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Jean-Pierre J. Issa
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Journal Articles

A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy

H. Josh Jang, Galen Hostetter, Alexander W. Macfarlane, Zachary Madaj, Eric A. Ross, Toshinori Hinoue, Justin R. Kulchycki, Ryan S. Burgos, Mahvish Tafseer, R. Katherine Alpaugh, Candice L. Schwebel, Rutika Kokate, Daniel M. Geynisman, Matthew R. Zibelman, Pooja Ghatalia, Peter W. Nichols, Woonbok Chung, Jozef Madzo, Noah M. Hahn, David I. Quinn, Jean-Pierre J. Issa, Michael J. Topper, Stephen B. Baylin, Hui Shen, Kerry S. Campbell, Peter A. Jones, Elizabeth R. Plimack
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (11): 2052–2065.
https://doi.org/10.1158/1078-0432.CCR-22-3642
Published: 01 June 2023
View article titled, A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy
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Includes: Supplementary data
Journal Articles

Abstract B22: Genome-wide methylation analysis reveals an independently validated CpG island methylator phenotype associated with favorable prognosis in acute myeloid leukemia.

Andrew D. Kelly, Heike Kroeger, Jumpei Yamazaki, Rodolphe Taby, Frank Neumann, Justin T. Lee, Rong He, Shoudan Liang, Yue Lu, Matteo Cesaroni, Sherry A. Pierce, Steven M. Kornblau, Carlos E. Bueso-Ramos, Farhad Ravandi, Hagop M. Kantarjian, Jean-Pierre J. Issa, Jaroslav Jelinek
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (17_Supplement): B22.
https://doi.org/10.1158/1557-3265.HEMMAL14-B22
Published: 19 August 2015
View article titled, Abstract B22: Genome-wide methylation analysis reveals an independently validated CpG island methylator phenotype associated with favorable prognosis in acute myeloid leukemia.
Journal Articles

Progesterone Receptor Isoform-Specific Promoter Methylation: Association of PRA Promoter Methylation with Worse Outcome in Breast Cancer Patients

Thushangi N. Pathiraja, Priya B. Shetty, Jaroslav Jelinek, Rong He, Ryan Hartmaier, Astrid L. Margossian, Susan G. Hilsenbeck, Jean-Pierre J. Issa, Steffi Oesterreich
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (12): 4177–4186.
https://doi.org/10.1158/1078-0432.CCR-10-2950
Published: 15 June 2011
View article titled, Progesterone Receptor Isoform-Specific Promoter Methylation: Association of <em>PRA</em> Promoter Methylation with Worse Outcome in Breast Cancer Patients
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Includes: Supplementary data
Journal Articles

Targeting DNA Methylation

Jean-Pierre J. Issa, Hagop M. Kantarjian
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (12): 3938–3946.
https://doi.org/10.1158/1078-0432.CCR-08-2783
Published: 15 June 2009
View article titled, Targeting DNA Methylation
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Journal Articles

Epigenetic-Genetic Interactions in the APC/WNT, RAS/RAF, and P53 Pathways in Colorectal Carcinoma

Yutaka Suehiro, Chi Wai Wong, Lucian R. Chirieac, Yutaka Kondo, Lanlan Shen, C. Renee Webb, Yee Wai Chan, Annie S.Y. Chan, Tsun Leung Chan, Tsung-Teh Wu, Asif Rashid, Yuichiro Hamanaka, Yuji Hinoda, Rhonda L. Shannon, Xuemei Wang, Jeffrey Morris, Jean-Pierre J. Issa, Siu Tsan Yuen, Suet Yi Leung, Stanley R. Hamilton
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (9): 2560–2569.
https://doi.org/10.1158/1078-0432.CCR-07-1802
Published: 01 May 2008
View article titled, Epigenetic-Genetic Interactions in the <em>APC/WNT, RAS/RAF</em>, and <em>P53</em> Pathways in Colorectal Carcinoma
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Journal Articles

Association between DNA Methylation and Shortened Survival in Patients with Advanced Colorectal Cancer Treated with 5-Fluorouracil–Based Chemotherapy

Lanlan Shen, Paul J. Catalano, Al B. Benson, III, Peter O'Dwyer, Stanley R. Hamilton, Jean-Pierre J. Issa
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (20): 6093–6098.
https://doi.org/10.1158/1078-0432.CCR-07-1011
Published: 18 October 2007
View article titled, Association between DNA Methylation and Shortened Survival in Patients with Advanced Colorectal Cancer Treated with 5-Fluorouracil–Based Chemotherapy
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Journal Articles

Effect of Cytarabine and Decitabine in Combination in Human Leukemic Cell Lines

Taichun Qin, Emile M. Youssef, Jaroslav Jelinek, Rong Chen, Allen S. Yang, Guillermo Garcia-Manero, Jean-Pierre J. Issa
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (14): 4225–4232.
https://doi.org/10.1158/1078-0432.CCR-06-2762
Published: 18 July 2007
View article titled, Effect of Cytarabine and Decitabine in Combination in Human Leukemic Cell Lines
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Journal Articles

Age-Related DNA Methylation Changes in Normal Human Prostate Tissues

Bernard Kwabi-Addo, Woonbok Chung, Lanlan Shen, Michael Ittmann, Thomas Wheeler, Jaroslav Jelinek, Jean-Pierre J. Issa
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (13): 3796–3802.
https://doi.org/10.1158/1078-0432.CCR-07-0085
Published: 02 July 2007
View article titled, Age-Related DNA Methylation Changes in Normal Human Prostate Tissues
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Journal Articles

DNA Methylation as a Therapeutic Target in Cancer

Jean-Pierre J. Issa
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (6): 1634–1637.
https://doi.org/10.1158/1078-0432.CCR-06-2076
Published: 15 March 2007
View article titled, DNA Methylation as a Therapeutic Target in Cancer
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Journal Articles

Phase I Trial of Sequential Low-Dose 5-Aza-2′-Deoxycytidine Plus High-Dose Intravenous Bolus Interleukin-2 in Patients with Melanoma or Renal Cell Carcinoma

Jared A. Gollob, Catherine J. Sciambi, Bercedis L. Peterson, Tina Richmond, Monica Thoreson, Kelly Moran, Holly K. Dressman, Jaroslav Jelinek, Jean-Pierre J. Issa
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (15): 4619–4627.
https://doi.org/10.1158/1078-0432.CCR-06-0883
Published: 09 August 2006
View article titled, Phase I Trial of Sequential Low-Dose 5-Aza-2′-Deoxycytidine Plus High-Dose Intravenous Bolus Interleukin-2 in Patients with Melanoma or Renal Cell Carcinoma
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Journal Articles

Differential Methylation Status of Tumor-Associated Genes in Head and Neck Squamous Carcinoma: Incidence and Potential Implications

Shin-ichiro Maruya, Jean-Pierre J. Issa, Randal S. Weber, David I. Rosenthal, Joie C. Haviland, Reuben Lotan, Adel K. El-Naggar
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (11): 3825–3830.
https://doi.org/10.1158/1078-0432.CCR-03-0370
Published: 01 June 2004
View article titled, Differential Methylation Status of Tumor-Associated Genes in Head and Neck Squamous Carcinoma: <subtitle>Incidence and Potential Implications</subtitle>
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Journal Articles

Identification of HRK as a Target of Epigenetic Inactivation in Colorectal and Gastric Cancer

Toshiro Obata, Minoru Toyota, Ayumi Satoh, Yasushi Sasaki, Kazuhiro Ogi, Kimishige Akino, Hiromu Suzuki, Masafumi Murai, Takefumi Kikuchi, Hiroaki Mita, Fumio Itoh, Jean-Pierre J. Issa, Takashi Tokino, Kohzoh Imai
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (17): 6410–6418.
Published: 24 December 2003
View article titled, Identification of <em>HRK</em> as a Target of Epigenetic Inactivation in Colorectal and Gastric Cancer
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Journal Articles

Methylation and Prognosis: Of Molecular Clocks and Hypermethylator Phenotypes

Jean-Pierre J. Issa
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (8): 2879–2881.
Published: 11 August 2003
View article titled, Methylation and Prognosis: <subtitle>Of Molecular Clocks and Hypermethylator Phenotypes</subtitle>
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Journal Articles

Imatinib Mesylate for Philadelphia Chromosome-positive, Chronic-Phase Myeloid Leukemia after Failure of Interferon-α: Follow-Up Results

Hagop M. Kantarjian, Moshe Talpaz, Susan O’Brien, Terry L. Smith, Francis J. Giles, Stefan Faderl, Deborah A. Thomas, Guillermo Garcia-Manero, Jean-Pierre J. Issa, Michael Andreeff, Steven M. Kornblau, Charles Koller, Milosav Beran, Michael Keating, Mary Beth Rios, Jenny Shan, Debra Resta, Renaud Capdeville, Kimberly Hayes, Maher Albitar, Emil J. Freireich, Jorge E. Cortes
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (7): 2177–2187.
Published: 01 July 2002
View article titled, Imatinib Mesylate for Philadelphia Chromosome-positive, Chronic-Phase Myeloid Leukemia after Failure of Interferon-α: <subtitle>Follow-Up Results</subtitle>
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Journal Articles

Treatment of Philadelphia Chromosome-positive, Accelerated-phase Chronic Myelogenous Leukemia with Imatinib Mesylate

Hagop M. Kantarjian, Susan O’Brien, Jorge E. Cortes, Terry L. Smith, Mary Beth Rios, Jianqin Shan, Ying Yang, Francis J. Giles, Deborah A. Thomas, Stefan Faderl, Guillermo Garcia-Manero, Sima Jeha, William Wierda, Jean-Pierre J. Issa, Steven M. Kornblau, Michael Keating, Debra Resta, Renaud Capdeville, Moshe Talpaz
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (7): 2167–2176.
Published: 01 July 2002
View article titled, Treatment of Philadelphia Chromosome-positive, Accelerated-phase Chronic Myelogenous Leukemia with Imatinib Mesylate
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Journal Articles

DNA Methylation of Multiple Promoter-associated CpG Islands in Adult Acute Lymphocytic Leukemia

Guillermo Garcia-Manero, Jerry Daniel, Terry L. Smith, Steven M. Kornblau, Ming-Sheng Lee, Hagop M. Kantarjian, Jean-Pierre J. Issa
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (7): 2217–2224.
Published: 01 July 2002
View article titled, DNA Methylation of Multiple Promoter-associated CpG Islands in Adult Acute Lymphocytic Leukemia
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Journal Articles

DNA Methylation Patterns at Relapse in Adult Acute Lymphocytic Leukemia

Guillermo Garcia-Manero, Carlos Bueso-Ramos, Jerry Daniel, Jason Williamson, Hagop M. Kantarjian, Jean-Pierre J. Issa
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (6): 1897–1903.
Published: 01 June 2002
View article titled, DNA Methylation Patterns at Relapse in Adult Acute Lymphocytic Leukemia
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Journal Articles

Estrogen Receptor Methylation Is Associated with Improved Survival in Adult Acute Myeloid Leukemia

Qing Li, Kenneth J. Kopecky, Avinash Mohan, Cheryl L. Willman, Frederick R. Appelbaum, James K. Weick, Jean-Pierre J. Issa
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (5): 1077–1084.
Published: 01 May 1999
View article titled, Estrogen Receptor Methylation Is Associated with Improved Survival in Adult Acute Myeloid Leukemia
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