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Jean-Yves Blay
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Journal Articles

A Phase I Study of FHD-609, a Heterobifunctional Degrader of Bromodomain-Containing Protein 9, in Patients with Advanced Synovial Sarcoma or SMARCB1-Deficient Tumors

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J. Andrew Livingston, Jean-Yves Blay, Jonathan Trent, Claudia Valverde, Mark Agulnik, Mrinal Gounder, Axel Le Cesne, Meredith McKean, Michael J. Wagner, Silvia Stacchiotti, Samuel Agresta, Alfonso Quintás-Cardama, Sarah A. Reilly, Kathleen Healy, Denice Hickman, Tina Zhao, Alex Ballesteros-Perez, Alexis Khalil, Michael P. Collins, Jessica Piel, Kim Horrigan, Ariel Lefkovith, Scott Innis, Alexander J. Lazar, Gregory M. Cote, Andrew J. Wagner
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (4): 628–638.
https://doi.org/10.1158/1078-0432.CCR-24-2583
Published: 17 February 2025
View articletitled, A Phase I Study of FHD-609, a Heterobifunctional Degrader of Bromodomain-Containing Protein 9, in Patients with Advanced Synovial Sarcoma or SMARCB1-Deficient Tumors
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Includes: Supplementary data
Journal Articles

Active Surveillance in Patients with Extra-abdominal Desmoid-Type Fibromatosis: A Pooled Analysis of Three Prospective Observational Studies

Open Access
Chiara Colombo, Stefanie Hakkesteegt, Axel Le Cesne, Francesco Barretta, Jean-Yves Blay, Dirk J. Grünhagen, Nicolas Penel, Laurent Lam, Marco Fiore, Elena Palassini, Giovanni Grignani, Francesco Tolomeo, Paola Collini, Alessandra Merlini, Federica Perrone, Silvia Stacchiotti, Cornelis Verhoef, for the Dutch Grafiti Group, Sylvie Bonvalot, for the French Sarcoma Group, Alessandro Gronchi
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (3): 603–610.
https://doi.org/10.1158/1078-0432.CCR-24-2340
Published: 03 February 2025
View articletitled, Active Surveillance in Patients with Extra-abdominal Desmoid-Type Fibromatosis: A Pooled Analysis of Three Prospective Observational Studies
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Includes: Supplementary data
Journal Articles

Lack of Prognostic Value of CTNNB1 Mutation Profile in Desmoid-Type Fibromatosis

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Nicolas Penel, Sylvie Bonvalot, André-Michel Bimbai, Alexandra Meurgey, François Le Loarer, Sébastien Salas, Sophie Piperno-Neumann, Christine Chevreau, Pascaline Boudou-Rouquette, Pascale Dubray-Longeras, Jean-Emmanuel Kurtz, Cécile Guillemet, Emmanuelle Bompas, Antoine Italiano, Axel Le Cesne, Daniel Orbach, Julien Thery, Marie-Cécile Le Deley, Jean-Yves Blay, Olivier Mir
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (18): 4105–4111.
https://doi.org/10.1158/1078-0432.CCR-21-4235
Published: 15 September 2022
View articletitled, Lack of Prognostic Value of CTNNB1 Mutation Profile in Desmoid-Type Fibromatosis
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Includes: Supplementary data
Journal Articles

Abstract A038: Enrollment of pediatric and adolescent patients with MAGE-A4+ advanced synovial sarcoma into cohort 2 of SPEARHEAD-1: a phase 2 trial of afamitresgene autoleucel (“afami-cel” [formerly ADP-A2M4])

Free
Colin Lunt, Sandra P. D’Angelo, Albiruni Ryan Abdul Razak, Michael J. Wagner, Brian A. Van Tine, Kristen Ganjoo, Jean-Yves Blay, Dejka M. Araujo, Mark Agulnik, John W. Glod, Erin Van Winkle, Erica Elefant, Swethajit Biswas, Dennis Williams, Axel Le Cesne
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (18_Supplement): A038.
https://doi.org/10.1158/1557-3265.SARCOMAS22-A038
Published: 15 September 2022
View articletitled, Abstract A038: Enrollment of pediatric and adolescent patients with MAGE-A4+ advanced synovial sarcoma into cohort 2 of SPEARHEAD-1: a phase 2 trial of afamitresgene autoleucel (“afami-cel” [formerly ADP-A2M4])
Journal Articles

Trabectedin plus Durvalumab in Patients with Advanced Pretreated Soft Tissue Sarcoma and Ovarian Carcinoma (TRAMUNE): An Open-Label, Multicenter Phase Ib Study

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Maud Toulmonde, Mehdi Brahmi, Antoine Giraud, Camille Chakiba, Alban Bessede, Michèle Kind, Emilie Toulza, Marina Pulido, Sabrina Albert, Jean-Philippe Guégan, Sophie Cousin, Simone Mathoulin-Pelissier, Raul Perret, Sabrina Croce, Jean-Yves Blay, Isabelle Ray-Coquard, Anne Floquet, Antoine Italiano
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (9): 1765–1772.
https://doi.org/10.1158/1078-0432.CCR-21-2258
Published: 02 May 2022
View articletitled, Trabectedin plus Durvalumab in Patients with Advanced Pretreated Soft Tissue Sarcoma and Ovarian Carcinoma (TRAMUNE): An Open-Label, Multicenter Phase Ib Study
Open the PDF for Trabectedin plus Durvalumab in Patients with Advanced Pretreated Soft Tissue Sarcoma and Ovarian Carcinoma (TRAMUNE): An Open-Label, Multicenter Phase Ib Study in another window
Includes: Supplementary data
Journal Articles

Adjuvant Imatinib in Patients with GIST Harboring Exon 9 KIT Mutations: Results from a Multi-institutional European Retrospective Study

Open Access
Bruno Vincenzi, Andrea Napolitano, Marta Fiocco, Olivier Mir, Piotr Rutkowski, Jean-Yves Blay, Peter Reichardt, Heikki Joensuu, Elena Fumagalli, Spyridon Gennatas, Nadia Hindi, Margherita Nannini, Mariella Spalato Ceruso, Antoine Italiano, Giovanni Grignani, Antonella Brunello, Silvia Gasperoni, Tommaso De Pas, Giuseppe Badalamenti, Maria A. Pantaleo, Winan J. van Houdt, Nikki S. IJzerman, Neeltje Steeghs, Hans Gelderblom, Ingrid M.E. Desar, Johanna Falkenhorst, Marianna Silletta, Marta Sbaraglia, Giuseppe Tonini, Javier Martin-Broto, Peter Hohenberger, Axel Le Cesne, Robin L. Jones, Angelo P. Dei Tos, Alessandro Gronchi, Sebastian Bauer, Paolo G. Casali
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (8): 1672–1679.
https://doi.org/10.1158/1078-0432.CCR-21-1665
Published: 14 April 2022
View articletitled, Adjuvant Imatinib in Patients with GIST Harboring Exon 9 KIT Mutations: Results from a Multi-institutional European Retrospective Study
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Includes: Supplementary data
Journal Articles

Co-Targeting of MDM2 and CDK4/6 with Siremadlin and Ribociclib for the Treatment of Patients with Well-Differentiated or Dedifferentiated Liposarcoma: Results from a Proof-of-Concept, Phase Ib Study

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Albiruni R. Abdul Razak, Sebastian Bauer, Cristina Suarez, Chia-Chi Lin, Richard Quek, Marie Luise Hütter-Krönke, Ricardo Cubedo, Stephane Ferretti, Nelson Guerreiro, Astrid Jullion, Elena J. Orlando, Giorgia Clementi, Janna Sand Dejmek, Ensar Halilovic, Claire Fabre, Jean-Yves Blay, Antoine Italiano
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (6): 1087–1097.
https://doi.org/10.1158/1078-0432.CCR-21-1291
Published: 14 March 2022
View articletitled, Co-Targeting of MDM2 and CDK4/6 with Siremadlin and Ribociclib for the Treatment of Patients with Well-Differentiated or Dedifferentiated Liposarcoma: Results from a Proof-of-Concept, Phase Ib Study
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Includes: Supplementary data
Journal Articles

Comprehensive Molecular Analysis of Inflammatory Myofibroblastic Tumors Reveals Diverse Genomic Landscape and Potential Predictive Markers for Response to Crizotinib

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Che-Jui Lee, Patrick Schöffski, Elodie Modave, Tom van Wezel, Bram Boeckx, Jozef Sufliarsky, Hans Gelderblom, Jean-Yves Blay, Maria Debiec-Rychter, Raf Sciot, Judith V.M.G. Bovée, Diether Lambrechts, Agnieszka Wozniak
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (24): 6737–6748.
https://doi.org/10.1158/1078-0432.CCR-21-1165
Published: 15 December 2021
View articletitled, Comprehensive Molecular Analysis of Inflammatory Myofibroblastic Tumors Reveals Diverse Genomic Landscape and Potential Predictive Markers for Response to Crizotinib
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Includes: Supplementary data
Journal Articles

Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study

Open Access
Sebastian Bauer, Michael C. Heinrich, Suzanne George, John R. Zalcberg, César Serrano, Hans Gelderblom, Robin L. Jones, Steven Attia, Gina D'Amato, Ping Chi, Peter Reichardt, Julie Meade, Ying Su, Rodrigo Ruiz-Soto, Jean-Yves Blay, Margaret von Mehren, Patrick Schöffski
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (23): 6333–6342.
https://doi.org/10.1158/1078-0432.CCR-21-1864
Published: 01 December 2021
View articletitled, Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study
Open the PDF for Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study in another window
Includes: Supplementary data
Journal Articles

Circulating Tumor DNA Genomics Reveal Potential Mechanisms of Resistance to BRAF-Targeted Therapies in Patients with BRAF-Mutant Metastatic Non–Small Cell Lung Cancer

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Sandra Ortiz-Cuaran, Laura Mezquita, Aurélie Swalduz, Mihalea Aldea, Julien Mazieres, Camille Leonce, Cecile Jovelet, Anne Pradines, Virginie Avrillon, Washington R. Chumbi Flores, Ludovic Lacroix, Yohann Loriot, Virginie Westeel, Maud Ngo-Camus, Claire Tissot, Christine Raynaud, Radj Gervais, Etienne Brain, Isabelle Monnet, Etienne Giroux Leprieur, Caroline Caramella, Celine Mahier-Aït Oukhatar, Natalie Hoog-Labouret, Frank de Kievit, Karen Howarth, Clive Morris, Emma Green, Luc Friboulet, Sylvie Chabaud, Jean-François Guichou, Maurice Perol, Benjamin Besse, Jean-Yves Blay, Pierre Saintigny, David Planchard
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (23): 6242–6253.
https://doi.org/10.1158/1078-0432.CCR-20-1037
Published: 01 December 2020
View articletitled, Circulating Tumor DNA Genomics Reveal Potential Mechanisms of Resistance to BRAF-Targeted Therapies in Patients with BRAF-Mutant Metastatic Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Role of Chemotherapy, VEGFR Inhibitors, and mTOR Inhibitors in Advanced Perivascular Epithelioid Cell Tumors (PEComas)

Free
Roberta Sanfilippo, Robin L. Jones, Jean-Yves Blay, Axel Le Cesne, Salvatore Provenzano, Georgios Antoniou, Olivier Mir, Giovanni Fucà, Elena Fumagalli, Rossella Bertulli, Silvia Stacchiotti, Mehdi Brahmi, Federica Grosso, Armelle Dufresne, Nadia Hindi, Marta Sbaraglia, Alessandro Gronchi, Paola Collini, Angelo P. Dei Tos, Paolo G. Casali
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (17): 5295–5300.
https://doi.org/10.1158/1078-0432.CCR-19-0288
Published: 03 September 2019
View articletitled, Role of Chemotherapy, VEGFR Inhibitors, and mTOR Inhibitors in Advanced Perivascular Epithelioid Cell Tumors (PEComas)
Open the PDF for Role of Chemotherapy, VEGFR Inhibitors, and mTOR Inhibitors in Advanced Perivascular Epithelioid Cell Tumors (PEComas) in another window
Includes: Supplementary data
Journal Articles

Correction: Activity and Safety of Palbociclib in Patients with Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib: A Biomarker-driven Phase II Study

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Maud Toulmonde, Jean-Yves Blay, Olivier Bouche, Olivier Mir, Nicolas Penel, Nicolas Isambert, Florence Duffaud, Emmanuelle Bompas, Thomas Esnaud, Romain Boidot, Damien Geneste, François Ghiringhelli, Carlo Lucchesi, Carine A. Bellera, François Le Loarer, Antoine Italiano
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (15): 4859.
https://doi.org/10.1158/1078-0432.CCR-19-1599
Published: 01 August 2019
View articletitled, Correction: Activity and Safety of Palbociclib in Patients with Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib: A Biomarker-driven Phase II Study
Open the PDF for Correction: Activity and Safety of Palbociclib in Patients with Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib: A Biomarker-driven Phase II Study in another window
Journal Articles

Activity and Safety of Palbociclib in Patients with Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib: A Biomarker-driven Phase II Study

Free
Maud Toulmonde, Jean-Yves Blay, Olivier Bouche, Olivier Mir, Nicolas Penel, Nicolas Isambert, Florence Duffaud, Emmanuelle Bompas, Thomas Esnaud, Romain Boidot, Damien Geneste, François Ghiringhelli, Carlo Lucchesi, Carine A. Bellera, François Le Loarer, Antoine Italiano
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (15): 4611–4615.
https://doi.org/10.1158/1078-0432.CCR-18-3127
Published: 01 August 2019
View articletitled, Activity and Safety of Palbociclib in Patients with Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib: A Biomarker-driven Phase II Study
Open the PDF for Activity and Safety of Palbociclib in Patients with Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib: A Biomarker-driven Phase II Study in another window
Includes: Supplementary data
Journal Articles

Predicting Survival in Patients Undergoing Resection for Locally Recurrent Retroperitoneal Sarcoma: A Study and Novel Nomogram from TARPSWG

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Chandrajit P. Raut, Dario Callegaro, Rosalba Miceli, Francesco Barretta, Piotr Rutkowski, Jean-Yves Blay, Guy Lahat, Dirk C. Strauss, Ricardo Gonzalez, Nita Ahuja, Giovanni Grignani, Vittorio Quagliuolo, Eberhard Stoeckle, Antonino De Paoli, Venu G. Pillarisetty, Carolyn Nessim, Carol J. Swallow, Sanjay Bagaria, Robert Canter, John Mullen, Hans J. Gelderblom, Elisabetta Pennacchioli, Frits van Coevorden, Kenneth Cardona, Marco Fiore, Mark Fairweather, Alessandro Gronchi
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (8): 2664–2671.
https://doi.org/10.1158/1078-0432.CCR-18-2700
Published: 15 April 2019
View articletitled, Predicting Survival in Patients Undergoing Resection for Locally Recurrent Retroperitoneal Sarcoma: A Study and Novel Nomogram from TARPSWG
Open the PDF for Predicting Survival in Patients Undergoing Resection for Locally Recurrent Retroperitoneal Sarcoma: A Study and Novel Nomogram from TARPSWG in another window
Includes: Supplementary data
Journal Articles

Impact of Concomitant Administration of Gastric Acid–Suppressive Agents and Pazopanib on Outcomes in Soft-Tissue Sarcoma Patients Treated within the EORTC 62043/62072 Trials

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Olivier Mir, Nathan Touati, Michela Lia, Saskia Litière, Axel Le Cesne, Stefan Sleijfer, Jean-Yves Blay, Michael Leahy, Robin Young, Ron H.J. Mathijssen, Nielka P. Van Erp, Hans Gelderblom, Winette T. Van der Graaf, Alessandro Gronchi
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (5): 1479–1485.
https://doi.org/10.1158/1078-0432.CCR-18-2748
Published: 01 March 2019
View articletitled, Impact of Concomitant Administration of Gastric Acid–Suppressive Agents and Pazopanib on Outcomes in Soft-Tissue Sarcoma Patients Treated within the EORTC 62043/62072 Trials
Open the PDF for Impact of Concomitant Administration of Gastric Acid–Suppressive Agents and Pazopanib on Outcomes in Soft-Tissue Sarcoma Patients Treated within the EORTC 62043/62072 Trials in another window
Includes: Supplementary data
Journal Articles

Abstract B32: Lymphocytes and immune checkpoint biomarker expression in sarcomas

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Amanda R. Dancsok, David Thomas, Jean-Yves Blay, Robert G. Maki, Torsten O. Nielsen, Elizabeth G. Demicco
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (2_Supplement): B32.
https://doi.org/10.1158/1557-3265.SARCOMAS17-B32
Published: 15 January 2018
View articletitled, Abstract B32: Lymphocytes and immune checkpoint biomarker expression in sarcomas
Journal Articles

Abstract CN1-2: Mutations and expression profile to guide treatment in sarcomas and GIST

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Jean-Yves Blay
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (7_Supplement): CN1-2.
https://doi.org/10.1158/1078-0432.TCME10-CN1-2
Published: 02 February 2016
View articletitled, Abstract CN1-2: Mutations and expression profile to guide treatment in sarcomas and GIST
Journal Articles

Gene Expression Profiling of Desmoid Tumors by cDNA Microarrays and Correlation with Progression-Free Survival

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Sébastien Salas, Celine Brulard, Philippe Terrier, Dominique Ranchere-Vince, Agnes Neuville, Louis Guillou, Marick Lae, Agnes Leroux, Olivier Verola, Kurtz Jean-Emmanuel, Sylvie Bonvalot, Jean-Yves Blay, Axel Le Cesne, Alain Aurias, Jean-Michel Coindre, Frederic Chibon
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2015) 21 (18): 4194–4200.
https://doi.org/10.1158/1078-0432.CCR-14-2910
Published: 14 September 2015
View articletitled, Gene Expression Profiling of Desmoid Tumors by cDNA Microarrays and Correlation with Progression-Free Survival
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Journal Articles

Tumor Genotype Is an Independent Prognostic Factor in Primary Gastrointestinal Stromal Tumors of Gastric Origin: A European Multicenter Analysis Based on ConticaGIST

Free
Agnieszka Wozniak, Piotr Rutkowski, Patrick Schöffski, Isabelle Ray-Coquard, Isabelle Hostein, Hans-Ulrich Schildhaus, Axel Le Cesne, Elzbieta Bylina, Janusz Limon, Jean-Yves Blay, Janusz A. Siedlecki, Eva Wardelmann, Raf Sciot, Jean-Michel Coindre, Maria Debiec-Rychter
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2014) 20 (23): 6105–6116.
https://doi.org/10.1158/1078-0432.CCR-14-1677
Published: 30 November 2014
View articletitled, Tumor Genotype Is an Independent Prognostic Factor in Primary Gastrointestinal Stromal Tumors of Gastric Origin: A European Multicenter Analysis Based on ConticaGIST
Open the PDF for Tumor Genotype Is an Independent Prognostic Factor in Primary Gastrointestinal Stromal Tumors of Gastric Origin: A European Multicenter Analysis Based on ConticaGIST in another window
Includes: Supplementary data
Journal Articles

DNA repair efficiency as a model for personalized therapy with Trabectedin

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Rafael Rosell, Federica Grosso, Patrick Schoffski, Paolo Casali, Robert Maki, Miquel Taron, Pedro Mendez, Imane Chaib, Antonio Nieto, Juan Carlos Tercero, Robin Jones, Ian Judson, Jean-Yves Blay, Axel Lecesne, Jose Jimeno
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (19_Supplement): A57.
Published: 15 August 2014
View articletitled, DNA repair efficiency as a model for personalized therapy with Trabectedin