlom
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Journal Articles

Abstract A16: Natural killer cell therapy efficacy is enhanced through inhibition of myeloid-derived suppressor cell trafficking

Sarah Greene, Yvette Robbins, Paul E. Clavijo, Dean Maeda, John Zebala, Jeffrey Schlom, Claudia Palena, Clint Allen
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (12_Supplement_2): A16.
https://doi.org/10.1158/1557-3265.AACRAHNS19-A16
Published: 15 June 2020
View article titled, Abstract A16: Natural killer cell therapy efficacy is enhanced through inhibition of myeloid-derived suppressor cell trafficking
Journal Articles

Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models

Sarah Greene, Yvette Robbins, Wojciech K. Mydlarz, Angel P. Huynh, Nicole C. Schmitt, Jay Friedman, Lucas A. Horn, Claudia Palena, Jeffrey Schlom, Dean Y. Maeda, John A. Zebala, Paul E. Clavijo, Clint Allen
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (6): 1420–1431.
https://doi.org/10.1158/1078-0432.CCR-19-2625
Published: 13 March 2020
View article titled, Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models
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Includes: Supplementary data
Journal Articles

Cooperative Immune-Mediated Mechanisms of the HDAC Inhibitor Entinostat, an IL15 Superagonist, and a Cancer Vaccine Effectively Synergize as a Novel Cancer Therapy

Kristin C. Hicks, Karin M. Knudson, Karin L. Lee, Duane H. Hamilton, James W. Hodge, William D. Figg, Peter Ordentlich, Frank R. Jones, Shahrooz Rabizadeh, Patrick Soon-Shiong, Jeffrey Schlom, Sofia R. Gameiro
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (3): 704–716.
https://doi.org/10.1158/1078-0432.CCR-19-0727
Published: 03 February 2020
View article titled, Cooperative Immune-Mediated Mechanisms of the HDAC Inhibitor Entinostat, an IL15 Superagonist, and a Cancer Vaccine Effectively Synergize as a Novel Cancer Therapy
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Includes: Supplementary data
Journal Articles

A Phase I Dose-Escalation Trial of BN-CV301, a Recombinant Poxviral Vaccine Targeting MUC1 and CEA with Costimulatory Molecules

Margaret E. Gatti-Mays, Julius Strauss, Renee N. Donahue, Claudia Palena, Jaydira Del Rivero, Jason M. Redman, Ravi A. Madan, Jennifer L. Marté, Lisa M. Cordes, Elizabeth Lamping, Alanvin Orpia, Andrea Burmeister, Eva Wagner, Cesar Pico Navarro, Christopher R. Heery, Jeffrey Schlom, James L. Gulley
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (16): 4933–4944.
https://doi.org/10.1158/1078-0432.CCR-19-0183
Published: 15 August 2019
View article titled, A Phase I Dose-Escalation Trial of BN-CV301, a Recombinant Poxviral Vaccine Targeting MUC1 and CEA with Costimulatory Molecules
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Includes: Supplementary data
Journal Articles

First-in-Human Phase I Trial of a Tumor-Targeted Cytokine (NHS-IL12) in Subjects with Metastatic Solid Tumors

Julius Strauss, Christopher R. Heery, Joseph W. Kim, Caroline Jochems, Renee N. Donahue, Agnes S. Montgomery, Sheri McMahon, Elizabeth Lamping, Jennifer L. Marté, Ravi A. Madan, Marijo Bilusic, Matthew R. Silver, Elisa Bertotti, Jeffrey Schlom, James L. Gulley
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (1): 99–109.
https://doi.org/10.1158/1078-0432.CCR-18-1512
Published: 03 January 2019
View article titled, First-in-Human Phase I Trial of a Tumor-Targeted Cytokine (NHS-IL12) in Subjects with Metastatic Solid Tumors
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Includes: Supplementary data
Journal Articles

Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, in Advanced Solid Tumors

Julius Strauss, Christopher R. Heery, Jeffrey Schlom, Ravi A. Madan, Liang Cao, Zhigang Kang, Elizabeth Lamping, Jennifer L. Marté, Renee N. Donahue, Italia Grenga, Lisa Cordes, Olaf Christensen, Lisa Mahnke, Christoph Helwig, James L. Gulley
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (6): 1287–1295.
https://doi.org/10.1158/1078-0432.CCR-17-2653
Published: 14 March 2018
View article titled, Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, in Advanced Solid Tumors
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Includes: Supplementary data
Journal Articles

Phase I Study of a Poxviral TRICOM-Based Vaccine Directed Against the Transcription Factor Brachyury

Christopher R. Heery, Claudia Palena, Sheri McMahon, Renee N. Donahue, Lauren M. Lepone, Italia Grenga, Ulrike Dirmeier, Lisa Cordes, Jenn Marté, William Dahut, Harpreet Singh, Ravi A. Madan, Romaine I. Fernando, Duane H. Hamilton, Jeffrey Schlom, James L. Gulley
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (22): 6833–6845.
https://doi.org/10.1158/1078-0432.CCR-17-1087
Published: 14 November 2017
View article titled, Phase I Study of a Poxviral TRICOM-Based Vaccine Directed Against the Transcription Factor Brachyury
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Includes: Supplementary data
Journal Articles

Serum Antibodies to Blood Group A Predict Survival on PROSTVAC-VF

Christopher T. Campbell, James L. Gulley, Oyindasola Oyelaran, James W. Hodge, Jeffrey Schlom, Jeffrey C. Gildersleeve
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (5): 1290–1299.
https://doi.org/10.1158/1078-0432.CCR-12-2478
Published: 03 March 2013
View article titled, Serum Antibodies to Blood Group A Predict Survival on PROSTVAC-VF
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Includes: Supplementary data
Journal Articles

Brachyury, a Driver of the Epithelial–Mesenchymal Transition, Is Overexpressed in Human Lung Tumors: An Opportunity for Novel Interventions against Lung Cancer

Mario Roselli, Romaine I. Fernando, Fiorella Guadagni, Antonella Spila, Jhessica Alessandroni, Raffaele Palmirotta, Leopoldo Costarelli, Mary Litzinger, Duane Hamilton, Bruce Huang, Joanne Tucker, Kwong-Yok Tsang, Jeffrey Schlom, Claudia Palena
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (14): 3868–3879.
https://doi.org/10.1158/1078-0432.CCR-11-3211
Published: 15 July 2012
View article titled, Brachyury, a Driver of the Epithelial–Mesenchymal Transition, Is Overexpressed in Human Lung Tumors: An Opportunity for Novel Interventions against Lung Cancer
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Includes: Supplementary data
Journal Articles

A Pilot Study of MUC-1/CEA/TRICOM Poxviral-Based Vaccine in Patients with Metastatic Breast and Ovarian Cancer

Mahsa Mohebtash, Kwong-Yok Tsang, Ravi A. Madan, Ngar-Yee Huen, Diane J. Poole, Caroline Jochems, Jacquin Jones, Theresa Ferrara, Christopher R. Heery, Philip M. Arlen, Seth M. Steinberg, Mary Pazdur, Myrna Rauckhorst, Elizabeth C. Jones, William L. Dahut, Jeffrey Schlom, James L. Gulley
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (22): 7164–7173.
https://doi.org/10.1158/1078-0432.CCR-11-0649
Published: 14 November 2011
View article titled, A Pilot Study of MUC-1/CEA/TRICOM Poxviral-Based Vaccine in Patients with Metastatic Breast and Ovarian Cancer
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Includes: Supplementary data
Journal Articles

A Viral Vaccine Encoding Prostate-Specific Antigen Induces Antigen Spreading to a Common Set of Self-Proteins in Prostate Cancer Patients

Nancy J. Nesslinger, Alvin Ng, Kwong-Yok Tsang, Theresa Ferrara, Jeffrey Schlom, James L. Gulley, Brad H. Nelson
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (15): 4046–4056.
https://doi.org/10.1158/1078-0432.CCR-10-0948
Published: 28 July 2010
View article titled, A Viral Vaccine Encoding Prostate-Specific Antigen Induces Antigen Spreading to a Common Set of Self-Proteins in Prostate Cancer Patients
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Includes: Supplementary data
Journal Articles

The Antitumor and Immunoadjuvant Effects of IFN-α in Combination with Recombinant Poxvirus Vaccines

Kenneth W. Hance, Connie J. Rogers, David A. Zaharoff, Daniel Canter, Jeffrey Schlom, John W. Greiner
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (7): 2387–2396.
https://doi.org/10.1158/1078-0432.CCR-08-1752
Published: 01 April 2009
View article titled, The Antitumor and Immunoadjuvant Effects of IFN-α in Combination with Recombinant Poxvirus Vaccines
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Includes: Supplementary data
Journal Articles

Translational Research Working Group Developmental Pathway for Immune Response Modifiers

Martin A. Cheever, Jeffrey Schlom, Louis M. Weiner, H. Kim Lyerly, Mary L. Disis, Addison Greenwood, Oren Grad, William G. Nelson, for the Translational Research Working Group
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (18): 5692–5699.
https://doi.org/10.1158/1078-0432.CCR-08-1266
Published: 14 September 2008
View article titled, Translational Research Working Group Developmental Pathway for Immune Response Modifiers
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Journal Articles

Safety and Immunologic Response of a Viral Vaccine to Prostate-Specific Antigen in Combination with Radiation Therapy when Metronomic-Dose Interleukin 2 Is Used as an Adjuvant

Robert J. Lechleider, Philip M. Arlen, Kwong-Yok Tsang, Seth M. Steinberg, Junko Yokokawa, Vittore Cereda, Kevin Camphausen, Jeffrey Schlom, William L. Dahut, James L. Gulley
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (16): 5284–5291.
https://doi.org/10.1158/1078-0432.CCR-07-5162
Published: 12 August 2008
View article titled, Safety and Immunologic Response of a Viral Vaccine to Prostate-Specific Antigen in Combination with Radiation Therapy when Metronomic-Dose Interleukin 2 Is Used as an Adjuvant
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Journal Articles

Analysis of Overall Survival in Patients with Nonmetastatic Castration-Resistant Prostate Cancer Treated with Vaccine, Nilutamide, and Combination Therapy

Ravi A. Madan, James L. Gulley, Jeffrey Schlom, Seth M. Steinberg, David J. Liewehr, William L. Dahut, Philip M. Arlen
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (14): 4526–4531.
https://doi.org/10.1158/1078-0432.CCR-07-5048
Published: 15 July 2008
View article titled, Analysis of Overall Survival in Patients with Nonmetastatic Castration-Resistant Prostate Cancer Treated with Vaccine, Nilutamide, and Combination Therapy
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Journal Articles

Vaccination with a Recombinant Saccharomyces cerevisiae Expressing a Tumor Antigen Breaks Immune Tolerance and Elicits Therapeutic Antitumor Responses

Elizabeth K. Wansley, Mala Chakraborty, Kenneth W. Hance, Michael B. Bernstein, Amanda L. Boehm, Zhimin Guo, Deborah Quick, Alex Franzusoff, John W. Greiner, Jeffrey Schlom, James W. Hodge
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (13): 4316–4325.
https://doi.org/10.1158/1078-0432.CCR-08-0393
Published: 01 July 2008
View article titled, Vaccination with a Recombinant <em>Saccharomyces cerevisiae</em> Expressing a Tumor Antigen Breaks Immune Tolerance and Elicits Therapeutic Antitumor Responses
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Journal Articles

The Use of Chelated Radionuclide (Samarium-153-Ethylenediaminetetramethylenephosphonate) to Modulate Phenotype of Tumor Cells and Enhance T Cell–Mediated Killing

Mala Chakraborty, Elizabeth K. Wansley, Jorge A. Carrasquillo, Sarah Yu, Chang H. Paik, Kevin Camphausen, Michael D. Becker, William F. Goeckeler, Jeffrey Schlom, James W. Hodge
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (13): 4241–4249.
https://doi.org/10.1158/1078-0432.CCR-08-0335
Published: 01 July 2008
View article titled, The Use of Chelated Radionuclide (Samarium-153-Ethylenediaminetetramethylenephosphonate) to Modulate Phenotype of Tumor Cells and Enhance T Cell–Mediated Killing
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Journal Articles

Combination of Docetaxel and Recombinant Vaccine Enhances T-Cell Responses and Antitumor Activity: Effects of Docetaxel on Immune Enhancement

Charlie T. Garnett, Jeffrey Schlom, James W. Hodge
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (11): 3536–3544.
https://doi.org/10.1158/1078-0432.CCR-07-4025
Published: 02 June 2008
View article titled, Combination of Docetaxel and Recombinant Vaccine Enhances T-Cell Responses and Antitumor Activity: Effects of Docetaxel on Immune Enhancement
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Journal Articles

Pilot Study of Vaccination with Recombinant CEA-MUC-1-TRICOM Poxviral-Based Vaccines in Patients with Metastatic Carcinoma

James L. Gulley, Philip M. Arlen, Kwong-Yok Tsang, Junko Yokokawa, Claudia Palena, Diane J. Poole, Cinzia Remondo, Vittore Cereda, Jacquin L. Jones, Mary P. Pazdur, Jack P. Higgins, James W. Hodge, Seth M. Steinberg, Herbert Kotz, William L. Dahut, Jeffrey Schlom
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (10): 3060–3069.
https://doi.org/10.1158/1078-0432.CCR-08-0126
Published: 15 May 2008
View article titled, Pilot Study of Vaccination with Recombinant CEA-MUC-1-TRICOM Poxviral-Based Vaccines in Patients with Metastatic Carcinoma
Open the PDF for Pilot Study of Vaccination with Recombinant CEA-MUC-1-TRICOM Poxviral-Based Vaccines in Patients with Metastatic Carcinoma in another window
Includes: Supplementary data
Journal Articles

Enhanced Functionality of CD4+CD25highFoxP3+ Regulatory T Cells in the Peripheral Blood of Patients with Prostate Cancer

Junko Yokokawa, Vittore Cereda, Cinzia Remondo, James L. Gulley, Philip M. Arlen, Jeffrey Schlom, Kwong Y. Tsang
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (4): 1032–1040.
https://doi.org/10.1158/1078-0432.CCR-07-2056
Published: 15 February 2008
View article titled, Enhanced Functionality of CD4<sup>+</sup>CD25<sup>high</sup>FoxP3<sup>+</sup> Regulatory T Cells in the Peripheral Blood of Patients with Prostate Cancer
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